NL300296I1 - Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym-, in het bijzonder renineremmende eigenschappen - Google Patents
Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym-, in het bijzonder renineremmende eigenschappenInfo
- Publication number
- NL300296I1 NL300296I1 NL300296C NL300296C NL300296I1 NL 300296 I1 NL300296 I1 NL 300296I1 NL 300296 C NL300296 C NL 300296C NL 300296 C NL300296 C NL 300296C NL 300296 I1 NL300296 I1 NL 300296I1
- Authority
- NL
- Netherlands
- Prior art keywords
- opt
- substd
- alkylene
- cooh
- mono
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH116994 | 1994-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
NL300296I1 true NL300296I1 (nl) | 2007-12-03 |
NL300296I2 NL300296I2 (nl) | 2008-02-01 |
Family
ID=4204102
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300296C NL300296I2 (nl) | 1994-04-18 | 2007-09-26 | Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym, in het bijzonder renineremmende eigenschappen |
NL300386C NL300386I1 (nl) | 1994-04-18 | 2009-04-24 | Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym-, in het bijzonder renineremmende eigenschappen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300386C NL300386I1 (nl) | 1994-04-18 | 2009-04-24 | Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym-, in het bijzonder renineremmende eigenschappen. |
Country Status (27)
Country | Link |
---|---|
US (5) | US5559111A (nl) |
EP (1) | EP0678503B1 (nl) |
JP (1) | JP3240322B2 (nl) |
KR (1) | KR100353779B1 (nl) |
CN (2) | CN1266118C (nl) |
AT (1) | ATE183997T1 (nl) |
AU (1) | AU699616B2 (nl) |
BR (1) | BR1100656A (nl) |
CA (1) | CA2147056C (nl) |
CY (4) | CY2208B1 (nl) |
CZ (1) | CZ287935B6 (nl) |
DE (4) | DE122007000071I2 (nl) |
DK (1) | DK0678503T3 (nl) |
ES (1) | ES2137478T3 (nl) |
FI (1) | FI118336B (nl) |
GR (1) | GR3031997T3 (nl) |
HK (1) | HK1070881A1 (nl) |
HU (2) | HU226860B1 (nl) |
IL (1) | IL113403A (nl) |
LU (2) | LU91373I2 (nl) |
MY (1) | MY119161A (nl) |
NL (2) | NL300296I2 (nl) |
NO (4) | NO310410B1 (nl) |
NZ (1) | NZ270936A (nl) |
RU (1) | RU95105970A (nl) |
TW (2) | TW366341B (nl) |
ZA (3) | ZA953051B (nl) |
Families Citing this family (152)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4408534A1 (de) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
EP0716077A1 (de) * | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
US6465650B1 (en) | 1995-03-13 | 2002-10-15 | Aventis Pharma Deutschland Gmbh | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids |
IL135314A0 (en) * | 1997-12-16 | 2001-05-20 | Warner Lambert Co | Novel amines as pharmaceutical agents |
US6846799B1 (en) | 1998-08-18 | 2005-01-25 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
US7354894B2 (en) * | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
US6423850B1 (en) | 1999-06-18 | 2002-07-23 | E.I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
US6833460B2 (en) * | 1999-06-18 | 2004-12-21 | E. I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
DK1200384T3 (da) * | 1999-07-29 | 2004-08-02 | Speedel Pharma Ag | 2-Alkyl-5-halogen-pent-4-encarboxylsyrer og deres fremstilling |
WO2002002487A1 (en) * | 2000-07-03 | 2002-01-10 | Speedel Pharma Ag | Process for the preparation of (r)-2-alkyl-3-phenyl-1-propanols |
