US7053070B2
(en)
*
|
2000-01-25 |
2006-05-30 |
Warner-Lambert Company |
Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
|
DK1417207T3
(da)
*
|
2000-08-04 |
2005-12-27 |
Warner Lambert Co |
Fremgangsmåde til fremstilling af 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-oner
|
WO2002012237A2
(en)
*
|
2000-08-04 |
2002-02-14 |
Warner-Lambert Company |
Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones
|
ES2249574T3
(es)
*
|
2001-02-12 |
2006-04-01 |
F. Hoffmann-La Roche Ag |
Pirido-pirimidinas 6-sustituidas.
|
CA2438294C
(en)
*
|
2001-02-26 |
2008-10-21 |
Tanabe Seiyaku Co., Ltd. |
Pyridopyrimidine or naphthyridine derivative
|
WO2003000270A1
(en)
*
|
2001-06-21 |
2003-01-03 |
Ariad Pharmaceuticals, Inc. |
Novel pyridopyrimidones and uses thereof
|
US20050154046A1
(en)
*
|
2004-01-12 |
2005-07-14 |
Longgui Wang |
Methods of treating an inflammatory-related disease
|
ME00230B
(me)
|
2002-01-22 |
2011-02-10 |
|
2-(piridin -2-ilamino)-pirido(2,3-d) pirimidin-7-oni
|
AU2003251661A1
(en)
|
2002-08-06 |
2004-02-25 |
F. Hoffmann-La Roche Ag |
6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
|
US7129351B2
(en)
|
2002-11-04 |
2006-10-31 |
Hoffmann-La Roche Inc. |
Pyrimido compounds having antiproliferative activity
|
US7759336B2
(en)
|
2002-12-10 |
2010-07-20 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing heterocyclic compounds and medicinal use thereof
|
KR100864393B1
(ko)
|
2003-04-10 |
2008-10-20 |
에프. 호프만-라 로슈 아게 |
피리미도 화합물
|
DE602004017474D1
(de)
*
|
2003-07-11 |
2008-12-11 |
Warner Lambert Co |
Isethionat salz eines selektiven cdk4 inhibitors
|
EP1651612B9
(en)
|
2003-07-22 |
2012-09-05 |
Astex Therapeutics Limited |
3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
|
WO2005011654A2
(en)
*
|
2003-07-29 |
2005-02-10 |
Xenon Pharmaceuticals Inc. |
Pyridyl derivatives and their use as therapeutic agents
|
JP4616839B2
(ja)
*
|
2003-11-13 |
2011-01-19 |
エフ.ホフマン−ラ ロシュ アーゲー |
ヒドロキシアルキル置換ピリド−7−ピリミジン−7−オン類
|
US20050171182A1
(en)
*
|
2003-12-11 |
2005-08-04 |
Roger Briesewitz |
Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
|
CA2553785C
(en)
*
|
2004-02-14 |
2011-02-08 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
WO2005082903A1
(en)
*
|
2004-02-18 |
2005-09-09 |
Warner-Lambert Company Llc |
2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
|
CA2561516A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Pfizer Products Inc. |
Combinations of signal transduction inhibitors
|
US7378423B2
(en)
|
2004-06-11 |
2008-05-27 |
Japan Tobacco Inc. |
Pyrimidine compound and medical use thereof
|
CN101912400B
(zh)
*
|
2004-06-11 |
2013-06-26 |
日本烟草产业株式会社 |
用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物
|
BRPI0517701A8
(pt)
|
2004-11-10 |
2018-01-23 |
Genzyme Corp |
métodos de tratamento de diabetes mellitus
|
US20060142312A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Pfizer Inc |
C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
|
AR054425A1
(es)
|
2005-01-21 |
2007-06-27 |
Astex Therapeutics Ltd |
Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
|
US8404718B2
(en)
|
2005-01-21 |
2013-03-26 |
Astex Therapeutics Limited |
Combinations of pyrazole kinase inhibitors
|
CA2593475A1
(en)
*
|
2005-01-21 |
2006-07-27 |
Astex Therapeutics Limited |
Combinations of pyrazole kinase inhibitors and further antitumor agents
|
US20080161251A1
(en)
*
|
2005-01-21 |
2008-07-03 |
Astex Therapeutics Limited |
Pharmaceutical Compounds
|
BRPI0606455A
(pt)
*
|
2005-01-21 |
2008-03-11 |
Astex Therapeutics Ltd |
compostos farmacêuticos
|
WO2006090853A1
(ja)
|
2005-02-25 |
2006-08-31 |
Ono Pharmaceutical Co., Ltd. |
含窒素複素環化合物およびその医薬用途
|
TWI389690B
(zh)
*
|
2005-03-25 |
2013-03-21 |
Glaxo Group Ltd |
新穎化合物(一)
|
TW200724142A
(en)
*
|
2005-03-25 |
2007-07-01 |
Glaxo Group Ltd |
Novel compounds
|
MY153424A
(en)
|
2005-05-10 |
2015-02-13 |
Incyte Corp |
Modulators of indoleamine 2,3-dioxygenase and methods of using the same
|
KR100734837B1
(ko)
*
|
2005-09-16 |
2007-07-03 |
한국전자통신연구원 |
다중 생체 인식 시스템 및 그 방법
|
WO2007036791A1
(en)
*
|
2005-09-28 |
2007-04-05 |
Ranbaxy Laboratories Limited |
Pyrido-pyridimidine derivatives useful as antiinflammatory agents
|
CN102746298A
(zh)
*
|
2005-10-07 |
2012-10-24 |
埃克塞里艾克西斯公司 |
PI3Kα的吡啶并嘧啶酮抑制剂
|
CA2623770C
(en)
*
|
2005-10-07 |
2014-05-27 |
Exelixis, Inc. |
Pyridopyrimidinone inhibitors of pi3k.alpha.
