BR112015007970A8 - processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona - Google Patents
processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona Download PDFInfo
- Publication number
- BR112015007970A8 BR112015007970A8 BR112015007970A BR112015007970A BR112015007970A8 BR 112015007970 A8 BR112015007970 A8 BR 112015007970A8 BR 112015007970 A BR112015007970 A BR 112015007970A BR 112015007970 A BR112015007970 A BR 112015007970A BR 112015007970 A8 BR112015007970 A8 BR 112015007970A8
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- piperazin
- morpholinothieno
- aminopyrimidin
- hydroxypropan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
Abstract
processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)- 7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1- il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona” métodos de processo de fabricação de inibidor dual mtor/pi3k gdc-0980, denominado (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4- morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona, e estereoisômeros, isômeros geométricos, tautômeros e sais farmaceuticamente aceitáveis destes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261711900P | 2012-10-10 | 2012-10-10 | |
PCT/EP2013/070994 WO2014056955A1 (en) | 2012-10-10 | 2013-10-09 | Process for making thienopyrimidine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015007970A2 BR112015007970A2 (pt) | 2017-07-04 |
BR112015007970A8 true BR112015007970A8 (pt) | 2019-08-27 |
Family
ID=49322377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015007970A BR112015007970A8 (pt) | 2012-10-10 | 2013-10-09 | processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona |
Country Status (13)
Country | Link |
---|---|
US (1) | US8895729B2 (pt) |
EP (1) | EP2906566B1 (pt) |
JP (1) | JP6123097B2 (pt) |
KR (1) | KR101698283B1 (pt) |
CN (2) | CN104718212B (pt) |
AR (1) | AR092960A1 (pt) |
BR (1) | BR112015007970A8 (pt) |
CA (1) | CA2883513A1 (pt) |
ES (1) | ES2594078T3 (pt) |
HK (2) | HK1211026A1 (pt) |
MX (1) | MX349551B (pt) |
RU (1) | RU2637309C2 (pt) |
WO (1) | WO2014056955A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2637309C2 (ru) * | 2012-10-10 | 2017-12-04 | Ф. Хоффманн-Ля Рош Аг | Способ получения соединений тиенопиримидина |
AR096178A1 (es) | 2013-05-06 | 2015-12-09 | Hoffmann La Roche | Procedimiento para la preparacion de intermediarios de acido boronico. |
US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
AU2017355385A1 (en) * | 2016-11-02 | 2019-05-30 | Curis, Inc. | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
WO2019180141A1 (en) | 2018-03-23 | 2019-09-26 | Bayer Aktiengesellschaft | Combinations of rogaratinib |
CN113717049A (zh) * | 2021-08-05 | 2021-11-30 | 江西兄弟医药有限公司 | 一种制备(s)-乙酰氧基丙酰氯的半连续方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
US5846824A (en) | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
US6395916B1 (en) | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
KR20040024564A (ko) | 2001-07-12 | 2004-03-20 | 아베시아 리미티드 | 마이크로캡슐화된 촉매, 이의 제조 방법 및 이의 사용 방법 |
GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
AU2007243457B2 (en) | 2006-04-26 | 2012-02-23 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
GB0608264D0 (en) * | 2006-04-26 | 2006-06-07 | Piramed Ltd | Pharmaceutical compounds |
US9487533B2 (en) * | 2006-12-07 | 2016-11-08 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