EP1296935B1 (en) * | 2000-07-05 | 2009-03-25 | Speedel Pharma AG | Process for the preparation of substituted octanoyl amides |
PT1303478E (pt) * | 2000-07-25 | 2004-10-29 | Speedel Pharma Ag | Processo para a preparacao de alcanoilamidas substituidas |
US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
PT1215201E (pt) | 2000-12-14 | 2007-02-28 | Speedel Pharma Ag | Processo para a preparação de ariloctanoil amidas |
JP3440082B2 (ja) | 2001-02-19 | 2003-08-25 | 科学技術振興事業団 | 電気自動車用インホイールモーター |
DE60235374D1 (de) | 2001-05-15 | 2010-04-01 | Novartis Ag | Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse |
CA2450557A1 (en) * | 2001-06-11 | 2002-12-19 | Michel Maillard | Substituted aminoalcohols useful in treatment of alzheimer's disease |
CA2463758A1 (en) * | 2001-10-18 | 2003-05-01 | Novartis Ag | Salts formed of an at1-receptor antagonist and a cardiovascular agent |
US20050101638A1 (en) * | 2002-11-08 | 2005-05-12 | Webb Randy L. | Combination of organic compounds |
KR20050008717A (ko) * | 2002-05-17 | 2005-01-21 | 노파르티스 아게 | 레닌 억제제, 칼슘 채널 차단제 및 이뇨제를 포함하는약제학적 조성물 |
GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
AU2003237546A1 (en) * | 2002-06-11 | 2003-12-22 | Elan Pharmaceuticals, Inc. | METHODS OF TREATING ALZHEIMER'S DISEASE USING AROMATICALLY SUBSTITUTED Omega-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES |
WO2003103653A1 (en) * | 2002-06-11 | 2003-12-18 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
JP4613130B2 (ja) * | 2002-08-23 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | ベンゾイミダゾールキノリノンおよびそれらの使用 |
US7049469B2 (en) | 2002-10-24 | 2006-05-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing (R)-salbutamol |
CA2507484A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
WO2004100871A2 (en) * | 2003-05-09 | 2004-11-25 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and a renin inhibitor |
BRPI0413838A (pt) * | 2003-08-25 | 2006-10-24 | Warner Lambert Co | compostos de ariloxazolidinona antimicrobianos |
RU2413716C2 (ru) * | 2003-11-26 | 2011-03-10 | Новартис Аг | АМИДЫ δ-АМИНО-γ-ГИДРОКСИ-ω-АРИЛАЛКАНОВОЙ КИСЛОТЫ |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
PE20050596A1 (es) * | 2003-12-19 | 2005-10-18 | Novartis Ag | Microemulsion que comprende un inhibidor renina |
RU2006130005A (ru) * | 2004-01-22 | 2008-02-27 | Новартис АГ (CH) | Комбинация органических соединений |
WO2005070871A2 (en) * | 2004-01-23 | 2005-08-04 | Speedel Experimenta Ag | Amino alcohol derivatives and their activity as renin inhibitors |
EP1735270B1 (en) * | 2004-01-23 | 2010-06-30 | Novartis Ag | Diamino alcohols and their use as renin inhibitors |
US20070191487A1 (en) * | 2004-03-17 | 2007-08-16 | Rigassi-Dietrich Petra G | Galenic formulations of organic compounds |
CA2558020A1 (en) | 2004-03-17 | 2005-09-29 | Novartis Ag | Use of renin inhibitors in therapy |
MY144477A (en) * | 2004-03-17 | 2011-09-30 | Novartis Ag | Galenic formulations of organic compounds |
JP4927704B2 (ja) * | 2004-03-19 | 2012-05-09 | シュペーデル・エクスペリメンタ・アーゲー | 有機化合物 |
ES2320030T3 (es) * | 2004-03-19 | 2009-05-18 | Speedel Experimenta Ag | Derivados de amida del 5-amino-4-hidroxi-8-(1h-indol-5-ilo) octan 2,7-sustituidos como inhibidores de la renina para el tratamiento de la hipertension. |
