CO6311051A2 - Compuestos de pirimidina, composiciones y metodos de uso - Google Patents
Compuestos de pirimidina, composiciones y metodos de usoInfo
- Publication number
- CO6311051A2 CO6311051A2 CO11022828A CO11022828A CO6311051A2 CO 6311051 A2 CO6311051 A2 CO 6311051A2 CO 11022828 A CO11022828 A CO 11022828A CO 11022828 A CO11022828 A CO 11022828A CO 6311051 A2 CO6311051 A2 CO 6311051A2
- Authority
- CO
- Colombia
- Prior art keywords
- compositions
- methods
- compounds
- mtor
- pikk
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Abstract
Se describen compuestos de la fórmula I, incluso sus estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos y sales farmacéuticamente aceptables, que son de utilidad en la modulación de la señalización de las quinasas relacionadas con PIKK, por ejemplo, mTOR y para el tratamiento de enfermedades (por ejemplo, cáncer) que son mediadas al menos en parte por la desregulación de la vía de señalización de PIKK (por ejemplo, mTOR).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8530908P | 2008-07-31 | 2008-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6311051A2 true CO6311051A2 (es) | 2011-08-22 |
Family
ID=41610758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11022828A CO6311051A2 (es) | 2008-07-31 | 2011-02-24 | Compuestos de pirimidina, composiciones y metodos de uso |
Country Status (23)
Country | Link |
---|---|
US (2) | US8163763B2 (es) |
EP (1) | EP2318377B1 (es) |
JP (1) | JP2011529920A (es) |
KR (1) | KR20110046514A (es) |
CN (1) | CN102171194A (es) |
AR (1) | AR073354A1 (es) |
AU (1) | AU2009276339B2 (es) |
BR (1) | BRPI0911688A2 (es) |
CA (1) | CA2729045A1 (es) |
CL (1) | CL2011000191A1 (es) |
CO (1) | CO6311051A2 (es) |
EC (1) | ECSP11010796A (es) |
ES (1) | ES2432821T3 (es) |
IL (1) | IL210462A0 (es) |
MA (1) | MA32580B1 (es) |
MX (1) | MX2011001196A (es) |
NZ (1) | NZ590777A (es) |
PE (1) | PE20110403A1 (es) |
RU (1) | RU2473549C2 (es) |
TW (1) | TW201018681A (es) |
UA (1) | UA101676C2 (es) |
WO (1) | WO2010014939A1 (es) |
ZA (1) | ZA201100110B (es) |
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JP2010503648A (ja) | 2006-09-14 | 2010-02-04 | アストラゼネカ アクチボラグ | 増殖性疾患の治療のためのpi3k及びmtor阻害剤としての2−ベンゾイミダゾリル−6−モルホリノ−4−(アゼチジン、ピロリジン、ピペリジン、又はアゼピン)ピリミジン誘導体 |
WO2008032072A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
WO2008032036A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
WO2008032089A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
KR101460816B1 (ko) | 2006-12-07 | 2014-11-12 | 에프. 호프만-라 로슈 아게 | 포스포이노시타이드 3-키나제 억제제 화합물 및 그의 사용 방법 |
KR101507182B1 (ko) | 2006-12-07 | 2015-03-30 | 제넨테크, 인크. | 포스포이노시타이드 3-키나제 억제제 화합물 및 그의 사용 방법 |
WO2008071974A2 (en) * | 2006-12-14 | 2008-06-19 | Medical Research Council | Use of pi3k m-tor and akt inhibitors to induce f0xp3 expression and generate regulatory t cells |
US20080233127A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
US20080234262A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
BRPI0810641A2 (pt) | 2007-04-12 | 2019-09-24 | Hoffmann La Roche | "compostos farmacêuticos". |
GB0707087D0 (en) | 2007-04-12 | 2007-05-23 | Piramed Ltd | Pharmaceutical compounds |
WO2008125833A1 (en) | 2007-04-12 | 2008-10-23 | Piramed Limited | Pharmaceutical compounds |
WO2008152390A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Thiazoliopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase |
WO2008152387A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Quinazoline derivatives as pi3 kinase inhibitors |
