MX349551B - Proceso para preparar compuestos tienopirimidinas. - Google Patents

Proceso para preparar compuestos tienopirimidinas.

Info

Publication number
MX349551B
MX349551B MX2015004467A MX2015004467A MX349551B MX 349551 B MX349551 B MX 349551B MX 2015004467 A MX2015004467 A MX 2015004467A MX 2015004467 A MX2015004467 A MX 2015004467A MX 349551 B MX349551 B MX 349551B
Authority
MX
Mexico
Prior art keywords
making
thienopyrimidine compounds
methyl
thienopyrimidine
compounds
Prior art date
Application number
MX2015004467A
Other languages
English (en)
Other versions
MX2015004467A (es
Inventor
Babu Srinivasan
Cheng Zhigang
Gosselin Francis
Hidber Pirmin
Hoffmann Ursula
Humphries Theresa
Reents Reinhard
Tian Qingping
Yajima Herbert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015004467A publication Critical patent/MX2015004467A/es
Publication of MX349551B publication Critical patent/MX349551B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Health & Medical Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

Métodos de procedimiento para preparar el inhibidor dual de Mtor/PI3K GDC-0980, denominado (S)-1-(4-((2-(2-aminopirimidín-5-il )-7-metil-4-morfolinotieno[3,2-d]pirimidín-6-il)metil)piperazín-1 -il)-2-hidroxipropán-1-ona, que presenta la estructura: y estereoisómeros, isómeros geométricos, tautómeros y sales farmacéuticamente aceptables de los mismos.
MX2015004467A 2012-10-10 2013-10-09 Proceso para preparar compuestos tienopirimidinas. MX349551B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261711900P 2012-10-10 2012-10-10
PCT/EP2013/070994 WO2014056955A1 (en) 2012-10-10 2013-10-09 Process for making thienopyrimidine compounds

Publications (2)

Publication Number Publication Date
MX2015004467A MX2015004467A (es) 2015-07-14
MX349551B true MX349551B (es) 2017-08-02

Family

ID=49322377

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004467A MX349551B (es) 2012-10-10 2013-10-09 Proceso para preparar compuestos tienopirimidinas.

Country Status (13)

Country Link
US (1) US8895729B2 (es)
EP (1) EP2906566B1 (es)
JP (1) JP6123097B2 (es)
KR (1) KR101698283B1 (es)
CN (2) CN107188898B (es)
AR (1) AR092960A1 (es)
BR (1) BR112015007970A8 (es)
CA (1) CA2883513A1 (es)
ES (1) ES2594078T3 (es)
HK (2) HK1211026A1 (es)
MX (1) MX349551B (es)
RU (1) RU2637309C2 (es)
WO (1) WO2014056955A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015007970A8 (pt) * 2012-10-10 2019-08-27 Hoffmann La Roche processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona
MX361673B (es) 2013-05-06 2018-12-11 Hoffmann La Roche Procedimiento para la preparación de intermediarios de ácido borónico.
IL286427B2 (en) 2014-01-28 2024-08-01 Mayo Found Medical Education & Res BCL-2 ANTI-APOPTOTIC PROTEIN FAMILY MEMBERS inhibitors for the treatment of a non-cancerous disease or a disease of the eye
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
KR20190077040A (ko) * 2016-11-02 2019-07-02 쿠리스 인코퍼레이션 아연 결합 모이어티를 갖는 포스포이노시티드 3-키나아제 억제제를 이용하는 조합 요법
WO2019180141A1 (en) 2018-03-23 2019-09-26 Bayer Aktiengesellschaft Combinations of rogaratinib
CN113717049A (zh) * 2021-08-05 2021-11-30 江西兄弟医药有限公司 一种制备（s）-乙酰氧基丙酰氯的半连续方法

Family Cites Families (23)

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GB9208135D0 (en) 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
US6274327B1 (en) 1992-04-13 2001-08-14 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
US5846824A (en) 1994-02-07 1998-12-08 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
EP1409125B1 (en) 2001-07-12 2016-04-20 Reaxa Limited Microencapsulated catalyst, methods of preparation and methods of use thereof
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
RU2443706C2 (ru) 2006-04-26 2012-02-27 Дженентек, Инк. Фармацевтические соединения
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
UA98946C2 (en) * 2006-12-07 2012-07-10 Ф. Хоффманн-Ля Рош Аг Phosphoinositide 3-kinase inhibitor compounds and methods of use
JP5500990B2 (ja) * 2006-12-07 2014-05-21 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法
CA2671782C (en) * 2006-12-07 2017-01-10 F. Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
TWI471134B (zh) 2007-09-12 2015-02-01 Genentech Inc 肌醇磷脂３－激酶抑制劑化合物及化療劑之組合及使用方法
CA2701292C (en) 2007-10-25 2015-03-24 Genentech, Inc. Process for making thienopyrimidine compounds
EP2231680B1 (en) 2007-12-12 2018-03-28 Massachusetts Institute of Technology Ligands for transition-metal-catalyzed cross-couplings, and methods of use thereof
CN102369011A (zh) * 2009-03-12 2012-03-07 健泰科生物技术公司 用于治疗造血恶性肿瘤的磷酸肌醇3-激酶抑制剂化合物与化学治疗剂的组合
WO2012164060A1 (en) 2011-06-03 2012-12-06 F. Hoffmann-La Roche Ag Methods of treating mesothelioma with a pi3k inhibitor compound
CN102399235A (zh) * 2011-10-25 2012-04-04 江苏弘和药物研发有限公司 一种2-氨基-5-嘧啶硼酸频哪醇酯的合成方法
CN102367260A (zh) * 2011-12-12 2012-03-07 南京药石药物研发有限公司 2-氨基嘧啶-5-硼酸的合成方法
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
BR112015007970A8 (pt) * 2012-10-10 2019-08-27 Hoffmann La Roche processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona
CN102993163A (zh) * 2012-12-07 2013-03-27 青岛前线生物工程有限公司 3-甲基噻吩-2-甲醛的合成方法

Also Published As

Publication number Publication date
US20140100366A1 (en) 2014-04-10
HK1244272A1 (zh) 2018-08-03
EP2906566B1 (en) 2016-08-24
MX2015004467A (es) 2015-07-14
RU2637309C2 (ru) 2017-12-04
KR20150054945A (ko) 2015-05-20
BR112015007970A8 (pt) 2019-08-27
BR112015007970A2 (pt) 2017-07-04
RU2015113747A (ru) 2016-12-10
CN107188898B (zh) 2019-12-03
CN107188898A (zh) 2017-09-22
ES2594078T3 (es) 2016-12-15
AR092960A1 (es) 2015-05-06
US8895729B2 (en) 2014-11-25
WO2014056955A1 (en) 2014-04-17
EP2906566A1 (en) 2015-08-19
CN104718212A (zh) 2015-06-17
KR101698283B1 (ko) 2017-01-19
JP6123097B2 (ja) 2017-05-10
JP2015534572A (ja) 2015-12-03
CN104718212B (zh) 2017-06-16
HK1211026A1 (en) 2016-05-13
CA2883513A1 (en) 2014-04-17

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