|
WO2007129062A1
(en)
*
|
2006-05-08 |
2007-11-15 |
Astex Therapeutics Limited |
Pharmaceutical combinations of diazole derivatives for cancer treatment
|
WO2007134086A2
(en)
|
2006-05-09 |
2007-11-22 |
Genzyme Corporation |
Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
|
WO2008032157A2
(en)
*
|
2006-09-08 |
2008-03-20 |
Pfizer Products Inc. |
Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
|
PT2074122E
(pt)
|
2006-09-15 |
2011-08-24 |
Pfizer Prod Inc |
Compostos de pirido(2,3-d)-pirimidinona e sua utilização como inibidores de pi3
|
CA2665384A1
(en)
*
|
2006-10-16 |
2008-04-24 |
Gpc Biotech Inc. |
Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors
|
EP1914234A1
(en)
|
2006-10-16 |
2008-04-23 |
GPC Biotech Inc. |
Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
|
WO2008150260A1
(en)
*
|
2007-06-06 |
2008-12-11 |
Gpc Biotech, Inc. |
8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
|
EP2094698A1
(en)
*
|
2006-11-09 |
2009-09-02 |
F. Hoffmann-Roche AG |
Substituted 6-phenyl-pyrido [2,3-d]pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
CA2701649C
(en)
|
2007-10-05 |
2016-05-24 |
Genzyme Corporation |
Method of treating polycystic kidney diseases with ceramide derivatives
|
EP2231656A1
(en)
|
2007-12-19 |
2010-09-29 |
Amgen Inc. |
Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
|
JP5530422B2
(ja)
|
2008-04-07 |
2014-06-25 |
アムジエン・インコーポレーテツド |
細胞周期阻害薬としてのgem−二置換およびスピロ環式アミノピリジン/ピリミジン
|
EP2112150B1
(en)
|
2008-04-22 |
2013-10-16 |
Forma Therapeutics, Inc. |
Improved raf inhibitors
|
EP2824100B1
(en)
|
2008-07-08 |
2018-02-21 |
Incyte Holdings Corporation |
1,2,5-Oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
|
JP2011529500A
(ja)
|
2008-07-28 |
2011-12-08 |
ジェンザイム コーポレーション |
虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害
|
US8685980B2
(en)
*
|
2008-08-22 |
2014-04-01 |
Novartis Ag |
Pyrrolopyrimidine compounds and their uses
|
JP2012504646A
(ja)
*
|
2008-10-01 |
2012-02-23 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
選択的サイクリン依存性キナーゼ4/6阻害剤を用いた化学療法化合物に対する造血系の防護
|
CN102231983A
(zh)
*
|
2008-10-01 |
2011-11-02 |
北卡罗来纳大学查珀尔希尔分校 |
使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗电离辐射的造血防护
|
WO2010039256A1
(en)
|
2008-10-03 |
2010-04-08 |
Genzyme Corporation |
2-acylaminopropoanol-type glucosylceramide synthase inhibitors
|
PA8852901A1
(es)
*
|
2008-12-22 |
2010-07-27 |
Lilly Co Eli |
Inhibidores de proteina cinasa
|
SG173178A1
(en)
|
2009-04-03 |
2011-09-29 |
Hoffmann La Roche |
Propane- i-sulfonic acid {3- [5- (4 -chloro-phenyl) -1h-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
|
ES2561216T3
(es)
|
2009-05-13 |
2016-02-25 |
The University Of North Carolina At Chapel Hill |
Inhibidores de cinasas dependientes de ciclina y procedimientos de uso
|
JPWO2011025006A1
(ja)
*
|
2009-08-31 |
2013-01-31 |
日本ケミファ株式会社 |
Gpr119作動薬
|
KR20120104200A
(ko)
*
|
2009-10-09 |
2012-09-20 |
아프락시스 인코포레이티드 |
Cns 장애의 치료를 위한 8에틸6(아릴)피리도[2,3d]피리미딘7(8h)온
|
WO2011057022A1
(en)
|
2009-11-06 |
2011-05-12 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
WO2011075616A1
(en)
*
|
2009-12-18 |
2011-06-23 |
Temple University - Of The Commonwealth System Of Higher Education |
Substituted pyrido[2,3-d]pyrimidin-7(8h)-ones and therapeutic uses thereof
|
PH12012501361A1
(en)
|
2009-12-31 |
2012-10-22 |
Centro Nac De Investigaciones Oncologicas Cnio |
Tricyclic compounds for use as kinase inhibitors
|
US20130035336A1
(en)
|
2010-04-13 |
2013-02-07 |
Novartis Ag |
Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase (cdk4/6) inhibitor for treating cancer
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
US8680099B2
(en)
*
|
2010-06-10 |
2014-03-25 |
Afraxis Holdings, Inc. |
6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders
|
EP4438734A3
(en)
|
2010-06-14 |
2024-12-25 |
The Scripps Research Institute |
Reprogramming of cells to a new fate
|
WO2012018540A1
(en)
|
2010-08-05 |
2012-02-09 |
Temple University - Of The Commonwealth System Of Higher Education |
2-substituted-8-alkyl-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidine-6-carbonitriles and uses thereof
|
LT2632467T
(lt)
|
2010-10-25 |
2016-09-12 |
G1 Therapeutics, Inc. |
Cdk inhibitoriai
|
US8691830B2
(en)
|
2010-10-25 |
2014-04-08 |
G1 Therapeutics, Inc. |
CDK inhibitors
|
AU2011329763A1
(en)
|
2010-11-17 |
2013-05-09 |
Brigham And Women's Hospital |
Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
|
US8754114B2
(en)
|
2010-12-22 |
2014-06-17 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
|
WO2012098387A1
(en)
|
2011-01-18 |
2012-07-26 |
Centro Nacional De Investigaciones Oncológicas (Cnio) |
6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
|
DK2672967T3
(da)
|
2011-02-07 |
2019-01-02 |
Plexxikon Inc |
Forbindelser og fremgangsmåder til kinasemodulering og indikationer derfor
|
KR20160035613A
(ko)
|
2011-03-23 |
2016-03-31 |
암젠 인크 |
Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제
|
JP2014522396A
(ja)
|
2011-05-27 |
2014-09-04 |
テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション |
置換2−ベンジリデン−2H−ベンゾ[b][1,4]チアジン−3(4H)−オン、その誘導体及びその治療上の使用
|
DK2834237T3
(en)
*
|
2012-03-14 |
2018-08-27 |
Lupin Ltd |
HETEROCYCLYL COMPOUNDS AS MEK INHITORS
|
AU2013239816B2
(en)
|
2012-03-29 |
2017-08-24 |
G1 Therapeutics, Inc. |
Lactam kinase inhibitors
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
ME03300B
(me)
|
2012-06-13 |
2019-07-20 |
Incyte Holdings Corp |
Supsтituisana triciklična jedinjenja као inhibiтori fgfr
|
SG11201500125QA
(en)
|
2012-07-11 |
2015-02-27 |
Blueprint Medicines Corp |
Inhibitors of the fibroblast growth factor receptor
|
CA2880764C
(en)
|
2012-08-03 |
2022-08-30 |
Foundation Medicine, Inc. |
Human papilloma virus as predictor of cancer prognosis
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
MX361499B
(es)
|
2012-08-17 |
2018-12-06 |
Concert Pharmaceuticals Inc |
Baricitinib deuterado.