WO2005095876A1 (en) | 2004-04-01 | 2005-10-13 | Cucumber Limited | Delivery and storage of goods |
GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
PT1799199E (pt) | 2004-10-08 | 2012-07-03 | Novartis Ag | Uso de inibidores da renina para a prevenção ou tratamento da disfunção diastólica ou insuficiência cardíaca diastólica |
TW200633983A (en) * | 2004-12-10 | 2006-10-01 | Speedel Experimenta Ag | 5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-nonanamides |
TW200631929A (en) * | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
CA2596444A1 (en) * | 2005-02-02 | 2006-08-10 | Vitae Pharmaceuticals, Inc. | 1-acylamino-2-hydroxy-3-amino-w-arylalkanes as renin inhibitors |
TW200700358A (en) * | 2005-03-11 | 2007-01-01 | Speedel Experimenta Ag | Organic compounds |
CN101171230A (zh) * | 2005-03-11 | 2008-04-30 | 斯皮德尔实验股份公司 | 用作肾素抑制剂的杂环取代的链烷酰胺 |
ATE451345T1 (de) * | 2005-03-17 | 2009-12-15 | Basf Se | Verfahren zur herstellung von optisch aktiven 3- phenylpropionsäurederivaten und folgeprodukte davon |
GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
EP1904469B1 (en) * | 2005-07-11 | 2011-09-21 | Novartis AG | New pyrocatechin derivatives |
EP1745778A3 (en) | 2005-07-20 | 2007-03-07 | Speedel Experimenta AG | Diaminoalcohols as therapeutic compounds |
US8063105B2 (en) | 2005-07-22 | 2011-11-22 | Merck Canada Inc. | Renin inhibitors |
DE602006014707D1 (de) * | 2005-09-17 | 2010-07-15 | Novartis Ag | Mit gesättigten o-heterocyclen substituierte alkansäureamide |
ES2328630T3 (es) * | 2005-09-17 | 2009-11-16 | Novartis Ag | Derivados de 5-amino-4-hydroxi-7-(imidazo (1,2-a>)piridin-6- ilmetil-8-metil-nonamida y compuestos relacionados como inhibidores de la renina para el tratamiento de la hipertension. |
EP1764098A1 (en) * | 2005-09-17 | 2007-03-21 | Speedel Experimenta AG | Diaminoalcohols derivatives for the treatment of Alzheimer, malaria, HIV |
GB0519764D0 (en) * | 2005-09-28 | 2005-11-09 | Novartis Ag | Organic compounds |
GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
WO2007045551A2 (en) * | 2005-10-18 | 2007-04-26 | Nicox S.A. | Renin inhibitors nitroderivatives |
CN101291662A (zh) | 2005-10-21 | 2008-10-22 | 诺瓦提斯公司 | 肾素抑制剂和抗血脂异常剂和/或抗肥胖剂的组合 |
GB2431649A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431648A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431642A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431645A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431646A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
DE102005052195A1 (de) * | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
TW200804241A (en) * | 2006-02-24 | 2008-01-16 | Novartis Ag | New salt |
GB0605688D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
WO2007123718A1 (en) * | 2006-03-31 | 2007-11-01 | Vitae Pharmaceuticals, Inc. | 1-HETEROCYCLYLAMINO-2-HYDROXY-3-AMINO-ω-ARYLALKANES |
WO2007120523A2 (en) * | 2006-03-31 | 2007-10-25 | Vitae Pharmaceuticals, Inc. | 6-(aminoalkyl)indazoles |
SG170830A1 (en) * | 2006-04-03 | 2011-05-30 | Novartis Ag | Renin inhibitors for the treatment of hypertension |
TW200815324A (en) * | 2006-06-23 | 2008-04-01 | Daiichi Sankyo Co Ltd | Straight chain amine compound |
GB0612540D0 (en) | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
