PL2148684T3 - Sposób leczenia niedoboru i deficytu witaminy D - Google Patents

Sposób leczenia niedoboru i deficytu witaminy D

Info

Publication number
PL2148684T3
PL2148684T3 PL08837933T PL08837933T PL2148684T3 PL 2148684 T3 PL2148684 T3 PL 2148684T3 PL 08837933 T PL08837933 T PL 08837933T PL 08837933 T PL08837933 T PL 08837933T PL 2148684 T3 PL2148684 T3 PL 2148684T3
Authority
PL
Poland
Prior art keywords
insufficiency
deficiency
treating vitamin
vitamin
treating
Prior art date
Application number
PL08837933T
Other languages
English (en)
Polish (pl)
Inventor
P Martin Petkovich
Christian F Helvig
Samir P Tabash
Original Assignee
Cytochroma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytochroma Inc filed Critical Cytochroma Inc
Publication of PL2148684T3 publication Critical patent/PL2148684T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL08837933T 2007-04-25 2008-04-25 Sposób leczenia niedoboru i deficytu witaminy D PL2148684T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91384907P 2007-04-25 2007-04-25
EP08837933A EP2148684B1 (en) 2007-04-25 2008-04-25 Method of treating vitamin d insufficiency and deficiency
PCT/IB2008/003480 WO2009047644A2 (en) 2007-04-25 2008-04-25 Method of treating vitamin d insufficiency and deficiency

Publications (1)

Publication Number Publication Date
PL2148684T3 true PL2148684T3 (pl) 2013-06-28

Family

ID=40445280

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08837933T PL2148684T3 (pl) 2007-04-25 2008-04-25 Sposób leczenia niedoboru i deficytu witaminy D

Country Status (11)

Country Link
US (1) US11752158B2 (cg-RX-API-DMAC7.html)
EP (1) EP2148684B1 (cg-RX-API-DMAC7.html)
JP (2) JP5444212B2 (cg-RX-API-DMAC7.html)
KR (1) KR101495578B1 (cg-RX-API-DMAC7.html)
CN (2) CN101668532B (cg-RX-API-DMAC7.html)
CA (1) CA2683628C (cg-RX-API-DMAC7.html)
DK (1) DK2148684T3 (cg-RX-API-DMAC7.html)
ES (1) ES2403107T3 (cg-RX-API-DMAC7.html)
PL (1) PL2148684T3 (cg-RX-API-DMAC7.html)
PT (1) PT2148684E (cg-RX-API-DMAC7.html)
WO (1) WO2009047644A2 (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3103745B2 (ja) 1995-05-24 2000-10-30 松下電器産業株式会社 高周波加熱装置
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
MX2007006546A (es) * 2004-11-22 2007-08-17 Wisconsin Alumni Res Found Analogos de 17,20(e)-deshidro vitamina d y sus usos.
ES2904546T3 (es) 2006-02-03 2022-04-05 Opko Renal Llc Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3
SI2037936T1 (sl) 2006-06-21 2014-11-28 Opko Renal, Llc Postopek zdravljenja in prepreäśevanja sekundarnega hiperparatiroidizma
CA2683628C (en) 2007-04-25 2018-03-06 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
PT2148661E (pt) 2007-04-25 2013-03-06 Proventiv Therapeutics Llc Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso
FI3225243T3 (fi) 2007-04-25 2025-10-13 Opko Renal Llc Menetelmä sekundaarisen hyperparatyreoosin turvalliseen ja tehokkaaseen hoitoon ja ehkäisyyn kroonisen munuaistaudin yhteydessä
MX2010008904A (es) 2008-02-13 2010-11-05 Dsm Ip Assets Bv Uso de 25-hidroxi-vitamina d3 para afectar la fisiologia muscular humana.
