NO160211B - Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme cefemderivater. - Google Patents
Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme cefemderivater. Download PDFInfo
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- NO160211B NO160211B NO781130A NO781130A NO160211B NO 160211 B NO160211 B NO 160211B NO 781130 A NO781130 A NO 781130A NO 781130 A NO781130 A NO 781130A NO 160211 B NO160211 B NO 160211B
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- 238000000034 method Methods 0.000 title description 2
- 239000007788 liquid Substances 0.000 claims description 25
- 230000005291 magnetic effect Effects 0.000 claims description 23
- 210000000056 organ Anatomy 0.000 claims description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 230000004907 flux Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Description
Anordning for behandling av væske, og magnet for en slik anordning.
Denne oppfinnelse angår en anordning
for behandling av væsker ved hjelp av
kraftlinjene i et magnetisk felt forsynt
med i det minste ett gjennomløp for den
væske som skal behandles, og organer for
over en del av nevnte gjennomløp å frembringe et magnetisk felt hvis kraftlinjer
står i hovedsaken vinkelrett på gjennom-løpets lengderetning.
Slike anordninger nyttes for behandling av væsker som forårsaker kalkholdige
skjelldannelser, likesom for generelt å redusere slike væskers tærende virkning.
Enn videre er den magnetiske kondisjonering av væsker allerede kjent, særlig
i henhold til de fremgangsmåter som ut-føres ved hjelp av de anordninger som tidligere er tilveiebragt av oppfinneren og
bl. a. ved hjelp av de anordninger som om-handles i de belgiske patenter nr. 460 560,
486 497 og 492 580.
Ved de hittil kjente anordninger frem-bringes imidlertid de magnetiske felt enten
av spoler som forsynes med veksel- eller
likestrøm, eller av permanentmagneter med
en mere eller mindre vanlig utførelse, f. eks.
rette, sylindriske eller halvsylindriske magneter.
Den foreliggende oppfinnelse angår
derimot i første rekke en anordning som
bygger på en fullstendig ny idé, som med-fører arbeids- og materialbesparelser, sam-tidig som den sikrer bedre resultater enn
tidligere.
For oppnåelse av disse formål består
de nevnte organer som frembringer det
magnetiske felt av to magneter som strekker seg parallelt med hverandre i lengderetningen av gjennomløpet, som på midten er forsynt med to mot hverandre vendte fremspring som danner poler med motsatt polaritet, idet det i begge ender av magnetene fins andre poler, som for en og samme magnet har motsatt polaritet av denne magnets midtre fremspringende pol.
Ved en foretrukket utføringsform for oppfinnelsen kan magnetene være gjensidig forbundet ved knaster som danner endepolene.
Oppfinnelsen omfatter ikke bare den ovenfor angitte anordning, men innbefat-ter også hver enkelt magnet konstruert for en slik anordning.
Andre detaljer og trekk ved oppfinnelsen vil fremgå av den etterfølgende beskri-velse av et utføringseksempel på en anordning for behandling av en væske, og en magnet for en slik anordning, under hen-visning til tegningen. Fig. 1 er et vertikalt lengdesnitt av et par magneter inngående i anordningen for behandling av en væske i henhold til oppfinnelsen; Fig. 2 viser den ene (undre) magnet i
fig. 1 i grunnriss;
Fig. 3 er et snitt gjennom en rekke samordnede magnetpar ifølge de foregå-ende figurer, med magnetene plassert på en fordelaktig måte i forhold til hverandre i anordningen for behandling av en væske i henhold til oppfinnelsen; snittet er tatt etter linjen III-III i fig. 1.
I de forskjellige figurer betegner like henvisningstall tilsvarende elementer.
Anordningen for behandling av væsker ved hjelp av kraftlinjene i magnetiske felt, for å redusere den tærende virkning av slike væsker og for å "forhindre nevnte væsker fra å forårsake kalkholdige skjelldannelser, kan bestå av et par permanentmagneter av den type som er vist i fig. 1. Som forklart nedenfor kan en slik anordning for væskebehandling omfatte mange slike magnetpar, så som vist i fig. 3.