NZ573720A (en) * | 2006-06-23 | 2011-01-28 | Daiichi Sankyo Co Ltd | Cyclic amine compound |
JP5042311B2 (ja) | 2006-07-20 | 2012-10-03 | ノバルティス アーゲー | Cetp阻害剤としてのアミノピペリジン誘導体 |
EP1911762A1 (en) | 2006-10-04 | 2008-04-16 | Speedel Experimenta AG | Amino alcohols and their use as renin inhibitors |
PE20081157A1 (es) * | 2006-11-07 | 2008-09-26 | Novartis Ag | Forma cristalina de hemifumarato de alisquireno |
JP2010509254A (ja) * | 2006-11-09 | 2010-03-25 | ノバルティス アーゲー | アリスキレンとオロチン酸の塩 |
EP1938812A1 (en) * | 2006-12-22 | 2008-07-02 | Speedel Pharma AG | Pharmaceutical composition using aliskiren and avosentan |
EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
AR065792A1 (es) * | 2007-03-21 | 2009-07-01 | Speedel Experimenta Ag | Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona |
EP1972335A1 (en) * | 2007-03-23 | 2008-09-24 | Krka | Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof |
NZ579792A (en) * | 2007-04-03 | 2012-03-30 | Novartis Ag | Processes for preparing lactone compounds |
US8088954B2 (en) | 2007-07-11 | 2012-01-03 | Dsm Ip Assets B.V. | Preparation of a saturated aldehyde |
US20090076062A1 (en) * | 2007-09-13 | 2009-03-19 | Juergen Klaus Maibaum | Organic Compounds |
US20090082458A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched aliskiren |
TWI436760B (zh) | 2007-09-28 | 2014-05-11 | Novartis Ag | 阿利克侖之蓋崙(galenical)調配物 |
DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
WO2009059943A1 (en) | 2007-11-05 | 2009-05-14 | Novartis Ag | 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
WO2009064479A1 (en) | 2007-11-13 | 2009-05-22 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of aliskiren hemifumarate and process for preparation thereof |
EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
PL2229356T3 (pl) | 2007-12-03 | 2012-03-30 | Novartis Ag | 1,2-Dipodstawione pochodne 4-benzyloamino-pirolidyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic |
EP2075244A1 (en) | 2007-12-24 | 2009-07-01 | DSMIP Assets B.V. | New route to building block for making renin inhibitors |
KR101164300B1 (ko) | 2008-02-22 | 2012-07-09 | 한올바이오파마주식회사 | 약제학적 제제 |
WO2009125981A2 (ko) | 2008-04-10 | 2009-10-15 | 한올제약주식회사 | 약제학적 제제 |
WO2009143423A1 (en) * | 2008-05-23 | 2009-11-26 | Teva Pharmaceutical Industries Ltd. | Aliskiren monofumarate and processes for preparation thereof |
KR20100135970A (ko) * | 2008-06-06 | 2010-12-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 알리스키렌 유리 염기의 고체 상태 |
EP2143425A1 (de) | 2008-07-11 | 2010-01-13 | Ratiopharm GmbH | Direktverpresste Aliskiren-Tabletten |
WO2010024772A1 (en) * | 2008-08-29 | 2010-03-04 | Medivir Ab | Aspartyl protease inhibitors |
EP2163245A1 (en) | 2008-09-10 | 2010-03-17 | Novartis Ag | Renin inhibitors for the treatment of psoriasis |
SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
MY153852A (en) | 2009-01-28 | 2015-03-31 | Novartis Ag | Galenic formulations of organic compounds |
EP2393489B1 (en) | 2009-02-05 | 2014-10-08 | Krka, tovarna zdravil, d.d., Novo mesto | Moisture-activated granulation process |
CN102046162A (zh) | 2009-02-05 | 2011-05-04 | 特瓦制药工业有限公司 | 阿利吉仑化合物的固态形式 |
WO2010107971A1 (en) | 2009-03-20 | 2010-09-23 | Novartis Ag | Galenical formulations of a fixed dose combination of valsartan and aliskiren |
