BR112021021075A2 - Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos - Google Patents
Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodosInfo
- Publication number
- BR112021021075A2 BR112021021075A2 BR112021021075A BR112021021075A BR112021021075A2 BR 112021021075 A2 BR112021021075 A2 BR 112021021075A2 BR 112021021075 A BR112021021075 A BR 112021021075A BR 112021021075 A BR112021021075 A BR 112021021075A BR 112021021075 A2 BR112021021075 A2 BR 112021021075A2
- Authority
- BR
- Brazil
- Prior art keywords
- modified
- cells
- tgfbr2
- recombinant receptor
- locus
- Prior art date
Links
- 108020003175 receptors Proteins 0.000 title abstract 6
- 102000005962 receptors Human genes 0.000 title abstract 6
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 title abstract 5
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 230000010354 integration Effects 0.000 abstract 2
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 abstract 1
- 108010092867 Transforming Growth Factor beta Receptors Proteins 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical class C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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Abstract
células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos. a presente invenção refere-se a células imunes modificadas, por exemplo, células t, que expressam um receptor recombinante, que contêm um locus do receptor do fator beta de crescimento transformador tipo 2 modificado (tgfbr2) que codifica o receptor recombinante ou uma porção do mesmo. em alguns aspectos, as células são modificadas por integração direcionada de uma sequência de transgene que codifica o receptor recombinante ou uma porção do mesmo, em um locus genômico de tgfbr2. também são fornecidas composições de células contendo as células imunes modificadas, ácidos nucleicos para células de modificação e métodos, kits e artigos de fabricação para a produção de células modificadas, tal como direcionando uma sequência de transgene que codifica um receptor recombinante ou uma porção do mesmo para integração em uma região de um locus genômico de tgfbr2. em algumas modalidades, as células modificadas, por exemplo, as células t podem ser usadas em conexão com a terapia celular, incluindo em conexão com a imunoterapia contra o câncer que compreende a transferência adotiva das células modificadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201962841575P | 2019-05-01 | 2019-05-01 | |
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2020
- 2020-04-30 AU AU2020265741A patent/AU2020265741A1/en active Pending
- 2020-04-30 MA MA055811A patent/MA55811A/fr unknown
- 2020-04-30 CA CA3136737A patent/CA3136737A1/en active Pending
- 2020-04-30 KR KR1020217039324A patent/KR20220016475A/ko unknown
- 2020-04-30 EP EP20729274.9A patent/EP3962520A1/en active Pending
- 2020-04-30 JP JP2021564439A patent/JP2022531222A/ja active Pending
- 2020-04-30 US US17/607,816 patent/US20220184131A1/en active Pending
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- 2020-04-30 MX MX2021013219A patent/MX2021013219A/es unknown
- 2020-04-30 SG SG11202111360YA patent/SG11202111360YA/en unknown
- 2020-04-30 WO PCT/US2020/030815 patent/WO2020223535A1/en unknown
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CA3136737A1 (en) | 2020-11-05 |
KR20220016475A (ko) | 2022-02-09 |
AU2020265741A1 (en) | 2021-11-25 |
MX2021013219A (es) | 2022-02-17 |
US20220184131A1 (en) | 2022-06-16 |
IL287207A (en) | 2021-12-01 |
JP2022531222A (ja) | 2022-07-06 |
EP3962520A1 (en) | 2022-03-09 |
MA55811A (fr) | 2022-03-09 |
SG11202111360YA (en) | 2021-11-29 |
WO2020223535A1 (en) | 2020-11-05 |
CN114025788A (zh) | 2022-02-08 |
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