SI3284754T1 - Protitelesa proti-CD38 - Google Patents
Protitelesa proti-CD38Info
- Publication number
- SI3284754T1 SI3284754T1 SI201131939T SI201131939T SI3284754T1 SI 3284754 T1 SI3284754 T1 SI 3284754T1 SI 201131939 T SI201131939 T SI 201131939T SI 201131939 T SI201131939 T SI 201131939T SI 3284754 T1 SI3284754 T1 SI 3284754T1
- Authority
- SI
- Slovenia
- Prior art keywords
- antibodies
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061428699P | 2010-12-30 | 2010-12-30 | |
| US201161470382P | 2011-03-31 | 2011-03-31 | |
| US201161470406P | 2011-03-31 | 2011-03-31 | |
| US201161485104P | 2011-05-11 | 2011-05-11 | |
| EP17189925.5A EP3284754B1 (en) | 2010-12-30 | 2011-12-30 | Anti-cd38 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3284754T1 true SI3284754T1 (sl) | 2021-03-31 |
Family
ID=45498158
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131939T SI3284754T1 (sl) | 2010-12-30 | 2011-12-30 | Protitelesa proti-CD38 |
| SI201131534T SI2658870T1 (sl) | 2010-12-30 | 2011-12-30 | Konjugirana protitelesa anti-CD38 |
| SI201131541T SI2658871T1 (sl) | 2010-12-30 | 2011-12-30 | Protitelesa anti-CD38 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131534T SI2658870T1 (sl) | 2010-12-30 | 2011-12-30 | Konjugirana protitelesa anti-CD38 |
| SI201131541T SI2658871T1 (sl) | 2010-12-30 | 2011-12-30 | Protitelesa anti-CD38 |
Country Status (38)
Families Citing this family (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL goldÂź-derived therapeutic antibodies specific for human CD3i |
| AU2005235811B2 (en) | 2004-02-06 | 2011-11-03 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
| NZ566915A (en) | 2005-10-12 | 2011-09-30 | Morphosys Ag | Generation and profiling of human derived therapeutic antibodies specific for human CD38 |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| PT2621531T (pt) | 2010-09-27 | 2017-03-13 | Morphosys Ag | Anticorpo anti-cd38 e lenalidomida ou bortezomibe para o tratamento de mieloma mĂșltiplo e linfoma nĂŁo-hodgkins |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | ۧÙŰŁŰŹŰłŰ§Ù Ű§ÙÙ Ű¶Ű§ŰŻŰ© ÙÙ cd38 |
| EA034989B1 (ru) | 2011-10-28 | 2020-04-15 | йДĐČĐ° ЀаŃĐŒĐ°ŃŃŃŃĐžĐșĐ°Đ» ĐĐČŃŃŃĐ°Đ»ĐžŃ ĐŃĐž ĐŃĐŽ | ĐĐŸĐ»ĐžĐżĐ”ĐżŃĐžĐŽĐœĐ°Ń ĐșĐŸĐœŃŃŃŃĐșŃĐžŃ ĐŽĐ»Ń ĐżŃĐžĐŒĐ”ĐœĐ”ĐœĐžŃ ĐżŃĐž лДŃĐ”ĐœĐžĐž ŃĐ°ĐșĐ°, ĐČĐșĐ»ŃŃĐ°ŃŃĐ°Ń Đ°ŃŃĐ”ĐœŃĐžŃĐŸĐČĐ°ĐœĐœŃĐč Đ°Đ»ŃŃĐ°-ĐžĐœŃĐ”ŃŃĐ”ŃĐŸĐœ |
| JP6224586B2 (ja) | 2012-07-10 | 2017-11-01 | æŠç°èŹćć·„æ„æ ȘćŒäŒç€Ÿ | æłšć°çšèŁœć€ |
| ES2658953T3 (es) | 2012-09-25 | 2018-03-13 | Morphosys Ag | Combinaciones y usos de los mismos |
| UA118255C2 (uk) * | 2012-12-07 | 2018-12-26 | ĐĄĐ°ĐœĐŸŃŃ | ĐĐŸĐŒĐżĐŸĐ·ĐžŃŃŃ, ŃĐșĐ° ĐŒŃŃŃĐžŃŃ Đ°ĐœŃĐžŃŃĐ»ĐŸ ĐŽĐŸ cd38 Ń Đ»Đ”ĐœĐ°Đ»ŃĐŽĐŸĐŒŃĐŽ |
| US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
| MA38567A1 (fr) * | 2013-04-16 | 2017-09-29 | Genentech Inc | Variantes de pertuzumab et leur Ă©valuation |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| UA113129C2 (xx) * | 2013-04-29 | 2016-12-12 | ĐĐĐйРĐĐĐХйРУĐĐŠĐĐŻ ĐĐĐąĐĐąĐĐĐ ĐĐ ĐйРCD38 Đ ĐĐĄĐĐĐĐĐĐĐĐ ĐĐĐąĐРЀĐĐ ĐĐĐĐ ĐĐĐŹĐ€Đ-2b | |
| TN2016000142A1 (en) * | 2013-10-31 | 2017-10-06 | Sanofi Sa | Specific anti-cd38 antibodies for treating human cancers. |
| US9493563B2 (en) | 2013-11-04 | 2016-11-15 | Glenmark Pharmaceuticals S.A. | Production of T cell retargeting hetero-dimeric immunoglobulins |
| EP3104882B1 (en) * | 2014-02-14 | 2019-06-05 | Centrose, Llc | Extracellular targeted drug conjugates |
| US9603927B2 (en) * | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) * | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | èŻșćèĄä»œæéć Źćž | äœżçšć”ćæććäœæČ»ççç |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | йДĐČĐ° ЀаŃĐŒĐ°ŃŃŃŃĐžĐșалз ĐŃŃŃĐ”ĐčĐ»ŃĐ° ĐŃŃ ĐŃĐŽ | ĐĐŸĐŒĐ±ŃĐœĐ°ŃŃŃ Đ»Đ”ĐœĐ°Đ»ŃĐŽĐŸĐŒŃĐŽŃ Đ°Đ±ĐŸ ĐżĐŸĐŒĐ°Đ»ŃĐŽĐŸĐŒŃĐŽŃ Ń ĐșĐŸĐœŃŃŃŃĐșŃŃŃ Đ°ĐœŃĐž-cd38 Đ°ĐœŃĐžŃŃĐ»ĐŸ-Đ°ŃĐ”ĐœŃĐčĐŸĐČĐ°ĐœĐžĐč ŃĐœŃĐ”ŃŃĐ”ŃĐŸĐœ Đ°Đ»ŃŃĐ°-2b ŃĐ° ŃĐżĐŸŃŃб Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃŃб'ŃĐșŃĐ°, ŃĐșĐžĐč ĐŒĐ°Ń cd38-Đ”ĐșŃĐżŃĐ”ŃŃŃŃŃ ĐżŃŃ Đ»ĐžĐœŃ |
| ES2959683T3 (es) | 2014-07-15 | 2024-02-27 | Juno Therapeutics Inc | CĂ©lulas manipuladas para terapia celular adoptiva |
| WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| MA40608A (fr) | 2014-09-09 | 2016-03-17 | Janssen Biotech Inc | Polythérapies avec des anticorps anti-cd38 |
| IL251822B2 (en) | 2014-10-29 | 2023-03-01 | Teva Pharmaceuticals Australia Pty Ltd | Variants of interferon alpha-2-b |