WO2008152394A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Pharmaceutical compounds |
ES2399774T3 (es) | 2007-09-24 | 2013-04-03 | Genentech, Inc. | Compuestos de tiazolopirimidina inhibidores de PI3K y métodos de uso |
EP2212333A1 (en) | 2007-10-16 | 2010-08-04 | Wyeth LLC | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mtor kinase and pi3 kinase inhibitors |
US20090149458A1 (en) | 2007-11-27 | 2009-06-11 | Wyeth | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS |
KR20110046514A (ko) | 2008-07-31 | 2011-05-04 | 제넨테크, 인크. | 피리미딘 화합물, 조성물 및 사용 방법 |
-
2009
- 2009-07-31 KR KR1020117004629A patent/KR20110046514A/ko not_active Application Discontinuation
- 2009-07-31 JP JP2011521363A patent/JP2011529920A/ja active Pending
- 2009-07-31 NZ NZ590777A patent/NZ590777A/xx not_active IP Right Cessation
- 2009-07-31 WO PCT/US2009/052469 patent/WO2010014939A1/en active Application Filing
- 2009-07-31 TW TW098125944A patent/TW201018681A/zh unknown
- 2009-07-31 ES ES09803674T patent/ES2432821T3/es active Active
- 2009-07-31 CN CN200980139005XA patent/CN102171194A/zh active Pending
- 2009-07-31 MX MX2011001196A patent/MX2011001196A/es active IP Right Grant
- 2009-07-31 BR BRPI0911688-5A patent/BRPI0911688A2/pt not_active IP Right Cessation
- 2009-07-31 EP EP09803674.2A patent/EP2318377B1/en active Active
- 2009-07-31 AU AU2009276339A patent/AU2009276339B2/en not_active Ceased
- 2009-07-31 RU RU2011107278/04A patent/RU2473549C2/ru not_active IP Right Cessation
- 2009-07-31 UA UAA201102282A patent/UA101676C2/uk unknown
- 2009-07-31 US US12/533,935 patent/US8163763B2/en not_active Expired - Fee Related
- 2009-07-31 CA CA2729045A patent/CA2729045A1/en not_active Abandoned
- 2009-07-31 PE PE2010001222A patent/PE20110403A1/es not_active Application Discontinuation
- 2009-07-31 AR ARP090102947A patent/AR073354A1/es unknown
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2011
- 2011-01-04 ZA ZA2011/00110A patent/ZA201100110B/en unknown
- 2011-01-05 IL IL210462A patent/IL210462A0/en unknown
- 2011-01-28 CL CL2011000191A patent/CL2011000191A1/es unknown
- 2011-01-31 EC EC2011010796A patent/ECSP11010796A/es unknown
- 2011-02-22 MA MA33637A patent/MA32580B1/fr unknown
- 2011-02-24 CO CO11022828A patent/CO6311051A2/es not_active Application Discontinuation
-
2012
- 2012-03-01 US US13/410,246 patent/US20120165313A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ECSP11010796A (es) | 2011-02-28 |
ZA201100110B (en) | 2012-04-25 |
JP2011529920A (ja) | 2011-12-15 |
CA2729045A1 (en) | 2010-02-04 |
NZ590777A (en) | 2012-11-30 |
IL210462A0 (en) | 2011-03-31 |
RU2011107278A (ru) | 2012-09-10 |
US8163763B2 (en) | 2012-04-24 |
AU2009276339A1 (en) | 2010-02-04 |
ES2432821T3 (es) | 2013-12-05 |
EP2318377A1 (en) | 2011-05-11 |
MA32580B1 (fr) | 2011-08-01 |
AU2009276339B2 (en) | 2012-06-07 |
AU2009276339A8 (en) | 2011-03-03 |
MX2011001196A (es) | 2011-05-30 |
PE20110403A1 (es) | 2011-07-04 |
CL2011000191A1 (es) | 2011-05-20 |
WO2010014939A1 (en) | 2010-02-04 |
US20100069357A1 (en) | 2010-03-18 |
US20120165313A1 (en) | 2012-06-28 |
UA101676C2 (uk) | 2013-04-25 |
BRPI0911688A2 (pt) | 2015-07-28 |
CN102171194A (zh) | 2011-08-31 |
EP2318377A4 (en) | 2012-05-09 |
EP2318377B1 (en) | 2013-08-21 |
RU2473549C2 (ru) | 2013-01-27 |
TW201018681A (en) | 2010-05-16 |
KR20110046514A (ko) | 2011-05-04 |
AR073354A1 (es) | 2010-11-03 |
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