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
WO2014109858A1
(en)
|
2013-01-14 |
2014-07-17 |
Amgen Inc. |
Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
|
TR201816077T4
(tr)
|
2013-02-21 |
2018-11-21 |
Pfizer |
Seçici bir cdk4/6 inhibitörünün katı formları.
|
WO2014150925A2
(en)
|
2013-03-15 |
2014-09-25 |
Concert Pharmaceuticals, Inc. |
Deuterated palbociclib
|
DK2968290T3
(da)
|
2013-03-15 |
2019-11-25 |
G1 Therapeutics Inc |
Transient beskyttelse af normale celler under kemoterapi
|
CN107417691B
(zh)
|
2013-03-15 |
2020-06-26 |
G1治疗公司 |
高效的抗赘生剂和抗增生剂
|
TWI715901B
(zh)
|
2013-04-19 |
2021-01-11 |
美商英塞特控股公司 |
作為fgfr抑制劑之雙環雜環
|
CN104470921B
(zh)
*
|
2013-05-17 |
2017-05-03 |
上海恒瑞医药有限公司 |
吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
|
WO2014203129A1
(en)
|
2013-06-19 |
2014-12-24 |
Olema Pharmaceuticals, Inc. |
Combinations of benzopyran compounds, compositions and uses thereof
|
DK3395814T3
(da)
|
2013-10-25 |
2022-07-04 |
Blueprint Medicines Corp |
Hæmmere af fibroblastvækstfaktorreceptoren
|
ES3033810T3
(en)
*
|
2013-12-20 |
2025-08-08 |
Biomed Valley Discoveries Inc |
Cancer treatments using combinations of cdk and erk inhibitors
|
HUE039504T2
(hu)
|
2013-12-31 |
2019-01-28 |
Xuanzhu Pharma Co Ltd |
Kináz inhibitor és alkalmazása
|
US9949976B2
(en)
|
2013-12-31 |
2018-04-24 |
Xuanzhu Pharma Co., Ltd. |
Kinase inhibitor and use thereof
|
WO2015108992A1
(en)
|
2014-01-15 |
2015-07-23 |
Blueprint Medicines Corporation |
Heterobicyclic compounds and their use as fgfr4 receptor inhibitors
|
WO2015161287A1
(en)
|
2014-04-17 |
2015-10-22 |
G1 Therapeutics, Inc. |
Tricyclic lactams for use in the protection of normal cells during chemotherapy
|
EP3148532B1
(en)
|
2014-05-28 |
2021-03-03 |
Piramal Enterprises Limited |
Pharmaceutical combination comprising a cdk inhibitor and a thioredoxin reductase inhibitor for the treatment of cancer
|
US9878994B2
(en)
|
2014-07-24 |
2018-01-30 |
Beta Pharma Inc. |
2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof
|
WO2016015598A1
(en)
|
2014-07-26 |
2016-02-04 |
Sunshine Lake Pharma Co., Ltd. |
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
|
US20170217962A1
(en)
*
|
2014-07-31 |
2017-08-03 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of palbociclib
|
US20170224819A1
(en)
*
|
2014-08-11 |
2017-08-10 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor
|
US20170240543A1
(en)
*
|
2014-08-14 |
2017-08-24 |
Sun Pharmaceutical Industries Limited |
Crystalline forms of palbociclib
|
WO2016040848A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
|
EP3191098A4
(en)
|
2014-09-12 |
2018-04-25 |
G1 Therapeutics, Inc. |
Combinations and dosing regimes to treat rb-positive tumors
|
CN105111201B
(zh)
*
|
2014-10-16 |
2017-01-11 |
上海页岩科技有限公司 |
5-甲基-2-(吡啶-2-基氨基)-8H-吡啶并[2,3-d]嘧啶-7-酮化合物
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
WO2016066420A1
(en)
*
|
2014-10-29 |
2016-05-06 |
Sandoz Ag |
Crystalline forms of palbociclib monohydrochloride
|
CN105622638B
(zh)
*
|
2014-10-29 |
2018-10-02 |
广州必贝特医药技术有限公司 |
嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
|
CN105616418A
(zh)
*
|
2014-11-07 |
2016-06-01 |
江苏豪森药业集团有限公司 |
含有细胞周期蛋白抑制剂的药物制剂及其制备方法
|
EP3218005B1
(en)
|
2014-11-12 |
2023-01-04 |
Seagen Inc. |
Glycan-interacting compounds and methods of use
|
CN104447743B
(zh)
*
|
2014-11-26 |
2016-03-02 |
苏州明锐医药科技有限公司 |
帕博西尼的制备方法
|
CN104496983B
(zh)
|
2014-11-26 |
2016-06-08 |
苏州明锐医药科技有限公司 |
一种帕博西尼的制备方法
|
WO2016090257A1
(en)
*
|
2014-12-05 |
2016-06-09 |
Crystal Pharmatech Inc. |
Salts and crystalline forms of 6-acetyl-8-cyclopentyl-5-methyl-2((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d] pyrimidin-7(8h)-one (palbociclib)
|
WO2016092442A1
(en)
*
|
2014-12-08 |
2016-06-16 |
Sun Pharmaceutical Industries Limited |
Processes for the preparation of crystalline forms of palbociclib acetate
|
CN105732615B
(zh)
*
|
2014-12-31 |
2018-05-01 |
山东轩竹医药科技有限公司 |
Cdk激酶抑制剂
|
JP6581197B2
(ja)
|
2014-12-31 |
2019-09-25 |