| MA40894A (fr) * | 2014-11-04 | 2017-09-12 | Glenmark Pharmaceuticals Sa | Immunoglobulines hétéro-dimÚres reciblant des lymphocytes t cd3/cd38 et leurs procédés de production |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| JP6802791B2 (ja) * | 2014-12-04 | 2020-12-23 | ă€ăłă»ăł ăă€ăȘăăăŻïŒă€ăłăłăŒăăŹăŒăăă | æ„æ§éȘšé«æ§çœèĄç ăźæČ»çăźăăăźæïœïœïŒïŒæäœ |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
| TW201702264A (zh) * | 2015-04-08 | 2017-01-16 | 玹ć«ć€é«çć Źćž | ç”ćïœïœïŒïŒäčæé«æČ»çć |
| WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| EP4553157A3 (en) | 2015-05-20 | 2025-07-23 | Janssen Biotech, Inc. | Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies |
| EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| UA125115C2 (uk) | 2015-06-22 | 2022-01-12 | ĐŻĐœŃŃĐ”Đœ ĐĐ°ĐčĐŸŃĐ”Đș, ĐĐœĐș. | ĐĄĐżĐŸŃŃб Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃŃб'ŃĐșŃĐ°, ŃĐșĐžĐč ĐŒĐ°Ń ĐŒĐœĐŸĐ¶ĐžĐœĐœŃ ĐŒŃŃĐ»ĐŸĐŒŃ (ĐŒĐŒ) |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| HRP20240338T1 (hr) * | 2015-06-24 | 2024-05-24 | Janssen Biotech, Inc. | Imunomodulacija i lijeÄenje solidnih tumora s protutijelima koja se specifiÄno veĆŸu na cd38 |
| SG10202010735PA (en) | 2015-07-06 | 2020-11-27 | UCB Biopharma SRL | Tau-binding antibodies |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| CN108348620A (zh) | 2015-09-28 | 2018-07-31 | æć°ŒèèŸŸć€§ćŠèŁäșäŒ | ć”ćæććäœ(car)tç»èäœäžșè·ćŸèȘäœć ç«ććç§ć ç«çæČ»çæ§ćčČéą |
| AU2016347058B2 (en) | 2015-10-25 | 2023-11-09 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of HIV infection |
| JP7027321B2 (ja) | 2015-11-03 | 2022-03-01 | ă€ăłă»ăł ăă€ăȘăăăŻïŒă€ăłăłăŒăăŹăŒăăă | æïœïœïŒïŒæäœăźçźäžèŁœć€ćăłăăźäœżçš |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| FI3380620T3 (fi) | 2015-11-23 | 2024-08-01 | Novartis Ag | Optimoituja lentiviruksen siirtovektoreita ja niiden kÀyttötapoja |
| EP4219689A3 (en) | 2015-12-30 | 2023-12-20 | Novartis AG | Immune effector cell therapies with enhanced efficacy |
| JP7362250B2 (ja) | 2016-03-04 | 2023-10-17 | ăąă«ăă©ă·ăčă»ăąăŒăČăŒ | ć€çșæ§éȘšé«è «ă«ăăăïœăżăłăăŻèłȘććżăźèšćșè©äŸĄ |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| IL262241B2 (en) | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with a crossover dual variable domain arm and a traditional antibody fab arm, pharmaceutical composition comprising said binding proteins and their uses in preventing and/or treating cancer or inflammatory diseases |
| PL3443006T3 (pl) | 2016-04-13 | 2024-01-29 | Sanofi | TrĂłjswoiste i/lub triwalentne biaĆka wiÄ ĆŒÄ ce |
| US11098124B2 (en) * | 2016-05-03 | 2021-08-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | CD31 shed as a molecular target for imaging of inflammation |
| EP3474895A1 (en) * | 2016-06-28 | 2019-05-01 | UMC Utrecht Holding B.V. | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
| JP7316930B2 (ja) * | 2016-07-15 | 2023-07-28 | æŠç°èŹćć·„æ„æ ȘćŒäŒç€Ÿ | ćœąèłȘèœçŽ°èćăłćœąèłȘ现èæŻæžçæłă«ćŻŸăăćżçăè©äŸĄăăăăăźæčæłćăłææ |
| CA3030926A1 (en) | 2016-07-19 | 2018-01-25 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-cd47 combination therapy |
| WO2018015498A1 (en) | 2016-07-20 | 2018-01-25 | Hybrigenics Sa | Combinations of inecalcitol with an anti-cd38 agent and their uses for treating cancer |
| EP4295918A3 (en) | 2016-11-02 | 2024-03-20 | Bristol-Myers Squibb Company | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
| WO2018082758A1 (en) * | 2016-11-04 | 2018-05-11 | Aarhus Universitet | Identification and treatment of tumors characterized by an overexpression of the neonatal fc receptor |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
| EP4043485A1 (en) | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| EP3577134A1 (en) | 2017-01-31 | 2019-12-11 | Novartis AG | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| US20200048359A1 (en) | 2017-02-28 | 2020-02-13 | Novartis Ag | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
| US20190381170A1 (en) * | 2017-03-01 | 2019-12-19 | Institute For Rheumatic Diseases Co., Ltd. | Prophylactic and/or therapeutic agent for autoimmune disease, and vaccine |
| CA3057808A1 (en) | 2017-03-24 | 2018-09-27 | Zenyaku Kogyo Co., Ltd. | Anti-igm/b cell surface antigen bispecific antibody |
| US11104737B2 (en) | 2017-03-28 | 2021-08-31 | Rigel Pharmaceuticals, Inc. | ACVR2A-specific antibody and method of treatment of muscle atrophy |
| CN110770345A (zh) | 2017-04-14 | 2020-02-07 | æć°ć„ć Źćž | ć ç«è°èć€æ žè·é žăæäœçŒćç©ćć ¶äœżçšæčæł |
| KR20250025513A (ko) * | 2017-06-08 | 2025-02-21 | ëžë ëČšíž í ëŒíší±ì€ 늏믞í°ë | Cd38 ìĄ°ì íìČŽ |
