HK1244272A1 - 製備噻吩並嘧啶化合物的方法 - Google Patents

製備噻吩並嘧啶化合物的方法

Info

Publication number
HK1244272A1
HK1244272A1 HK18103640.8A HK18103640A HK1244272A1 HK 1244272 A1 HK1244272 A1 HK 1244272A1 HK 18103640 A HK18103640 A HK 18103640A HK 1244272 A1 HK1244272 A1 HK 1244272A1
Authority
HK
Hong Kong
Prior art keywords
making
thienopyrimidine compounds
thienopyrimidine
compounds
making thienopyrimidine
Prior art date
Application number
HK18103640.8A
Other languages
English (en)
Inventor
S.巴布
Z.程
F．戈賽林
P．希德伯
U.霍夫曼
T．漢弗萊斯
R．倫茨
Q．田
H．耶基瑪
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1244272A1 publication Critical patent/HK1244272A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Health & Medical Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
HK18103640.8A 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法 HK1244272A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261711900P 2012-10-10 2012-10-10

Publications (1)

Publication Number Publication Date
HK1244272A1 true HK1244272A1 (zh) 2018-08-03

Family

ID=49322377

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18103640.8A HK1244272A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法
HK15111757.3A HK1211026A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15111757.3A HK1211026A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法

Country Status (13)

Country Link
US (1) US8895729B2 (zh)
EP (1) EP2906566B1 (zh)
JP (1) JP6123097B2 (zh)
KR (1) KR101698283B1 (zh)
CN (2) CN104718212B (zh)
AR (1) AR092960A1 (zh)
BR (1) BR112015007970A8 (zh)
CA (1) CA2883513A1 (zh)
ES (1) ES2594078T3 (zh)
HK (2) HK1244272A1 (zh)
MX (1) MX349551B (zh)
RU (1) RU2637309C2 (zh)
WO (1) WO2014056955A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104718212B (zh) * 2012-10-10 2017-06-16 霍夫曼-拉罗奇有限公司 制备噻吩并嘧啶化合物的方法
CN105189519B (zh) 2013-05-06 2018-01-30 豪夫迈·罗氏有限公司 用于制备硼酸中间体的方法
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
CN106163557B (zh) 2014-01-28 2020-07-14 巴克老龄化研究所 用于杀死衰老细胞和用于治疗衰老相关疾病和病症的方法和组合物
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
MA46728A (fr) * 2016-11-02 2019-09-11 Curis Inc Polythérapie avec un inhibiteur de phosphoinositide 3-kinase avec une fraction de liaison au zinc
WO2019180141A1 (en) 2018-03-23 2019-09-26 Bayer Aktiengesellschaft Combinations of rogaratinib
CN113717049A (zh) * 2021-08-05 2021-11-30 江西兄弟医药有限公司 一种制备（s）-乙酰氧基丙酰氯的半连续方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846824A (en) 1994-02-07 1998-12-08 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
GB9208135D0 (en) 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
US6274327B1 (en) 1992-04-13 2001-08-14 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US8828902B2 (en) 2001-07-12 2014-09-09 Reaxa Limited Microencapsulated catalyst methods of preparation and method of use thereof
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
MX2008013584A (es) 2006-04-26 2009-03-23 Genentech Inc Compuestos farmaceuticos.
TW200829594A (en) * 2006-12-07 2008-07-16 Piramed Ltd Phosphoinositide 3-kinase inhibitor compounds and methods of use
CN101600720A (zh) * 2006-12-07 2009-12-09 霍夫曼-拉罗奇有限公司 磷酸肌醇3-激酶抑制剂化合物及使用方法
PE20081679A1 (es) 2006-12-07 2008-12-18 Hoffmann La Roche Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
AR068402A1 (es) * 2007-09-12 2009-11-18 Genentech Inc Combinaciones de compuestos inhibidores de fosfoinositida 3-quinasa y agentes quimioterapeuticos y los metodos de uso
ES2439705T3 (es) 2007-10-25 2014-01-24 Genentech, Inc. Proceso para la preparación de compuestos de tienopirimidina
EP2231680B1 (en) 2007-12-12 2018-03-28 Massachusetts Institute of Technology Ligands for transition-metal-catalyzed cross-couplings, and methods of use thereof
CA2753285A1 (en) * 2009-03-12 2010-09-16 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
WO2012164060A1 (en) 2011-06-03 2012-12-06 F. Hoffmann-La Roche Ag Methods of treating mesothelioma with a pi3k inhibitor compound
CN102399235A (zh) * 2011-10-25 2012-04-04 江苏弘和药物研发有限公司 一种2-氨基-5-嘧啶硼酸频哪醇酯的合成方法
CN102367260A (zh) * 2011-12-12 2012-03-07 南京药石药物研发有限公司 2-氨基嘧啶-5-硼酸的合成方法
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
CN104718212B (zh) * 2012-10-10 2017-06-16 霍夫曼-拉罗奇有限公司 制备噻吩并嘧啶化合物的方法
CN102993163A (zh) * 2012-12-07 2013-03-27 青岛前线生物工程有限公司 3-甲基噻吩-2-甲醛的合成方法