KR20100126375A (ko) * 2008-02-13 2010-12-01 디에스엠 아이피 어셋츠 비.브이. 비타민 d와 25-하이드록시비타민 d3의 조합물
US8962239B2 (en) 2008-04-02 2015-02-24 Opko Renal, Llc Methods useful for vitamin D deficiency and related disorders
CA2731382C (en) * 2008-07-24 2020-04-28 Wisconsin Alumni Research Foundation Once-a-week administration of 25-hydroxy vitamin d3 to sustain elevated steady-state pharmacokinetic blood concentration
US20100331412A1 (en) * 2009-03-30 2010-12-30 Patricia Lawler Kenet Two container skin care product
US8518917B2 (en) * 2009-10-02 2013-08-27 Wisconsin Alumni Research Foundation 2-methylene-19-nor-vitamin D analogs and their uses
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
ES2712740T3 (es) 2010-12-06 2019-05-14 Dsm Ip Assets Bv Tratamiento de afecciones asociadas con eotaxina incrementada con 25-hidroxivitamina D3
CN103141433A (zh) * 2013-03-07 2013-06-12 青岛农业大学 维生素a临界缺乏家禽动物模型的构建方法
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 d 방출 제형
JP2017523220A (ja) * 2014-08-07 2017-08-17 オプコ アイルランド グローバル ホールディングス リミテッド 25−ヒドロキシビタミンdを用いる補助的療法
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
US20160131574A1 (en) * 2014-11-06 2016-05-12 The Chinese University Of Hong Kong Method for screening vitamin d insufficiency using skin colourimetry
EP3053598A1 (en) 2015-02-06 2016-08-10 Faes Farma, S.A. Calcifediol soft capsules
BR112018008186B1 (pt) * 2015-11-20 2021-11-23 Société des Produits Nestlé S.A. Composição que compreende micelas de proteína de soro de leite, e seus usos
UA129792C2 (uk) 2016-03-28 2025-08-06 Ейрджен Фарма Лтд. Способи лікування вітаміном d
JP7590184B2 (ja) 2018-04-03 2024-11-26 オプコ アイルランド グローバル ホールディングス リミテッド 肥満外科手術患者におけるカルシフェジオールの使用
WO2020161543A1 (en) 2019-02-06 2020-08-13 Opko Ireland Global Holdings, Limited Method of controlling progression of hyperparathyroidism with calcifediol, and compositions for use therein
EP3708171A1 (en) * 2019-03-11 2020-09-16 Roger Bouillon Treatment of vitamin d deficiency with 25(oh) vitamin d in critically ill patients
MX2022012599A (es) 2020-04-07 2022-11-07 Carbogen Amcis B V 25-hidroxivitamina d2 y/o d3 para usarse en la obesidad.
CN114748486A (zh) * 2022-03-25 2022-07-15 南京盛德生物科技研究院有限公司 一种含有维生素k2改善心血管钙化的药物组合物及其制备方法与应用
WO2025094144A1 (en) 2023-11-02 2025-05-08 Eirgen Pharma Ltd. Controlling loss of kidney function

Family Cites Families (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565924A (en) 1968-07-01 1971-02-23 Wisconsin Alumni Res Found 25-hydroxycholfcalciferol
US3833622A (en) 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3974272A (en) 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US3880894A (en) 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4004003A (en) 1974-08-28 1977-01-18 The Upjohn Company 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis
US4335120A (en) 1979-03-21 1982-06-15 Hoffmann-La Roche Inc. Administration of biologically active vitamin D3 and vitamin D2 materials
US4230701A (en) 1979-03-21 1980-10-28 Hoffmann-La Roche Inc. Administration of biologically active vitamin D3 and vitamin D2 materials
JPS55139320A (en) 1979-04-16 1980-10-31 Teijin Ltd Bone metabolism regulator
US4338312A (en) * 1981-05-11 1982-07-06 Wisconsin Alumni Research Foundation Method for preventing parturient paresis in dairy cattle
US4442093A (en) 1981-05-15 1984-04-10 Kureha Kagaku Kogyo Kabushiki Kaisha Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia
JPS57188520A (en) 1981-05-15 1982-11-19 Kureha Chem Ind Co Ltd Antihyperkalemia
JPS5832823A (ja) 1981-08-20 1983-02-25 Chugai Pharmaceut Co Ltd 脱癌剤
JPS58206524A (ja) 1982-05-26 1983-12-01 Kureha Chem Ind Co Ltd 抗腫瘍剤
US4448721A (en) 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4721613A (en) 1982-12-13 1988-01-26 Alza Corporation Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use
JPS59155309A (ja) 1983-02-22 1984-09-04 Teijin Ltd 活性型ビタミンd↓3類組成物
US4684524A (en) 1984-03-19 1987-08-04 Alza Corporation Rate controlled dispenser for administering beneficial agent