Hver av magnetene i det i fig. 1 viste magnetpar består av et magnetisk legeme som strekker seg i hovedsaken i lengderetningen og parallelt med væskestrømmen.'
Den øvre magnet er betegnet med hen-visningstallet 1 og den undre magnet med 2. Hver magnet har en pol med samme polaritet i begge ender, og er midt mellom endepolene utformet med et fremspringende parti 5 resp. 6, som har motsatt polaritet av endepolene for en og samme magnet. Den undre magnet 2 har en nordpol i hver ende og en sydpol på midten som dannes av fremspringet 5. Den øvre magnet 1 har en sydpol i hver ende og en nordpol på midten dannet av fremspringet 6. Endepolene av magnetene 1 og 2 har motsatt polaritet, så at legemene 1 og 2 trekkes mot hverandre av den magnetiske tiltreknings-kraft, som ikke bare virker i endene av magnetene, men også i området for fremspringene 5, 6, ettersom hver ende av en magnet kommer i kontakt med en ende av den annen magnet som danner en pol med motsatt polaritet, og fremspringet på den ene magnet er vendt mot et fremspring på den annen magnet som danner en pol med motsatt polaritet.
Endene av magnetene er utformet som knaster 3 og 4, som berører og tiltrekker hverandre langs plane flater. Høyden på knastene 3 og 4 er større enn høyden på fremspringene 5 og 6, på en slik måte at det med magnetene i sammensatt tilstand (fig. 1) med knastene 3 og 4 i kontakt, gjenstår et fritt gjennomløp mellom fremspringene 5, 6. Avstanden mellom fremspringene 5, 6 er imidlertid vesentlig mindre enn avstanden mellom magnetene 1, 2 på de øvrige steder, selvsagt med unntakelse av området for kontaktflatene av knastene 3 og 4. Mellom parene av knaster 3 resp. 4 er det imidlertid en betydelig fri gjennomgangsåpning for væske. Kraftlinjene i de magnetiske felt befinner seg selv-følgelig nesten utelukkende inne i magnetene, med unntakelse av den korte vei kraftlinjene må følge mellom fremspringene 5, 6. Luftgapet på dette sted er således meget smalt, på en slik måte at den magnetiske fluks kan være sterkt konsentrert i dette luftgap. Det magnetiske felt utnyttes således nesten 100 pst., hvilket betyr en gevinst på ca. 30 pst. i magnetisk mate-riale i forhold til de vanlige utførelser.
I området for dette luftgap, dvs. mellom fremspringene 5 og 6, står kraftlinjene i det magnetiske felt antydet med 7 i hovedsaken vinkelrett på «væsketrådene» som er parallelle med pilene 8 som angir strømningsretningen for væsken.
Det skal bemerkes at det i fig. 1 viste magnetpar eller en rekke identiske magnetpar som vist i fig. 3 er anbragt inne i et rør som således omslutter magnetene som er anbragt side ved side i kontakt med hverandre. Dette rør tjener bare til å holde de enkelte magneter på deres resp. plass og har således ingen betydning med hensyn til styrken av de magnetiske felt. Røret er ikke vist på tegningsfigurene. Det består fortrinnsvis av ikke-ferromagnetisk mate-riale.
Væsken som passerer gjennom anordningen i retning av pilene 8 finner et gjen-nomløp med tilstrekkelig stort tverrsnitt mellom knastene 3, 4, hvilket gjennomløp forblir stort nok mellom magnetene 1, 2 også bakenfor knastene, men har et meget mere begrenset område mellom fremspringene 5 og 6. Ettersom magnetparet er sym-metrisk i forhold til et tverrsnitts- (parallelt med snittlinjen III-III) plan gjennom fremspringene 5, 6, får væskegjennomløpet bakenfor området for fremspringene 5, 6 igjen et meget større areal, på en slik måte at den fullstendige kanal mellom de to magneter 1,2 får form av en venturi, der den minste avstand forefinnes i området for luftgapet, hvor magnetfeltet er sterkest, d.v.s. mellom fremspringene 5, 6. Væskens strømningshastighet er således størst i luftgapet, hvilket er overordentlig fordelaktig, ettersom effektiviteten av den magnetiske kondisjonering på den ene side er avhengig av feltstyrken og på den annen side av væskens strømningshastighet. Det lille strømningsareal i området for luftgapet resulterer i en større hastighet og den lille avstand mellom de to fremspring som danner motsatte poler bevirker stor konsentra-sjon av den magnetiske fluks. Venturifor-men minsker den hydrauliske motstand.
