AR125768A1 - Compuestos para la degradación dirigida de la tirosina cinasa de bruton - Google Patents
Compuestos para la degradación dirigida de la tirosina cinasa de brutonInfo
- Publication number
- AR125768A1 AR125768A1 ARP220101179A ARP220101179A AR125768A1 AR 125768 A1 AR125768 A1 AR 125768A1 AR P220101179 A ARP220101179 A AR P220101179A AR P220101179 A ARP220101179 A AR P220101179A AR 125768 A1 AR125768 A1 AR 125768A1
- Authority
- AR
- Argentina
- Prior art keywords
- btk
- compounds
- degradation
- dsm
- linker
- Prior art date
Links
- 230000015556 catabolic process Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000006731 degradation reaction Methods 0.000 title abstract 4
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 230000034512 ubiquitination Effects 0.000 abstract 1
- 238000010798 ubiquitination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta descripción se refiere a compuestos de fórmula (A): BTK L DSM (A), o una sal farmacéuticamente aceptable de los mismos, en donde DSM es un resto de señalización de degradación que se enlaza covalentemente al enlazador L, L es un enlazador que enlaza covalentemente BTK a DSM, y BTK es un resto de unión a Btk representado por la fórmula (1) o la fórmula (2) que está enlazado covalentemente al enlazador L, en el que todas las variables son las definidas en la solicitud. Los compuestos o sus sales farmacéuticamente aceptables, como se describe en el presente documento, son capaces de activar la ubiquitinación selectiva de las proteínas Btk a través de las vías de ubiquitina-proteasoma (UPP) y provocar la degradación de las proteínas Btk. La presente descripción también proporciona métodos para tratar trastornos que responden a la modulación de la actividad de Btk y/o degradación de Btk con al menos un compuesto descrito en el presente documento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163184439P | 2021-05-05 | 2021-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR125768A1 true AR125768A1 (es) | 2023-08-09 |
Family
ID=82115630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101179A AR125768A1 (es) | 2021-05-05 | 2022-05-05 | Compuestos para la degradación dirigida de la tirosina cinasa de bruton |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP4333899A1 (es) |
| JP (1) | JP2024519496A (es) |
| KR (1) | KR20240017814A (es) |
| CN (1) | CN117580592A (es) |
| AR (1) | AR125768A1 (es) |
| AU (1) | AU2022268977A1 (es) |
| BR (1) | BR112023023065A2 (es) |
| CA (1) | CA3217417A1 (es) |
| CO (1) | CO2023016743A2 (es) |
| IL (1) | IL308219A (es) |
| TW (1) | TW202309039A (es) |
| UY (1) | UY39756A (es) |
| WO (1) | WO2022235945A1 (es) |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| WO2015160845A2 (en) | 2014-04-14 | 2015-10-22 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2016105518A1 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| KR20200052995A (ko) | 2015-01-20 | 2020-05-15 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법 |
| BR112017019751A2 (pt) | 2015-03-18 | 2018-05-29 | Arvinas Inc | composto bifuncional, composição farmacêutica, e, métodos para tratar ou prevenir uma doença ou um distúrbio, e para degradar uma proteína alvo em uma célula |
| BR112017025975B1 (pt) | 2015-06-04 | 2023-12-12 | Arvinas Operations, Inc | Composto, composição, método in vitro para induzir degradação de uma proteína alvo em uma célula, e, uso de uma composição |
| US20180147202A1 (en) | 2015-06-05 | 2018-05-31 | Arvinas, Inc. | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| EP3319944A4 (en) | 2015-07-10 | 2019-04-24 | Arvinas, Inc. | MDM2-BASED PROTEASE MODULATORS AND METHODS OF USE THEREOF |