US4555364A (en) 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
US4695591A (en) 1985-03-29 1987-09-22 Schering Corporation Controlled release dosage forms comprising hydroxypropylmethylcellulose
US4668517A (en) 1985-04-04 1987-05-26 Norwich Eaton Pharmaceuticals, Inc. Furazolidone dosage form
EP0207638B1 (en) 1985-06-04 1990-12-19 Teijin Limited Sustained-release pharmaceutical preparation
JPS61293911A (ja) 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
US5167965A (en) 1987-02-09 1992-12-01 The Dow Chemical Company Palatable cholestyramine granules, tablets and methods for preparation thereof
US4892821A (en) 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
US4997824A (en) 1987-07-22 1991-03-05 Teva Pharmaceutical Industries Ltd. Combination of cholecalciferol derivatives for the treatment of renal bone disease
US5602116A (en) 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
JP2893191B2 (ja) 1988-11-08 1999-05-17 武田薬品工業株式会社 放出制御性マトリックス剤
JP2525478B2 (ja) 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンd▲下3▼類固型製剤
JPH02240024A (ja) 1989-03-13 1990-09-25 Ss Pharmaceut Co Ltd 活性型ビタミンd↓3類製剤用組成物
US5026559A (en) 1989-04-03 1991-06-25 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
GB9004544D0 (en) 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
JP2845342B2 (ja) 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンd▲下3▼誘導体含有固形製剤組成物
JPH04198129A (ja) 1990-11-28 1992-07-17 Sumitomo Pharmaceut Co Ltd 活性型ビタミンd↓3類含有組成物
JP2893140B2 (ja) 1990-11-30 1999-05-17 エスエス製薬株式会社 安定なビタミンd製剤
JPH04288016A (ja) 1991-03-14 1992-10-13 Tokai Capsule Kk 活性型ビタミンd3類軟カプセル剤の製造方法
ES2094290T3 (es) 1991-04-09 1997-01-16 Takeda Chemical Industries Ltd Preparacion estabilizada de vitamina d.
US5693615A (en) 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
BR9206110A (pt) * 1991-06-05 1995-07-11 Procter & Gamble Composições terapêuticas para osteoindução
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5160742A (en) 1991-12-31 1992-11-03 Abbott Laboratories System for delivering an active substance for sustained release
DE69304279T2 (de) * 1992-05-20 1997-02-20 Hoffmann La Roche Fluorierte Analoge Vitamins D3
US5795882A (en) 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
CA2116238C (en) 1992-06-22 2007-09-04 Joyce C. Knutson Oral 1 .alpha.-hydroxyprevitamin d
US5354743A (en) 1992-09-15 1994-10-11 Thys Jacobs Susan Method for the treatment of premenstrual syndrome with vitamin D
US5431917A (en) 1992-10-08 1995-07-11 Japan Elanco Company, Ltd. Hard capsule for pharmaceutical drugs and method for producing the same
US5342626A (en) 1993-04-27 1994-08-30 Merck & Co., Inc. Composition and process for gelatin-free soft capsules
JP2684587B2 (ja) 1993-06-21 1997-12-03 呉羽化学工業株式会社 腎性骨異栄養症における骨量減少抑制剤
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
JPH07242550A (ja) 1994-03-02 1995-09-19 Teijin Ltd 二次性副甲状腺機能亢進症治療剤
IL110117A0 (en) 1994-06-24 1994-10-07 Univ Ben Gurion Pharmaceutical compositions comprising vitamin-d analogs
SE9402422D0 (sv) 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
JPH10504291A (ja) 1994-07-22 1998-04-28 ジー.ディー.サール アンド カンパニー 自己乳化性ドラッグデリバリーシステム
JPH0892098A (ja) 1994-09-27 1996-04-09 Teijin Ltd 肺結核治療剤
EP1275635A1 (en) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US5756123A (en) 1994-12-01 1998-05-26 Japan Elanco Co., Ltd. Capsule shell
US20020183288A1 (en) 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US20040043971A1 (en) 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6376479B1 (en) 1995-04-03 2002-04-23 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
KR100327922B1 (ko) 1995-09-21 2002-05-09 리차드 에이취 리저 칼시트리올유도체및그의용도
DE19549243A1 (de) 1995-12-21 1997-06-26 Schering Ag Pharmazeutische Präparate enthaltend Clathrate von Cyclodextrinen und nichtnatürliche Vitamin D-Analoga
NO971934L (no) 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