| WO2018224685A1 (en) | 2017-06-08 | 2018-12-13 | Tusk Therapeutics Ltd | Cd38 modulating antibody |
| US11780930B2 (en) | 2017-06-08 | 2023-10-10 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| CN114058590B (zh) | 2017-06-20 | 2024-08-06 | ć± éç 究æ | Suv39h1çŒșé·çć ç«ç»è |
| EP4509143A3 (en) * | 2017-06-20 | 2025-04-23 | Sorrento Therapeutics, Inc. | Cd38 antibody drug conjugate |
| EP3434692A1 (en) * | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US11542338B2 (en) | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| WO2019034753A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | ANTIBODY CD38 |
| WO2019034752A1 (en) * | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | CD38 MODULATOR ANTIBODY |
| CN111133007A (zh) | 2017-09-13 | 2020-05-08 | çčć°Œć„„çç©èĄä»œæéć Źćž | äžèć€é ¶ç»ćçééŸæäœ |
| AU2018348093A1 (en) * | 2017-10-10 | 2020-05-28 | Sanofi | Anti-CD38 antibodies and combinations with anti-CD3 and anti-CD28 antibodies |
| CN111566124A (zh) | 2017-10-25 | 2020-08-21 | èŻșćèĄä»œæéć Źćž | ć¶ć€èĄšèŸŸć”ćæććäœçç»èçæčæł |
| WO2019081983A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | CD32B TARGETING ANTIBODIES AND METHODS OF USE |
| US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
| JP2021502961A (ja) | 2017-10-31 | 2021-02-04 | ă€ăłă»ăł ăă€ăȘăăăŻïŒă€ăłăłăŒăăŹăŒăăă | é«ăȘăčăŻć€çșæ§éȘšé«è «ăźæČ»çæčæł |
| TW201932482A (zh) | 2017-11-01 | 2019-08-16 | çŸćć„è«ŸæČ»çæéć Źćž | ć°b现èæçæćć ·çčç°æ§äčć”ćæććé«ćç·šçąŒèæ žè·é ž |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| KR20200074997A (ko) | 2017-11-01 | 2020-06-25 | ìŁŒë ž ìëŹíší°íŹì€ ìžìœíŒë ìŽí°ë | B-ìžíŹ ì±ì íìì íčìŽì ìž íìČŽ ë° í€ë©ëŠ íì ìì©ìČŽ |
| CN111615556A (zh) | 2017-11-01 | 2020-09-01 | æ±èŻșæČ»çćŠèĄä»œæéć Źćž | äș§çtç»èç»ćç©çæčæł |
| MX2020004240A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Proceso para generar composiciones terapeuticas de celulas modificadas. |
| CN111542545A (zh) | 2017-11-03 | 2020-08-14 | çŽąäŒŠææČ»çæéć Źćž | Cd38ćźćć”ćæććäœæć»șäœ |
| CN111918876B (zh) * | 2017-11-30 | 2024-02-02 | è±Ș怫èżÂ·çœæ°æéć Źćž | æpd-l1æäœćäœżçšć ¶æŁæ”pd-l1çæčæł |
| JP7437705B2 (ja) * | 2017-12-05 | 2024-02-26 | 㶠ăĄăăŁă«ă« ăȘă”ăŒăïŒ ă€ăłăă©ăčăă©ăŻăăŁăŒïŒ ăąăłă ăă«ăč ă”ăŒăŽăŁă·ăŒăș ăăĄăłă ăȘă 㶠ăă« ăąăŽăŁăŽ ăĄăăŁă«ă« ă»ăłăżăŒ | æïœïœïŒïŒćăłæïœïœïŒïŒïŒăăĄă©æćććźčäœăć«ăïœçŽ°èăćăłăăźçšé |
| MX2020005908A (es) | 2017-12-08 | 2020-10-07 | Juno Therapeutics Inc | Proceso para producir una composicion de celulas t modificadas. |
| AU2018379091A1 (en) | 2017-12-08 | 2020-06-25 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
| KR102862251B1 (ko) | 2017-12-08 | 2025-09-22 | ìŁŒë ž ìëŹíší°íŹì€ ìžìœíŒë ìŽí°ë | ìžíŹ ìëČì ìí ííí ë§ì»€ ë° êŽë š ë°©ëČ |
| CN112739715A (zh) * | 2018-01-12 | 2021-04-30 | æŠç°èŻćć·„äžæ ȘćŒäŒç€Ÿ | æcd38æäœççźäžç»èŻ |
| CN110144008B (zh) * | 2018-02-12 | 2021-03-19 | æć·ć°ć„çç©ææŻæéć Źćž | Cd38èçœæäœćć ¶ćșçš |
| MX2020010144A (es) * | 2018-03-28 | 2020-12-07 | Takeda Pharmaceuticals Co | DosificaciĂłn subcutĂĄnea de anticuerpos anti grupo de diferenciaciĂłn 38 (cd38). |
| CN108318689A (zh) * | 2018-04-09 | 2018-07-24 | ćäșŹć€§ćŠæ·±ćłç 究çéą | äžç§ć€ćæ§éȘšé«ç€çèŻææčæł |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| US12048745B2 (en) | 2018-05-01 | 2024-07-30 | Augusta University Research Institute, Inc. | Methods for detecting and reversing immune therapy resistance |
| WO2019227003A1 (en) | 2018-05-25 | 2019-11-28 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
| US20210123075A1 (en) | 2018-06-08 | 2021-04-29 | Novartis Ag | Compositions and methods for immunooncology |
| CN108752475B (zh) * | 2018-06-14 | 2021-07-30 | ćäșŹæșä»çŸćçç©ç§ææéć Źćž | æäșșcd38æäœćć ¶çšé |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| CN120865412A (zh) | 2018-07-13 | 2025-10-31 | æ čé©ŹćžèĄä»œć Źćž | Cd38æäœćäœćć ¶çšé |
| EP3820890A1 (en) | 2018-07-13 | 2021-05-19 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
| US20210230671A1 (en) | 2018-08-09 | 2021-07-29 | Juno Therapeutics, Inc. | Methods for assessing integrated nucleic acids |
| AU2019338999A1 (en) | 2018-09-11 | 2021-03-18 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD38 antibody, antigen-binding fragment thereof, and pharmaceutical use |
| CN109053892B (zh) | 2018-09-19 | 2021-03-26 | èć·æćŠç»Žçç©ææŻèĄä»œæéć Źćž | çčćŒç»ćäșșćçŽcd38æćçćć éæäœćć ¶ć¶ć€æčæłäžćșçš |
| US11530268B2 (en) | 2018-10-09 | 2022-12-20 | Sanofi | Trispecific anti-CD38, anti-CD28, and anti-CD3 binding proteins and methods of use for treating viral infection |