| US20170037004A1 (en) | 2015-07-13 | 2017-02-09 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
| US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| CN113788818A (zh) | 2016-04-06 | 2021-12-14 | 密执安大学评议会 | Mdm2蛋白质降解剂 |
| CA3020541A1 (en) | 2016-04-12 | 2017-10-19 | The Regents Of The University Of Michigan | Bet protein degraders |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EP3454856A4 (en) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| EP3512842B1 (en) | 2016-09-15 | 2024-01-17 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
| DK3660004T3 (da) | 2016-10-11 | 2023-05-08 | Arvinas Operations Inc | Forbindelser og fremgangsmåder til målrettet degradering af androgenreceptor |
| KR102570992B1 (ko) | 2016-11-01 | 2023-08-28 | 아비나스 오퍼레이션스, 인코포레이티드 | 타우(Tau)-단백질 표적화 프로탁(PROTAC) 및 관련 사용 방법 |
| KR102173464B1 (ko) | 2016-12-01 | 2020-11-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 및 테트라히드로이소퀴놀린 유도체 |
| EP3559002A4 (en) | 2016-12-23 | 2021-02-17 | Arvinas Operations, Inc. | CHEMERICAL MOLECULES TARGETING EGFR PROTEOLYSIS AND RELATED METHODS OF USE |
| CN110741004B (zh) | 2016-12-23 | 2023-10-17 | 阿尔维纳斯运营股份有限公司 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
| EP3559006A4 (en) | 2016-12-23 | 2021-03-03 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| UY37559A (es) * | 2017-01-06 | 2018-05-31 | Pharmacyclics Llc | Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton |
| EP3573977A4 (en) | 2017-01-26 | 2020-12-23 | Arvinas Operations, Inc. | EESTROGEN RECEPTOR PROTEOLYSIS MODULATORS AND RELATED METHOD OF USE |
| MX2019009046A (es) | 2017-01-31 | 2019-10-30 | Arvinas Operations Inc | Ligandos de cereblon y compuestos bifuncionales que comprenden el mismo. |
| WO2018226542A1 (en) | 2017-06-09 | 2018-12-13 | Arvinas, Inc. | Modulators of proteolysis and associated methods of use |
| WO2018237026A1 (en) | 2017-06-20 | 2018-12-27 | C4 Therapeutics, Inc. | N / O-LINKED DEGRONS AND DEGRONIMERS FOR DEGRADATION OF PROTEINS |
| RU2020108515A (ru) | 2017-07-28 | 2021-08-27 | Эрвинэс Оперейшнс, Инк. | Соединения и способы целевого расщепления андрогенного рецептора |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| CN111936498B (zh) * | 2018-03-26 | 2024-04-16 | 诺华股份有限公司 | N-(3-(7H-吡咯并[2,3-d]嘧啶-4-基)苯基)苯甲酰胺衍生物 |
| CN117186108A (zh) * | 2018-03-26 | 2023-12-08 | 诺华股份有限公司 | 布鲁顿酪氨酸激酶降解剂 |
| WO2019195201A1 (en) | 2018-04-01 | 2019-10-10 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
| IL310860A (en) | 2018-04-13 | 2024-04-01 | Arvinas Operations Inc | Servalon ligands and bifunctional compounds containing them |
| EP3781156A4 (en) | 2018-04-16 | 2022-05-18 | C4 Therapeutics, Inc. | SPIROCYCLIC COMPOUNDS |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN DEGRADATION |
| EP3935050A4 (en) | 2019-03-06 | 2023-01-04 | C4 Therapeutics, Inc. | HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT |
| JP2022527216A (ja) | 2019-04-12 | 2022-05-31 | シー４ セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬 |
| EP4031247A1 (en) * | 2019-09-16 | 2022-07-27 | Novartis AG | Bifunctional degraders and their methods of use |
| WO2021087112A1 (en) * | 2019-10-30 | 2021-05-06 | Biogen Ma Inc. | Condensed bi-heterocycles as inhibiting agents for bruton's tyrosine kinase |
| EP4051679A1 (en) * | 2019-10-30 | 2022-09-07 | Biogen MA Inc. | Condensed pyridazine or pyrimidine as btk inhibitors |
| EP4077319A1 (en) | 2019-12-20 | 2022-10-26 | Calico Life Sciences LLC | Protein tyrosine phosphatase degraders and methods of use thereof |
| KR20230003161A (ko) * | 2020-04-30 | 2023-01-05 | 베이진 엘티디 | 브루톤의 티로신 키나제(btk) 억제제와 e3 리가제 리간드의 접합에 의한 btk의 분해 및 사용 방법 |
-
2022
