TR200400401T4 - Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem - Google Patents

Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem

Info

Publication number
TR200400401T4
TR200400401T4 TR2004/00401T TR200400401T TR200400401T4 TR 200400401 T4 TR200400401 T4 TR 200400401T4 TR 2004/00401 T TR2004/00401 T TR 2004/00401T TR 200400401 T TR200400401 T TR 200400401T TR 200400401 T4 TR200400401 T4 TR 200400401T4
Authority
TR
Turkey
Prior art keywords
group
aminotetralins
nitrogen
preparation
formula
Prior art date
Application number
TR2004/00401T
Other languages
English (en)
Inventor
Minaskanian Gevork
Rippel Keith
Original Assignee
Aderis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals, Inc. filed Critical Aderis Pharmaceuticals, Inc.
Publication of TR200400401T4 publication Critical patent/TR200400401T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Bu bulus, optik olarak aktif ve aktif olmayan (resamik) Formül (I)'deki nitrojen-degisimli 2-aminotetralinlerin hazirlanmasina iliskin bir islemle ilgilidir. Burada R1 OA'dir; R2, H ve OA 'dan olusan bir gruptan seçilmektedir; A, H'tir veya 1 ila 3 karbon atomuna sahip, (a), (b), (c) ve (d)'deki düz veya dallanmis alkil zincirinden olusan gruptan seçilmektedir; R5, C1-C20 alkil, C6-C10 aril ve C7-C20 arilalkilden olusan gruptan seçilmektedir; R3, alkoksi, sikloalkoksi, seçenekli olarak degisimli fenil, 3-piridil, 4-piridil, (e), (f) ve (g)'den olusan gruptan seçilmektedir, ki burada X, ya S, ya O ya da NH'tir; R4, 1 ila 3 karbon atomuna sahip dallanmamis bir alkil zinciridir; n, 1 ile 5 arasinda bir tam sayidir; buradaki islem, Formül (II)' deki ilgili degisimsiz 2- aminotetralini, Formül (III): Z-(CHz)n-R3' ün bir tepkenini (reaktantini) alkillendirmekten olusmaktadir; burada R3 ve n, yukarida tanimlandigi gibidir; Z ise, alkali metal karbonat ve alkali metal bikarbonattan olusan bir
TR2004/00401T 1999-11-23 2000-11-16 Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem TR200400401T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16700999P 1999-11-23 1999-11-23

Publications (1)

Publication Number Publication Date
TR200400401T4 true TR200400401T4 (tr) 2004-03-22

Family

ID=22605581

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00401T TR200400401T4 (tr) 1999-11-23 2000-11-16 Nitrojen-değişimli aminotetralinlerin hazırlanması için geliştirilmiş yöntem

Country Status (15)

Country Link
US (1) US6372920B1 (tr)
EP (1) EP1232152B1 (tr)
CN (1) CN1185225C (tr)
AR (1) AR026505A1 (tr)
AT (1) ATE258927T1 (tr)
AU (1) AU1613101A (tr)
CA (1) CA2392563C (tr)
DE (1) DE60008136T2 (tr)
DK (1) DK1232152T3 (tr)
ES (1) ES2216992T3 (tr)
HK (2) HK1049156B (tr)
PL (1) PL202805B1 (tr)
PT (1) PT1232152E (tr)
TR (1) TR200400401T4 (tr)
WO (1) WO2001038321A1 (tr)

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DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246979B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) * 2003-12-18 2005-07-28 Schwarz Pharma Ag (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) * 2004-02-20 2005-09-08 Schwarz Pharma Ag Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
EP2170323A2 (en) * 2007-05-30 2010-04-07 Chemagis Ltd. Crystalline rotigotine base and preparation process therefor
WO2009053697A1 (en) * 2007-10-26 2009-04-30 Pliva Hrvatska D.O.O. Polymorphic forms of ( s ) -rotigotine hydrochloride
WO2009056791A1 (en) * 2007-11-02 2009-05-07 Pliva Hrvatska D.O.O. Processes for preparing pharmaceutical compounds
SG10201610626PA (en) 2007-11-28 2017-01-27 Ucb Pharma Gmbh Polymorphic form of rotigotine
US20090202647A1 (en) * 2008-02-11 2009-08-13 Mayur Devjibhai Khunt Solid form of racemic rotigotine
IT1392387B1 (it) 2008-09-26 2012-03-02 Solmag S P A Ora Fidia Farmaceutici S P A Processo per la preparazione di rotigotina
WO2010066755A1 (en) * 2008-12-09 2010-06-17 Interquim, S.A. Process for the preparation of (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotine)
WO2010073124A2 (en) 2008-12-26 2010-07-01 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
CN102010400B (zh) 2009-09-07 2015-02-04 药源药物化学（上海）有限公司 S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀
WO2011048491A2 (en) 2009-10-19 2011-04-28 Actavis Group Ptc Ehf Amorphous rotigotine co-precipitates
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
AU2010334805B2 (en) 2009-12-22 2015-01-22 Lts Lohmann Therapie-Systeme Ag Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
US8729306B2 (en) 2010-02-05 2014-05-20 Ucb Pharma Gmbh Process for the preparation of nitrogen substituted aminotetralins derivatives
AU2011268871C1 (en) * 2010-06-25 2015-06-04 Ucb Pharma Gmbh Processes for the resolution of nitrogen substituted (S) - 5 -alkoxy- 2 -aminotetralin derivatives
CN103649071B (zh) * 2011-06-27 2014-07-30 山东绿叶制药有限公司 一种氮取代的氨基5,6,7,8-四氢化萘酚工业化制备方法
CN103768043B (zh) * 2012-10-22 2015-12-09 苏州药明康德新药开发股份有限公司 采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法
US10611749B2 (en) 2018-02-15 2020-04-07 Solara Active Pharma Sciences Limited Process for preparation of Rotigotine and intermediates thereof

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Also Published As

Publication number Publication date
US6372920B1 (en) 2002-04-16
ES2216992T3 (es) 2004-11-01
CA2392563C (en) 2011-02-15
PL202805B1 (pl) 2009-07-31
EP1232152B1 (en) 2004-02-04
HK1049156A1 (en) 2003-05-02
CA2392563A1 (en) 2001-05-31
CN1185225C (zh) 2005-01-19
DK1232152T3 (da) 2004-04-05
AR026505A1 (es) 2003-02-12
DE60008136D1 (de) 2004-03-11
DE60008136T2 (de) 2004-09-09
EP1232152A1 (en) 2002-08-21
HK1052514A1 (zh) 2003-09-19
CN1391569A (zh) 2003-01-15
HK1049156B (zh) 2004-12-10
ATE258927T1 (de) 2004-02-15
WO2001038321A1 (en) 2001-05-31
PT1232152E (pt) 2004-06-30
PL355607A1 (en) 2004-05-04
AU1613101A (en) 2001-06-04

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