ID18079A (id) 1996-08-26 1998-02-26 Takeda Chemical Industries Ltd Komposisi farmasi yang mengandung bahan pemercepat osteogenesis
US5958451A (en) 1996-09-03 1999-09-28 Yung Shin Pharm Ind. Co., Ltd. Process for producing porous, controlled-release capsules and encapsulated composition
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
CA2269806C (en) 1996-10-28 2006-01-24 Bernhard H. Van Lengerich Embedding and encapsulation of controlled release particles
JPH10158171A (ja) 1996-12-02 1998-06-16 Kita:Kk ビタミンd化合物を配合した眼内投与剤
US20020128240A1 (en) 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US20030129194A1 (en) 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
US6034075A (en) 1997-03-20 2000-03-07 The Trustees Of Columbia University In The City Of New York Method of treating polycystic ovarian syndrome
US5872113A (en) 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
DE69834195T2 (de) 1997-07-02 2007-03-29 Euro-Celtique S.A. Stabilisierte tramadol formulierungen mit verzögerter freisetzung
JPH1175863A (ja) 1997-07-10 1999-03-23 Kyowa Hakko Kogyo Co Ltd 25−ヒドロキシビタミンD3−1α−水酸化酵素および該酵素をコードするDNA
US6096876A (en) 1997-08-06 2000-08-01 Shriners Hospitals For Children 1-α-hydroxylase materials and methods
WO1999011272A1 (en) 1997-09-02 1999-03-11 Johns Hopkins University School Of Medicine Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
US5919986A (en) 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
JPH11158074A (ja) 1997-12-03 1999-06-15 Hayashi Tomie 高アミノ酸付加活性型ビタミンd強化組成物
US20030059471A1 (en) 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
CN1301298A (zh) 1998-03-25 2001-06-27 卡坦诺根公司 用于预防和治疗癌症的方法
US6521608B1 (en) 1998-03-27 2003-02-18 Oregon Health & Science University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US8133694B2 (en) 1998-06-25 2012-03-13 Immundiagnostik Ag Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D
US6214376B1 (en) 1998-08-25 2001-04-10 Banner Pharmacaps, Inc. Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture
SE9803871D0 (sv) 1998-11-11 1998-11-11 Pharmacia & Upjohn Ab Therapeutic method and formulation
US6770295B1 (en) 1998-08-27 2004-08-03 Pharmacia Ab Therapeutic formulation for administering tolterodine with controlled release
US6139875A (en) 1998-09-29 2000-10-31 Eastman Chemical Company Aqueous enteric coating composition and low gastric permeability enteric coating
AU6283299A (en) 1998-10-01 2000-04-17 Elan Pharma International Limited Controlled release nanoparticulate compositions
PT1119345E (pt) 1998-10-09 2009-07-27 Gen Mills Inc Encapsulação de componentes líquidos sensíveis numa matriz para obter partículas discretas de longa conservação
JP3449253B2 (ja) 1998-10-29 2003-09-22 シオノギクオリカプス株式会社 硬質カプセルの製造方法
JP2000206312A (ja) 1998-11-12 2000-07-28 Olympus Optical Co Ltd 光学素子
CA2354472C (en) 1998-12-17 2009-02-24 Alza Corporation Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6432936B1 (en) 1999-01-20 2002-08-13 Wisconsin Alumni Research Foundation Crystalline 1α-hydroxyvitamin D2 and method of purification thereof
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
DK1180035T3 (da) 1999-04-01 2007-03-05 Univ Johns Hopkins Ikke kalcemiske, antiproliferative, transkriptionsmæssigt aktive svovlholdige analoger af 1-alpha, 25-dihydroxy-vitamin D3
US7648826B1 (en) 1999-04-02 2010-01-19 The Regents Of The University Of California Detecting CYP24 expression level as a marker for predisposition to cancer
DE19916419B4 (de) 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
AU5139600A (en) 1999-05-27 2000-12-18 Drugtech Corporation Nutritional formulations
US6340473B1 (en) 1999-07-07 2002-01-22 R.P. Scherer Technologies, Inc. Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same
US6274169B1 (en) 1999-08-02 2001-08-14 Abbott Laboratories Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
JP4070459B2 (ja) 1999-08-31 2008-04-02 中外製薬株式会社 軟カプセル剤
US20060034937A1 (en) 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
