SG10201805670QA - Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders - Google Patents
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disordersInfo
- Publication number
- SG10201805670QA SG10201805670QA SG10201805670QA SG10201805670QA SG10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA SG 10201805670Q A SG10201805670Q A SG 10201805670QA
- Authority
- SG
- Singapore
- Prior art keywords
- disorders
- senescence
- methods
- diseases
- senescent cells
- Prior art date
Links
- 208000037765 diseases and disorders Diseases 0.000 title abstract 6
- 230000009758 senescence Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 229940125381 senolytic agent Drugs 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461932711P | 2014-01-28 | 2014-01-28 | |
US201461932704P | 2014-01-28 | 2014-01-28 | |
US201461979911P | 2014-04-15 | 2014-04-15 | |
US201462002709P | 2014-05-23 | 2014-05-23 | |
US201462042708P | 2014-08-27 | 2014-08-27 | |
US201462044664P | 2014-09-02 | 2014-09-02 | |
US201462057825P | 2014-09-30 | 2014-09-30 | |
US201462057820P | 2014-09-30 | 2014-09-30 | |
US201462057828P | 2014-09-30 | 2014-09-30 | |
US201462061629P | 2014-10-08 | 2014-10-08 | |
US201462061627P | 2014-10-08 | 2014-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201805670QA true SG10201805670QA (en) | 2018-08-30 |
Family
ID=53757701
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201805670QA SG10201805670QA (en) | 2014-01-28 | 2015-01-28 | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
SG11201606239UA SG11201606239UA (en) | 2014-01-28 | 2015-01-28 | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201606239UA SG11201606239UA (en) | 2014-01-28 | 2015-01-28 | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
Country Status (15)
Country | Link |
---|---|
US (19) | US9993472B2 (zh) |
EP (2) | EP3669881B1 (zh) |
JP (5) | JP6688224B2 (zh) |
KR (1) | KR102496146B1 (zh) |
CN (3) | CN110623956A (zh) |
AU (3) | AU2015211021B2 (zh) |
BR (1) | BR112016017564A8 (zh) |
CA (2) | CA3100140C (zh) |
HK (1) | HK1231392A1 (zh) |
IL (3) | IL311537A (zh) |
MX (2) | MX2016009753A (zh) |
NZ (1) | NZ723035A (zh) |
RU (1) | RU2716256C2 (zh) |
SG (2) | SG10201805670QA (zh) |
WO (1) | WO2015116740A1 (zh) |
Families Citing this family (105)
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EP2294178B1 (en) | 2008-05-23 | 2014-07-16 | Siwa Corporation | Methods for facilitating regeneration |
WO2012047629A2 (en) | 2010-09-27 | 2012-04-12 | Siwa Corporation | Selective removal of age-modified cells for treatment of ather0sclerosis |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
CA3100140C (en) | 2014-01-28 | 2023-10-24 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
CN106456699B (zh) | 2014-05-05 | 2021-07-02 | 生物风险投资有限责任公司 | 作为抗老化剂抑制抗凋亡的Bcl-2蛋白的组合物和方法 |
WO2015171723A1 (en) * | 2014-05-06 | 2015-11-12 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy |
AU2015292710A1 (en) | 2014-07-22 | 2017-02-16 | Bioventures, Llc. | Compositions and methods for selectively depleting senescent cells |
BR112017005517A2 (pt) | 2014-09-19 | 2017-12-05 | Siwa Corp | anticorpos antiage para o tratamento de inflama-ção e de transtornos autoimunes |
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US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
US20180000816A1 (en) * | 2015-02-06 | 2018-01-04 | Unity Biotechnology, Inc. | Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions |
CA2981753A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditions |
US20180345047A1 (en) * | 2015-02-26 | 2018-12-06 | Yeda Research And Development Co. Ltd. | Method of promoting hair growth |
US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
WO2017002120A1 (en) * | 2015-07-02 | 2017-01-05 | Yeda Research And Development Co. Ltd. | Selective inhibitors of senescent cells and uses thereof |
US11111259B2 (en) | 2015-12-18 | 2021-09-07 | Unity Biotechnology, Inc. | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders |
EP3337829B1 (en) | 2016-02-19 | 2020-01-08 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
MY197785A (en) * | 2016-03-15 | 2023-07-13 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for the treatment of hematological malignancies |
WO2017181116A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
US10807977B2 (en) | 2016-04-21 | 2020-10-20 | Bioventures, Llc | Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof |
US20190054097A1 (en) * | 2016-04-21 | 2019-02-21 | Bioventures, Llc | Compositions targeting senescent cells and the uses thereof |
WO2017223107A1 (en) * | 2016-06-20 | 2017-12-28 | Unity Biotechnology, Inc. | Genome modifying enzyme therapy for diseases modulated by senescent cells |
US11213585B2 (en) | 2016-06-23 | 2022-01-04 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
CA3044066A1 (en) | 2016-12-13 | 2018-06-21 | Princeton Drug Discovery Inc | Protein kinase inhibitors |
JP2020511951A (ja) | 2017-01-03 | 2020-04-23 | バイオアトラ、エルエルシー | 老化細胞の処置のためのタンパク質療法 |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
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