AR026505A1 - Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno - Google Patents

Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno

Info

Publication number
AR026505A1
AR026505A1 ARP000106056A ARP000106056A AR026505A1 AR 026505 A1 AR026505 A1 AR 026505A1 AR P000106056 A ARP000106056 A AR P000106056A AR P000106056 A ARP000106056 A AR P000106056A AR 026505 A1 AR026505 A1 AR 026505A1
Authority
AR
Argentina
Prior art keywords
group
preparation
formula
aminotetralines
nitrogen
Prior art date
Application number
ARP000106056A
Other languages
English (en)
Original Assignee
Aderis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals Inc filed Critical Aderis Pharmaceuticals Inc
Publication of AR026505A1 publication Critical patent/AR026505A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invencion se relaciona con un proceso para la preparacion2-aminotetralinas sustituidas con nitrogeno opticamente activas o racémicas de lasiguiente formula general (1) en la cual R1 es OA; R2 es seleccionado entre el grupo que consiste en una cadena alquílica recta o ramificada con 1 a 3 átomosde carbono, donde R5 es seleccionado entre que consiste en alquilo C1-20, arilo C6-10 y arilalquilo C7-20; R3 ese seleccionado entre el grupo que consiste enalcoxi, cicloalcoxi, fenilo optativa mente sustituido, 3-piridilo, 4-piridilo, donde X es S, O, o NH; R4 es una cadena alquílica no ramificada con 1 a 3 átomosde carbono y n es un entero de 1 a 5, proceso que comprende la alquilacion de la correspondiente 2-aminotetralina de la formula (2) con un reactivo de laformula Z-(CH2)n-R3 en la cual R3 y n son como se los definiera anteriormente y Z es un grupo saliente, en presencia de una base, donde la base es seleccionadaentre el grupo que consiste en carbonato de metal alcalino y bicar bonato de metal alcalino y donde la cantidad es inferior a aproximadamente 1,9 veces elexceso mlar con respecto a la cantidad de 2-aminotetralina.
ARP000106056A 1999-11-23 2000-11-16 Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno AR026505A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16700999P 1999-11-23 1999-11-23

Publications (1)

Publication Number Publication Date
AR026505A1 true AR026505A1 (es) 2003-02-12

Family

ID=22605581

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106056A AR026505A1 (es) 1999-11-23 2000-11-16 Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno

Country Status (15)

Country Link
US (1) US6372920B1 (es)
EP (1) EP1232152B1 (es)
CN (1) CN1185225C (es)
AR (1) AR026505A1 (es)
AT (1) ATE258927T1 (es)
AU (1) AU1613101A (es)
CA (1) CA2392563C (es)
DE (1) DE60008136T2 (es)
DK (1) DK1232152T3 (es)
ES (1) ES2216992T3 (es)
HK (2) HK1049156B (es)
PL (1) PL202805B1 (es)
PT (1) PT1232152E (es)
TR (1) TR200400401T4 (es)
WO (1) WO2001038321A1 (es)

Families Citing this family (34)

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DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041479A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) * 2003-12-18 2005-07-28 Schwarz Pharma Ag (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) * 2004-02-20 2005-09-08 Schwarz Pharma Ag Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
WO2008146284A2 (en) * 2007-05-30 2008-12-04 Chemagis Ltd. Crystalline rotigotine base and preparation process therefor
WO2009053697A1 (en) * 2007-10-26 2009-04-30 Pliva Hrvatska D.O.O. Polymorphic forms of ( s ) -rotigotine hydrochloride
WO2009056791A1 (en) * 2007-11-02 2009-05-07 Pliva Hrvatska D.O.O. Processes for preparing pharmaceutical compounds
US8592477B2 (en) * 2007-11-28 2013-11-26 Ucb Pharma Gmbh Polymorphic form of rotigotine and process for production
US20090202647A1 (en) * 2008-02-11 2009-08-13 Mayur Devjibhai Khunt Solid form of racemic rotigotine
IT1392387B1 (it) * 2008-09-26 2012-03-02 Solmag S P A Ora Fidia Farmaceutici S P A Processo per la preparazione di rotigotina
MX2011005979A (es) 2008-12-09 2011-06-27 Interquim Sa Procedimiento de obtencion de (6s)-(-)-5,6,7,8-tetrahidro-6-[propi l-(2-tienil)etil]amino-1-naftol(rotigotina).
WO2010073124A2 (en) 2008-12-26 2010-07-01 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
CN102010400B (zh) 2009-09-07 2015-02-04 药源药物化学（上海）有限公司 S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀
EP2490673A2 (en) 2009-10-19 2012-08-29 Actavis Group Ptc Ehf Amorphous rotigotine co-precipitates
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
DK2515887T3 (en) 2009-12-22 2018-09-17 Ucb Biopharma Sprl Polyvinylpyrrolidone to stabilize a solid dispersion of the non-crystalline form of rotigotine
EP2531486B1 (en) 2010-02-05 2017-06-21 UCB Biopharma SPRL Novel process for the preparation of nitrogen substituted aminotetralins derivatives
AU2011268871C1 (en) * 2010-06-25 2015-06-04 Ucb Pharma Gmbh Processes for the resolution of nitrogen substituted (S) - 5 -alkoxy- 2 -aminotetralin derivatives
ES2626024T3 (es) 2011-06-27 2017-07-21 Shan Dong Luye Pharmaceutical Co., Ltd. Procedimiento para preparar industrialmente amino-5,6,7,8-tetrahidronaftol sustituido con nitrógeno
CN103768043B (zh) * 2012-10-22 2015-12-09 苏州药明康德新药开发股份有限公司 采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法
US10611749B2 (en) 2018-02-15 2020-04-07 Solara Active Pharma Sciences Limited Process for preparation of Rotigotine and intermediates thereof

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EP0026848B1 (de) 1979-09-14 1983-05-04 Sandoz Ag Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten
US4564628A (en) 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US4968837A (en) 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
US5382596A (en) * 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins

Also Published As

Publication number Publication date
CA2392563A1 (en) 2001-05-31
CA2392563C (en) 2011-02-15
PL202805B1 (pl) 2009-07-31
TR200400401T4 (tr) 2004-03-22
DE60008136D1 (de) 2004-03-11
CN1391569A (zh) 2003-01-15
HK1052514A1 (zh) 2003-09-19
PL355607A1 (en) 2004-05-04
US6372920B1 (en) 2002-04-16
EP1232152B1 (en) 2004-02-04
DE60008136T2 (de) 2004-09-09
EP1232152A1 (en) 2002-08-21
CN1185225C (zh) 2005-01-19
ATE258927T1 (de) 2004-02-15
AU1613101A (en) 2001-06-04
DK1232152T3 (da) 2004-04-05
WO2001038321A1 (en) 2001-05-31
ES2216992T3 (es) 2004-11-01
PT1232152E (pt) 2004-06-30
HK1049156B (zh) 2004-12-10
HK1049156A1 (en) 2003-05-02

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