GB0007419D0 (en) * 2000-03-27 2000-05-17 Smithkline Beecham Gmbh Composition
US6375981B1 (en) 2000-06-01 2002-04-23 A. E. Staley Manufacturing Co. Modified starch as a replacement for gelatin in soft gel films and capsules
AU2001278956B2 (en) 2000-07-18 2007-04-05 Genzyme Corporation Stabilized 1alpha-hydroxy vitamin d
US6491950B1 (en) 2000-08-07 2002-12-10 Kos Pharmaceuticals, Inc. Controlled release pharmaceutical composition
WO2002017848A1 (fr) 2000-08-29 2002-03-07 Nisshin Kasei Co., Ltd. Capsule en dur
US6887493B2 (en) 2000-10-25 2005-05-03 Adi Shefer Multi component controlled release system for oral care, food products, nutraceutical, and beverages
HU230875B1 (hu) 2000-10-30 2018-11-29 Euro-Celtique S.A. Szabályozott hatóanyag-leadású hidrokodon készítmények
US6479649B1 (en) 2000-12-13 2002-11-12 Fmc Corporation Production of carrageenan and carrageenan products
JP2002302447A (ja) 2001-04-03 2002-10-18 Shimizu Pharmaceutical Co Ltd 局所投与用癌治療剤
RU2262922C2 (ru) 2001-05-15 2005-10-27 Уорнер-Ламберт Компани Ллс Способ прессования для получения лекарственной формы фенитоина натрия
AU2002315779B2 (en) 2001-07-05 2007-03-22 Wakunaga Pharmaceutical Co.,Ltd Soft capsules
US6870833B2 (en) 2001-07-20 2005-03-22 Net2Phone, Inc. Active voice messaging
US7166585B2 (en) 2001-08-22 2007-01-23 Cytochroma Inc. 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3
US7033996B2 (en) 2001-08-31 2006-04-25 University Of Medicine & Dentistry Of New Jersey Method for the treatment of vitamin D related disease
DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
ES2283593T3 (es) 2001-10-12 2007-11-01 Johns Hopkins University Analogos de oxima poco calcemicos de 1alfa,25-dihidroxi vitamina d3.
US6524788B1 (en) 2001-11-02 2003-02-25 Thomas L. Cantor Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism
US7056655B2 (en) 2001-11-02 2006-06-06 Scantibodies Laboratory, Inc. Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism
ITMI20012366A1 (it) 2001-11-09 2003-05-09 Farmatron Ltd Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali
KR101042131B1 (ko) 2001-11-22 2011-06-20 모리시타 진탄 가부시키가이샤 비젤라틴계 캡슐 피막 조성물 및 이를 이용한 캡슐
GB0128415D0 (en) 2001-11-27 2002-01-16 Univ Sheffield Medicaments
CN100391464C (zh) 2001-12-03 2008-06-04 诺瓦西股份有限公司 含活性维生素d化合物的药物组合物
US6627622B2 (en) * 2002-02-18 2003-09-30 Wisconsin Alumni Research Foundation (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
FR2829142B1 (fr) 2001-12-27 2004-02-13 Ulice Composition filmogene d'heteroxylanes pour la fabrication de capsules ainsi obtenues
US7632518B2 (en) 2002-01-15 2009-12-15 Dsm Ip Assets B.V. 25-hydroxy vitamin D3 compositions
US6949256B2 (en) 2002-01-18 2005-09-27 Banner Pharmacaps, Inc. Non-gelatin capsule shell formulation
NO20021592D0 (no) 2002-04-04 2002-04-04 Fmc Biopolymer As Polysakkaridkapsler og fremgangsmåte ved fremstilling derav
JP2005531532A (ja) * 2002-04-05 2005-10-20 メルク エンド カムパニー インコーポレーテッド アレンドロナートおよびビタミンd製剤を用いる骨吸収阻害法
AU2003220689A1 (en) 2002-04-10 2003-10-27 Miller, Fred H Multi-phase, multi-compartment capsular system
AU2003222699A1 (en) 2002-05-02 2003-11-17 Cytochroma Inc. Stable cytochrome p450 24 (cyp24) expressing cell line and methods and uses thereof
EP1511725B1 (en) 2002-06-13 2012-02-01 Johns Hopkins University 24-sulfoximine vitamin d3 compounds
ATE482694T1 (de) 2002-07-05 2010-10-15 Temrel Ltd Zusammensetzung zur kontrollierten wirkstoffabgabe
AR040672A1 (es) 2002-07-25 2005-04-13 Glaxo Group Ltd Forma de dosificacion farmaceutica multicomponenete, cuerpo apropiado para ser utilizado en la misma y procedimiento para prepararla
CN1684670A (zh) 2002-07-29 2005-10-19 阿尔扎公司 用于控制释放帕潘立酮的方法和剂型
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
AU2002368245A1 (en) 2002-09-26 2004-04-19 Young-Kweon Choi Matrix type patch for transdermal administration of vitamin d analog and the use thereof
