MX2016009753A - Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud. - Google Patents

Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud.

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Publication number
MX2016009753A
MX2016009753A MX2016009753A MX2016009753A MX2016009753A MX 2016009753 A MX2016009753 A MX 2016009753A MX 2016009753 A MX2016009753 A MX 2016009753A MX 2016009753 A MX2016009753 A MX 2016009753A MX 2016009753 A MX2016009753 A MX 2016009753A
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MX
Mexico
Prior art keywords
disorders
senescence
methods
diseases
senescent cells
Prior art date
Application number
MX2016009753A
Other languages
English (en)
Inventor
Campisi Judith
Zhu Yi
Martin Laberge Remi-
DAVALOS Albert
Demaria Marco
David Nathaniel
Philippe Vasserot Alain
J Baker Darren
g childs Bennett
L Kirkland James
TCHKONIA Tamar
M A Van Deursen Jan
Elisseeff Jennifer
Kim Chaekyu
JEON Okhee
Original Assignee
Buck Inst For Res On Aging
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Publication date
Application filed by Buck Inst For Res On Aging filed Critical Buck Inst For Res On Aging
Publication of MX2016009753A publication Critical patent/MX2016009753A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Abstract

Se proporcionan métodos en la presente para exterminar selectivamente células senescentes y para tratar enfermedades y trastornos asociados con la senectud al administrar un agente senolítico. Las enfermedades y trastornos asociados con la senectud tratables por los métodos usando los agentes senolíticos descritos en la presente incluyen enfermedades y trastornos cardiovasculares asociados con o provocados por arteriosclerosis, tal como aterosclerosis; fibrosis pulmonar idiopática; enfermedad pulmonar obstructiva crónica; osteoartritis; enfermedades y trastornos oftálmicos asociados con la senectud; y enfermedades y trastornos dermatológicos asociados con la senectud.
MX2016009753A 2014-01-28 2015-01-28 Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud. MX2016009753A (es)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201461932704P 2014-01-28 2014-01-28
US201461932711P 2014-01-28 2014-01-28
US201461979911P 2014-04-15 2014-04-15
US201462002709P 2014-05-23 2014-05-23
US201462042708P 2014-08-27 2014-08-27
US201462044664P 2014-09-02 2014-09-02
US201462057828P 2014-09-30 2014-09-30
US201462057820P 2014-09-30 2014-09-30
US201462057825P 2014-09-30 2014-09-30
US201462061629P 2014-10-08 2014-10-08
US201462061627P 2014-10-08 2014-10-08
PCT/US2015/013387 WO2015116740A1 (en) 2014-01-28 2015-01-28 Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Publications (1)

Publication Number Publication Date
MX2016009753A true MX2016009753A (es) 2017-07-07

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016009753A MX2016009753A (es) 2014-01-28 2015-01-28 Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud.
MX2021012547A MX2021012547A (es) 2014-01-28 2016-07-27 Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud.

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MX2021012547A MX2021012547A (es) 2014-01-28 2016-07-27 Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud.

Country Status (15)

Country Link
US (18) US9993472B2 (es)
EP (2) EP3669881B1 (es)
JP (5) JP6688224B2 (es)
KR (1) KR102496146B1 (es)
CN (3) CN112274641A (es)
AU (3) AU2015211021B2 (es)
BR (1) BR112016017564A8 (es)
CA (2) CA2939121C (es)
HK (1) HK1231392A1 (es)
IL (2) IL286427B1 (es)
MX (2) MX2016009753A (es)
NZ (1) NZ723035A (es)
RU (1) RU2716256C2 (es)
SG (2) SG11201606239UA (es)
WO (1) WO2015116740A1 (es)

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