Also Published As

Publication number Publication date
US8895729B2 (en) 2014-11-25
US20140100366A1 (en) 2014-04-10
WO2014056955A1 (en) 2014-04-17
RU2637309C2 (ru) 2017-12-04
HK1211026A1 (zh) 2016-05-13
CN107188898B (zh) 2019-12-03
CA2883513A1 (en) 2014-04-17
MX2015004467A (es) 2015-07-14
JP6123097B2 (ja) 2017-05-10
JP2015534572A (ja) 2015-12-03
KR20150054945A (ko) 2015-05-20
BR112015007970A8 (pt) 2019-08-27
RU2015113747A (ru) 2016-12-10
CN104718212B (zh) 2017-06-16
EP2906566A1 (en) 2015-08-19
AR092960A1 (es) 2015-05-06
CN104718212A (zh) 2015-06-17
BR112015007970A2 (pt) 2017-07-04
EP2906566B1 (en) 2016-08-24
CN107188898A (zh) 2017-09-22
MX349551B (es) 2017-08-02
KR101698283B1 (ko) 2017-01-19
ES2594078T3 (es) 2016-12-15

Similar Documents

Publication Publication Date Title
ZA201500664B (en) Process for making isoquinoline compounds
ZA201501866B (en) Production method for centre-pillar reinforcement
EP2867189A4 (en) PROCESS FOR PRODUCING ACRYLATE
EP2890672A4 (en) NEW PROCESS
GB201223032D0 (en) Method for forming shaped preform
HK1244272A1 (zh) 製備噻吩並嘧啶化合物的方法
EP2814796A4 (en) METHOD FOR PRODUCING TETRAFLUORPROPES
HK1203933A1 (zh) 噻吩並嘧啶化合物
HK1208673A1 (zh) 用於製造羥基化的環戊基嘧啶化合物的方法
HK1208451A1 (zh) 用於製造羥基化的環戊基嘧啶化合物的方法
EP2938814A4 (en) METHOD FOR PRODUCING OIL
EP2852660A4 (en) PROCESS
GB2488894B (en) Process for producing V-Coelenterazine compounds
HK1204607A1 (zh) 製備 -氨基- -聯苯- -基- -羥甲基- -甲基-戊酸化合物的方法
PL2914574T3 (pl) Nowy sposób
GB2523708B (en) Method for ion production
EP2855433A4 (en) PROCESS FOR THE PREPARATION OF DIHALOPYRIDINES
SG11201501831WA (en) Aminoethylation process for producing aryloxyalkylene amine compounds
EP2819995A4 (en) PROCESS FOR THE PREPARATION OF 3-METHYLSULFONYLPROPIONITRIL
GB2524201B (en) Process for making confections
IL233433A0 (en) A process for preparing affluents
HUP1200614A2 (en) Process for development catalayzer
EP2831054A4 (en) IMPROVED PROCESS FOR THE PRODUCTION OF (S) -EQUOL
GB201204381D0 (en) Novel process
GB201202098D0 (en) New process