US20050101576A1 (en) 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US8999372B2 (en) 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
JP2004175750A (ja) * 2002-11-28 2004-06-24 Kose Corp 皮膚障害抑制剤、皮膚障害改善剤、及びそれらを含有する皮膚外用剤
US20050026877A1 (en) 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
DE20321698U1 (de) 2002-12-16 2008-12-24 Teva Pharmaceutical Industries Ltd. Medikament zur Erhöhung der Bioverfügbarkeit von Alendronat oder einem anderen Bisphosphonat durch Verabreichen einer Vordosis eines Vitamin-D-Derivats
GB2411116B (en) 2002-12-16 2009-04-29 Teva Pharma Increasing the bioavailability of alendronate by predose administration of alphacalcidol
AU2003292920A1 (en) 2002-12-18 2004-07-09 Cytochroma Inc. 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
JP2006517593A (ja) 2003-02-11 2006-07-27 アルザ・コーポレーシヨン 投薬形態物の層形状修飾方法およびそのような修飾を受けさせた投薬形態物
US7816341B2 (en) 2003-04-14 2010-10-19 Fmc Corporation Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom
BRPI0409357B8 (pt) 2003-04-14 2021-05-25 Dupont Nutrition Usa Inc película de gel termorreversível homogênea, processo para fabricar as películas de gel, cápsulas moles, processo para fabricar as cápsulas moles, e, forma sólida
US20070032461A1 (en) 2003-04-30 2007-02-08 Bioxell S.P.A. 1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof
WO2004110391A2 (en) 2003-06-16 2004-12-23 Solx, Inc. Shunt for the treatment of glaucoma
ES2379466T3 (es) 2003-06-26 2012-04-26 Psivida Us, Inc. Sistema de suministro de fármacos de liberación sostenida bioerosionables
AU2003903382A0 (en) 2003-07-03 2003-07-17 Medvet Science Pty Ltd Inhibition of calcitriol mediated cyp24 induction screening for compounds therefor and uses thereof
WO2005002549A1 (en) 2003-07-04 2005-01-13 Nycomed Danmark Aps Parathyroid hormone (pth) containing pharmaceutical compositions for oral use
US20050124591A1 (en) 2003-07-29 2005-06-09 Jin Tian Use of vitamin Ds to treat kidney disease
US20050148557A1 (en) 2003-07-29 2005-07-07 Jin Tian Use of Vitamin Ds to treat kidney disease
AU2004279318C1 (en) 2003-09-12 2020-06-25 Amgen Inc. Rapid dissolution formulation of a calcium receptor-active compound
US7053075B2 (en) 2003-11-25 2006-05-30 Deluca Hector F Methods for reducing body fat using vitamin D compounds
CA2494572A1 (en) 2003-12-19 2005-06-19 Cytochroma Inc. Cytochrome p450 24 (cyp24) monoclonal antibody and methods and uses thereof
US20060009425A1 (en) 2004-05-28 2006-01-12 Leticia Delgado-Herrera Oral formulations of paricalcitol
JP2008502605A (ja) 2004-06-16 2008-01-31 スマート ドラッグ システムズ インコーポレイティド 徐放性ワクチン組成物
WO2006007323A2 (en) 2004-06-28 2006-01-19 Alza Corporation Dosage forms for low solubility and/or low dissolution rate free acid pharmaceutical agents
US20060019933A1 (en) 2004-07-22 2006-01-26 David Boardman Process for preparing stabilized vitamin D
BRPI0513909A (pt) 2004-07-29 2008-05-20 Sanofi Aventis comprimido farmacêutico de camada múltipla para a liberação controlada de ingredientes ativos com solubilidade altamente dependente do ph
US8231896B2 (en) 2004-11-08 2012-07-31 R.P. Scherer Technologies, Llc Non-gelatin soft capsule system
AU2004325362B2 (en) 2004-12-03 2012-09-06 Council Of Scientific And Industrial Research Process of preparation of biodegradable films from semi refined kappa carrageenan
US8318210B2 (en) 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
AU2006236564B2 (en) 2005-04-15 2011-02-17 Besins Healthcare Luxembourg S.A.R.L. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
US20060257481A1 (en) 2005-04-21 2006-11-16 Decode Genetics Ehf. Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy
US9205047B2 (en) 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix
US20080134937A1 (en) 2005-05-25 2008-06-12 Joo Hwan Yang Cellulose hard capsule enhancing mechanical film strength
AR055099A1 (es) 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
ES2323900T3 (es) 2005-09-29 2009-07-27 F. Hoffmann-La Roche Ag Anticuerpos contra la 25-hidroxivitamina d.