| CA3100232A1 (en) | 2018-10-26 | 2020-04-30 | Teneobio, Inc. | Heavy chain antibodies binding to cd38 |
| BR112021007626A2 (pt) | 2018-11-01 | 2021-10-13 | Juno Therapeutics, Inc. | Receptores antigĂȘnicos quimĂ©ricos especĂficos pa-ra receptor acoplado Ă proteĂna g receptor de classe c, grupo 5, membro d (gprc5d) |
| SG11202104188VA (en) | 2018-11-01 | 2021-05-28 | Juno Therapeutics Inc | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| MX2021007047A (es) | 2018-12-14 | 2021-10-26 | Morphosys Ag | Formulaciones de anticuerpos. |
| JP2022514315A (ja) | 2018-12-20 | 2022-02-10 | ăăă«ăăŁăč ăąăŒăČăŒ | ïŒïŒïŒïŒïŒăȘăăœă€ăœă€ăłăăȘăłïŒïŒïŒă€ă«ïŒăăăȘăžăłïŒïŒïŒïŒïŒăžăȘăłèȘć°äœăć«ăæäžèšç»ćăłèŹć€ç”ăżćăă |
| CN113710324B (zh) * | 2019-01-23 | 2025-02-14 | ć犧ć¶èŻć Źćž | æcd38æäœ |
| BR112021014574A2 (pt) * | 2019-01-23 | 2021-10-05 | Encefa | Competidores cd31 e usos dos mesmos |
| AU2020213103A1 (en) | 2019-01-23 | 2021-07-29 | Millennium Pharmaceuticals, Inc. | CD38-binding proteins comprising de-immunized Shiga toxin a subunit effectors |
| EP3924054B1 (en) | 2019-02-15 | 2025-04-02 | Novartis AG | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| AU2020222346B2 (en) | 2019-02-15 | 2021-12-09 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| KR20220002891A (ko) | 2019-03-15 | 2022-01-07 | ëȘšë„ŽíŹìì€ ìêČ | ìê°íìČŽ-ë§€ê° ìê°ë©Žì ì§ëłì ìčëŁë„Œ ìí í-cd38 íìČŽ ë° ìŽì ìœì íì ìĄ°ì±ëŹŒ |
| WO2020194243A1 (en) * | 2019-03-28 | 2020-10-01 | Janssen Biotech, Inc. | Clinically proven subcutaneous pharmaceutical compositions comprising anti-cd38 antibodies and their uses in combination with lenalidomide and dexamethasone |
| WO2020194245A1 (en) * | 2019-03-28 | 2020-10-01 | Janssen Biotech, Inc. | Clinically proven subcutaneous pharmaceutical compositions comprising anti-cd38 antibodies and their uses in combination with bortezomib, melphalan and prednisone |
| US20200308296A1 (en) * | 2019-03-28 | 2020-10-01 | Janssen Biotech, Inc. | Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Pomalidomide and Dexamethasone |
| US20200316197A1 (en) * | 2019-03-28 | 2020-10-08 | Janssen Biotech, Inc. | Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Bortezomib and Dexamethasone |
| EP3947465A4 (en) * | 2019-03-29 | 2023-01-04 | Sorrento Therapeutics, Inc. | MODIFIED VARIANT ANTIBODIES BINDING TO CD38 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| KR20210149141A (ko) * | 2019-04-09 | 2021-12-08 | ìŹë žíŒ | ìŒì€íčìŽì êČ°í© ëšë°±ì§, ìŽì ë°©ëČ ë° ì©ë |
| BR112021021200A2 (pt) | 2019-05-01 | 2021-12-21 | Juno Therapeutics Inc | CĂ©lulas expressando um receptor quimĂ©rico de um locus cd247 modificado, polinucleotĂdeos relacionados e mĂ©todos |
| BR112021021075A2 (pt) | 2019-05-01 | 2021-12-14 | Editas Medicine Inc | CĂ©lulas que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotĂdeos relacionados e mĂ©todos |
| CR20210576A (es) | 2019-05-21 | 2021-12-15 | Novartis Ag | Moléculas de unión a cd19 y usos de las mismas |
| CN113993543B (zh) * | 2019-06-10 | 2024-07-12 | æŠç°èŻćć·„äžæ ȘćŒäŒç€Ÿ | äœżçšæcd38æäœçç»ćçæł |
| EP3990009A1 (en) | 2019-06-27 | 2022-05-04 | CRISPR Therapeutics AG | Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer |
| AU2020299600A1 (en) * | 2019-07-03 | 2022-01-06 | Crystal Bioscience Inc. | Anti-CD38 antibody and methods of use thereof |
| US20220251572A1 (en) | 2019-07-23 | 2022-08-11 | Mnemo Therapeutics | Immune cells defective for suv39h1 |
| CN112538114B (zh) * | 2019-09-20 | 2025-05-02 | äžæ”·æźéçç©ç§ææéć Źćž | æäșșcd38æäœćć ¶ćșçš |
| EP4054714A4 (en) * | 2019-11-07 | 2023-12-06 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS RELATING TO SELECTIVE INTRACELLULAR DELIVERY OF CD38 INHIBITORS |
| CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | ćș·èŻșäșçç©ć»èŻç§æïŒæéœïŒæéć Źćž | èŻç©ç»ćç©ćć ¶ć¶ć€æčæłććșçš |
| BR112022011824A2 (pt) | 2019-12-18 | 2022-08-30 | Teneofour Inc | Anticorpos de cadeia pesada que se ligam a cd38 |
| US20230057071A1 (en) | 2019-12-20 | 2023-02-23 | Novartis Ag | Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome |
| BR112022013553A2 (pt) | 2020-01-16 | 2022-09-06 | Genmab As | Composição farmacĂȘutica, anticorpo, e, mĂ©todo para tratar uma doença |
| EP4110830A4 (en) | 2020-02-28 | 2024-09-11 | Tallac Therapeutics, Inc. | TRANSGLUTAMINASE-MEDIATED CONJUGATION |
| KR20230005163A (ko) | 2020-03-26 | 2023-01-09 | ìšì ìžíŹ. | ë€ë°ì± êłšììą ìčëŁ ë°©ëČ |