深▲セン▼市薬欣生物科技有限公司Shenzhen Pharmacin Co., Ltd. |
医薬組成物及びその製造方法
|
CN104610254B
(zh)
*
|
2015-01-26 |
2017-02-01 |
新发药业有限公司 |
一种帕博赛布的低成本制备方法
|
CZ201589A3
(cs)
|
2015-02-11 |
2016-08-24 |
Zentiva, K.S. |
Pevné formy soli Palbociclibu
|
TWI690533B
(zh)
|
2015-02-12 |
2020-04-11 |
南北兄弟藥業投資有限公司 |
Cdk類小分子抑制劑的化合物及其用途
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
CA2976790C
(en)
|
2015-02-20 |
2024-02-27 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
AR104068A1
(es)
|
2015-03-26 |
2017-06-21 |
Hoffmann La Roche |
Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
|
WO2016156070A1
(en)
|
2015-04-02 |
2016-10-06 |
Sandoz Ag |
Modified particles of palbociclib
|
EP3078663A1
(en)
|
2015-04-09 |
2016-10-12 |
Sandoz Ag |
Modified particles of palbociclib
|
CN106795159B
(zh)
*
|
2015-04-22 |
2018-12-28 |
江苏恒瑞医药股份有限公司 |
一种周期素依赖性蛋白激酶抑制剂的结晶形式及其制备方法
|
TWI696617B
(zh)
*
|
2015-04-28 |
2020-06-21 |
大陸商上海復尚慧創醫藥研究有限公司 |
特定蛋白質激酶抑制劑
|
DK3305785T3
(da)
*
|
2015-05-29 |
2021-10-11 |
Teijin Pharma Ltd |
Pyrido[3,4-d]pyrimidinderivat og farmaceutisk acceptabelt salt deraf
|
WO2016193860A1
(en)
*
|
2015-06-04 |
2016-12-08 |
Pfizer Inc. |
Solid dosage forms of palbociclib
|
CN104892604B
(zh)
*
|
2015-06-19 |
2016-08-24 |
北京康立生医药技术开发有限公司 |
一种cdk4抑制剂的合成方法
|
CN106699785A
(zh)
*
|
2015-07-13 |
2017-05-24 |
南开大学 |
作为CDK4/6抑制剂的2-(N-氧化吡啶-2基氨基)-吡啶并[2,3-d]嘧啶-7-酮类化合物
|
ES2741958T3
(es)
|
2015-08-05 |
2020-02-12 |
Ratiopharm Gmbh |
Nueva forma cristalina y aductos de ácido acético de palbociclib
|
CN105085517B
(zh)
*
|
2015-08-06 |
2016-11-23 |
天津华洛康生物科技有限公司 |
一种结晶型帕博西尼游离碱水合物及其制备方法
|
CN105130986B
(zh)
*
|
2015-09-30 |
2017-07-18 |
广州科擎新药开发有限公司 |
嘧啶或吡啶并吡啶酮类化合物及其应用
|
HU230962B1
(hu)
|
2015-10-28 |
2019-06-28 |
Egis Gyógyszergyár Zrt. |
Palbociclib sók
|
CN106632311B
(zh)
*
|
2015-11-02 |
2021-05-18 |
上海科胜药物研发有限公司 |
一种帕博西尼晶型a和晶型b的制备方法
|
IL258768B2
(en)
|
2015-11-12 |
2023-11-01 |
Siamab Therapeutics Inc |
Compounds interacting with glycans and methods of use
|
CN105418603A
(zh)
*
|
2015-11-17 |
2016-03-23 |
重庆莱美药业股份有限公司 |
一种高纯度帕布昔利布及其反应中间体的制备方法
|
CN106810536A
(zh)
*
|
2015-11-30 |
2017-06-09 |
甘李药业股份有限公司 |
一种蛋白激酶抑制剂及其制备方法和医药用途
|
EP3386981B1
(en)
*
|
2015-12-13 |
2021-10-13 |
Hangzhou Innogate Pharma Co., Ltd. |
Heterocycles useful as anti-cancer agents
|
CN105418609B
(zh)
*
|
2015-12-31 |
2017-06-23 |
山东大学 |
4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
|
CN106928219B
(zh)
|
2015-12-31 |
2021-08-20 |
上海医药集团股份有限公司 |
含氮稠杂环化合物、制备方法、中间体、组合物和应用
|
CN106967061A
(zh)
*
|
2016-01-13 |
2017-07-21 |
常州方楠医药技术有限公司 |
帕博西林的盐、晶型及其制备方法
|
WO2017130219A1
(en)
|
2016-01-25 |
2017-08-03 |
Mylan Laboratories Limited |
Amorphous solid dispersion of palbociclib
|
WO2017145054A1
(en)
|
2016-02-24 |
2017-08-31 |
Lupin Limited |
Modified particles of crystalline palbociclib free base and process for the preparation thereof
|
US11077110B2
(en)
|
2016-03-18 |
2021-08-03 |
Tufts Medical Center |
Compositions and methods for treating and preventing metabolic disorders
|
US10449195B2
(en)
|
2016-03-29 |
2019-10-22 |
Shenzhen Pharmacin Co., Ltd. |
Pharmaceutical formulation of palbociclib and a preparation method thereof
|
CN107266421B
(zh)
*
|
2016-04-08 |
2020-12-04 |
正大天晴药业集团股份有限公司 |
取代的苯并咪唑类衍生物
|
CN107286180B
(zh)
*
|
2016-04-11 |
2019-07-02 |
上海勋和医药科技有限公司 |
杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
|
CA3018434A1
(en)
*
|
2016-04-22 |
2017-10-26 |
Dana-Farber Cancer Institute, Inc. |
Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
|
CN106336411B
(zh)
*
|
2016-04-27 |
2018-03-06 |
上海医药集团股份有限公司 |
Cdk4/6抑制剂帕博西尼高纯度原料药的制备工艺及用途
|
CN105949189B
(zh)
*
|
2016-06-05 |
2017-09-22 |
童明琼 |
一种用于治疗乳腺癌的帕博西尼的制备方法
|
WO2018005863A1
(en)
|
2016-07-01 |
2018-01-04 |
G1 Therapeutics, Inc. |
Pyrimidine-based compounds for the treatment of cancer
|
WO2018005533A1
(en)
|
2016-07-01 |
2018-01-04 |
G1 Therapeutics, Inc. |
Antiproliferative pyrimidine-based compounds
|
MX2019000200A
(es)
|
2016-07-01 |
2019-09-26 |
G1 Therapeutics Inc |
Agentes antiproliferativos basados en pirimidina.