ITFI20050206A1 (it) 2005-09-30 2007-04-01 Valpharma Sa Composizione farmaceutica a rilascio controllato di venlafaxina cloridrato, e processo per la sua preparazione
JP5303276B2 (ja) * 2005-10-12 2013-10-02 プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー 25−ヒドロキシビタミンd不足および欠乏を治療するための方法および製品
CA2627292C (en) 2005-10-26 2012-04-17 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system
CA2627351C (en) 2005-10-26 2012-05-01 Banner Pharmacaps, Inc. Lipophilic vehicle-based dual controlled release matrix system
AP2878A (en) 2005-11-01 2014-03-31 Cp Kelco Us Inc High viscocity diutan gums and methods of producing
WO2007068287A1 (en) 2005-12-15 2007-06-21 Laboratoria Qualiphar Sustained release vitamin preparation
MXPA05014091A (es) 2005-12-20 2007-06-20 Leopoldo De Jesus Espinosa Abdala Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus
JP2009525030A (ja) 2006-01-31 2009-07-09 ヘルス リサーチ インコーポレイテッド 変化したビタミンd代謝を同定するための方法
US7528122B2 (en) * 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
ES2904546T3 (es) 2006-02-03 2022-04-05 Opko Renal Llc Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3
GB0606426D0 (en) 2006-03-30 2006-05-10 Novartis Ag Benzimidazole derivatives
CA2660613A1 (en) 2006-06-06 2007-12-21 Fmc Corporation Kappa-2 carrageenan composition and products made therefrom
US20080109983A1 (en) 2006-11-10 2008-05-15 Kegel, Llc Zero Turning Radius Lane Maintenance Machine
SI2037936T1 (sl) 2006-06-21 2014-11-28 Opko Renal, Llc Postopek zdravljenja in prepreäśevanja sekundarnega hiperparatiroidizma
EP1912400A1 (en) 2006-10-10 2008-04-16 Matsushita Electric Industrial Co., Ltd. Method and apparatus for mobile IP route optimization
ES2895666T3 (es) 2006-10-27 2022-02-22 Capsugel Belgium Nv Cápsulas duras de hidroxipropilmetilcelulosa y proceso de fabricación
WO2008097646A1 (en) 2007-02-09 2008-08-14 Schering Corporation Methods to treat and/or prevent mucositis
US8491937B2 (en) 2007-02-15 2013-07-23 Wyeth Llc Stability in vitamin and mineral supplements
WO2008116113A1 (en) 2007-03-20 2008-09-25 Electrolock, Inc. Roebel winding with conductive felt
WO2008116133A1 (en) 2007-03-21 2008-09-25 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
PT2148661E (pt) 2007-04-25 2013-03-06 Proventiv Therapeutics Llc Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso
CA2683628C (en) 2007-04-25 2018-03-06 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
CA2684778C (en) 2007-04-25 2017-09-05 Cytochroma Inc. Methods and compounds for vitamin d therapy
FI3225243T3 (fi) 2007-04-25 2025-10-13 Opko Renal Llc Menetelmä sekundaarisen hyperparatyreoosin turvalliseen ja tehokkaaseen hoitoon ja ehkäisyyn kroonisen munuaistaudin yhteydessä
US20090004284A1 (en) 2007-06-26 2009-01-01 Watson Pharmaceuticals, Inc. Controlled release tamsulosin hydrochloride formulation
KR100836960B1 (ko) 2007-09-07 2008-06-10 주식회사 서울제약 새로운 나이아신 제어방출형 제제
EP2042165A1 (de) 2007-09-28 2009-04-01 Swiss Caps Rechte und Lizenzen AG Hot-Melt-Befüllte Weichkapseln
EP2229155A4 (en) 2007-12-12 2010-12-29 Northern Innovations And Formulations Corp Particles in a capsule
EA018580B1 (ru) 2008-02-13 2013-09-30 ДСМ АйПи АССЕТС Б.В. Комбинированное применение 25-гидроксивитамина d3 и витамина d3 для повышения плотности минерального вещества костей и для лечения остеопороза
KR20100126375A (ko) 2008-02-13 2010-12-01 디에스엠 아이피 어셋츠 비.브이. 비타민 d와 25-하이드록시비타민 d3의 조합물
ES2588241T3 (es) 2008-02-13 2016-10-31 Dsm Ip Assets B.V. Tratamiento de la hiperglucemia con 25-hidroxivitamina D3 y vitamina D
MX2010008904A (es) 2008-02-13 2010-11-05 Dsm Ip Assets Bv Uso de 25-hidroxi-vitamina d3 para afectar la fisiologia muscular humana.