| CN115916223A (zh) | 2020-04-10 | 2023-04-04 | æ±èŻșæČ»çćŠèĄä»œæéć Źćž | äžçšé¶ćbç»èæçæćçć”ćæććäœć·„çšćçç»èçæłçžć łçæčæłćçšé |
| WO2021226584A1 (en) * | 2020-05-08 | 2021-11-11 | University Of Southern California | Site-specific antibody-drug conjugates by adp-ribosyl cyclases |
| EP4150640A1 (en) | 2020-05-13 | 2023-03-22 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| WO2021252920A1 (en) | 2020-06-11 | 2021-12-16 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| JP2023531676A (ja) | 2020-06-23 | 2023-07-25 | ăăă«ăăŁăč ăąăŒăČăŒ | ïŒïŒïŒïŒïŒăȘăăœă€ăœă€ăłăăȘăłïŒïŒïŒă€ă«ïŒăășăȘăžăłïŒïŒïŒïŒïŒăžăȘăłèȘć°äœăć«ăæäžăŹăžăĄăł |
| KR20230042283A (ko) | 2020-06-26 | 2023-03-28 | ìŁŒë ž í ëŒíší±ì€ êČì ëČ í | ìŹìĄ°í© ìì©ìČŽë„Œ ìĄ°ê±Žë¶ëĄ ë°ííë ìĄ°ìë ïœ ìžíŹ, êŽë šë íŽëŠŹëŽíŽë ì€í°ë ë° ë°©ëČ |
| EP4171585A1 (en) | 2020-06-26 | 2023-05-03 | CRISPR Therapeutics AG | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| WO2022023576A1 (en) | 2020-07-30 | 2022-02-03 | Institut Curie | Immune cells defective for socs1 |
| CN116134027B (zh) | 2020-08-03 | 2025-01-24 | èŻșćèĄä»œæéć Źćž | æèłćșć代ç3-(1-æ°§ä»ŁćŒćČćć-2-ćș)ćć¶-2,6-äșé źèĄçç©ćć ¶çšé |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ăžă„ăăŒ ă»ă©ăă„ăŒăăŁăŻăč ă€ăłăłăŒăăŹă€ăăă | æčć€ăăăă€ăłăăȘăąăłăïœïœïŒć ç«ă°ăăăȘăłăčăŒăăŒăăĄăăȘăŒééșäŒććș§ăăăăĄă©ććźčäœăçșçŸăă现èăȘăăłă«éąéŁăăăăȘăăŻăŹăȘăăăăăłæčæł |
| JP2024508207A (ja) | 2020-12-02 | 2024-02-26 | ăă€ăąă€ăăŒ ăă€ăŒăăăăăȘă„ | ăăă«ćŻŸăăç”ăżćăăæČ»çă«ăăăïœïœïœïœăąăŽăăčă |
| US20220202859A1 (en) | 2020-12-23 | 2022-06-30 | Crispr Therapeutics Ag | Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor |
| CN117693508A (zh) | 2021-03-03 | 2024-03-12 | æ±èŻșæČ»çćŠèĄä»œæéć Źćž | Tç»èçæłćdgkæć¶ćçç»ć |
| CN116997654A (zh) | 2021-03-17 | 2023-11-03 | 珏äžäžć ±æ ȘćŒäŒç€Ÿ | çŒç æäčé °èçą±ćäœèȘèș«æäœçć”ććäœçćșć |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | ç棫ćè«ŸèŻć Źćž | æÎČæé«ćć ¶ä»æČ»çćçšæŒæČ»çćąæźæ§çŸç äčçšé |
| AR125468A1 (es) | 2021-04-27 | 2023-07-19 | Novartis Ag | Sistema de producciĂłn de vectores virales |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ăžă„ăă»ă»ă©ăă„ăŒăăŁăŻăčă»ăČăŒă«ă·ăŁăăă»ăăăă»ăă·ă„ăŹăłăŻăă«ă»ăăăăłă° | 现èăćșæżăăćœąèłȘć°ć „ăăæčæł |
| EP4337763A1 (en) | 2021-05-10 | 2024-03-20 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
| TW202309077A (zh) | 2021-05-12 | 2023-03-01 | ç棫ćïŒŁïœïœïœïœïœæČ»çć Źćž | çšæŒæČ»ç毊æ§ç€çé¶ćïœïœïŒïŒçćșć ć·„çšćć ç«çŽ°è |
| WO2022238962A1 (en) | 2021-05-12 | 2022-11-17 | Crispr Therapeutics Ag | Genetically engineered immune cells targeting cd70 for use in treating hematopoietic malignancies |
| US20240261446A1 (en) * | 2021-05-17 | 2024-08-08 | Université de LiÚge | Anti-cd38 single domain antibodies in disease monitoring and treatment |
| US20250304915A1 (en) | 2021-05-25 | 2025-10-02 | Institut Curie | Myeloid Cells Overexpressing BCL2 |
| WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
| EP4376869A1 (en) | 2021-07-28 | 2024-06-05 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers |
| WO2023017392A1 (en) | 2021-08-13 | 2023-02-16 | 3M Innovative Properties Company | Antistatic fabric article |
| CN113896802A (zh) * | 2021-10-09 | 2022-01-07 | ćźææç§çç©ć»èŻææŻïŒäžæ”·ïŒæéć Źćž | é¶ćcd47ćcd38çéç»èćèçœćć ¶ć¶ć€ćçšé |
| JP2025501272A (ja) | 2021-12-28 | 2025-01-17 | ă ăăąă»ă»ă©ăă„ăŒăăŁăŻăč | äžæŽ»æ§ćăăăïœïœïœïŒïŒïœïŒćăłæčć€ïœïœïœăæăăć ç«çŽ°è |
| JP2025504002A (ja) | 2022-01-28 | 2025-02-06 | ăžă„ăăŒ ă»ă©ăă„ăŒăăŁăŻăč ă€ăłăłăŒăăŹă€ăăă | 现èç”æç©ăèŁœé ăăæčæł |
| MX2024010003A (es) | 2022-02-18 | 2024-09-30 | Rakuten Medical Inc | Moléculas de anticuerpo anti-ligando 1 de muerte programada (pd-l1), polinucleótidos que las codifican y métodos de uso. |
| US20250213614A1 (en) | 2022-03-31 | 2025-07-03 | Institut Curie | Modified RELA Protein for Inducing Interferon Expression and Engineered Immune Cells with Improved Interferon Expression |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| EP4532695A1 (en) | 2022-05-25 | 2025-04-09 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| CN120152717A (zh) | 2022-09-08 | 2025-06-13 | æ±èŻșæČ»çćŠèĄä»œæéć Źćž | Tç»èçæłćèżç»æéŽædgkæć¶ćç»èŻçç»ć |
| CN119923276A (zh) * | 2022-09-09 | 2025-05-02 | æŠç°èŻćć·„äžæ ȘćŒäŒç€Ÿ | çšäșæČ»çæŁæäžćșŠèłéćșŠçł»ç»æ§çșąæçŒçźçæŁè çæcd38æäœççźäžç»èŻ |
| TW202423970A (zh) | 2022-10-10 | 2024-06-16 | ç棫ć蔫ććæçŸ èĄä»œć Źćž | ïœïœïœïŒïœ ïœïœïœćïœïœïŒïŒæé«äčç”ćçæł |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| US20250382378A1 (en) | 2022-10-31 | 2025-12-18 | Genmab A/S | Cd38 antibodies and uses thereof |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| EP4646435A1 (en) | 2023-01-06 | 2025-11-12 | Takeda Pharmaceutical Company Limited | Anti-cd38 antibodies for the treatment of autoimmune diseases |