|
WO2018007927A1
(en)
|
2016-07-04 |
2018-01-11 |
Dr. Reddy's Laboratories Limited |
Process for preparation of palbociclib
|
US10597393B2
(en)
|
2016-07-07 |
2020-03-24 |
Plantex Ltd. |
Solid state forms of Palbociclib dimesylate
|
LT3497103T
(lt)
*
|
2016-08-15 |
2021-07-26 |
Pfizer Inc. |
Piridopirimidinono cdk2/4/6 inhibitoriai
|
ES2966469T3
(es)
|
2016-08-23 |
2024-04-22 |
Eisai R&D Man Co Ltd |
Terapias combinadas para el tratamiento del carcinoma hepatocelular
|
US20190192522A1
(en)
|
2016-09-08 |
2019-06-27 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors
|
US10710999B2
(en)
|
2016-10-07 |
2020-07-14 |
Mylan Laboratories Limited |
Polymorph of an intermediate for palbociclib synthesis
|
US10849903B2
(en)
|
2016-10-20 |
2020-12-01 |
Pfizer Inc. |
Anti-proliferative agents for treating PAH
|
WO2018073574A1
(en)
|
2016-10-20 |
2018-04-26 |
Cipla Limited |
Polymorphic forms of palbociclib
|
CN106565707B
(zh)
*
|
2016-11-03 |
2019-01-04 |
杭州科巢生物科技有限公司 |
帕博西尼新合成方法
|
EP3538148A1
(en)
|
2016-11-08 |
2019-09-18 |
Dana-Farber Cancer Institute |
Compositions and methods of modulating anti-tumor immunity
|
CA3043681A1
(en)
|
2016-11-16 |
2018-05-24 |
Pfizer Inc. |
Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer
|
EP3541847A4
(en)
|
2016-11-17 |
2020-07-08 |
Seattle Genetics, Inc. |
COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
|
PT3546456T
(pt)
|
2016-11-28 |
2022-02-28 |
Teijin Pharma Ltd |
Cristal de derivado da pirido[3,4-d]pirimidina ou seu solvato
|
US11084814B2
(en)
|
2016-11-28 |
2021-08-10 |
Teijin Pharma Limited |
Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof
|
MX389786B
(es)
|
2016-12-16 |
2025-03-20 |
Cstone Pharmaceuticals Shanghai Co Ltd |
Derivados de 4-metil 7-{[5-heterociclilpirazina-2-il]amino}1,2- dihidro-1,6-naftiridina-5-ona como compuestos inhibidores de cdk4/6 y el uso de los mismos para el tratamiento de cáncer.
|
AU2018205262A1
(en)
|
2017-01-06 |
2019-07-11 |
G1 Therapeutics, Inc. |
Combination therapy for the treatment of cancer
|
CN108191857B
(zh)
*
|
2017-01-24 |
2020-10-23 |
晟科药业(江苏)有限公司 |
6-取代的吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂
|
US10729692B2
(en)
*
|
2017-02-26 |
2020-08-04 |
Institute For Cancer Research |
Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death
|
CN110809576B
(zh)
*
|
2017-03-03 |
2022-08-30 |
奥克兰联合服务有限公司 |
Fgfr激酶抑制剂和药物用途
|
CA3054939A1
(en)
|
2017-03-03 |
2018-09-07 |
Seattle Genetics, Inc. |
Glycan-interacting compounds and methods of use
|
MA47776A
(fr)
|
2017-03-16 |
2020-01-22 |
Eisai R&D Man Co Ltd |
Polythérapies pour le traitement du cancer du sein
|
CN108658855A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种含氮双环化合物及其制备方法和用途
|
CN108658854A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种生物碱化合物及其制备方法和作为海洋防污剂的应用
|
EP3606518A4
(en)
|
2017-04-01 |
2021-04-07 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF A GENE SIGNATURE OF RESISTANCE TO IMMUNOTHERAPY IN CANCER
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
SG11201911859QA
(en)
|
2017-06-16 |
2020-01-30 |
Beta Pharma Inc |
Pharmaceutical formulations of n-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and salts thereof
|
CN110913861B
(zh)
|
2017-06-29 |
2024-01-09 |
G1治疗公司 |
G1t38的形态学形式及其制造方法
|
EA036060B1
(ru)
*
|
2017-07-17 |
2020-09-21 |
Пфайзер Инк. |
Пиридопиримидиноновые ингибиторы cdk2/4/6
|
US11529353B2
(en)
|
2017-07-28 |
2022-12-20 |
Synthon B.V. |
Pharmaceutical composition comprising Palbociclib
|
CN109384767B
(zh)
*
|
2017-08-08 |
2020-05-05 |
江苏恒瑞医药股份有限公司 |
一种吡啶并嘧啶类衍生物的制备方法及其中间体
|
CN119193825A
(zh)
|
2017-08-31 |
2024-12-27 |
诺华股份有限公司 |
选择针对癌症患者的治疗的方法
|
CN107488175A
(zh)
*
|
2017-09-04 |
2017-12-19 |
上海微巨实业有限公司 |
一种帕博西林关键中间体的制备方法
|
EP3695408A4
(en)
|
2017-10-02 |
2021-12-15 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
RU2020124138A
(ru)
|
2017-12-22 |
2022-01-24 |
Хиберселл, Инк. |
Производные аминопиридина в качестве ингибиторов фосфатидилинозитолфосфаткиназы
|
CN108586452A
(zh)
*
|
2018-01-12 |
2018-09-28 |
重庆市碚圣医药科技股份有限公司 |
一种帕博西尼中间体的合成方法
|
CA3088381A1
(en)
|
2018-01-29 |
2019-08-01 |
Beta Pharma, Inc. |
2h-indazole derivatives as cdk4 and cdk6 inhibitors and therapeutic uses thereof
|
CN108218861B
(zh)
*
|
2018-02-05 |
2019-07-23 |
黑龙江中医药大学 |
一种预防和治疗糖尿病的药物及其制备方法
|
KR102765922B1
(ko)
|
2018-02-06 |
2025-02-11 |
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 |
선택적인 에스트로겐 수용체 분해제로서의 치환된 벤조티오펜 유사체
|
CN117903140A
(zh)
|
2018-02-27 |
2024-04-19 |
因赛特公司 |
作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
|
US20200405809A1
(en)
|
2018-02-27 |
