PT1232152E - Processo melhorado para a preparacao de aminotetralinas substituidas no azoto - Google Patents

Processo melhorado para a preparacao de aminotetralinas substituidas no azoto

Info

Publication number
PT1232152E
PT1232152E PT00978699T PT00978699T PT1232152E PT 1232152 E PT1232152 E PT 1232152E PT 00978699 T PT00978699 T PT 00978699T PT 00978699 T PT00978699 T PT 00978699T PT 1232152 E PT1232152 E PT 1232152E
Authority
PT
Portugal
Prior art keywords
aminotetralines
nitrogen
replaced
preparation
improved process
Prior art date
Application number
PT00978699T
Other languages
English (en)
Inventor
Gevork Minaskanian
Keith Rippel
Original Assignee
Aderis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals Inc filed Critical Aderis Pharmaceuticals Inc
Publication of PT1232152E publication Critical patent/PT1232152E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
PT00978699T 1999-11-23 2000-11-16 Processo melhorado para a preparacao de aminotetralinas substituidas no azoto PT1232152E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16700999P 1999-11-23 1999-11-23

Publications (1)

Publication Number Publication Date
PT1232152E true PT1232152E (pt) 2004-06-30

Family

ID=22605581

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00978699T PT1232152E (pt) 1999-11-23 2000-11-16 Processo melhorado para a preparacao de aminotetralinas substituidas no azoto

Country Status (15)

Country Link
US (1) US6372920B1 (pt)
EP (1) EP1232152B1 (pt)
CN (1) CN1185225C (pt)
AR (1) AR026505A1 (pt)
AT (1) ATE258927T1 (pt)
AU (1) AU1613101A (pt)
CA (1) CA2392563C (pt)
DE (1) DE60008136T2 (pt)
DK (1) DK1232152T3 (pt)
ES (1) ES2216992T3 (pt)
HK (2) HK1049156B (pt)
PL (1) PL202805B1 (pt)
PT (1) PT1232152E (pt)
TR (1) TR200400401T4 (pt)
WO (1) WO2001038321A1 (pt)

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Publication number Priority date Publication date Assignee Title
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) 2003-12-18 2005-07-28 Schwarz Pharma Ag (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) * 2004-02-20 2005-09-08 Schwarz Pharma Ag Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
US8344165B2 (en) * 2007-05-30 2013-01-01 Chemagis Ltd. Crystalline rotigotine base and preparation process therefor
WO2009053697A1 (en) * 2007-10-26 2009-04-30 Pliva Hrvatska D.O.O. Polymorphic forms of ( s ) -rotigotine hydrochloride
WO2009056791A1 (en) * 2007-11-02 2009-05-07 Pliva Hrvatska D.O.O. Processes for preparing pharmaceutical compounds
EA017836B1 (ru) * 2007-11-28 2013-03-29 ЮСиБи ФАРМА ГМБХ Новая полиморфная форма ротиготина и способ ее получения
US20090202647A1 (en) * 2008-02-11 2009-08-13 Mayur Devjibhai Khunt Solid form of racemic rotigotine
IT1392387B1 (it) * 2008-09-26 2012-03-02 Solmag S P A Ora Fidia Farmaceutici S P A Processo per la preparazione di rotigotina
EP2376470B1 (en) * 2008-12-09 2013-04-10 Interquim, S.A Process for the preparation of (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotine)
WO2010073124A2 (en) 2008-12-26 2010-07-01 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
CN102010400B (zh) 2009-09-07 2015-02-04 药源药物化学（上海）有限公司 S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀
EP2490673A2 (en) 2009-10-19 2012-08-29 Actavis Group Ptc Ehf Amorphous rotigotine co-precipitates
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
RS57457B1 (sr) 2009-12-22 2018-09-28 Ucb Biopharma Sprl Polivinilpirolidon za stabilizaciju čvrste disperzije nekristalnog oblika rotigotina
WO2011095539A2 (en) 2010-02-05 2011-08-11 Ucb Pharma Gmbh Novel process for the preparation of nitrogen substituted aminotetralins derivatives
EP2585428B1 (en) 2010-06-25 2017-05-10 UCB Biopharma SPRL Processes for the resolution of nitrogen substituted (s)-5-alkoxy-2-aminotetralin derivatives
AU2012276179B2 (en) * 2011-06-27 2015-09-24 Shan Dong Luye Pharmaceutical Co., Ltd. Method for industrially preparing nitrogen substituted amino-5,6,7,8-tetrahydronaphthol
CN103768043B (zh) * 2012-10-22 2015-12-09 苏州药明康德新药开发股份有限公司 采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法
US10611749B2 (en) 2018-02-15 2020-04-07 Solara Active Pharma Sciences Limited Process for preparation of Rotigotine and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026848B1 (de) * 1979-09-14 1983-05-04 Sandoz Ag Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten
US4564628A (en) 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US4968837A (en) 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
US5382596A (en) * 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins

Also Published As

Publication number Publication date
DK1232152T3 (da) 2004-04-05
AU1613101A (en) 2001-06-04
US6372920B1 (en) 2002-04-16
PL355607A1 (en) 2004-05-04
EP1232152A1 (en) 2002-08-21
CA2392563C (en) 2011-02-15
HK1049156B (zh) 2004-12-10
WO2001038321A1 (en) 2001-05-31
CN1391569A (zh) 2003-01-15
ES2216992T3 (es) 2004-11-01
CN1185225C (zh) 2005-01-19
ATE258927T1 (de) 2004-02-15
DE60008136T2 (de) 2004-09-09
DE60008136D1 (de) 2004-03-11
PL202805B1 (pl) 2009-07-31
CA2392563A1 (en) 2001-05-31
TR200400401T4 (tr) 2004-03-22
HK1052514A1 (zh) 2003-09-19
EP1232152B1 (en) 2004-02-04
HK1049156A1 (en) 2003-05-02
AR026505A1 (es) 2003-02-12

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