PL3689868T3 - Pochodne tetrahydronaftalenu i tetrahydroizochinoliny jako degradery receptorów estrogenowych - Google Patents

Pochodne tetrahydronaftalenu i tetrahydroizochinoliny jako degradery receptorów estrogenowych

Info

Publication number
PL3689868T3
PL3689868T3 PL20150584.9T PL20150584T PL3689868T3 PL 3689868 T3 PL3689868 T3 PL 3689868T3 PL 20150584 T PL20150584 T PL 20150584T PL 3689868 T3 PL3689868 T3 PL 3689868T3
Authority
PL
Poland
Prior art keywords
tetrahydronaphthalene
estrogen receptor
tetrahydroisoquinoline derivatives
receptor degraders
degraders
Prior art date
Application number
PL20150584.9T
Other languages
English (en)
Inventor
Andrew P. Crew
Yimin Qian
Hanqing Dong
Jing Wang
Keith R. Hornberger
Original Assignee
Arvinas Operations, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arvinas Operations, Inc. filed Critical Arvinas Operations, Inc.
Publication of PL3689868T3 publication Critical patent/PL3689868T3/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
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  • Other In-Based Heterocyclic Compounds (AREA)
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PL20150584.9T 2016-12-01 2017-12-01 Pochodne tetrahydronaftalenu i tetrahydroizochinoliny jako degradery receptorów estrogenowych PL3689868T3 (pl)

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US201662429041P 2016-12-01 2016-12-01
US201762540049P 2017-08-01 2017-08-01

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US (6) US10647698B2 (pl)
EP (2) EP3548483A4 (pl)
JP (5) JP6957620B2 (pl)
KR (3) KR102173464B1 (pl)
CN (2) CN114656452B (pl)
AU (5) AU2017366693B2 (pl)
BR (1) BR112019011200B1 (pl)
CA (1) CA3042968C (pl)
CO (1) CO2019007091A2 (pl)
DK (1) DK3689868T3 (pl)
ES (1) ES2967404T3 (pl)
FI (1) FI3689868T3 (pl)
HR (1) HRP20231537T1 (pl)
HU (1) HUE064609T2 (pl)
IL (4) IL266842B (pl)
LT (1) LT3689868T (pl)
MX (2) MX2019006402A (pl)
PL (1) PL3689868T3 (pl)
PT (1) PT3689868T (pl)
RS (1) RS64976B1 (pl)
RU (1) RU2750484C2 (pl)
SI (1) SI3689868T1 (pl)
WO (1) WO2018102725A1 (pl)

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