På grunn av den meget store strøm-ningshastighet, medtas urenhetene, f. eks. jernoksydene, av væsken og de kastes således for en stor del ut av apparatet, på en slik måte at det er mindre fare for tilstop-ping av anordningen innenfor det magnetiske gap.
Alle disse fordelaktige trekk tillater bruk av vanlige magneter for kondisjonering av forskjellige væsker, mens det tidligere av tekniske årsaker var nødvendig å velge magnetene med hensyn til det nød-vendige magnetiske felt, som på sin side måtte velges ut fra den elektrolytiske for-mel for den væske som skulle behandles.
Fig. 3 viser hvordan det er mulig å bygge opp et batteri av magnetpar, hvor hvert magnetpar tjener samme formål som beskrevet ovenfor. Det fremgår mere tyde-lig av fig. 3. at magnetene, som er plassert rygg mot rygg og som tilhører to forskjellige par, f. eks. magnetene 9 og 10, har like poler i endene og således også på midten. Magnentene 9 og 10 har således nordpoler i endene og en sydpol på midten. Med mag-netparene således anordnet rygg mot rygg med lik polaritet, rettes den magnetiske fluks sterkere mot luftgapene, ettersom den ikke har anledning til å unnslippe andre steder, og den tiltrekkes i luftgapet.
Selvom de viste magneter har rektan-gulært tverrsnitt, kan magneter ifølge oppfinnelsen istedenfor ha en hvilken som helst annen geometrisk form. Formen må imidlertid fortrinnsvis tillate en perfekt sammenstilling av magnetene som beskrevet i forbindelse med fig. 3, men dette krav kan tilsidesettes når det er tale om magneter anordnet i individuelle par inne i et rør.
Claims (2)
1. Anordning for behandling av en væske ved hjelp av kraftlinjene i et magnetisk felt med i det minste et gjennomløp for den væske som skal behandles og organer for over en del av nevnte gjennomløp å frembringe et magnetisk felt hvis kraftlinjer står i hovedsaken vinkelrett på lengderetningen av gjennomløpet, karakterisert ved at nevnte organer som frembringer det magnetiske felt består av to magneter (1, 2) som strekker seg parallelt med hverandre i lengderetningen av gjennomløpet, idet de på midten er forsynt med fremspring (5, 6) som er vendt mot hverandre og danner poler med motsatt polaritet, og at det i begge ender av magnetene (1, 2) forefinnes andre poler (3, 4) som for en og samme magnet har motsatt polaritet i forhold til det tilhør-ende fremspring.