2020-12-31 |
Pfizer Inc. |
Combination of a cyclin dependent kinase inhibitor and a bet- bromodomain inhibitor
|
CR20200590A
(es)
|
2018-05-04 |
2021-04-26 |
Incyte Corp |
Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
|
PE20210919A1
(es)
|
2018-05-04 |
2021-05-19 |
Incyte Corp |
Sales de un inhibidor de fgfr
|
PL3793609T3
(pl)
|
2018-05-14 |
2024-05-13 |
Pfizer Inc. |
Preparat w postaci doustnego roztworu
|
MX2020012376A
(es)
|
2018-05-18 |
2021-03-09 |
Incyte Corp |
Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
|
HUE064895T2
(hu)
|
2018-05-24 |
2024-04-28 |
Synthon Bv |
Eljárás palbociklib elõállítására
|
AU2019297361B2
(en)
|
2018-07-05 |
2024-06-27 |
Incyte Corporation |
Fused pyrazine derivatives as A2A / A2B inhibitors
|
TW202430189A
(zh)
|
2018-07-23 |
2024-08-01 |
瑞士商赫孚孟拉羅股份公司 |
用pi3k抑制劑gdc-0077治療癌症之方法
|
EP3840756A4
(en)
|
2018-08-24 |
2022-04-27 |
G1 Therapeutics, Inc. |
IMPROVED SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE
|
JP6952747B2
(ja)
|
2018-09-18 |
2021-10-20 |
ファイザー・インク |
がん処置のためのTGFβ阻害剤およびCDK阻害剤の組合せ
|
EP3863618A1
(en)
|
2018-10-08 |
2021-08-18 |
F. Hoffmann-La Roche AG |
Methods of treating cancer with pi3k alpha inhibitors and metformin
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
US12358911B2
(en)
|
2018-12-07 |
2025-07-15 |
Hangzhou Innogate Pharma Co., Ltd. |
Heterocyclic comipound as CDK-HDAC dual pathway inhibitor
|
BR112021011894A2
(pt)
|
2018-12-21 |
2021-09-08 |
Daiichi Sankyo Company, Limited |
Composição farmacêutica
|
CA3124574A1
(en)
*
|
2018-12-28 |
2020-07-02 |
Spv Therapeutics Inc. |
Cyclin-dependent kinase inhibitors
|
EP3902805A4
(en)
|
2018-12-28 |
2023-03-01 |
SPV Therapeutics Inc. |
CYCLINE-DEPENDENT KINASE INHIBITORS
|
TWI829857B
(zh)
|
2019-01-29 |
2024-01-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
|
US20220125777A1
(en)
|
2019-02-01 |
2022-04-28 |
Pfizer Inc. |
Combination of a cdk inhibitor and a pim inhibitor
|
US20200316064A1
(en)
|
2019-02-15 |
2020-10-08 |
Incyte Corporation |
Cyclin-dependent kinase 2 biomarkers and uses thereof
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
WO2020186101A1
(en)
|
2019-03-12 |
2020-09-17 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
CA3141452A1
(en)
|
2019-05-24 |
2020-12-03 |
Pfizer Inc. |
Combination therapies using cdk inhibitors
|
JP2022534889A
(ja)
|
2019-05-24 |
2022-08-04 |
ファイザー・インコーポレイテッド |
Cdk阻害剤を使用した組合せ療法
|
CN112010844B
(zh)
*
|
2019-05-31 |
2023-07-25 |
中国药科大学 |
N-(嘧啶-2-基)香豆素-7-胺衍生物作为蛋白激酶抑制剂的制法和应用
|
TW202112767A
(zh)
|
2019-06-17 |
2021-04-01 |
美商佩特拉製藥公司 |
作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
|
CN112094272A
(zh)
|
2019-06-18 |
2020-12-18 |
北京睿熙生物科技有限公司 |
Cdk激酶抑制剂
|
CN113993505B
(zh)
*
|
2019-06-20 |
2023-12-12 |
江苏恒瑞医药股份有限公司 |
一种药物组合物以及其制备方法
|
CN110143948B
(zh)
*
|
2019-06-21 |
2021-05-14 |
上海博悦生物科技有限公司 |
Cdk4/6抑制剂、其药物组合物、制备方法及应用
|
EP3993785A4
(en)
|
2019-07-07 |
2023-08-02 |
Olema Pharmaceuticals, Inc. |
ESTROGEN RECEPTOR ANTAGONIST SCHEMES
|
WO2021007269A1
(en)
|
2019-07-09 |
2021-01-14 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
MX2022001133A
(es)
|
2019-08-01 |
2022-04-25 |
Incyte Corp |
Regimen de dosificacion para un inhibidor de indolamina 2,3-dioxigenasa (ido).
|
US11427567B2
(en)
|
2019-08-14 |
2022-08-30 |
Incyte Corporation |
Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
|
BR112022003490A2
(pt)
|
2019-08-26 |
2022-05-24 |
Arvinas Operations Inc |
Método de tratamento do câncer de mama e mama metastático, método para degradação seletiva, método para inibir uma quinase, kit, composição líquida, e, método de produção de uma composição líquida
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
WO2021072232A1
(en)
|
2019-10-11 |
2021-04-15 |
Incyte Corporation |
Bicyclic amines as cdk2 inhibitors
|
CN115835908A
(zh)
|
2019-10-14 |
2023-03-21 |
因赛特公司 |
作为fgfr抑制剂的双环杂环
|
WO2021076728A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
CN112759589B
(zh)
*
|
2019-11-01 |
2022-04-08 |
暨南大学 |
嘧啶并吡啶酮类化合物及其应用
|
US11697648B2
(en)
|
2019-11-26 |
2023-07-11 |
Theravance Biopharma R&D Ip, Llc |
Fused pyrimidine pyridinone compounds as JAK inhibitors
|
EP4069218A1
(en)
|
2019-12-03 |
2022-10-12 |
Genentech, Inc. |
Combination therapies for treatment of breast cancer
|
WO2021113462A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Derivatives of an fgfr inhibitor
|
JP7720840B2
(ja)
|
2019-12-04 |
2025-08-08 |
インサイト・コーポレイション |
Fgfr阻害剤としての三環式複素環
|
MX2022007488A
(es)
*
|
2019-12-16 |
2022-08-02 |
Lunella Biotech Inc |
Agentes terapeuticos selectivos contra el cancer inhibidores de cdk4/6.