MX2011009844A (es) | 2009-03-20 | 2011-09-29 | Novartis Ag | Composicion farmaceutica que comprende alisquireno. |
US20120149895A1 (en) | 2009-04-01 | 2012-06-14 | Lek Pharmaceuticals D.D. | Process for dimethylation of active methylene groups |
EP2464623B1 (en) | 2009-08-11 | 2020-11-04 | Novartis AG | The ring opening of lactones and lactams |
WO2011028919A2 (en) | 2009-09-03 | 2011-03-10 | Teva Pharmaceutical Industries Ltd. | Solid forms of aliskiren hemifumarate and processes for preparation thereof |
UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
WO2011048523A1 (en) * | 2009-10-21 | 2011-04-28 | CarboDesign LLC | Process for the manufacture of enantiomerically pure aryloctanoic acids as aliskiren |
US8203005B2 (en) * | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
AU2010315946A1 (en) * | 2009-11-09 | 2012-05-31 | Medivir Ab | Novel 1,3-oxazolidine compounds and their use as renin inhibitors |
US20110113995A1 (en) * | 2009-11-13 | 2011-05-19 | Lindsay Corporation | Method and apparatus for planting and irrigation |
US20110137047A1 (en) * | 2009-12-07 | 2011-06-09 | CarboDesign LLC | Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren |
JP5815552B2 (ja) | 2009-12-08 | 2015-11-17 | ケース ウェスタン リザーブ ユニバーシティCase Westernreserve University | 眼疾患を治療する化合物および方法 |
CN101774986B (zh) | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
CN102140068B (zh) * | 2010-01-30 | 2015-03-11 | 浙江华海药业股份有限公司 | 阿利吉仑中间体3-氨基-2,2-二甲基丙酰胺的制备方法 |
EP2523934A1 (en) * | 2010-02-10 | 2012-11-21 | Ratiopharm GmbH | Salts of aliskiren |
WO2011116115A1 (en) | 2010-03-16 | 2011-09-22 | Novartis Ag | Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing |
TR201002256A1 (tr) * | 2010-03-24 | 2011-10-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Stabil aliskiren formülasyonları |
EP2382967A1 (de) | 2010-04-21 | 2011-11-02 | ratiopharm GmbH | Aliskiren in Form einer festen Dispersion |
US20110268797A1 (en) | 2010-04-30 | 2011-11-03 | Sanovel IIac Sanayi Ve Ticaret Anonim Sirketi | Multicoated aliskiren formulations |
CN102241650B (zh) * | 2010-05-14 | 2014-05-07 | 浙江九洲药业股份有限公司 | 用于制备阿立克仑的中间体化合物及相关制备方法 |
IT1400961B1 (it) * | 2010-06-04 | 2013-07-05 | Chemo Iberica Sa | Processo per la produzione di aliskiren |
IT1402925B1 (it) * | 2010-12-10 | 2013-09-27 | Chemo Iberica Sa | Processo per la produzione di aliskiren |
TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
CN101913998A (zh) * | 2010-07-06 | 2010-12-15 | 上海朴颐化学科技有限公司 | 4-溴-2-(3-甲氧基丙氧基)-苯甲醚的制备方法 |
WO2012034065A1 (en) | 2010-09-09 | 2012-03-15 | Teva Pharmaceutical Industries Ltd. | Aliskiren intermediates and a process for analyzing the purity of aliskiren |
SI2630118T1 (sl) | 2010-10-19 | 2015-03-31 | Mylan Laboratories Limited | Sinteza aliskirena |
CN102001920B (zh) | 2010-11-09 | 2013-05-15 | 常州制药厂有限公司 | 一种药物中间体的制备方法 |
CN102161627A (zh) * | 2011-02-24 | 2011-08-24 | 中国药科大学 | ω-(N取代-氨基烷基)辛酰胺 |
EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
CN102942477B (zh) * | 2011-08-14 | 2015-12-02 | 浙江华海药业股份有限公司 | 辛烯酸衍生物及其制备方法 |
CN102351734B (zh) * | 2011-09-05 | 2014-02-26 | 浙江普洛医药科技有限公司 | 一种阿利克仑的制备方法 |
WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
US8703976B2 (en) * | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
