PT1303478E - Processo para a preparacao de alcanoilamidas substituidas - Google Patents

Processo para a preparacao de alcanoilamidas substituidas

Info

Publication number
PT1303478E
PT1303478E PT01940048T PT01940048T PT1303478E PT 1303478 E PT1303478 E PT 1303478E PT 01940048 T PT01940048 T PT 01940048T PT 01940048 T PT01940048 T PT 01940048T PT 1303478 E PT1303478 E PT 1303478E
Authority
PT
Portugal
Prior art keywords
alcanoylamides
replaced
preparation
replaced alcanoylamides
Prior art date
Application number
PT01940048T
Other languages
English (en)
Inventor
Stefan Stutz
Peter Herold
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Publication of PT1303478E publication Critical patent/PT1303478E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT01940048T 2000-07-25 2001-06-26 Processo para a preparacao de alcanoilamidas substituidas PT1303478E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH14642000 2000-07-25

Publications (1)

Publication Number Publication Date
PT1303478E true PT1303478E (pt) 2004-10-29

Family

ID=4565499

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01940048T PT1303478E (pt) 2000-07-25 2001-06-26 Processo para a preparacao de alcanoilamidas substituidas

Country Status (17)

Country Link
US (1) US6800769B2 (pt)
EP (1) EP1303478B1 (pt)
JP (1) JP4853888B2 (pt)
AR (1) AR029870A1 (pt)
AT (1) ATE267800T1 (pt)
AU (1) AU2001273764A1 (pt)
CA (1) CA2412452C (pt)
CY (1) CY2007029I1 (pt)
DE (2) DE60103545T2 (pt)
DK (1) DK1303478T3 (pt)
ES (1) ES2220776T3 (pt)
FR (1) FR07C0070I2 (pt)
NL (1) NL300305I2 (pt)
PT (1) PT1303478E (pt)
TR (1) TR200401871T4 (pt)
TW (1) TWI222434B (pt)
WO (1) WO2002008172A1 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154926A1 (en) * 2002-06-11 2006-07-13 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
DE60312214T3 (de) 2002-12-09 2015-02-26 Asahi Glass Co., Ltd. Verfahren zur herstellung von(4e)-5-chloro-2-isopropyl-4-pentensäureester und optischaktivem isomer davon
WO2006041062A1 (ja) * 2004-10-15 2006-04-20 Asahi Glass Company, Limited （４ｅ）－５－クロロ－２－イソプロピル－４－ペンテン酸エステルおよびその光学活性体の製造方法
TW200631929A (en) * 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
AU2006268907B2 (en) * 2005-07-11 2010-06-10 Novartis Ag New pyrocatechin derivatives
GB2431644A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431643A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431651A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431652A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431654A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431640A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431650A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431647A (en) * 2005-10-25 2007-05-02 Novartis Ag Synthesis of aryl-octanoyl amide compounds
GB2431641A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
JP5182615B2 (ja) * 2005-12-16 2013-04-17 旭硝子株式会社 光学活性な（４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸またはその塩基性アミノ酸塩の製造方法
US20080306311A1 (en) * 2005-12-23 2008-12-11 Basf Se Method for Producing an Alpha-Chiral Chloromethyl Compound in a Pure Form
DE102006017681A1 (de) * 2006-04-12 2007-10-18 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Aryl-Octanoylderivaten
TW200837046A (en) * 2006-11-08 2008-09-16 Speedel Experimenta Ag Process for preparing organic compounds
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
WO2008113835A1 (en) * 2007-03-21 2008-09-25 Novartis Ag Process for preparing (r or s)-5-{1-azido-3-[6-methoxy-5-(3-methoxy-propoxy)-pyridin-3-ylmethyl]-4-methyl-pentyl}-3-alkyl-dihydro-furan-2-one
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
WO2010089105A2 (en) 2009-02-05 2010-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Moisture-activated granulation process
WO2011051853A1 (en) 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
CN101774986B (zh) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
CN102241650B (zh) * 2010-05-14 2014-05-07 浙江九洲药业股份有限公司 用于制备阿立克仑的中间体化合物及相关制备方法
WO2011148392A1 (en) * 2010-05-28 2011-12-01 Msn Laboratories Limited Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
IT1402925B1 (it) * 2010-12-10 2013-09-27 Chemo Iberica Sa Processo per la produzione di aliskiren
TW201202178A (en) 2010-06-04 2012-01-16 Chemo Iberica Sa Process for producing Aliskiren
WO2012034065A1 (en) * 2010-09-09 2012-03-15 Teva Pharmaceutical Industries Ltd. Aliskiren intermediates and a process for analyzing the purity of aliskiren
PL2630118T3 (pl) 2010-10-19 2015-04-30 Mylan Laboratories Ltd Synteza Aliskirenu
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
ITMI20111719A1 (it) * 2011-09-23 2013-03-24 Friulchem Spa Sintesi totale di aliskiren con alta resa e purezza elevata per applicazione industriale
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013061224A1 (en) 2011-10-25 2013-05-02 Jubilant Life Sciences Limited Process for the preparation of aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
US9090537B2 (en) 2012-02-17 2015-07-28 Mylan Laboratories Limited Process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN103130677B (zh) * 2013-03-12 2015-01-07 博瑞生物医药技术(苏州)有限公司 一种阿利克仑的制备方法
CN103351300A (zh) * 2013-06-30 2013-10-16 北京万全德众医药生物技术有限公司 一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法
CN103896794B (zh) * 2014-04-23 2015-10-07 中国科学院长春应用化学研究所 阿利克仑中间体以及阿利克仑的制备方法
CN105294478B (zh) * 2014-07-01 2017-06-13 华润双鹤药业股份有限公司 阿利吉仑的一种非对映异构体、其制备方法及用途
CN113387828A (zh) * 2020-03-14 2021-09-14 江巨东 一种阿利克仑中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5659065A (en) 1994-04-18 1997-08-19 Novartis Corporation Alpha-aminoalkanoic acids and reduction products
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
US5606078A (en) * 1994-04-18 1997-02-25 Ciba-Geigy Corporation 3,5-Disubstituted tetrahydrofuran-2-ones

Also Published As

Publication number Publication date
NL300305I2 (nl) 2008-02-01
AU2001273764A1 (en) 2002-02-05
AR029870A1 (es) 2003-07-16
US6800769B2 (en) 2004-10-05
TWI222434B (en) 2004-10-21
JP2004504373A (ja) 2004-02-12
FR07C0070I2 (pt) 2009-01-15
DE60103545T2 (de) 2005-08-25
CY2007029I2 (el) 2009-11-04
ATE267800T1 (de) 2004-06-15
US20030181765A1 (en) 2003-09-25
DE122007000077I2 (de) 2008-08-21
JP4853888B2 (ja) 2012-01-11
EP1303478A1 (en) 2003-04-23
CA2412452A1 (en) 2002-01-31
DE60103545D1 (de) 2004-07-01
ES2220776T3 (es) 2004-12-16
CY2007029I1 (el) 2009-11-04
EP1303478B1 (en) 2004-05-26
TR200401871T4 (tr) 2004-08-23
CA2412452C (en) 2008-12-30
WO2002008172A1 (en) 2002-01-31
FR07C0070I1 (pt) 2008-01-02
NL300305I1 (nl) 2008-01-02
DK1303478T3 (da) 2004-08-30
DE122007000077I1 (de) 2008-02-14

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