UY33985A - Sales de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida - Google Patents

Sales de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida

Info

Publication number
UY33985A
UY33985A UY0001033985A UY33985A UY33985A UY 33985 A UY33985 A UY 33985A UY 0001033985 A UY0001033985 A UY 0001033985A UY 33985 A UY33985 A UY 33985A UY 33985 A UY33985 A UY 33985A
Authority
UY
Uruguay
Prior art keywords
dihydroimidazo
salts
substituted quinazoline
quinazoline
substituted
Prior art date
Application number
UY0001033985A
Other languages
English (en)
Inventor
Dr Jan-Georg Peters
Dr Hans-Christian Militzer
Dr Hartwig Mueller
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43984137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY33985(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY33985A publication Critical patent/UY33985A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Sal de diclorhidrato de 2-amino-N-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin- 5-il]pirimidin-5-carboxamida de Fórmula (II), o un tautómero, solvato o hidrato de la misma.
UY0001033985A 2011-04-05 2012-03-28 Sales de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida UY33985A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11161111A EP2508525A1 (en) 2011-04-05 2011-04-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts

Publications (1)

Publication Number Publication Date
UY33985A true UY33985A (es) 2012-10-31

Family

ID=43984137

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033985A UY33985A (es) 2011-04-05 2012-03-28 Sales de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida

Country Status (42)

Country Link
US (2) US10383876B2 (es)
EP (2) EP2508525A1 (es)
JP (2) JP5763834B2 (es)
KR (1) KR101937501B1 (es)
CN (1) CN103649091B (es)
AP (1) AP3709A (es)
AR (1) AR085718A1 (es)
AU (1) AU2012238891B2 (es)
BR (1) BR112013025549A2 (es)
CA (1) CA2832123C (es)
CL (1) CL2013002870A1 (es)
CO (1) CO6781534A2 (es)
CR (1) CR20130511A (es)
CU (1) CU24208B1 (es)
CY (1) CY1116231T1 (es)
DK (1) DK2694508T3 (es)
DO (1) DOP2013000223A (es)
EA (1) EA023646B1 (es)
EC (1) ECSP13013006A (es)
ES (1) ES2529653T3 (es)
GT (1) GT201300234A (es)
HK (1) HK1195907A1 (es)
HR (1) HRP20150138T1 (es)
IL (1) IL228561A (es)
JO (1) JO2958B1 (es)
MA (1) MA35014B1 (es)
ME (1) ME02021B (es)
MX (1) MX336057B (es)
MY (1) MY169452A (es)
PE (1) PE20141038A1 (es)
PL (1) PL2694508T3 (es)
PT (1) PT2694508E (es)
RS (1) RS53811B1 (es)
SG (1) SG193595A1 (es)
SI (1) SI2694508T1 (es)
SM (1) SMT201500037B (es)
TN (1) TN2013000401A1 (es)
TW (2) TWI549954B (es)
UA (1) UA111604C2 (es)
UY (1) UY33985A (es)
WO (1) WO2012136553A1 (es)
ZA (1) ZA201307105B (es)

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AR064106A1 (es) 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
EP2168583A1 (en) 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
EP2508525A1 (en) * 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
JO3733B1 (ar) 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
JP6368353B2 (ja) * 2013-04-08 2018-08-01 バイエル ファーマ アクチエンゲゼルシャフト 置換された2,3−ジヒドロイミダゾ[1,2−c]キナゾリン類のリンパ腫治療への使用
RU2016100892A (ru) 2013-06-14 2017-07-19 Байер Фарма Акциенгезельшафт Антитела против tweakr и их применение
CN103694319B (zh) * 2013-12-20 2018-02-27 深圳翰宇药业股份有限公司 一种布舍瑞林的纯化方法
EP3018131A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018127A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3268005A1 (en) * 2015-03-09 2018-01-17 Bayer Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
US10406162B2 (en) 2015-03-09 2019-09-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-C]quinazoline-containing combinations
ES2768784T3 (es) 2015-03-23 2020-06-23 Bayer Pharma AG Anticuerpos anti-CEACAM6 y usos de los mismos
US10722527B2 (en) 2015-04-10 2020-07-28 Capsugel Belgium Nv Abiraterone acetate lipid formulations
AU2017214230A1 (en) 2016-02-01 2018-08-09 Bayer Pharma Aktiengesellschaft Copanlisib biomarkers
SG11201806512VA (en) 2016-02-01 2018-08-30 Bayer Pharma AG Copanlisib biomarkers
CN114272389B (zh) 2016-03-02 2023-04-18 卫材研究发展管理有限公司 基于艾日布林的抗体-药物偶联物和使用方法
CA3016584A1 (en) 2016-03-08 2017-09-14 Bayer Pharma Aktiengesellschaft 2-amino-n-[7-methoxy-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamides
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
CA3037626A1 (en) 2016-09-23 2018-03-29 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
CN110049783A (zh) 2016-12-14 2019-07-23 塔弗达治疗有限公司 Hsp90-靶向缀合物及其制剂
EP3585437B1 (en) 2017-02-24 2022-12-21 Bayer Pharma Aktiengesellschaft Combinations of copanlisib with anti-pd-1 antibody
US11185549B2 (en) 2017-06-28 2021-11-30 Bayer Consumer Care Ag Combination of a PI3K-inhibitor with an androgen receptor antagonist
EP3498266A1 (en) 2017-12-15 2019-06-19 Bayer Consumer Care AG Formulations of copanlisib
CU24607B1 (es) 2017-09-08 2022-06-06 Bayer Consumer Care Ag Sólido estable, liofilizado, que contiene copanlisib, útil para dilución y aplicaciones terapéuticas
WO2019105734A1 (en) 2017-11-28 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib
WO2019105835A1 (en) 2017-11-29 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib and anetumab ravtansine
WO2019197269A1 (en) 2018-04-11 2019-10-17 Bayer Aktiengesellschaft Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer
EP3843743A1 (en) 2018-08-28 2021-07-07 Bayer AS Combination of pi3k-inhibitors and targeted thorium conjugates
US20210369724A1 (en) * 2018-10-16 2021-12-02 Bayer Aktiengesellschaft Combination of atr kinase inhibitors with 2,3-dihydroimidazo[1,2-c]quinazoline compounds
EP3866923A1 (en) * 2018-10-17 2021-08-25 Sandoz AG Co-crystals comprising levothyroxine and a dicarboxylic acid
AU2019416623B2 (en) * 2018-12-27 2022-12-08 Holosmedic Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity
WO2020164997A1 (en) 2019-02-12 2020-08-20 Bayer Aktiengesellschaft Combination of pi3k-inhibitors
WO2023218032A1 (en) 2022-05-13 2023-11-16 Synthon B.V. Solid forms of copanlisib salts