| AU2024214593A1 (en) | 2023-02-03 | 2025-08-07 | C3S2 Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| AU2024276994A1 (en) | 2023-05-24 | 2025-10-23 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| WO2025042742A1 (en) | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
| WO2025153973A1 (en) | 2024-01-16 | 2025-07-24 | MorphoSys GmbH | Highly concentrated liquid formulations for antibodies |
| WO2025193746A1 (en) | 2024-03-12 | 2025-09-18 | Takeda Pharmaceutical Company Limited | Dosing regimens of anti-cd38 antibodies for treatment of subjects with immune thrombocytopenia |
| WO2025235919A1 (en) | 2024-05-09 | 2025-11-13 | Takeda Pharmaceutical Company Limited | Dosing regimens of anti-cd38 antibodies for treatment of subjects with immunoglobulin a nephropathy |
| CN119119277B (zh) * | 2024-10-24 | 2025-09-09 | æ·±ćłææŻć€§ćŠ | äžç§é¶ćcd38ççșłç±łæäœăèŻç©ç»ćç©ćć ¶ćșçš |
Family Cites Families (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4169888A (en) | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | ćłăźçŽ æ ȘćŒäŒç€Ÿ | 代çšèĄæ¶Č |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | ăă”ăă„ăŒă»ăăă»ă€ăłăčăăă„ăŒăă»ăȘăă»ăăŻăăăžăŒ | çłăżăłăăŻćźćźæ§ăźćŒ·ćæčæł |
| WO1987006265A1 (fr) | 1986-04-17 | 1987-10-22 | Kyowa Hakko Kogyo Co., Ltd. | Nouveaux composes dc-88a et dc-89a1, et procede pour leur preparation |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| US5084468A (en) | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2598116B2 (ja) | 1988-12-28 | 1997-04-09 | ććéé ”ć·„æ„æ ȘćŒäŒç€Ÿ | æ°èŠç©èłȘïœïœïŒïŒïŒ |
| US5187186A (en) | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
| JP2510335B2 (ja) | 1989-07-03 | 1996-06-26 | ććéé ”ć·„æ„æ ȘćŒäŒç€Ÿ | ïœâïŒïŒïœèȘć°äœ |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| WO1991017158A1 (en) | 1990-05-07 | 1991-11-14 | Scripps Clinic And Research Foundation | Intermediates in the formation of the calicheamicin and esperamicin oligosaccharides |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| DK0563475T3 (da) | 1992-03-25 | 2000-09-18 | Immunogen Inc | Konjugater af cellebindende midler og derivater af CC-1065 |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| AU6123894A (en) * | 1993-01-29 | 1994-08-15 | Board Of Trustees Of The Leland Stanford Junior University | Modulation of physiological responses of lymphocytes by cd38 or antibodies thereto |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ATE282630T1 (de) | 1993-10-01 | 2004-12-15 | Teikoku Hormone Mfg Co Ltd | Dolastatin-derivate |
| US5641780A (en) | 1994-04-22 | 1997-06-24 | Kyowa Hakko Kogyo Co., Ltd. | Pyrrolo-indole derivatives |
| JPH07309761A (ja) | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | ăă„ăȘă«ă«ăă€ă·ăłèȘć°äœăźćźćźćæł |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5550246A (en) | 1994-09-07 | 1996-08-27 | The Scripps Research Institute | Calicheamicin mimics |
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| JP2000503639A (ja) | 1995-12-22 | 2000-03-28 | ăăȘăčăă«âăă€ă€ăŒăș ăčăŻă€ă ă«ăłăăăŒ | ćæăăă©ăŸăłăźăȘăłă«ăŒéĄ |
| ATE293640T1 (de) | 1997-04-07 | 2005-05-15 | Genentech Inc | Anti-vegf antikörper |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhĂŠngig cellulĂŠr cytotoksicitet |
| US7112661B1 (en) | 1998-10-30 | 2006-09-26 | The Research Foundation Of State University Of New York | Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein Ib alpha |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| ES2420835T3 (es) | 1999-04-09 | 2013-08-27 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de las moléculas inmunofuncionales |
| US6939545B2 (en) | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| AU7950400A (en) | 1999-10-19 | 2001-04-30 | Kyowa Hakko Kogyo Co. Ltd. | Process for producing polypeptide |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| EP3263702A1 (en) | 2000-10-06 | 2018-01-03 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| AU2001294175A1 (en) | 2000-10-06 | 2002-04-22 | Kyowa Hakko Kogyo Co. Ltd. | Method of purifying antibody |
| IT1320715B1 (it) | 2000-10-19 | 2003-12-10 | Cselt Centro Studi Lab Telecom | Modulo generatore di circuiti per la decodifica di codiciconvoluzionali, metodo per la generazione di tale tipo di circuito e |