- 2022-05-05 AR ARP220101179A patent/AR125768A1/es unknown
- 2022-05-05 WO PCT/US2022/027888 patent/WO2022235945A1/en active Application Filing
- 2022-05-05 JP JP2023567962A patent/JP2024519496A/ja active Pending
- 2022-05-05 EP EP22731839.1A patent/EP4333899A1/en active Pending
- 2022-05-05 KR KR1020237041952A patent/KR20240017814A/ko unknown
- 2022-05-05 TW TW111116998A patent/TW202309039A/zh unknown
- 2022-05-05 CN CN202280047793.5A patent/CN117580592A/zh active Pending
- 2022-05-05 AU AU2022268977A patent/AU2022268977A1/en active Pending
- 2022-05-05 UY UY0001039756A patent/UY39756A/es unknown
- 2022-05-05 BR BR112023023065A patent/BR112023023065A2/pt unknown
- 2022-05-05 IL IL308219A patent/IL308219A/en unknown
- 2022-05-05 CA CA3217417A patent/CA3217417A1/en active Pending
-
2023
- 2023-12-01 CO CONC2023/0016743A patent/CO2023016743A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202309039A (zh) | 2023-03-01 |
| WO2022235945A1 (en) | 2022-11-10 |
| UY39756A (es) | 2022-11-30 |
| JP2024519496A (ja) | 2024-05-14 |
| IL308219A (en) | 2024-01-01 |
| KR20240017814A (ko) | 2024-02-08 |
| EP4333899A1 (en) | 2024-03-13 |
| CN117580592A (zh) | 2024-02-20 |
| AU2022268977A1 (en) | 2023-11-30 |
| CO2023016743A2 (es) | 2023-12-29 |
| CA3217417A1 (en) | 2022-11-10 |
| BR112023023065A2 (pt) | 2024-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR121047A1 (es) | Inhibidores de map4k1 | |
| CO2022018811A2 (es) | Inhibidores de la proteína kras g12c y usos de estos | |
| UY27169A1 (es) | Derivados del ácido isoftálico como inhibidores de metalproteinasas de la matriz | |
| CR7785A (es) | Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos | |
| UY27234A1 (es) | Inhibidores novedosos de tirosina cinasa | |
| ECSP055572A (es) | Derivados ciclotiocarbamativos como moduladores pr y el uso de los mismos en el tratamiento de enfermedades de la piel. | |
| NI200300039A (es) | Compuestos que modulan la actividad de ppar. | |
| DOP2010000261A (es) | Derivados biciclicos heterociclicos o espirobicicicos heterociclicos enlazados , de pirazolo[1,5-a] pirimidinas, procedimientos para su preparacion y usos de los mismos | |
| GT200100022A (es) | Derivados de nicotinamida benzocondensada-heterociclilo utiles como inhibidores selectivos de las isozimas pde4. | |
| UY27872A1 (es) | Inhibidores de caspasa y usos de los mismos. | |
| PA8478501A1 (es) | Compuestos heterociclicos como inhibidores de enzimas de rotamasa | |
| UY29343A1 (es) | Pirazolopiridinas y sales de las mismas, una composición farmacéutica que comprende dichos compuestos, un método para prepararlos y su uso. | |
| PA8566501A1 (es) | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades | |
| PA8566301A1 (es) | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades | |
| ES2159043T3 (es) | Derivado carboestirilico para el tratamiento de enfermedades oculares. | |
| CO2021014210A2 (es) | Compuestos de pirrol | |
| TR200401669T1 (tr) | Neoplastik hastalıkların tedavisi için metarix-metalloproteinazları önleyen kompozisyon. | |
| CO2023010940A2 (es) | Compuestos moduladores de gcn2 y usos de los mismos | |
| CO2022018655A2 (es) | Compuestos heterocíclicos como anthelmínticos | |
| ES2190471T3 (es) | Procedimiento para producir derivados de guanidina, intermedios de dichos compuestos y su produccion. | |
| ECSP22079768A (es) | Una composición para el control de la enfermedad sigatoka | |
| AR125768A1 (es) | Compuestos para la degradación dirigida de la tirosina cinasa de bruton | |
| UY28006A1 (es) | Agonistas ppar quirales | |
| BR112022024661A2 (pt) | Derivados microbiocidas | |
| CL2023002966A1 (es) | Compuestos de oxoisoindolina sustituidos con piridinilo |