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EP2168583A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
EP2168582A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Combinations of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
MA34158B1 (fr) 2010-04-16 2013-04-03 Bayer Ip Gmbh Combinaisons contenant une 2,3-dihydroimidazo{1,2-c]quinazoline substituée
UA113280C2 (xx) 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
EP2508525A1 (en) * 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
JP6368353B2 (ja) * 2013-04-08 2018-08-01 バイエル ファーマ アクチエンゲゼルシャフト 置換された2,3−ジヒドロイミダゾ[1,2−c]キナゾリン類のリンパ腫治療への使用
JP6499657B2 (ja) 2013-12-03 2019-04-10 バイエル ファーマ アクチエンゲゼルシャフト Pi3k阻害剤の組み合わせ
EP3018127A1 (en) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018131A1 (en) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
US10406162B2 (en) 2015-03-09 2019-09-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-C]quinazoline-containing combinations
EP3268005A1 (en) * 2015-03-09 2018-01-17 Bayer Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines

Also Published As

Publication number Publication date
CN103649091B (zh) 2016-06-22
CU24208B1 (es) 2016-11-29
JP2014510119A (ja) 2014-04-24
US10383876B2 (en) 2019-08-20
RS53811B1 (en) 2015-06-30
CA2832123C (en) 2018-09-11
UA111604C2 (uk) 2016-05-25
TW201249847A (en) 2012-12-16
WO2012136553A1 (en) 2012-10-11
HRP20150138T1 (hr) 2015-05-08
KR20140021637A (ko) 2014-02-20
CA2832123A1 (en) 2012-10-11
US9636344B2 (en) 2017-05-02
AP3709A (en) 2016-05-31
CY1116231T1 (el) 2017-02-08
EP2508525A1 (en) 2012-10-10
JP5826961B2 (ja) 2015-12-02
AU2012238891A1 (en) 2013-10-24
ECSP13013006A (es) 2013-12-31
US20160193219A1 (en) 2016-07-07
IL228561A (en) 2015-10-29
MY169452A (en) 2019-04-11
HK1195907A1 (zh) 2014-11-28
CO6781534A2 (es) 2013-10-31
MA35014B1 (fr) 2014-04-03
JP2015164936A (ja) 2015-09-17
JP5763834B2 (ja) 2015-08-12
CL2013002870A1 (es) 2014-06-20
ZA201307105B (en) 2014-11-26
EA023646B1 (ru) 2016-06-30
EP2694508A1 (en) 2014-02-12
AU2012238891B2 (en) 2016-12-01
PT2694508E (pt) 2015-02-10
CN103649091A (zh) 2014-03-19
KR101937501B1 (ko) 2019-01-10
TWI592158B (zh) 2017-07-21
ES2529653T3 (es) 2015-02-24
US20140072529A1 (en) 2014-03-13
AP2013007219A0 (en) 2013-10-31
PE20141038A1 (es) 2014-09-05
DK2694508T3 (en) 2015-02-16
MX336057B (es) 2016-01-07
EP2694508B1 (en) 2014-11-19
NZ616198A (en) 2015-09-25
SMT201500037B (it) 2015-05-05
GT201300234A (es) 2015-01-16
CU20130133A7 (es) 2014-01-29
EA201391470A1 (ru) 2014-03-31
CR20130511A (es) 2013-12-04
TW201637656A (zh) 2016-11-01
IL228561A0 (en) 2013-12-31
MX2013011583A (es) 2013-12-16
BR112013025549A2 (pt) 2016-12-27
TN2013000401A1 (en) 2015-03-30
SG193595A1 (en) 2013-10-30
TWI549954B (zh) 2016-09-21
SI2694508T1 (sl) 2015-03-31
ME02021B (me) 2015-05-20
PL2694508T3 (pl) 2015-04-30
JO2958B1 (en) 2016-03-15
DOP2013000223A (es) 2013-11-15
AR085718A1 (es) 2013-10-23

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