|
CR20220343A
(es)
|
2019-12-16 |
2023-02-28 |
Lunella Biotech Inc |
Agentes terapéuticos selectivos contra el cáncer inhibidores de cdk4/6
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
WO2021176349A1
(en)
|
2020-03-05 |
2021-09-10 |
Pfizer Inc. |
Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor
|
MX2022010860A
(es)
|
2020-03-06 |
2022-12-02 |
Incyte Corp |
Terapia combinada que comprende inhibidores de axl/mer y pd-1/pd-l1.
|
WO2021183994A1
(en)
*
|
2020-03-13 |
2021-09-16 |
Prosenestar Llc |
Pyrido[2,3-d]pyrimidin-7(8h)-ones as cdk inhibitors
|
EP4126244A4
(en)
*
|
2020-03-27 |
2024-03-27 |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd. |
COMBINATION OF ANTI-HER2 ANTIBODIES AND CDK INHIBITOR FOR THE TREATMENT OF TUMORS
|
JP2021167301A
(ja)
|
2020-04-08 |
2021-10-21 |
ファイザー・インク |
Cdk2阻害剤に対する腫瘍適応を抑制するためのcdk4/6およびcdk2阻害剤による同時処置
|
CR20220584A
(es)
|
2020-04-16 |
2023-02-15 |
Incyte Corp |
Inhibidores de kras tricíclicos fusionados
|
US11739102B2
(en)
|
2020-05-13 |
2023-08-29 |
Incyte Corporation |
Fused pyrimidine compounds as KRAS inhibitors
|
EP4153597B1
(en)
|
2020-05-19 |
2025-09-10 |
Pharmacosmos Holding A/S |
Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
|
US20230132667A1
(en)
*
|
2020-05-28 |
2023-05-04 |
University Of Washington |
Drug-like molecules and methods for the therapeutic targeting of viral rna structures
|
US10988479B1
(en)
|
2020-06-15 |
2021-04-27 |
G1 Therapeutics, Inc. |
Morphic forms of trilaciclib and methods of manufacture thereof
|
CN113880809B
(zh)
|
2020-07-03 |
2022-10-18 |
盛世泰科生物医药技术(苏州)有限公司 |
一种嘧啶类衍生物及其制备方法和应用
|
EP4181920B1
(en)
|
2020-07-15 |
2025-09-10 |
Pfizer Inc. |
Kat6 inhibitor and combinations for breast cancer treatment
|
US20230321042A1
(en)
|
2020-07-20 |
2023-10-12 |
Pfizer Inc. |
Combination therapy
|
US11999752B2
(en)
|
2020-08-28 |
2024-06-04 |
Incyte Corporation |
Vinyl imidazole compounds as inhibitors of KRAS
|
CN114246841B
(zh)
*
|
2020-09-24 |
2024-02-02 |
南京济群医药科技股份有限公司 |
一种羟乙磺酸哌柏西利的组合物及药物
|
CN114306245A
(zh)
|
2020-09-29 |
2022-04-12 |
深圳市药欣生物科技有限公司 |
无定形固体分散体的药物组合物及其制备方法
|
US11767320B2
(en)
|
2020-10-02 |
2023-09-26 |
Incyte Corporation |
Bicyclic dione compounds as inhibitors of KRAS
|
WO2022091001A1
(en)
|
2020-10-29 |
2022-05-05 |
Pfizer Ireland Pharmaceuticals |
Process for preparation of palbociclib
|
WO2022123419A1
(en)
|
2020-12-08 |
2022-06-16 |
Pfizer Inc. |
Treatment of luminal subtypes of hr-positive, her2-negative early breast cancer with palbociclib
|
CN112569361B
(zh)
*
|
2020-12-30 |
2023-01-10 |
扬子江药业集团上海海尼药业有限公司 |
一种哌柏西利干混悬组合物及其制备方法
|
WO2022155941A1
(en)
|
2021-01-25 |
2022-07-28 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors
|
WO2022162122A1
(en)
|
2021-01-29 |
2022-08-04 |
Biotx.Ai Gmbh |
Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
|
WO2022206888A1
(en)
|
2021-03-31 |
2022-10-06 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors and use thereof
|
JP2024513575A
(ja)
|
2021-04-12 |
2024-03-26 |
インサイト・コーポレイション |
Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
|
JP2024522189A
(ja)
|
2021-06-09 |
2024-06-11 |
インサイト・コーポレイション |
Fgfr阻害剤としての三環式ヘテロ環
|
JP2024523020A
(ja)
*
|
2021-06-09 |
2024-06-25 |
ティーワイケー メディシンズ(ジョンジョウ),インコーポレーテッド |
Cdkキナーゼ阻害剤として使用される化合物およびその応用
|
TW202313610A
(zh)
|
2021-06-09 |
2023-04-01 |
美商英塞特公司 |
作為fgfr抑制劑之三環雜環
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
TW202317565A
(zh)
|
2021-07-07 |
2023-05-01 |
美商英塞特公司 |
作為kras抑制劑的三環化合物
|
EP4370515A1
(en)
|
2021-07-14 |
2024-05-22 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
MX2024001266A
(es)
|
2021-07-26 |
2024-04-16 |
Celcuity Inc |
1-(4-{[4-(dimetilamino)piperidin-1-il]carbonil}fenil)-3-[4-(4,6-d imorfolin-4-il-1,3,5-triazin-2-il)fenil]urea (gedatolisib) y sus combinaciones para usarse en el tratamiento de cancer.