US9056816B2 (en) | 2011-10-25 | 2015-06-16 | Jubilant Life Sciences Limited | Process for the preparation of aliskiren |
WO2013118138A1 (en) | 2011-12-13 | 2013-08-15 | Laboratories Ltd Mylan | Novel process for the preparation of renin inhibitors |
CN103172533B (zh) * | 2011-12-20 | 2016-05-04 | 博瑞生物医药(苏州)股份有限公司 | 一种阿利克仑半富马酸盐的新晶型及其制备方法和用途 |
CN103204834A (zh) * | 2012-01-11 | 2013-07-17 | 南京欧信医药技术有限公司 | 阿利克伦中间体及其制备方法和应用 |
EP2814806B1 (en) | 2012-02-17 | 2016-05-25 | Mylan Laboratories Ltd. | An improved process for the preparation of aliskiren |
WO2013124868A2 (en) | 2012-02-21 | 2013-08-29 | Mylan Laboratories Limited | Solid form of aliskiren intermediate |
ITMI20120354A1 (it) * | 2012-03-07 | 2013-09-08 | Friulchem Spa | Processo per la produzione di aliskirene |
WO2013144979A1 (en) | 2012-03-28 | 2013-10-03 | Maylan Laboratories Ltd | Process for the preparation of aliskiren |
KR102063542B1 (ko) | 2012-05-11 | 2020-01-09 | 필립스-메디사이즈 에이/에스 | 분배 장치 |
WO2013171767A1 (en) | 2012-05-18 | 2013-11-21 | Mylan Laboratories Limited | An improved process for the preparation of aliskiren |
EP2810644A1 (en) | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
BR112015032514B1 (pt) * | 2013-06-27 | 2021-01-26 | Dpx Holdings B.V. | preparo de reagentes de grignard usando um leito fluidizado |
JP2021528735A (ja) | 2018-06-14 | 2021-10-21 | アストラゼネカ・ユーケイ・リミテッドAstraZeneca UK Limited | アンジオテンシンii受容体遮断薬医薬組成物による高血圧症の治療方法 |
CN112679448B (zh) * | 2020-12-31 | 2022-08-19 | 苏州昊帆生物股份有限公司 | N-(2-氨基乙基)吗啉的制备方法 |
CN115340472B (zh) * | 2022-09-19 | 2024-05-07 | 合肥工业大学 | 一种谷氨酸衍生物及其合成方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4337207A (en) * | 1980-09-04 | 1982-06-29 | Regents Of The University Of California | Biologically active catecholamine derivatives |
US4729985A (en) * | 1985-08-09 | 1988-03-08 | Pfizer Inc. | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
JPH02124884A (ja) * | 1988-07-08 | 1990-05-14 | Zhongguo Yixuekexueyuan Yaowo Yanjiusuo | N―置換アミド誘導体 |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
-
1995
- 1995-03-30 MY MYPI95000816A patent/MY119161A/en unknown
- 1995-04-04 US US08/416,242 patent/US5559111A/en not_active Expired - Lifetime
- 1995-04-07 EP EP95810236A patent/EP0678503B1/de not_active Expired - Lifetime
- 1995-04-07 AT AT95810236T patent/ATE183997T1/de active
- 1995-04-07 DK DK95810236T patent/DK0678503T3/da not_active Application Discontinuation
- 1995-04-07 ES ES95810236T patent/ES2137478T3/es not_active Expired - Lifetime
- 1995-04-07 DE DE122007000071C patent/DE122007000071I2/de active Active
- 1995-04-07 DE DE59506707T patent/DE59506707D1/de not_active Expired - Lifetime
- 1995-04-07 DE DE122009000020C patent/DE122009000020I1/de active Pending
- 1995-04-10 TW TW084103730A patent/TW366341B/zh active
- 1995-04-12 NO NO19951441A patent/NO310410B1/no not_active IP Right Cessation
- 1995-04-12 AU AU16421/95A patent/AU699616B2/en not_active Ceased
- 1995-04-12 FI FI951771A patent/FI118336B/fi not_active IP Right Cessation
- 1995-04-13 NZ NZ270936A patent/NZ270936A/en not_active IP Right Cessation
- 1995-04-13 ZA ZA953051A patent/ZA953051B/xx unknown
- 1995-04-13 RU RU95105970/04A patent/RU95105970A/ru unknown
- 1995-04-13 ZA ZA953050A patent/ZA953050B/xx unknown
- 1995-04-13 ZA ZA953052A patent/ZA953052B/xx unknown
