HK1211026A1 - 製備噻吩並嘧啶化合物的方法 - Google Patents

製備噻吩並嘧啶化合物的方法

Info

Publication number
HK1211026A1
HK1211026A1 HK15111757.3A HK15111757A HK1211026A1 HK 1211026 A1 HK1211026 A1 HK 1211026A1 HK 15111757 A HK15111757 A HK 15111757A HK 1211026 A1 HK1211026 A1 HK 1211026A1
Authority
HK
Hong Kong
Prior art keywords
making
thienopyrimidine compounds
thienopyrimidine
compounds
making thienopyrimidine
Prior art date
Application number
HK15111757.3A
Other languages
English (en)
Inventor
Srinivasan Babu
Zhigang Cheng
Francis Gosselin
Pirmin Hidber
Ursula Hoffmann
Theresa Humphries
Reinhard Reents
Qingping Tian
Herbert Yajima
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1211026A1 publication Critical patent/HK1211026A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Health & Medical Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
HK15111757.3A 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法 HK1211026A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261711900P 2012-10-10 2012-10-10
PCT/EP2013/070994 WO2014056955A1 (en) 2012-10-10 2013-10-09 Process for making thienopyrimidine compounds

Publications (1)

Publication Number Publication Date
HK1211026A1 true HK1211026A1 (zh) 2016-05-13

Family

ID=49322377

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18103640.8A HK1244272A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法
HK15111757.3A HK1211026A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18103640.8A HK1244272A1 (zh) 2012-10-10 2015-11-30 製備噻吩並嘧啶化合物的方法

Country Status (13)

Country Link
US (1) US8895729B2 (zh)
EP (1) EP2906566B1 (zh)
JP (1) JP6123097B2 (zh)
KR (1) KR101698283B1 (zh)
CN (2) CN107188898B (zh)
AR (1) AR092960A1 (zh)
BR (1) BR112015007970A8 (zh)
CA (1) CA2883513A1 (zh)
ES (1) ES2594078T3 (zh)
HK (2) HK1244272A1 (zh)
MX (1) MX349551B (zh)
RU (1) RU2637309C2 (zh)
WO (1) WO2014056955A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092960A1 (es) * 2012-10-10 2015-05-06 Hoffmann La Roche Procedimiento para preparar compuestos tienopirimidina
CA2910541C (en) * 2013-05-06 2020-07-21 F. Hoffmann-La Roche Ag Process for the preparation of boronic acid intermediates
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
MA46728A (fr) * 2016-11-02 2019-09-11 Curis Inc Polythérapie avec un inhibiteur de phosphoinositide 3-kinase avec une fraction de liaison au zinc
WO2019180141A1 (en) 2018-03-23 2019-09-26 Bayer Aktiengesellschaft Combinations of rogaratinib
CN113717049A (zh) * 2021-08-05 2021-11-30 江西兄弟医药有限公司 一种制备（s）-乙酰氧基丙酰氯的半连续方法

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US6274327B1 (en) 1992-04-13 2001-08-14 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
GB9208135D0 (en) 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
US5846824A (en) 1994-02-07 1998-12-08 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US8828902B2 (en) 2001-07-12 2014-09-09 Reaxa Limited Microencapsulated catalyst methods of preparation and method of use thereof
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
EP2402347A1 (en) 2006-04-26 2012-01-04 F. Hoffmann-La Roche AG Pharmaceutical compounds
ZA200904534B (en) * 2006-12-07 2010-09-29 Hoffmann La Roche Phosphoinositide 3-kinase inhibitor compounds and methods of use
US9487533B2 (en) 2006-12-07 2016-11-08 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and methods of use
EP2114949A1 (en) 2006-12-07 2009-11-11 F.Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
PE20090678A1 (es) 2007-09-12 2009-06-27 Genentech Inc Combinaciones de compuestos inhibidores de fosfoinositida 3-quinasa y agentes quimioterapeuticos y los metodos de uso
JP5348725B2 (ja) 2007-10-25 2013-11-20 ジェネンテック， インコーポレイテッド チエノピリミジン化合物の製造方法
WO2009076622A2 (en) 2007-12-12 2009-06-18 Massachusetts Institute Of Technology Ligands for transition-metal-catalyzed cross-couplings, and methods of use thereof
WO2010105008A2 (en) * 2009-03-12 2010-09-16 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
JP2014515390A (ja) 2011-06-03 2014-06-30 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｐｉ３ｋ阻害剤化合物を用いた中皮腫の治療法
CN102399235A (zh) * 2011-10-25 2012-04-04 江苏弘和药物研发有限公司 一种2-氨基-5-嘧啶硼酸频哪醇酯的合成方法
CN102367260A (zh) * 2011-12-12 2012-03-07 南京药石药物研发有限公司 2-氨基嘧啶-5-硼酸的合成方法
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
AR092960A1 (es) * 2012-10-10 2015-05-06 Hoffmann La Roche Procedimiento para preparar compuestos tienopirimidina
CN102993163A (zh) * 2012-12-07 2013-03-27 青岛前线生物工程有限公司 3-甲基噻吩-2-甲醛的合成方法

Also Published As

Publication number Publication date
CN104718212B (zh) 2017-06-16
CN104718212A (zh) 2015-06-17
JP6123097B2 (ja) 2017-05-10
CA2883513A1 (en) 2014-04-17
RU2637309C2 (ru) 2017-12-04
AR092960A1 (es) 2015-05-06
KR101698283B1 (ko) 2017-01-19
WO2014056955A1 (en) 2014-04-17
EP2906566A1 (en) 2015-08-19
MX2015004467A (es) 2015-07-14
EP2906566B1 (en) 2016-08-24
BR112015007970A2 (pt) 2017-07-04
RU2015113747A (ru) 2016-12-10
KR20150054945A (ko) 2015-05-20
CN107188898A (zh) 2017-09-22
MX349551B (es) 2017-08-02
HK1244272A1 (zh) 2018-08-03
JP2015534572A (ja) 2015-12-03
BR112015007970A8 (pt) 2019-08-27
ES2594078T3 (es) 2016-12-15
US20140100366A1 (en) 2014-04-10
CN107188898B (zh) 2019-12-03
US8895729B2 (en) 2014-11-25

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