ZA200904534B (en) * | 2006-12-07 | 2010-09-29 | Hoffmann La Roche | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
MY180595A (en) | 2006-12-07 | 2020-12-03 | Genentech Inc | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
US8247397B2 (en) | 2007-09-12 | 2012-08-21 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
US8354528B2 (en) | 2007-10-25 | 2013-01-15 | Genentech, Inc. | Process for making thienopyrimidine compounds |
JP5591714B2 (ja) | 2007-12-12 | 2014-09-17 | マサチューセッツ インスティテュート オブ テクノロジー | 遷移金属触媒によるクロスカップリングのためのリガンド、およびその使用方法 |
BRPI1006189A2 (pt) * | 2009-03-12 | 2020-08-18 | Genentech Inc | uso de uma combinação terapêutica, formulação farmacêutica, artigo de manufatura, produto, método para determinar compostos a serem utilizados em combinação para o tratamento de uma malignidade hematopoiética e método para selecionar compostos a serem utilizados em combinação para o tratamento de câncer |
WO2012164060A1 (en) | 2011-06-03 | 2012-12-06 | F. Hoffmann-La Roche Ag | Methods of treating mesothelioma with a pi3k inhibitor compound |
CN102399235A (zh) * | 2011-10-25 | 2012-04-04 | 江苏弘和药物研发有限公司 | 一种2-氨基-5-嘧啶硼酸频哪醇酯的合成方法 |
CN102367260A (zh) * | 2011-12-12 | 2012-03-07 | 南京药石药物研发有限公司 | 2-氨基嘧啶-5-硼酸的合成方法 |
CN102675323B (zh) * | 2012-06-01 | 2014-04-09 | 南京药石药物研发有限公司 | 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途 |
RU2637309C2 (ru) * | 2012-10-10 | 2017-12-04 | Ф. Хоффманн-Ля Рош Аг | Способ получения соединений тиенопиримидина |
CN102993163A (zh) * | 2012-12-07 | 2013-03-27 | 青岛前线生物工程有限公司 | 3-甲基噻吩-2-甲醛的合成方法 |
-
2013
- 2013-10-09 RU RU2015113747A patent/RU2637309C2/ru not_active IP Right Cessation
- 2013-10-09 CN CN201380052049.5A patent/CN104718212B/zh active Active
- 2013-10-09 JP JP2015536109A patent/JP6123097B2/ja active Active
- 2013-10-09 ES ES13774174.0T patent/ES2594078T3/es active Active
- 2013-10-09 EP EP13774174.0A patent/EP2906566B1/en active Active
- 2013-10-09 KR KR1020157009108A patent/KR101698283B1/ko not_active Application Discontinuation
- 2013-10-09 MX MX2015004467A patent/MX349551B/es active IP Right Grant
- 2013-10-09 CN CN201710374289.7A patent/CN107188898B/zh active Active
- 2013-10-09 AR ARP130103666A patent/AR092960A1/es unknown
- 2013-10-09 BR BR112015007970A patent/BR112015007970A8/pt not_active Application Discontinuation
- 2013-10-09 WO PCT/EP2013/070994 patent/WO2014056955A1/en active Application Filing
- 2013-10-09 US US14/049,477 patent/US8895729B2/en active Active
- 2013-10-09 CA CA2883513A patent/CA2883513A1/en not_active Abandoned
-
2015
- 2015-11-30 HK HK15111757.3A patent/HK1211026A1/xx unknown
- 2015-11-30 HK HK18103640.8A patent/HK1244272A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20140100366A1 (en) | 2014-04-10 |
CN104718212A (zh) | 2015-06-17 |
WO2014056955A1 (en) | 2014-04-17 |
KR101698283B1 (ko) | 2017-01-19 |
EP2906566B1 (en) | 2016-08-24 |
JP6123097B2 (ja) | 2017-05-10 |
CN104718212B (zh) | 2017-06-16 |
MX349551B (es) | 2017-08-02 |
HK1211026A1 (en) | 2016-05-13 |
US8895729B2 (en) | 2014-11-25 |
JP2015534572A (ja) | 2015-12-03 |
CN107188898B (zh) | 2019-12-03 |
ES2594078T3 (es) | 2016-12-15 |
RU2015113747A (ru) | 2016-12-10 |
BR112015007970A2 (pt) | 2017-07-04 |
EP2906566A1 (en) | 2015-08-19 |
CN107188898A (zh) | 2017-09-22 |
KR20150054945A (ko) | 2015-05-20 |
RU2637309C2 (ru) | 2017-12-04 |
CA2883513A1 (en) | 2014-04-17 |
HK1244272A1 (zh) | 2018-08-03 |
AR092960A1 (es) | 2015-05-06 |
MX2015004467A (es) | 2015-07-14 |
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