RU2017133485A - Композиция для лечения заболеваний, связанных с ил-6 - Google Patents
Композиция для лечения заболеваний, связанных с ил-6 Download PDFInfo
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- RU2017133485A RU2017133485A RU2017133485A RU2017133485A RU2017133485A RU 2017133485 A RU2017133485 A RU 2017133485A RU 2017133485 A RU2017133485 A RU 2017133485A RU 2017133485 A RU2017133485 A RU 2017133485A RU 2017133485 A RU2017133485 A RU 2017133485A
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- 108090001005 Interleukin-6 Proteins 0.000 title claims 6
- 201000010099 disease Diseases 0.000 title claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 4
- 239000000203 mixture Substances 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 102000004889 Interleukin-6 Human genes 0.000 claims 5
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 3
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 3
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
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- 230000002062 proliferating effect Effects 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
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- 102000005962 receptors Human genes 0.000 claims 2
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
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Claims (15)
1. Фармацевтическая композиция, используемая при лечении заболевания, связанного с ИЛ-6, включающая ингибитор ИЛ-6 в качестве активного ингредиента, при этом фармацевтическую композицию вводят стандартным способом после кратковременного периода введения дозы, когда дозу, аналогичную стандартной дозе, вводят многократно через более короткий интервал по сравнению со стандартным интервалом введения дозы.
2. Фармацевтическая композиция по п. 1, стандартный интервал введения которой составляет от 3 до 5 недель.
3. Фармацевтическая композиция по п. 1, стандартный интервал введения которой составляет 4 недели.
4. Фармацевтическая композиция по любому из пп. 1-3, где интервал введения дозы в течение кратковременного периода введения, когда дозу вводят многократно через более короткий интервал по сравнению со стандартным интервалом введения, составляет от одной до двух недель.
5. Фармацевтическая композиция по любому из пп. 1-3, где интервал введения дозы в течение кратковременного периода введения, когда дозу вводят многократно через более короткий интервал по сравнению со стандартным интервалом введения, составляет две недели.
6. Фармацевтическая композиция по любому из пп. 1-5, где кратковременный интервал введения дозы составляет четыре недели после первичного введения.
7. Фармацевтическая композиция по любому из пп. 1-6, где стандартная доза составляет от 50 до 800 мг в составе однократной дозы.
8. Фармацевтическая композиция по любому из пп. 1-7, где стандартная доза составляет 120 мг в составе однократной дозы.
9. Фармацевтическая композиция по любому из пп. 1-8, где ингибитором ИЛ-6 является антитело к рецептору ИЛ-6.
10. Фармацевтическая композиция по п. 9, где антителом к рецептору ИЛ-6 является химерное антитело, гуманизированное антитело или антитело человека.
11. Фармацевтическая композиция по п. 9, где антитело к рецептору ИЛ-6 включает вариабельную область тяжелой цепи с последовательностью SEQ ID NO: 1 и вариабельную область легкой цепи с последовательностью SEQ ID NO: 2.
12. Фармацевтическая композиция по п. 9, где антитело к рецептору ИЛ-6 включает тяжелую цепь с последовательностью SEQ ID NO: 3, и легкую цепь с последовательностью SEQ ID NO: 4.
13. Фармацевтическая композиция по п. 9, где антителом к рецептору ИЛ-6 является SA237.
14. Фармацевтическая композиция по любому из пп. 1-13, где заболеванием, связанным с ИЛ-6, является ревматоидный артрит, юношеский идиопатический артрит, ювенильный идиопатический артрит с системным началом, болезнь Кастельмана, системная красная волчанка (SLE), волчаночный нефрит, болезнь Крона, лимфома, язвенный колит, анемия, васкулит, болезнь Кавасаки, болезнь Стилла, амилоидоз, рассеянный склероз, трансплантация, возрастная макулярная дистрофия, анкилозирующий спондилоартрит, псориаз, псориатический артрит, хроническое обструктивное заболевание легких (ХОЗЛ), первичная нефропатия IgA-типа, остеоартрит, астма, диабетическая нефропатия, реакция отторжения трансплантата (ТПХ), эндометриоз, гепатит (неалкогольный стеатогепатит), инфаркт миокарда, артериосклероз, сепсис, остеопороз, диабет, множественная миелома, рак предстательной железы, рак почки, В-клеточная неходжкинская лимфома, рак поджелудочной железы, рак легкого, рак пищевода, рак ободочной кишки, раковая кахексия, инвазия раковых нервных клеток, инфаркт миокарда, миопическая хориоидальная неоваскуляризация, идиопатическая хориоидальная неоваскуляризация, увеит, хронический тироидит, замедленная гиперчувствительность, контактный дерматит, атопический дерматит, мезотелиома, полимиозит, дерматомиозит, панувеит, передний увеит, средний увеит, воспаление склеры, воспаление роговицы, орбитальный воспалительный синдром, неврит зрительного нерва, диабетическая ретинопатия, пролиферативная витреоретинопатия, синдром сухого глаза, послеоперационный воспалительный синдром, нейромиелит зрительного нерва, тяжелая псевдопаралитическая миастения или легочная гипертензия.
15. Фармацевтическая композиция по любому из пп. 1-14, где фармацевтической композицией является состав для подкожного введения.
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