BRPI0907954A2 (pt) * 2008-02-13 2015-08-04 Dsm Ip Assets Bv Tratamento de hipertensão com 25-hidroxivitamina d3
US8962239B2 (en) 2008-04-02 2015-02-24 Opko Renal, Llc Methods useful for vitamin D deficiency and related disorders
CA2731382C (en) 2008-07-24 2020-04-28 Wisconsin Alumni Research Foundation Once-a-week administration of 25-hydroxy vitamin d3 to sustain elevated steady-state pharmacokinetic blood concentration
MX2011003047A (es) 2008-09-24 2011-04-14 Evonik Roehm Gmbh Composicion farmaceutica de opioide de liberacion controlada ph dependiente con resistencia contra la influencia de etanol.
EP2179727B1 (en) 2008-10-27 2013-05-29 Roquette Freres Water insoluble polymer: modified starch derivative-based film coatings for colon targeting
BRPI1006902A2 (pt) 2009-01-23 2016-02-16 Aziende Chimiche Riunte Angelini Francesco A C R A F S P A formulação farmacêutica ou alimentícia de liberação controlada, processo para a produção de uma forma farmacêutica ou alimentícia, sistema de liberação controlada, e, uso de um sistema de liberação controlada
CH700543A2 (de) 2009-03-03 2010-09-15 Innogel Ag Film auf Basis von Stärke.
EP2475395B1 (en) 2009-09-10 2019-11-13 DuPont Nutrition USA, Inc. High strength seamless alginate capsules
IT1396937B1 (it) 2009-11-26 2012-12-20 Bruzzese Formulazioni di bisfosfonati e vitamina d idonee alla somministrazione intermittente per via intramuscolare e sottocutanea
FR2953139B1 (fr) 2009-11-27 2012-04-13 Servier Lab Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine
US8101203B2 (en) 2010-01-14 2012-01-24 Karl Wei Cao Hard capsule composition and method of use
US8101204B2 (en) 2010-01-14 2012-01-24 Karl Wei Cao Hard capsule composition and method of use
WO2011095388A1 (en) 2010-02-04 2011-08-11 Synthon Bv Tolterodine bead
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
WO2012006475A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
KR20120005228A (ko) 2010-07-08 2012-01-16 주식회사 네비팜 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법
BR112013002721B8 (pt) 2010-08-04 2021-05-25 Scherer Technologies Llc R P composição formadora de filme para cápsulas moles, cápsulas moles e seu invólucro
US20120135103A1 (en) 2010-11-30 2012-05-31 Mead Johnson Nutrition Company Staged Infant Feeding Regimen To Promote Healthy Development And Growth
ES2712740T3 (es) 2010-12-06 2019-05-14 Dsm Ip Assets Bv Tratamiento de afecciones asociadas con eotaxina incrementada con 25-hidroxivitamina D3
AU2011353202B2 (en) 2010-12-28 2015-07-09 Future Diagnostics B.V. Release reagent for vitamin D
DK2680826T3 (en) 2011-03-02 2017-10-09 D3 Pharma Ltd VITAMIN D COMPOSITION
SG194542A1 (en) 2011-04-20 2013-12-30 Mico Bio Inc Composition and method for enhancing an immune response
ES2617654T3 (es) 2011-04-20 2017-06-19 Suheung Co., Ltd. Composición de la cubierta de cápsula blanda de origen no animal que tiene dureza de la cubierta y desintegración, mejoradas
CN102771688A (zh) 2011-05-13 2012-11-14 富曼实(上海)商贸有限公司 可食用液体填充的多糖胶囊
US20130085121A1 (en) 2011-09-30 2013-04-04 Jianguo Wang Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d
WO2014029953A1 (en) 2012-08-21 2014-02-27 Cipla Limited Hot melt extruded (hme) pharmaceutical composition of cinacalcet
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 d 방출 제형
PT106978A (pt) 2013-05-31 2014-12-02 Tecnimede Sociedade Tecnico Medicinal S A Composição sólida oral contendo ácido ibandrónico e vitamina d
EP2815745A1 (en) 2013-06-21 2014-12-24 Swiss Caps Rechte und Lizenzen AG Soft shell capsule and process for its manufacture
CN103495176B (zh) 2013-10-26 2015-01-28 中山市凯博思淀粉材料科技有限公司 一种共混挤出法制备淀粉基软胶囊的方法
CN103520133B (zh) 2013-10-26 2015-02-04 中山市凯博思淀粉材料科技有限公司 一种淀粉基软胶囊的制备方法
JP2017523220A (ja) 2014-08-07 2017-08-17 オプコ アイルランド グローバル ホールディングス リミテッド 25−ヒドロキシビタミンdを用いる補助的療法
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor

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