MX354373B - Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. - Google Patents

Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Info

Publication number
MX354373B
MX354373B MX2014013855A MX2014013855A MX354373B MX 354373 B MX354373 B MX 354373B MX 2014013855 A MX2014013855 A MX 2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A MX 354373 B MX354373 B MX 354373B
Authority
MX
Mexico
Prior art keywords
salts
making
compounds
cyclopentapyrimidine compounds
hydroxylated cyclopentapyrimidine
Prior art date
Application number
MX2014013855A
Other languages
English (en)
Other versions
MX2014013855A (es
Inventor
Srinivasan Babu
Francis Gosselin
Yingqing Ran
Travis Remarchuk
Scott J Savage
Jeffrey Stults
Herbert Yajima
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2014013855A publication Critical patent/MX2014013855A/es
Publication of MX354373B publication Critical patent/MX354373B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a nuevos procesos para elaborar y purificar sales de compuestos de ciclopentapirimidina hidroxilada, mismas que son útiles como inhibidores de AKT usados en el tratamiento de enfermedades como el cáncer, que incluyen la sal de monohidrocloruro de (S) -2- (4-clorofenil) -1- (4- ((5R, 7R) -7-hidroxi-5-metil-6,7-dihidro-5H-ciclopenta[d]pirimidin-4-il) piperazin-1-il) -3-(isopropilamino) propan-1-ona.
MX2014013855A 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. MX354373B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261648535P 2012-05-17 2012-05-17
PCT/US2013/041695 WO2013173784A1 (en) 2012-05-17 2013-05-17 Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof

Publications (2)

Publication Number Publication Date
MX2014013855A MX2014013855A (es) 2016-03-21
MX354373B true MX354373B (es) 2018-02-28

Family

ID=48534508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013855A MX354373B (es) 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Country Status (17)

Country Link
US (1) US9315471B2 (es)
EP (1) EP2850200A1 (es)
JP (1) JP6355625B2 (es)
KR (1) KR102123131B1 (es)
CN (1) CN104471070B (es)
AU (1) AU2013262521B2 (es)
BR (1) BR112014028573B1 (es)
CA (1) CA2873661C (es)
IL (1) IL235699B (es)
MA (1) MA37647A1 (es)
MX (1) MX354373B (es)
MY (1) MY169029A (es)
NZ (1) NZ702950A (es)
RU (1) RU2642311C2 (es)
SG (1) SG11201407591PA (es)
WO (1) WO2013173784A1 (es)
ZA (1) ZA201409226B (es)

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Publication number Priority date Publication date Assignee Title
JP6284928B2 (ja) 2012-05-17 2018-02-28 アレイ バイオファーマ、インコーポレイテッド ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス
DK2861583T3 (en) 2012-05-17 2016-10-03 Array Biopharma Inc METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER
NZ702939A (en) 2012-05-17 2016-08-26 Genentech Inc Process for making amino acid compounds
RS60417B9 (sr) 2012-05-17 2021-07-30 Genentech Inc Amorfni oblik aktivnog jedinjenja koje inhibira pirimidinil-ciklopentansko jedinjenje, smeše i njegove metode
SG10201901578UA (en) * 2013-11-15 2019-03-28 Hoffmann La Roche Processes for the preparation of pyrimidinylcyclopentane compounds
US10457648B2 (en) * 2014-09-26 2019-10-29 Genentech Inc. Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
KR20250023595A (ko) 2016-08-10 2025-02-18 에프. 호프만-라 로슈 아게 Akt 단백질 키나아제 저해제를 포함하는 약학 조성물
CN110268067A (zh) * 2016-08-16 2019-09-20 伊美格生物科学公司 用于产生立体异构纯的氨基环丙烷的组合物和方法
WO2019122421A1 (en) * 2017-12-22 2019-06-27 Astrazeneca Ab Stereoselective ketone reduction using a ketoreductase enzyme
CA3186565A1 (en) * 2020-07-22 2022-01-27 Lei Miao Unit dosage composition of akt inhibitor
US20230271958A1 (en) * 2020-07-22 2023-08-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
WO2023043869A1 (en) 2021-09-15 2023-03-23 Teva Pharmaceuticals International Gmbh Solid state forms of ipatasertib citrate

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AU700579B2 (en) 1993-12-12 1999-01-07 Agrogene Ltd A novel method to protect plants from fungal infection
CA2286239A1 (en) 1997-04-07 1998-10-15 Merck & Co., Inc. A method of treating cancer
US6201023B1 (en) 1997-06-10 2001-03-13 Agrogene Ltd. Methods and compositions to protect crops against plant parasitic nematodes
AU1302999A (en) * 1997-11-04 1999-05-24 Eli Lilly And Company Ketoreductase gene and protein from yeast
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
JP2003524618A (ja) 1999-03-03 2003-08-19 メルク エンド カムパニー インコーポレーテッド プレニル蛋白トランスフェラーゼ阻害剤
WO2001022963A1 (en) 1999-09-27 2001-04-05 Merck & Co., Inc. Method of preventing osteoporosis
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
EP1636200A2 (en) 2003-06-09 2006-03-22 Boehringer Ingelheim International GmbH Inhibitors of papilloma virus
DK1898903T3 (da) * 2005-06-10 2013-07-01 Merck Sharp & Dohme Inhibitorer af Akt-aktivitet
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
WO2009036404A2 (en) * 2007-09-13 2009-03-19 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
MX2010007546A (es) * 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
RU2541571C2 (ru) 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
EA020151B1 (ru) 2009-10-23 2014-09-30 Эли Лилли Энд Компани Ингибиторы akt и фармацевтические составы, их содержащие
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DK2861583T3 (en) 2012-05-17 2016-10-03 Array Biopharma Inc METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER
JP6284928B2 (ja) 2012-05-17 2018-02-28 アレイ バイオファーマ、インコーポレイテッド ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス
NZ702939A (en) 2012-05-17 2016-08-26 Genentech Inc Process for making amino acid compounds
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AU2014237198A1 (en) 2013-03-15 2015-11-05 Shifa Biomedical Corporation Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases

Also Published As

Publication number Publication date
RU2014151014A (ru) 2016-07-10
NZ702950A (en) 2016-09-30
ZA201409226B (en) 2017-09-27
US9315471B2 (en) 2016-04-19
BR112014028573A2 (pt) 2018-04-24
KR102123131B1 (ko) 2020-06-15
JP2015518715A (ja) 2015-07-06
EP2850200A1 (en) 2015-03-25
US20150099880A1 (en) 2015-04-09
HK1208500A1 (en) 2016-03-04
AU2013262521A1 (en) 2015-01-22
KR20150018579A (ko) 2015-02-23
IL235699B (en) 2018-12-31
CN104471070A (zh) 2015-03-25
MA37647A1 (fr) 2016-03-31
RU2642311C2 (ru) 2018-01-24
AU2013262521B2 (en) 2017-03-02
SG11201407591PA (en) 2015-01-29
CA2873661C (en) 2020-07-21
CN104471070B (zh) 2018-09-25
BR112014028573B1 (pt) 2021-11-16
IL235699A0 (en) 2015-01-29
MY169029A (en) 2019-02-04
WO2013173784A1 (en) 2013-11-21
CA2873661A1 (en) 2013-11-21
MX2014013855A (es) 2016-03-21
JP6355625B2 (ja) 2018-07-11

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