2. Anordning som angitt i påstand 1, karakterisert ved at magnetene sammenholdes gjensidig gjennom knaster (3, 4) dannende endepolene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772714880 DE2714880A1 (de) | 1977-04-02 | 1977-04-02 | Cephemderivate und verfahren zu ihrer herstellung |
DE19772716707 DE2716707A1 (de) | 1977-04-02 | 1977-04-15 | Cephemderivate und verfahren zu ihrer herstellung |
Publications (3)
Publication Number | Publication Date |
---|---|
NO781130L NO781130L (no) | 1978-10-03 |
NO160211B true NO160211B (no) | 1988-12-12 |
NO160211C NO160211C (no) | 1989-03-22 |
Family
ID=25771827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO781130A NO160211C (no) | 1977-04-02 | 1978-03-31 | Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme cefemderivater. |
Country Status (28)
Country | Link |
---|---|
US (4) | US4758556A (no) |
JP (2) | JPS5858354B2 (no) |
AT (1) | AT367425B (no) |
AU (1) | AU528277B2 (no) |
BE (1) | BE865632A (no) |
CA (1) | CA1259606A (no) |
CH (1) | CH638810A5 (no) |
CS (1) | CS208747B2 (no) |
DD (1) | DD137231A5 (no) |
DE (2) | DE2714880A1 (no) |
DK (1) | DK165060C (no) |
ES (2) | ES468475A1 (no) |
FI (1) | FI70221C (no) |
FR (3) | FR2385722B1 (no) |
GB (1) | GB1604971A (no) |
GR (1) | GR73632B (no) |
HK (1) | HK39083A (no) |
IE (1) | IE47211B1 (no) |
IL (1) | IL54407A (no) |
IT (1) | IT1093750B (no) |
LU (1) | LU79350A1 (no) |
NL (1) | NL7803486A (no) |
NO (1) | NO160211C (no) |
NZ (1) | NZ186842A (no) |
OA (1) | OA05928A (no) |
PT (1) | PT67856B (no) |
SE (2) | SE448378B (no) |
YU (1) | YU41827B (no) |
Families Citing this family (235)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4493833A (en) * | 1976-04-12 | 1985-01-15 | Fujisawa Pharmaceutical Co., Ltd. | Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds |
US4304770A (en) | 1976-04-12 | 1981-12-08 | Fujisawa Pharmaceutical Co., Ltd. | Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof |
BE878514A (fr) * | 1978-09-04 | 1980-02-29 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
BE878433A (fr) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
US4409217A (en) * | 1977-03-14 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
PH17188A (en) | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
US4427674A (en) | 1977-03-14 | 1984-01-24 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
FR2399418A1 (fr) * | 1977-03-14 | 1979-03-02 | Fujisawa Pharmaceutical Co | Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques |
US5089490A (en) * | 1977-04-02 | 1992-02-18 | Hoechst Aktiengesellschaft | Cephem derivatives |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
JPS5444695A (en) * | 1977-09-13 | 1979-04-09 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation |
FR2410655A1 (fr) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2387235A1 (fr) | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
SE7902598L (sv) * | 1978-03-25 | 1979-10-04 | Kyowa Hakko Kogyo Kk | Cephalosporinanaloger |
JPS5936914B2 (ja) * | 1978-06-24 | 1984-09-06 | 協和醗酵工業株式会社 | セフアロスポリン類縁体 |
NO790956L (no) * | 1978-03-25 | 1979-09-26 | Kyowa Hakko Kogyo Kk | Analogifremgangsmaate til fremstilling av cefalosporinanaloge eller farmasoeytisk akseptable salter derav |
FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
SE448379B (sv) * | 1978-03-31 | 1987-02-16 | Roussel Uclaf | O-substituerade oximderivat av 7-amino-tiazolyl-acetamidocefalosporansyra |
US4374834A (en) * | 1978-04-07 | 1983-02-22 | Roussel Uclaf | Novel compounds |
FR2421907A1 (fr) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments |
AR231986A1 (es) * | 1978-05-26 | 1985-04-30 | Glaxo Group Ltd | Procedimiento para preparar antibioticos de cefalosporina |
AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
DE2967356D1 (en) * | 1978-07-17 | 1985-02-28 | Fujisawa Pharmaceutical Co | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
US4372952A (en) | 1978-07-31 | 1983-02-08 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
FR2453161A1 (fr) * | 1978-08-31 | 1980-10-31 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus |
US4341775A (en) * | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
BE878637A (fr) * | 1978-09-11 | 1980-03-06 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes |
DE2945248A1 (de) * | 1978-11-13 | 1980-05-22 | Fujisawa Pharmaceutical Co | Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel |
JPS5585594A (en) * | 1978-11-13 | 1980-06-27 | Fujisawa Pharmaceut Co Ltd | Cephem compound and their preparation |
SE7909501L (sv) * | 1978-11-17 | 1980-05-18 | Glaxo Group Ltd | Cefalosporin-antibiotika |
JPS5579393A (en) * | 1978-12-11 | 1980-06-14 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
JPS6058920B2 (ja) * | 1978-12-26 | 1985-12-23 | 協和醗酵工業株式会社 | セフアロスポリン類縁体 |
FR2448543A1 (fr) | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
JPS55108877A (en) * | 1979-02-10 | 1980-08-21 | Kyowa Hakko Kogyo Co Ltd | Optically active cephalosporin analog |
JPS5616491A (en) * | 1979-07-19 | 1981-02-17 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
NO155547C (no) * | 1979-02-10 | 1987-04-15 | Kyowa Hakko Kogyo Kk | Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling. |
JPS5671092A (en) * | 1979-11-14 | 1981-06-13 | Kyowa Hakko Kogyo Co Ltd | Optical active cephalosporin analogous derivative |
NO155548C (no) * | 1979-02-10 | 1987-04-15 | Kyowa Hakko Kogyo Kk | Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger. |
NZ193212A (en) * | 1979-03-22 | 1982-12-07 | Glaxo Group Ltd | Cephalosporin antibiotics and pharmaceutical compsitions |
US4339449A (en) | 1979-03-27 | 1982-07-13 | Fujisawa Pharmaceutical Company, Limited | Analogous compounds of cephalosporins, and pharmaceutical composition comprising the same |
US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
FR2461713A1 (fr) * | 1979-07-19 | 1981-02-06 | Roussel Uclaf | Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
EP0025199B1 (en) | 1979-09-03 | 1984-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
US4271157A (en) | 1980-02-28 | 1981-06-02 | E. R. Squibb & Sons, Inc. | Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
US4443443A (en) * | 1979-12-17 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4405617A (en) * | 1980-02-11 | 1983-09-20 | Fujisawa Pharmaceutical Co., Ltd. | 3-(Propynyltetrazol)thiomethyl-3-cephems |
FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
EP0104671B1 (fr) * | 1980-02-18 | 1990-05-23 | Roussel-Uclaf | Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl-7 amino thiazolylacétamido céphalosporaniques, leur préparation, leur application comme médicaments et les compositions les renfermant |
JPS56131591A (en) * | 1980-02-20 | 1981-10-15 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent |
DE3006888A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
JPS56118085A (en) * | 1980-02-25 | 1981-09-16 | Takeda Chem Ind Ltd | 2-methylcephalosporin derivative and its preparation |
FR2476647A2 (fr) * | 1980-02-26 | 1981-08-28 | Roussel Uclaf | Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn |
US4252802A (en) | 1980-03-13 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
FR2479229B1 (fr) * | 1980-03-26 | 1986-01-17 | Clin Midy | Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives |
US4482551A (en) * | 1980-06-26 | 1984-11-13 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
US4308267A (en) * | 1980-07-03 | 1981-12-29 | Smithkline Corporation | 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins |
US4443444A (en) * | 1980-08-11 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4399132A (en) * | 1980-08-11 | 1983-08-16 | American Cyanamid Company | 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof |
US4416879A (en) * | 1980-09-08 | 1983-11-22 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
US4507293A (en) * | 1980-09-26 | 1985-03-26 | Fujisawa Pharmaceutical Co., Ltd. | Antimicrobial cephem compounds |
JPS5759894A (en) * | 1980-09-30 | 1982-04-10 | Sankyo Co Ltd | Cephalosporin for oral administration |
US4486425A (en) | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
DK379581A (da) * | 1980-10-06 | 1982-04-07 | Hoffmann La Roche | Fremgangsmaade til fremstilling af acylderivater |
US4367228A (en) | 1980-10-29 | 1983-01-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compound and composition |
FR2494279A1 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent |
FR2494276A2 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouvelles vinyl-3 cephalosporines, et leur preparation |
FR2494275A2 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouveaux derives de vinyl-3 cephalosporines et leur preparation |
FR2494280A1 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouveaux derives de la cephalosporine et leur preparation |
ES8303422A1 (es) * | 1980-12-15 | 1983-02-01 | Fujisawa Pharmaceutical Co | Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico . |
JPS6052754B2 (ja) * | 1981-01-29 | 1985-11-21 | 山之内製薬株式会社 | 7−アミノ−3−ハロゲノメチル−△↑3−セフェム−4−カルボン酸類およびその製法 |
EP0058250A3 (de) * | 1981-02-17 | 1983-08-17 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Cephalosporinderivate, deren Herstellung und entsprechende pharmazeutische Präparate |
JPS57154175A (en) * | 1981-03-16 | 1982-09-22 | Mitsui Toatsu Chem Inc | 2-thiazoleamine derivative, its preparation, and drug composition comprising it |
JPS57156495A (en) * | 1981-03-23 | 1982-09-27 | Kyoto Yakuhin Kogyo Kk | Cephalosporin derivative and remedy for microbism used in oral administration |
JPS6011917B2 (ja) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | 新規なセファロスポリン化合物 |
DE3117438A1 (de) * | 1981-05-02 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Cephemderivate und verfahren zu ihrer herstellung |
FR2505339A1 (fr) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | Nouvelles oxacephalosporines et leur preparation |
FR2505338A1 (fr) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | Nouvelles oxacephalosporines et leur preparation |
DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
FR2505840A1 (fr) * | 1981-05-13 | 1982-11-19 | Roussel Uclaf | Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments |
FR2552089B2 (fr) * | 1981-05-13 | 1985-10-25 | Roussel Uclaf | Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments |
JPS57193489A (en) * | 1981-05-21 | 1982-11-27 | Fujisawa Pharmaceut Co Ltd | Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation |
FR2508458A1 (fr) * | 1981-06-29 | 1982-12-31 | Sandoz Sa | Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments |
US4406898A (en) * | 1981-09-08 | 1983-09-27 | Eli Lilly And Company | Oxazole and oxadiazole cephalosporins |
US4396619A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
US4577014A (en) * | 1981-09-08 | 1986-03-18 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
US4382932A (en) * | 1981-09-08 | 1983-05-10 | Eli Lilly And Company | Isoquinolinium substituted cephalosporins |
US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
IL66726A0 (en) * | 1981-09-08 | 1982-12-31 | Lilly Co Eli | Improvements in or relating to thieno and furopyridinium-substituted cephalosporin derivatives |
JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