| AU2002248184C1 (en) | 2000-12-12 | 2018-01-04 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| ATE374214T1 (de) * | 2001-04-27 | 2007-10-15 | Kirin Brewery | Monoklonaler anti-cd-40-antikörper |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| KR20030033007A (ko) | 2001-05-31 | 2003-04-26 | ìœìží° íëšžìí°ì»Ź, ìžìœíŹë ìŽí°ë | ìžíŹë ì, ìœëŹŒì ê”ŹìČŽ, ë§ì»€ ë° ìŽì ì ì©í ìì íì |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| EP2298809A3 (en) | 2001-07-12 | 2012-02-15 | FOOTE, Jefferson | Super humanized antibodies |
| DE60215819T2 (de) | 2001-08-03 | 2007-09-06 | Tyco Healthcare Group Lp, Norwalk | Marker zur verwendung mit einem gewebemarkierungsgerÀt |
| US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| DE10246870B3 (de) | 2002-10-08 | 2004-04-29 | Renk Aktiengesellschaft | Elektro-Hydrodynamische Ăberlagerungslenkung |
| CN100526460C (zh) * | 2002-11-08 | 2009-08-12 | éșéșć»èŻæ ȘćŒäŒç€Ÿ | æç æŻèçœæŽ»æ§éäœçèœŹćșć æèčç±»ćšç©ćć ¶çšé |
| WO2004043493A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| US7610156B2 (en) | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
| PT1651162E (pt) | 2003-05-20 | 2016-02-22 | Immunogen Inc | Agentes citotĂłxicos melhorados compreendendo novos maitansinĂłides |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US20070148170A1 (en) | 2005-10-03 | 2007-06-28 | Desjarlais John R | Fc Variants With Optimized Fc Receptor Binding Properties |
| DK1725249T3 (en) | 2003-11-06 | 2014-03-17 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugating to ligands. |
| JP5064037B2 (ja) | 2004-02-23 | 2012-10-31 | ăžă§ăăłăăăŻïŒ ă€ăłăłăŒăăŹă€ăăă | è€çŽ ç°ćŒèȘćŁçăȘăłă«ăŒăăăłç”ćäœ |
| WO2005084390A2 (en) | 2004-03-02 | 2005-09-15 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
| RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | ĐДЎаŃĐ”ĐșŃ, ĐĐœĐș. | Đ„ĐžĐŒĐžŃĐ”ŃĐșОД Đ»ĐžĐœĐșĐ”ŃŃ Đž ĐžŃ ĐșĐŸĐœŃŃгаŃŃ |
| BRPI0510909A2 (pt) | 2004-05-19 | 2008-12-16 | Medarex Inc | composto de ligaĂço fĂrmaco-ligante citotĂ xico, formulaĂço farmacĂutica, mĂtodo para matar uma cĂlula e mĂtodo para retardar ou interromper o crescimento de tumor |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingenierĂa genĂ©tica con cisteĂna |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| MX2007011064A (es) * | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| AU2006236225C1 (en) | 2005-04-19 | 2013-05-02 | Seagen Inc. | Humanized anti-CD70 binding agents and uses thereof |
| US20090123950A1 (en) * | 2005-05-24 | 2009-05-14 | Morphosys Ag | Generation And Profiling Of Fully Human Hucal GoldÂź-Derived Therapeutic Antibodies Specific For Human CD38 |
| AU2006269940C1 (en) | 2005-07-18 | 2013-11-07 | Seagen Inc. | Beta-glucuronide-linker drug conjugates |
| EP1909846B1 (en) | 2005-08-05 | 2018-12-26 | Syntarga B.V. | Triazole-containing releasable linkers, conjugates comprising the same and processes for their preparation |
| NZ566915A (en) | 2005-10-12 | 2011-09-30 | Morphosys Ag | Generation and profiling of human derived therapeutic antibodies specific for human CD38 |
| JP5116686B2 (ja) | 2005-10-26 | 2013-01-09 | ăĄăăŹăăŻăč ă€ăłăłăŒăăŹă€ăăă | ïŒŁïœâïŒïŒïŒïŒéĄäŒŒäœăźèȘżèŁœæčæłćăłèȘżèŁœçšććç© |
| WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| AU2007210377B2 (en) | 2006-02-02 | 2012-08-09 | Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts (Ohne Bereich Humanmedizin) | Water-soluble CC-1065 analogs and their conjugates |
| WO2008007648A1 (fr) | 2006-07-10 | 2008-01-17 | Institute For Antibodies Co., Ltd. | Procédé de classification d'antigÚne, procédé d'identification d'antigÚne, procédé d'obtention d' un ensemble d'antigÚnes ou d'anticorps, procédés de construction d'un panel d'anticorps, anticorps et ens |
| TR201910145T4 (tr) | 2006-09-26 | 2019-08-21 | Genmab As | TĂŒmörlerin tedavi edilmesine yönelik anti-CD38 artı kortikosteroidler artı bir kortikosteroid-olmayan kemoterapötik. |
| EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| WO2009017394A1 (en) | 2007-08-01 | 2009-02-05 | Syntarga B.V. | Substituted cc-1065 analogs and their conjugates |
| US20090076249A1 (en) | 2007-09-19 | 2009-03-19 | Michel De Weers | Antibodies against CD38 for treatment of multiple myeloma |
| CN102216329A (zh) * | 2007-12-17 | 2011-10-12 | èŸçæéć Źćž | éŽèŽšæ§èè±ççæČ»ç |
| MX2010013833A (es) | 2008-06-16 | 2011-02-15 | Immunogen Inc | Nuevos efectos sinergisticos. |
| WO2010021874A2 (en) * | 2008-08-20 | 2010-02-25 | Centocor Ortho Biotech Inc. | Engineered anti-il-13 antibodies, compositions, methods and uses |
