TR200400401T4 - Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem - Google Patents
Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntemInfo
- Publication number
- TR200400401T4 TR200400401T4 TR2004/00401T TR200400401T TR200400401T4 TR 200400401 T4 TR200400401 T4 TR 200400401T4 TR 2004/00401 T TR2004/00401 T TR 2004/00401T TR 200400401 T TR200400401 T TR 200400401T TR 200400401 T4 TR200400401 T4 TR 200400401T4
- Authority
- TR
- Turkey
- Prior art keywords
- group
- aminotetralins
- nitrogen
- preparation
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Bu bulus, optik olarak aktif ve aktif olmayan (resamik) Formül (I)'deki nitrojen-degisimli 2-aminotetralinlerin hazirlanmasina iliskin bir islemle ilgilidir. Burada R1 OA'dir; R2, H ve OA 'dan olusan bir gruptan seçilmektedir; A, H'tir veya 1 ila 3 karbon atomuna sahip, (a), (b), (c) ve (d)'deki düz veya dallanmis alkil zincirinden olusan gruptan seçilmektedir; R5, C1-C20 alkil, C6-C10 aril ve C7-C20 arilalkilden olusan gruptan seçilmektedir; R3, alkoksi, sikloalkoksi, seçenekli olarak degisimli fenil, 3-piridil, 4-piridil, (e), (f) ve (g)'den olusan gruptan seçilmektedir, ki burada X, ya S, ya O ya da NH'tir; R4, 1 ila 3 karbon atomuna sahip dallanmamis bir alkil zinciridir; n, 1 ile 5 arasinda bir tam sayidir; buradaki islem, Formül (II)' deki ilgili degisimsiz 2- aminotetralini, Formül (III): Z-(CHz)n-R3' ün bir tepkenini (reaktantini) alkillendirmekten olusmaktadir; burada R3 ve n, yukarida tanimlandigi gibidir; Z ise, alkali metal karbonat ve alkali metal bikarbonattan olusan bir
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16700999P | 1999-11-23 | 1999-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200400401T4 true TR200400401T4 (tr) | 2004-03-22 |
Family
ID=22605581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/00401T TR200400401T4 (tr) | 1999-11-23 | 2000-11-16 | Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem |
Country Status (15)
Country | Link |
---|---|
US (1) | US6372920B1 (tr) |
EP (1) | EP1232152B1 (tr) |
CN (1) | CN1185225C (tr) |
AR (1) | AR026505A1 (tr) |
AT (1) | ATE258927T1 (tr) |
AU (1) | AU1613101A (tr) |
CA (1) | CA2392563C (tr) |
DE (1) | DE60008136T2 (tr) |
DK (1) | DK1232152T3 (tr) |
ES (1) | ES2216992T3 (tr) |
HK (2) | HK1049156B (tr) |
PL (1) | PL202805B1 (tr) |
PT (1) | PT1232152E (tr) |
TR (1) | TR200400401T4 (tr) |
WO (1) | WO2001038321A1 (tr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19814084B4 (de) | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
DE10359528A1 (de) * | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
DE102004014841B4 (de) | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途 |
EP1987815A1 (en) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
EP2170323A2 (en) * | 2007-05-30 | 2010-04-07 | Chemagis Ltd. | Crystalline rotigotine base and preparation process therefor |
WO2009053697A1 (en) * | 2007-10-26 | 2009-04-30 | Pliva Hrvatska D.O.O. | Polymorphic forms of ( s ) -rotigotine hydrochloride |
WO2009056791A1 (en) * | 2007-11-02 | 2009-05-07 | Pliva Hrvatska D.O.O. | Processes for preparing pharmaceutical compounds |
SG10201610626PA (en) | 2007-11-28 | 2017-01-27 | Ucb Pharma Gmbh | Polymorphic form of rotigotine |
