BR112021021075A2 - Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos - Google Patents

Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos

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Publication number
BR112021021075A2
BR112021021075A2 BR112021021075A BR112021021075A BR112021021075A2 BR 112021021075 A2 BR112021021075 A2 BR 112021021075A2 BR 112021021075 A BR112021021075 A BR 112021021075A BR 112021021075 A BR112021021075 A BR 112021021075A BR 112021021075 A2 BR112021021075 A2 BR 112021021075A2
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Brazil
Prior art keywords
modified
cells
tgfbr2
recombinant receptor
locus
Prior art date
Application number
BR112021021075A
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English (en)
Inventor
D Sather Blythe
Cedric Cleyrat
Heath Nye Christopher
Christopher Wilson
Fred Harbinski
Grant Welstead G
Melissa Chin
Queenie Vong
Michael Burleigh Stephen
Original Assignee
Editas Medicine Inc
Juno Therapeutics Inc
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Publication date
Application filed by Editas Medicine Inc, Juno Therapeutics Inc filed Critical Editas Medicine Inc
Publication of BR112021021075A2 publication Critical patent/BR112021021075A2/pt

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Abstract

células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos. a presente invenção refere-se a células imunes modificadas, por exemplo, células t, que expressam um receptor recombinante, que contêm um locus do receptor do fator beta de crescimento transformador tipo 2 modificado (tgfbr2) que codifica o receptor recombinante ou uma porção do mesmo. em alguns aspectos, as células são modificadas por integração direcionada de uma sequência de transgene que codifica o receptor recombinante ou uma porção do mesmo, em um locus genômico de tgfbr2. também são fornecidas composições de células contendo as células imunes modificadas, ácidos nucleicos para células de modificação e métodos, kits e artigos de fabricação para a produção de células modificadas, tal como direcionando uma sequência de transgene que codifica um receptor recombinante ou uma porção do mesmo para integração em uma região de um locus genômico de tgfbr2. em algumas modalidades, as células modificadas, por exemplo, as células t podem ser usadas em conexão com a terapia celular, incluindo em conexão com a imunoterapia contra o câncer que compreende a transferência adotiva das células modificadas.
BR112021021075A 2019-05-01 2020-04-30 Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos BR112021021075A2 (pt)

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US201962841575P 2019-05-01 2019-05-01
PCT/US2020/030815 WO2020223535A1 (en) 2019-05-01 2020-04-30 Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods

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BR112021021075A2 true BR112021021075A2 (pt) 2021-12-14

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US (1) US20220184131A1 (pt)
EP (1) EP3962520A1 (pt)
JP (1) JP2022531222A (pt)
KR (1) KR20220016475A (pt)
CN (1) CN114025788A (pt)
AU (1) AU2020265741A1 (pt)
BR (1) BR112021021075A2 (pt)
CA (1) CA3136737A1 (pt)
IL (1) IL287207A (pt)
MA (1) MA55811A (pt)
MX (1) MX2021013219A (pt)
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WO2022232277A1 (en) * 2021-04-27 2022-11-03 TCR2 Therapeutics Inc. COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND TGFβR SWITCH
WO2022232840A1 (en) * 2021-04-29 2022-11-03 The Regents Of The University Of California Systems and methods for genetic editing with increased efficiency
EP4355879A2 (en) * 2021-06-14 2024-04-24 Graphite Bio, Inc. Methods to genetically engineer hematopoietic stem and progenitor cells for red cell specific expression of therapeutic proteins
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WO2023010436A1 (zh) * 2021-08-05 2023-02-09 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
CN115918611A (zh) * 2021-10-25 2023-04-07 百奥赛图(北京)医药科技股份有限公司 Tgfbr2基因人源化非人动物及其构建方法和应用
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
US20230372485A1 (en) * 2021-11-15 2023-11-23 Neogene Therapeutics B.V. Engineered t cells with reduced tgf-beta receptor signaling
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