US4402955A (en) * | 1981-10-02 | 1983-09-06 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
DE3143537A1 (de) * | 1981-11-03 | 1983-05-11 | Hoechst Ag, 6230 Frankfurt | Kristalline salze von cefodizim und verfahren zu ihrer herstellung |
US4474954A (en) * | 1981-12-07 | 1984-10-02 | Bristol-Myers Company | Intermediates for cephalosporin derivatives |
US4394503A (en) * | 1981-12-07 | 1983-07-19 | Bristol-Myers Company | Cephalosporin derivatives |
US4576938A (en) * | 1981-12-08 | 1986-03-18 | Tanabe Seiyaku Co., Ltd. | Cephalosporin compound and process for preparing the same |
US4501739A (en) * | 1982-01-19 | 1985-02-26 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
JPS58167594A (ja) * | 1982-03-26 | 1983-10-03 | Sankyo Co Ltd | 経口用セフアロスポリン化合物 |
US4457929A (en) * | 1982-03-29 | 1984-07-03 | Bristol-Myers Company | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
JPS58210093A (ja) * | 1982-05-20 | 1983-12-07 | グラクソ・グル−プ・リミテツド | セフアロスポリン抗生物質 |
ATE30724T1 (de) | 1982-06-28 | 1987-11-15 | Bristol Myers Co | Cephalosporinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten. |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
NL8302309A (nl) * | 1982-06-30 | 1984-01-16 | Glaxo Group Ltd | Cefalosporinen, preparaten die ze bevatten, en werkwijzen voor de bereiding daarvan. |
JPS5913787A (ja) * | 1982-06-30 | 1984-01-24 | グラクソ・グル−プ・リミテツド | セフアロスポリン化合物 |
US4616081A (en) * | 1982-07-07 | 1986-10-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Cephalosporin compounds |
JPS59193889A (ja) * | 1983-04-18 | 1984-11-02 | Asahi Chem Ind Co Ltd | セフアロスポリン系化合物 |
JPS5910591A (ja) * | 1982-07-09 | 1984-01-20 | Meiji Seika Kaisha Ltd | 1−オキサデチアセフアロスポリン化合物及びそれを含む抗菌剤 |
JPS5951291A (ja) * | 1982-09-16 | 1984-03-24 | Meiji Seika Kaisha Ltd | オキサデチアセフアロスポリン中間体およびその製造法 |
JPS5946287A (ja) * | 1982-07-23 | 1984-03-15 | Meiji Seika Kaisha Ltd | 新規1−オキサ−1−デチア−セフアロスポリン誘導体 |
IL69246A (en) * | 1982-08-07 | 1986-07-31 | Tanabe Seiyaku Co | 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
FR2532936A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation |
US4473577A (en) * | 1982-10-22 | 1984-09-25 | Mitsui Toatsu Chemicals, Incorporated | 2-Thiazolamine derivatives, process for preparing same, and pharmaceutical compositions comprising same |
DK521883A (da) * | 1982-11-17 | 1984-05-18 | Toyama Chemical Co Ltd | Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor |
JPS59106492A (ja) * | 1982-11-24 | 1984-06-20 | グラクソ・グル−プ・リミテツド | セフアロスポリン抗生物質 |
JPS59116291A (ja) * | 1982-12-06 | 1984-07-05 | Fujisawa Pharmaceut Co Ltd | 7−置換−3−セフエム−4−カルボン酸エステルおよびその製法 |
JPS59104389A (ja) * | 1982-12-06 | 1984-06-16 | Shionogi & Co Ltd | オキサセファム誘導体 |
US4608373A (en) * | 1982-12-13 | 1986-08-26 | Yamanouchi Pharmaceutical Co., Ltd. | Cephem compounds |
DE3247614A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4681877A (en) * | 1982-12-24 | 1987-07-21 | Kureha Kagaku Kogyo Kabushiki Kaisha | Pivaloyloxymethyl 7-β-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-(2-amino-1,3-thiadiazolyl-5-thiomethyl)-3-cepheme-4-carboxylate and pharmaceutical composition containing the same |
JPS59118793A (ja) * | 1982-12-24 | 1984-07-09 | Kureha Chem Ind Co Ltd | セフアロスポリン誘導体及び該誘導体を含有する医薬 |
JPS59161386A (ja) * | 1983-03-01 | 1984-09-12 | Kureha Chem Ind Co Ltd | セフアロスポリン誘導体及び該誘導体を含有する医薬 |
US4499088A (en) * | 1983-01-04 | 1985-02-12 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
JPS59155391A (ja) * | 1983-02-22 | 1984-09-04 | Tanabe Seiyaku Co Ltd | 新規セファロスポリン誘導体 |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
EP0132501A3 (en) * | 1983-03-31 | 1985-09-18 | Ajinomoto Co., Inc. | Cephalosporin derivatives, their preparation and pharmaceutical compositions |