US20090202647A1 (en) * | 2008-02-11 | 2009-08-13 | Mayur Devjibhai Khunt | Solid form of racemic rotigotine |
IT1392387B1 (it) | 2008-09-26 | 2012-03-02 | Solmag S P A Ora Fidia Farmaceutici S P A | Processo per la preparazione di rotigotina |
WO2010066755A1 (en) * | 2008-12-09 | 2010-06-17 | Interquim, S.A. | Process for the preparation of (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotine) |
WO2010073124A2 (en) | 2008-12-26 | 2010-07-01 | Actavis Group Ptc Ehf | Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof |
EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
CN102010400B (zh) | 2009-09-07 | 2015-02-04 | 药源药物化学(上海)有限公司 | S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀 |
WO2011048491A2 (en) | 2009-10-19 | 2011-04-28 | Actavis Group Ptc Ehf | Amorphous rotigotine co-precipitates |
DE102009052972A1 (de) | 2009-11-12 | 2011-09-15 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
AU2010334805B2 (en) | 2009-12-22 | 2015-01-22 | Lts Lohmann Therapie-Systeme Ag | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
US8729306B2 (en) | 2010-02-05 | 2014-05-20 | Ucb Pharma Gmbh | Process for the preparation of nitrogen substituted aminotetralins derivatives |
AU2011268871C1 (en) * | 2010-06-25 | 2015-06-04 | Ucb Pharma Gmbh | Processes for the resolution of nitrogen substituted (S) - 5 -alkoxy- 2 -aminotetralin derivatives |
CN103649071B (zh) * | 2011-06-27 | 2014-07-30 | 山东绿叶制药有限公司 | 一种氮取代的氨基5,6,7,8-四氢化萘酚工业化制备方法 |
CN103768043B (zh) * | 2012-10-22 | 2015-12-09 | 苏州药明康德新药开发股份有限公司 | 采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法 |
US10611749B2 (en) | 2018-02-15 | 2020-04-07 | Solara Active Pharma Sciences Limited | Process for preparation of Rotigotine and intermediates thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3062971D1 (en) | 1979-09-14 | 1983-06-09 | Sandoz Ag | Derivatives of tetraline, their preparation and medicaments containing these compounds |
US4564628A (en) | 1983-01-03 | 1986-01-14 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4968837A (en) | 1989-07-28 | 1990-11-06 | Ethyl Corporation | Resolution of racemic mixtures |
US5382596A (en) * | 1993-08-05 | 1995-01-17 | Whitby Research, Inc. | Substituted 2-aminotetralins |
-
2000
- 2000-11-16 AU AU16131/01A patent/AU1613101A/en not_active Abandoned
- 2000-11-16 AR ARP000106056A patent/AR026505A1/es not_active Application Discontinuation
- 2000-11-16 CA CA2392563A patent/CA2392563C/en not_active Expired - Lifetime
- 2000-11-16 TR TR2004/00401T patent/TR200400401T4/tr unknown
- 2000-11-16 ES ES00978699T patent/ES2216992T3/es not_active Expired - Lifetime
- 2000-11-16 DE DE60008136T patent/DE60008136T2/de not_active Expired - Lifetime
- 2000-11-16 DK DK00978699T patent/DK1232152T3/da active
- 2000-11-16 CN CNB008160945A patent/CN1185225C/zh not_active Expired - Lifetime
- 2000-11-16 AT AT00978699T patent/ATE258927T1/de active
- 2000-11-16 WO PCT/US2000/031415 patent/WO2001038321A1/en active IP Right Grant
- 2000-11-16 US US09/713,308 patent/US6372920B1/en not_active Expired - Lifetime
- 2000-11-16 PT PT00978699T patent/PT1232152E/pt unknown
- 2000-11-16 PL PL355607A patent/PL202805B1/pl unknown