|
CA3229855A1
(en)
|
2021-08-31 |
2023-03-09 |
Incyte Corporation |
Naphthyridine compounds as inhibitors of kras
|
CN113683612B
(zh)
*
|
2021-09-07 |
2022-06-17 |
山东铂源药业股份有限公司 |
一种帕布昔利布的制备方法
|
WO2023040914A1
(zh)
*
|
2021-09-14 |
2023-03-23 |
甘李药业股份有限公司 |
一种cdk4/6抑制剂的医药用途
|
WO2023049697A1
(en)
|
2021-09-21 |
2023-03-30 |
Incyte Corporation |
Hetero-tricyclic compounds as inhibitors of kras
|
US12030884B2
(en)
|
2021-10-01 |
2024-07-09 |
Incyte Corporation |
Pyrazoloquinoline KRAS inhibitors
|
AU2022367432A1
(en)
|
2021-10-14 |
2024-05-02 |
Incyte Corporation |
Quinoline compounds as inhibitors of kras
|
EP4436578A1
(en)
|
2021-11-22 |
2024-10-02 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a kras inhibitor
|
US20230203010A1
(en)
|
2021-12-03 |
2023-06-29 |
Incyte Corporation |
Bicyclic amine cdk12 inhibitors
|
IL313422A
(en)
|
2021-12-10 |
2024-08-01 |
Lilly Co Eli |
CDK4 and 6 inhibitor in combination with FULVESTRANT for the treatment of advanced or metastatic breast cancer in patients with advanced or metastatic breast cancer before CDK 4 and 4
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
WO2023107705A1
(en)
|
2021-12-10 |
2023-06-15 |
Incyte Corporation |
Bicyclic amines as cdk12 inhibitors
|
US20250049802A1
(en)
|
2021-12-14 |
2025-02-13 |
Pfizer Inc. |
Combination therapies and uses for treating cancer
|
WO2023114264A1
(en)
|
2021-12-15 |
2023-06-22 |
Eli Lilly And Company |
Combination for treatment of high-risk metastatic hormone-sensitive prostate cancer
|
KR20240136984A
(ko)
|
2021-12-22 |
2024-09-19 |
인사이트 코포레이션 |
Fgfr 억제제의 염과 고체 형태 및 이의 제조 방법
|
WO2023168686A1
(en)
|
2022-03-11 |
2023-09-14 |
Qilu Regor Therapeutics Inc. |
Substituted cyclopentanes as cdk2 inhibitors
|
WO2023116884A1
(en)
|
2021-12-24 |
2023-06-29 |
Qilu Regor Therapeutics Inc. |
Cdk2 inhibitors and use thereof
|
CN114456180B
(zh)
*
|
2022-02-18 |
2023-07-25 |
贵州大学 |
用于治疗和/或预防恶性肿瘤的化合物及药物制剂和应用
|
MX2024010863A
(es)
|
2022-03-07 |
2024-09-11 |
Incyte Corp |
Formas solidas, sales y procesos de preparacion de un inhibidor de cinasas dependientes de ciclina 2 (cdk2).
|
HU231594B1
(hu)
*
|
2022-05-10 |
2025-03-28 |
Egis Gyógyszergyár Zrt. |
Palbociclibet és letrozolt tartalmazó gyógyszerkészítmény
|
TW202413359A
(zh)
|
2022-06-22 |
2024-04-01 |
美商英塞特公司 |
雙環胺cdk12抑制劑
|
EP4302832A1
(en)
|
2022-07-07 |
2024-01-10 |
Lotus Pharmaceutical Co., Ltd. |
Palbociclib formulation containing glucono delta lactone
|
EP4302755B1
(en)
|
2022-07-07 |
2025-08-20 |
Lotus Pharmaceutical Co., Ltd. |
Palbociclib formulation containing an amino acid
|
WO2024015731A1
(en)
|
2022-07-11 |
2024-01-18 |
Incyte Corporation |
Fused tricyclic compounds as inhibitors of kras g12v mutants
|
CN117430597A
(zh)
*
|
2022-07-14 |
2024-01-23 |
浙江同源康医药股份有限公司 |
用作cdk4激酶抑制剂的化合物及其应用
|
AU2023315227A1
(en)
|
2022-07-29 |
2025-02-13 |
Ctxt Pty Ltd |
Dosing regimens comprising a kat6 inhibitor for the treatment of cancer
|
CN120112291A
(zh)
|
2022-08-31 |
2025-06-06 |
阿尔维纳斯运营股份有限公司 |
雌激素受体降解剂的给药方案
|
EP4611739A1
(en)
|
2022-11-02 |
2025-09-10 |
Petra Pharma Corporation |
Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
|
CN120187416A
(zh)
|
2022-11-11 |
2025-06-20 |
阿斯利康(瑞典)有限公司 |
用于治疗癌症的组合疗法
|
TW202440571A
(zh)
*
|
2022-12-16 |
2024-10-16 |
大陸商上海岸闊醫藥科技有限公司 |
化合物及其用途
|
WO2024132652A1
(en)
|
2022-12-22 |
2024-06-27 |
Synthon B.V. |
Pharmaceutical composition comprising palbociclib
|
WO2024133726A1
(en)
|
2022-12-22 |
2024-06-27 |
Synthon B.V. |
Pharmaceutical composition comprising palbociclib
|
WO2024201334A1
(en)
|
2023-03-30 |
2024-10-03 |
Pfizer Inc. |
Kat6a as a predictive biomarker for treatment with a kat6a inhibitor and methods of treatment thereof
|
WO2024201340A1
(en)
|
2023-03-30 |
2024-10-03 |
Pfizer Inc. |
Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof
|
WO2024220532A1
(en)
|
2023-04-18 |
2024-10-24 |
Incyte Corporation |
Pyrrolidine kras inhibitors
|
WO2024220645A1
(en)
|
2023-04-18 |
2024-10-24 |
Incyte Corporation |
2-azabicyclo[2.2.1]heptane kras inhibitors
|
TW202508598A
(zh)
|
2023-05-05 |
2025-03-01 |
瑞典商阿斯特捷利康公司 |
癌症療法
|
WO2024235844A1
(en)
|
2023-05-12 |
2024-11-21 |
Institut National de la Santé et de la Recherche Médicale |
Methods of preventing on-target genotoxicity induced by nucleases
|
WO2024254245A1
(en)
|
2023-06-09 |
2024-12-12 |
Incyte Corporation |
Bicyclic amines as cdk2 inhibitors
|
WO2025051337A1
(en)
|
2023-09-06 |
2025-03-13 |
Afyx Development A/S |
Compositions and methods for treating and preventing oral cancer
|
WO2025096738A1
(en)
|
2023-11-01 |
2025-05-08 |
Incyte Corporation |
Kras inhibitors
|
WO2025122470A1
(en)
|
2023-12-04 |
2025-06-12 |
Genentech, Inc. |
Combination therapies for treatment of breast cancer
|
US20250195536A1
(en)
|
2023-12-13 |
2025-06-19 |
Incyte Corporation |
Bicyclooctane kras inhibitors
|