| MX2011004625A (es) | 2008-11-03 | 2011-07-20 | Syntarga Bv | Analogos cc-1065 novedosos y sus conjugados. |
| EP2191843A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
| EP2191842A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
| EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
| WO2010109924A1 (ja) | 2009-03-25 | 2010-09-30 | ćœç«ć€§ćŠæłäșșæ±ćć€§ćŠ | ïŒŹïœćäșéçčç°æ§æäœ |
| US10817851B2 (en) | 2009-12-23 | 2020-10-27 | Aristocrat Technologies Australia Pty Limited | System and method for cashless gaming |
| EP2580243B1 (en) | 2010-06-09 | 2019-10-16 | Genmab A/S | Antibodies against human cd38 |
| PT2621531T (pt) | 2010-09-27 | 2017-03-13 | Morphosys Ag | Anticorpo anti-cd38 e lenalidomida ou bortezomibe para o tratamento de mieloma mĂșltiplo e linfoma nĂŁo-hodgkins |
| UA112170C2 (uk) | 2010-12-10 | 2016-08-10 | ĐĄĐ°ĐœĐŸŃŃ | ĐŃĐŸŃОпŃŃ Đ»ĐžĐœĐœĐ° ĐșĐŸĐŒĐ±ŃĐœĐ°ŃŃŃ, ŃĐŸ ĐŒŃŃŃĐžŃŃ Đ°ĐœŃĐžŃŃĐ»ĐŸ, ŃĐșĐ” ŃпДŃĐžŃŃŃĐœĐŸ ŃĐŸĐ·ĐżŃĐ·ĐœĐ°Ń cd38, Ń Đ±ĐŸŃŃĐ”Đ·ĐŸĐŒŃб |
| GB2486424A (en) | 2010-12-13 | 2012-06-20 | Univ Sussex | Markers for plasma cell disorders |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | ۧÙŰŁŰŹŰłŰ§Ù Ű§ÙÙ Ű¶Ű§ŰŻŰ© ÙÙ cd38 |
| BR112013021725A2 (pt) | 2011-02-28 | 2016-11-01 | Genentech Inc | marcadores biológicos e métodos para prever resposta aos antagonistas de células b |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | ă€ăă„ăŒăăĄăăŁăŻăčăă€ăłăłăŒăăŹă€ăăăïœïœïœïœïœïœïœ ïœïœïœïœïŒ ïœïœïŒ | ć°ćźčéæäžçšăźăąăăżă€ăéžææäœăźéć€æżŸéæżçžź |
| GB201203938D0 (en) | 2012-03-06 | 2012-04-18 | Binding Site Group The Ltd | Assay system |
| GB201212900D0 (en) | 2012-07-20 | 2012-09-05 | Binding Site Group The Ltd | Triage scoring system |
| US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
| UA118255C2 (uk) | 2012-12-07 | 2018-12-26 | ĐĄĐ°ĐœĐŸŃŃ | ĐĐŸĐŒĐżĐŸĐ·ĐžŃŃŃ, ŃĐșĐ° ĐŒŃŃŃĐžŃŃ Đ°ĐœŃĐžŃŃĐ»ĐŸ ĐŽĐŸ cd38 Ń Đ»Đ”ĐœĐ°Đ»ŃĐŽĐŸĐŒŃĐŽ |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | çŹç«èĄæżæłäșș ćœç«çČŸç„ă»ç„ç”ć»çç 究ă»ăłăżăŒ | ćçșćŻè§Łćć€çșæ§çĄŹćçïŒïœïœïœïœïŒæŁè ăźæČ»çäșćŸäșæžŹæčæłăćăłæ°èŠæČ»çé©ćżć€ææčæł |
| CN105745226B (zh) | 2013-07-30 | 2020-03-06 | Sbiçç©ææŻæéć Źćž | ć ć«æ-磷èé ¶d4æäœçèŻç© |
| TN2016000142A1 (en) | 2013-10-31 | 2017-10-06 | Sanofi Sa | Specific anti-cd38 antibodies for treating human cancers. |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | йДĐČĐ° ЀаŃĐŒĐ°ŃŃŃŃĐžĐșалз ĐŃŃŃĐ”ĐčĐ»ŃĐ° ĐŃŃ ĐŃĐŽ | ĐĐŸĐŒĐ±ŃĐœĐ°ŃŃŃ Đ»Đ”ĐœĐ°Đ»ŃĐŽĐŸĐŒŃĐŽŃ Đ°Đ±ĐŸ ĐżĐŸĐŒĐ°Đ»ŃĐŽĐŸĐŒŃĐŽŃ Ń ĐșĐŸĐœŃŃŃŃĐșŃŃŃ Đ°ĐœŃĐž-cd38 Đ°ĐœŃĐžŃŃĐ»ĐŸ-Đ°ŃĐ”ĐœŃĐčĐŸĐČĐ°ĐœĐžĐč ŃĐœŃĐ”ŃŃĐ”ŃĐŸĐœ Đ°Đ»ŃŃĐ°-2b ŃĐ° ŃĐżĐŸŃŃб Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃŃб'ŃĐșŃĐ°, ŃĐșĐžĐč ĐŒĐ°Ń cd38-Đ”ĐșŃĐżŃĐ”ŃŃŃŃŃ ĐżŃŃ Đ»ĐžĐœŃ |
| US10617757B2 (en) | 2014-08-08 | 2020-04-14 | The Regents Of The University Of California | Methods for treating multiple myeloma |
| MA40608A (fr) | 2014-09-09 | 2016-03-17 | Janssen Biotech Inc | Polythérapies avec des anticorps anti-cd38 |
| MA41555A (fr) | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
| HUE054271T2 (hu) | 2015-05-13 | 2021-08-30 | Morphosys Ag | Mielóma Multiplex (MM) kezelése |
| EP4553157A3 (en) | 2015-05-20 | 2025-07-23 | Janssen Biotech, Inc. | Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies |
| JP7027321B2 (ja) | 2015-11-03 | 2022-03-01 | ă€ăłă»ăł ăă€ăȘăăăŻïŒă€ăłăłăŒăăŹăŒăăă | æïœïœïŒïŒæäœăźçźäžèŁœć€ćăłăăźäœżçš |
| US20170121417A1 (en) | 2015-11-03 | 2017-05-04 | Janssen Biotech, Inc. | Subcutaneous Formulations of Anti-CD38 Antibodies and Their Uses |
| JP7316930B2 (ja) * | 2016-07-15 | 2023-07-28 | æŠç°èŹćć·„æ„æ ȘćŒäŒç€Ÿ | ćœąèłȘèœçŽ°èćăłćœąèłȘ现èæŻæžçæłă«ćŻŸăăćżçăè©äŸĄăăăăăźæčæłćăłææ |
| US20180117150A1 (en) | 2016-11-01 | 2018-05-03 | Janssen Biotech, Inc. | Combination Therapies for CD38-Positive Hematological Malignances with ANTI-CD38 Antibodies and Cyclophosphamide |
| US11392902B2 (en) | 2017-06-06 | 2022-07-19 | United Parcel Service Of America, Inc. | Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery |
| JP2021502961A (ja) | 2017-10-31 | 2021-02-04 | ă€ăłă»ăł ăă€ăȘăăăŻïŒă€ăłăłăŒăăŹăŒăăă | é«ăȘăčăŻć€çșæ§éȘšé«è «ăźæČ»çæčæł |
| CN112739715A (zh) * | 2018-01-12 | 2021-04-30 | æŠç°èŻćć·„äžæ ȘćŒäŒç€Ÿ | æcd38æäœççźäžç»èŻ |
| MX2021000307A (es) * | 2018-07-11 | 2021-09-08 | Momenta Pharmaceuticals Inc | Composiciones y mĂ©todos relacionados con constructos de dominio de uniĂłn a antĂgeno-fc dirigidos a cd38 diseñados por ingenierĂa genĂ©tica. |
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