- 1995-04-13 CA CA002147056A patent/CA2147056C/en not_active Expired - Lifetime
- 1995-04-14 HU HU9501076A patent/HU226860B1/hu active Protection Beyond IP Right Term
- 1995-04-14 HU HU9501078A patent/HUT71701A/hu unknown
- 1995-04-14 CZ CZ1995976A patent/CZ287935B6/cs not_active IP Right Cessation
- 1995-04-15 TW TW084103732A patent/TW402582B/zh not_active IP Right Cessation
- 1995-04-17 KR KR1019950008959A patent/KR100353779B1/ko not_active IP Right Cessation
- 1995-04-17 IL IL11340395A patent/IL113403A/en active Protection Beyond IP Right Term
- 1995-04-17 CN CNB2004100346824A patent/CN1266118C/zh not_active Expired - Lifetime
- 1995-04-17 CN CNB951050370A patent/CN1153759C/zh not_active Expired - Lifetime
- 1995-04-18 JP JP09253295A patent/JP3240322B2/ja not_active Expired - Lifetime
-
1996
- 1996-07-02 US US08/674,555 patent/US5654445A/en not_active Expired - Lifetime
- 1996-07-25 US US08/687,277 patent/US5646143A/en not_active Expired - Lifetime
- 1996-07-25 US US08/687,878 patent/US5627182A/en not_active Expired - Lifetime
-
1997
- 1997-02-14 US US08/800,671 patent/US5705658A/en not_active Expired - Lifetime
- 1997-05-07 BR BR1100656-0A patent/BR1100656A/pt active IP Right Grant
-
1999
- 1999-11-30 GR GR990403090T patent/GR3031997T3/el unknown
-
2000
- 2000-12-01 CY CY0000064A patent/CY2208B1/xx unknown
-
2005
- 2005-04-29 HK HK05103691A patent/HK1070881A1/xx not_active IP Right Cessation
-
2007
- 2007-09-26 NL NL300296C patent/NL300296I2/nl unknown
- 2007-10-31 CY CY200700027C patent/CY2007027I2/el unknown
- 2007-10-31 LU LU91373C patent/LU91373I2/fr unknown
- 2007-10-31 NO NO2007011C patent/NO2007011I1/no unknown
-
2009
- 2009-04-24 NL NL300386C patent/NL300386I1/nl unknown
- 2009-05-06 LU LU91564C patent/LU91564I2/fr unknown
- 2009-05-11 CY CY2009006C patent/CY2009006I1/el unknown
- 2009-05-18 NO NO2009011C patent/NO2009011I2/no unknown
-
2011
- 2011-09-20 NO NO2011020C patent/NO2011020I1/no unknown
- 2011-09-27 CY CY2011015C patent/CY2011015I1/el unknown
- 2011-09-28 DE DE201112100052 patent/DE122011100052I1/de active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL300296I1 (nl) | Delta-amino-gamma-hydroxy-omega-aryl-alkaanzuuramiden met enzym-, in het bijzonder renineremmende eigenschappen | |
CY1105466T1 (el) | Ουδετepο λιποπολυμepες και λιποσωματικες συνθεσεις που το πepιεχουν | |
AR017111A1 (es) | Composiciones detergentes para el lavado de ropa con polimeros a base de aminas lineales para proporcionar beneficios en cuanto a aspecto exterior eintegridad a las telas lavadas con las mismas | |
AU6796598A (en) | Novel compositions and methods for inhibiting light-induced inactivation of biological reagents | |
ES2108520T3 (es) | Di(met)acrilatos con grupos carbonato ciclicos. | |
PE20020676A1 (es) | Compuestos de mutilina como antibacterianos | |
EP0403062A3 (en) | Tickened acidic liquid composition with amine fwa useful as a bleaching agent vehicle | |
FI894082A0 (fi) | Foerbaettringar i anslutning till polymerfoereningar. | |
TR199902282T2 (en) | Konv�lsiyonlara kar�� isoquinolyl-benzamid t�revleri. | |
DK0953563T3 (da) | Fremgangsmåde til fremstilling af depsipeptidderivater samt hidtil ukendte intermediater derfor | |
NO308472B1 (no) | Akronycinanaloger | |
DE69120694D1 (de) | Polymerverbindungen |