US4514564A (en) * | 1983-04-18 | 1985-04-30 | Eli Lilly And Company | 7β-(2'-(1",3",5"-Triazepin-4"-one)-2'-(oxime ether)-acetamido)-3-substituted cephalosporins |
JPS59225193A (ja) * | 1983-06-02 | 1984-12-18 | Takeda Chem Ind Ltd | セフアロスポリンエステル |
JPS6041683A (ja) * | 1983-07-06 | 1985-03-05 | Asahi Chem Ind Co Ltd | 経口用セフアロスボリン誘導体 |
DE3330605A1 (de) * | 1983-08-25 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4690921A (en) * | 1983-10-11 | 1987-09-01 | Yamanouchi Pharmaceutical Co., Ltd. | Cephalosporin compounds and salts thereof |
US4692443A (en) * | 1983-10-17 | 1987-09-08 | Eli Lilly And Company | 3-bicyclicpyridinium-methyl cephalosporins |
GB8329030D0 (en) * | 1983-10-31 | 1983-11-30 | Fujisawa Pharmaceutical Co | Cephem compounds |
DE150507T1 (de) * | 1983-12-29 | 1987-02-26 | Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
JPS60142987A (ja) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体 |
EP0150609A3 (en) * | 1983-12-30 | 1986-04-23 | Glaxo Group Limited | Cephalosporin antibiotics |
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-
1977
- 1977-04-02 DE DE19772714880 patent/DE2714880A1/de not_active Withdrawn
- 1977-04-15 DE DE19772716707 patent/DE2716707A1/de active Granted
-
1978
- 1978-03-30 FI FI780966A patent/FI70221C/fi not_active IP Right Cessation
- 1978-03-30 US US06/891,850 patent/US4758556A/en not_active Ceased
- 1978-03-30 GB GB12461/78A patent/GB1604971A/en not_active Expired
- 1978-03-30 CH CH341178A patent/CH638810A5/de not_active IP Right Cessation
- 1978-03-31 LU LU79350A patent/LU79350A1/de unknown
- 1978-03-31 CA CA000300245A patent/CA1259606A/en not_active Expired
- 1978-03-31 NL NL7803486A patent/NL7803486A/xx not_active Application Discontinuation
- 1978-03-31 NO NO781130A patent/NO160211C/no unknown
- 1978-03-31 IL IL54407A patent/IL54407A/xx unknown
- 1978-03-31 NZ NZ186842A patent/NZ186842A/xx unknown
- 1978-03-31 JP JP53038745A patent/JPS5858354B2/ja not_active Expired
- 1978-03-31 AT AT0229078A patent/AT367425B/de not_active IP Right Cessation
- 1978-03-31 YU YU765/78A patent/YU41827B/xx unknown
- 1978-03-31 AU AU34648/78A patent/AU528277B2/en not_active Expired
- 1978-03-31 IE IE642/78A patent/IE47211B1/en active Protection Beyond IP Right Term
- 1978-03-31 SE SE7803660A patent/SE448378B/sv not_active IP Right Cessation
- 1978-03-31 IT IT21901/78A patent/IT1093750B/it active Protection Beyond IP Right Term
- 1978-03-31 FR FR7809661A patent/FR2385722B1/fr not_active Expired
- 1978-03-31 DD DD78204534A patent/DD137231A5/xx unknown
- 1978-03-31 DK DK143378A patent/DK165060C/da not_active IP Right Cessation
- 1978-03-31 PT PT67856A patent/PT67856B/pt unknown
- 1978-04-01 ES ES468475A patent/ES468475A1/es not_active Expired
- 1978-04-01 OA OA56457A patent/OA05928A/xx unknown
- 1978-04-01 GR GR55860A patent/GR73632B/el unknown
- 1978-04-03 BE BE186522A patent/BE865632A/xx not_active IP Right Cessation
- 1978-04-03 CS CS782144A patent/CS208747B2/cs unknown
-
1979
- 1979-02-09 ES ES477591A patent/ES477591A1/es not_active Expired
-
1980
- 1980-07-21 US US06/170,839 patent/US4278793A/en not_active Expired - Lifetime
-
1981
- 1981-04-07 JP JP5233981A patent/JPS5716887A/ja active Granted
- 1981-05-22 FR FR8110233A patent/FR2485017A1/fr active Granted
- 1981-05-22 FR FR8110234A patent/FR2485018A1/fr active Granted
-
1983
- 1983-10-06 HK HK390/83A patent/HK39083A/xx not_active IP Right Cessation
- 1983-12-16 SE SE8306994A patent/SE8306994D0/xx not_active Application Discontinuation
-
1990
- 1990-07-11 US US07/551,615 patent/USRE35754E/en not_active Expired - Lifetime
-
1994
- 1994-07-22 US US08/279,097 patent/US5710146A/en not_active Expired - Lifetime
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