- 2000-11-16 EP EP00978699A patent/EP1232152B1/en not_active Expired - Lifetime
-
2003
- 2003-01-22 HK HK03100524.2A patent/HK1049156B/zh not_active IP Right Cessation
- 2003-07-09 HK HK03104901.7A patent/HK1052514A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US6372920B1 (en) | 2002-04-16 |
ES2216992T3 (es) | 2004-11-01 |
CA2392563C (en) | 2011-02-15 |
PL202805B1 (pl) | 2009-07-31 |
EP1232152B1 (en) | 2004-02-04 |
HK1049156A1 (en) | 2003-05-02 |
CA2392563A1 (en) | 2001-05-31 |
CN1185225C (zh) | 2005-01-19 |
DK1232152T3 (da) | 2004-04-05 |
AR026505A1 (es) | 2003-02-12 |
DE60008136D1 (de) | 2004-03-11 |
DE60008136T2 (de) | 2004-09-09 |
EP1232152A1 (en) | 2002-08-21 |
HK1052514A1 (zh) | 2003-09-19 |
CN1391569A (zh) | 2003-01-15 |
HK1049156B (zh) | 2004-12-10 |
ATE258927T1 (de) | 2004-02-15 |
WO2001038321A1 (en) | 2001-05-31 |
PT1232152E (pt) | 2004-06-30 |
PL355607A1 (en) | 2004-05-04 |
AU1613101A (en) | 2001-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200400401T4 (tr) | Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem | |
YU20094A (sh) | Hidrazidi 1-h-indol-3-sirćetne kisleine kao inhibitori spla2 | |
TR200402512T4 (tr) | Hipoglisemik ve hipolipidemik aktiviteye sahip 5-üyeli N-heterosiklik bileşikler | |
CY1106381T1 (el) | Βιοκτονος συνθεση καθαρισμου | |
DE59606352D1 (de) | Reinigungsmittel für harte oberflächen | |
CA2377309A1 (en) | Compounds for the modulation of ppar.gamma. activity | |
HUT76657A (en) | 2-(1',2',4'-triazol-3'-yloxymethylene)-anilides, process for producing them and their use as pestcontrol agents | |
MY122255A (en) | Acrylonitrile compounds, process for their production and pesticides containing them | |
CA2324418A1 (en) | Novel opiate compounds, methods of making and methods of use | |
EA201000017A1 (ru) | Предварительная композиция серного цемента и способ приготовления предварительной композиции серного цемента | |
JP2009501281A5 (tr) | ||
HUP9800087A2 (hu) | Alkoxi-imino-ecetsav-amidok, e vegyületeket tartalmazó növényvédő szerek, valamint eljárás kártevők leküzdésére, továbbá e vegyületek előállítására | |
FI954016A (fi) | Uudet yhdisteet | |
FR2699918B1 (fr) | Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments. | |
TR200202096T2 (tr) | Sitalopram hazırlamak için yöntem | |
DE60011916D1 (de) | Heteroaryloxypropanolamine als beta3-adrenergischer rezeptor-agonisten | |
ATE314352T1 (de) | Anilide als acat-hemmer | |
EA200200611A1 (ru) | Новые тетрагидропиридины, способ их получения и содержащие их фармацевтические композиции | |
PT1290034E (pt) | Novo tipo de produto de amido cationico sua preparacao e utilizacao | |
TWI265161B (en) | Oxime compounds, their use, and intermediates for their production | |
TR200402650T4 (tr) | Yeni positif alosterik ampa-reseptör modülatörleri (paarm), bunların imalatı için yöntem ve bunların ilaç olarak kullanımları | |
TR199902873T2 (tr) | Miyozun modülasyonu için 17 -aliloksi(tiyo)alkil-androstan türevleri. | |
ATE370957T1 (de) | Herstellung von halogenierten monoorganoxysilanen,verwendung als zwischenverbindungen | |
DE60100493D1 (de) | Flammhemmende thermoplastische Harzzusammensetzung und Verfahren zu dessen Herstellung | |
AP2000001924A0 (en) | Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines. |