MX2014013855A - Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. - Google Patents

Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Info

Publication number
MX2014013855A
MX2014013855A MX2014013855A MX2014013855A MX2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A
Authority
MX
Mexico
Prior art keywords
salts
making
compounds
cyclopentapyrimidine compounds
hydroxylated cyclopentapyrimidine
Prior art date
Application number
MX2014013855A
Other languages
English (en)
Other versions
MX354373B (es
Inventor
Srinivasan Babu
Francis Gosselin
Yingqing Ran
Travis Remarchuk
Scott J Savage
Jeffrey Stults
Herbert Yajima
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2014013855A publication Critical patent/MX2014013855A/es
Publication of MX354373B publication Critical patent/MX354373B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona nuevos procesos para elaborar y purificar sales de compuestos de ciclopentapirimidina hidroxilada, mismas que son útiles como inhibidores de AKT usados en el tratamiento de enfermedades como el cáncer, que incluyen la sal de monohidrocloruro de (S) -2- (4-clorofenil) -1- (4- ((5R, 7R) -7-hidroxi-5-metil-6,7-dihidro-5H-ciclopenta[d]pirimidin-4-il) piperazin-1-il) -3-(isopropilamino) propan-1-ona.
MX2014013855A 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. MX354373B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261648535P 2012-05-17 2012-05-17
PCT/US2013/041695 WO2013173784A1 (en) 2012-05-17 2013-05-17 Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof

Publications (2)

Publication Number Publication Date
MX2014013855A true MX2014013855A (es) 2016-03-21
MX354373B MX354373B (es) 2018-02-28

Family

ID=48534508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013855A MX354373B (es) 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Country Status (18)

Country Link
US (1) US9315471B2 (es)
EP (1) EP2850200A1 (es)
JP (1) JP6355625B2 (es)
KR (1) KR102123131B1 (es)
CN (1) CN104471070B (es)
AU (1) AU2013262521B2 (es)
BR (1) BR112014028573B1 (es)
CA (1) CA2873661C (es)
HK (1) HK1208500A1 (es)
IL (1) IL235699B (es)
MA (1) MA37647A1 (es)
MX (1) MX354373B (es)
MY (1) MY169029A (es)
NZ (1) NZ702950A (es)
RU (1) RU2642311C2 (es)
SG (1) SG11201407591PA (es)
WO (1) WO2013173784A1 (es)
ZA (1) ZA201409226B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014028593A2 (pt) 2012-05-17 2017-12-19 Genentech Inc forma amorfa de um composto de pirimidinil-ciclopentano inibidor de akt, composições e métodos dos mesmos"
CN104487430B (zh) 2012-05-17 2016-08-24 阵列生物制药公司 用于制造羟基化的环戊基嘧啶化合物的方法
CA2873658C (en) 2012-05-17 2021-01-26 Genentech, Inc. Process for making amino acid compounds
CA2873654C (en) 2012-05-17 2021-06-22 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
ES2765511T3 (es) * 2013-11-15 2020-06-09 Hoffmann La Roche Procesos para la preparación de compuestos de pirimidinilciclopentano
EP3197875B1 (en) * 2014-09-26 2019-08-14 F.Hoffmann-La Roche Ag Processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
CN115350192A (zh) 2016-08-10 2022-11-18 豪夫迈·罗氏有限公司 包含Akt蛋白激酶抑制剂的药物组合物
US20220025424A1 (en) * 2016-08-16 2022-01-27 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes
WO2019122421A1 (en) * 2017-12-22 2019-06-27 Astrazeneca Ab Stereoselective ketone reduction using a ketoreductase enzyme
US20230271958A1 (en) * 2020-07-22 2023-08-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
CN115916350A (zh) * 2020-07-22 2023-04-04 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物
WO2023043869A1 (en) 2021-09-15 2023-03-23 Teva Pharmaceuticals International Gmbh Solid state forms of ipatasertib citrate

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BR9408197A (pt) 1993-12-12 1997-08-26 Agrogene Ltd Método para proteger plantas contra doenças fúngicas
JP2001524079A (ja) 1997-04-07 2001-11-27 メルク エンド カンパニー インコーポレーテッド ガンの治療方法
US6201023B1 (en) 1997-06-10 2001-03-13 Agrogene Ltd. Methods and compositions to protect crops against plant parasitic nematodes
WO1999023242A1 (en) 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
US6376496B1 (en) 1999-03-03 2002-04-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU7715300A (en) 1999-09-27 2001-04-30 Merck & Co., Inc. Method of preventing osteoporosis
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
JP4550811B2 (ja) 2003-06-09 2010-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング パピローマウイルスのインヒビター
CA2610888C (en) * 2005-06-10 2011-02-08 Merck & Co., Inc. Inhibitors of akt activity
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UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8748143B2 (en) * 2007-09-13 2014-06-10 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
MX2010007546A (es) 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
RU2541571C2 (ru) 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
EP2491032B1 (en) 2009-10-23 2014-04-16 Eli Lilly and Company Akt inhibitors
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CA2873654C (en) 2012-05-17 2021-06-22 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
CA2873658C (en) 2012-05-17 2021-01-26 Genentech, Inc. Process for making amino acid compounds
CN104487430B (zh) 2012-05-17 2016-08-24 阵列生物制药公司 用于制造羟基化的环戊基嘧啶化合物的方法
CA2889855A1 (en) 2012-11-01 2014-05-08 Robert S. Katz Methods for treating fibromyalgia
JP2016513112A (ja) 2013-02-18 2016-05-12 ザ スクリプス リサーチ インスティテュート 治療的潜在能力を有するバソプレッシン受容体のモジュレーター
US10131637B2 (en) 2013-03-15 2018-11-20 Shifa Biomedical Corporation Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases

Also Published As

Publication number Publication date
NZ702950A (en) 2016-09-30
WO2013173784A1 (en) 2013-11-21
JP6355625B2 (ja) 2018-07-11
CA2873661C (en) 2020-07-21
US20150099880A1 (en) 2015-04-09
KR102123131B1 (ko) 2020-06-15
CA2873661A1 (en) 2013-11-21
HK1208500A1 (en) 2016-03-04
CN104471070B (zh) 2018-09-25
RU2014151014A (ru) 2016-07-10
KR20150018579A (ko) 2015-02-23
MA37647A1 (fr) 2016-03-31
CN104471070A (zh) 2015-03-25
ZA201409226B (en) 2017-09-27
AU2013262521A1 (en) 2015-01-22
BR112014028573A2 (pt) 2018-04-24
BR112014028573B1 (pt) 2021-11-16
US9315471B2 (en) 2016-04-19
MY169029A (en) 2019-02-04
AU2013262521B2 (en) 2017-03-02
RU2642311C2 (ru) 2018-01-24
IL235699A0 (en) 2015-01-29
SG11201407591PA (en) 2015-01-29
EP2850200A1 (en) 2015-03-25
IL235699B (en) 2018-12-31
JP2015518715A (ja) 2015-07-06
MX354373B (es) 2018-02-28

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