ES2188184T3 - Compuestos de beta-carbolinas. - Google Patents

Compuestos de beta-carbolinas.

Info

Publication number
ES2188184T3
ES2188184T3 ES99928479T ES99928479T ES2188184T3 ES 2188184 T3 ES2188184 T3 ES 2188184T3 ES 99928479 T ES99928479 T ES 99928479T ES 99928479 T ES99928479 T ES 99928479T ES 2188184 T3 ES2188184 T3 ES 2188184T3
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
optionally substituted
group
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99928479T
Other languages
English (en)
Inventor
Christophe Alain Thurieau
Lydie Francine Poitout
Marie-Odile Galcera
Christophe Philippe Moinet
Thomas D Gordon
Barry A Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Application granted granted Critical
Publication of ES2188184T3 publication Critical patent/ES2188184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

Un compuesto de fórmula (I), **(Fórmula)** las mezclas racémico - diastereoméricas y los isómeros ópticos de dicho compuesto de fórmula (I), las sales o profármacos farmacéuticamente aceptables del mismo o una sal farmacéuticamente aceptable de dicho profármaco, en donde ------ representa un enlace opcional; X es N o N - R4, donde X es N cuando ambos enlaces opcionales están presentes y X es N - R4 cuando los enlaces opcionales no están presentes; R1 es: H, - (CH2)m - C(O) - (CH2)m - Z1, - (CH2)m - Z1, - (CH2)m - O - Z1 o alquil(C0 - C6) C(O) - NH - (CH2)m - Z3; Z1 es un resto opcionalmente sustituid escogido entre el grupo formado por: alquilo(C1 - C12), benzo[b]tiofeno, fenilo, naftilo, benzo[b]furanilo, tiofeno, isoxazolilo, indolilo, **(Fórmula)** R2 es: alquilo(C1 - C12), alquil(C0 - C5) - C(O) - O - Z5, alquil(C0 - C6) - C(O) - NH - (CH2)m - Z3 o fenilo opcionalmente sustituido; Z5 es: H, alquilo(C1 - C12) o (CH2)m - arilo; Z3 es: amino, alquil(C1 - C12)amino, N, N - di - alquil(C1 -C12)amino, - NH - C(O) - O - (CH2)m fenilo, - NH - C(O) - O - (CH2)m - alquilo(C1 - C6) o un resto opcionalmente sustituido escogido entre el grupo formado por: imidazolilo, piridinilo y morfolinilo, piperidinilo, piperacinilo, pirazolidinilo, furanilo y tiofeno R3 es: H; R4 es: H, - C(=Y) - N(X1X2), C(=O)X2 o X2; Y es: O o S; X2 es: - (CH2)m - Y1 - X3 0 X3 es: H o un resto opcionalmente sustituido escogido entre el grupo formado por: alquilo(C1 C12), cicloalquilo(C3 - C8), alcoxi(C1 - C12), ariloxi, alquil(C1 - C12) - amino, N, N - di - alquil(C1 C12) - amino, - CH - di - alcoxi(C1 - C12) o fenilo; R5 es: alquilo(C1 - C12), - (CH2), , , , - Y1 - (CH2), , , , - fenil - (X1), , , , cicloalquilo(C3 - C12), - (CH2), , , , S - alquilo(C1 - C12), alquil(C1 - C12) - S - S - alquilo(C1 - C12), - (CH2)m - alquenilo(C1 - C12) o un resto opcionalmente sustituido escogido entre el grupo formado por: fenilo, furanilo, tiofeno, pirrolilo, piridinilo y **Fórmula** Y1 es: O, S, NH o un enlace; R6 es H o SO2 - fenilo; R7 es H, alquilo opcionalmente sustituido con alcoxi o dialquilamino; en donde un resto opcionalmente sustituido un fenilo opcionalmente sustituido, se sustituye opcionalmente por uno o más sustituyentes, cada uno escogido independientemente entre el grupo formado por: Cl, F, Br, I, CF3, NO2, OH, SO2NH2, CN, N3, - OCF3, alcoxi(C1 - C12), - (CH2), , , , - fenil - (X1), , , , - NH - CO - alquilo(C1 - C6), - S - fenil - (X1), , , , O - (CH2), , , . - fenil - (X1), , , , - (CH2), , , . - C(O) O - alquilo(C1 - C6), - (CH2), , , , , - C(O) - alquilo(C1 - C6), - O - (CH), , , , , - NH - alquilo(C1 - C6), - O - (CH2)-, , , , - N - di - (alquilo(C1 - C6)) y alquil(C0 - C12) - (X1)n; X1, cada vez que aparezca se escoge independientemente entre el grupo formado por: hidrógeno, Cl, F, Br, I, NO2, OH, - CF3, - OCF3 - , alquilo(C1 - C12), alcoxi(C1 - C12), - S - alquilo(C1 - C6), - (CH2)-, , , , - amino, - (CH2)-, , , , - NH - alquilo(C1 - C6), - (CH2)-, , , , - N - di - (alquilo(C1 - C6)),- (CH2)-, , , , fenilo y, - (CH2)-, , , , - NH - cicloalquilo(C3 - C6); m, cada vez que aparezca, es independientemente 0 ¿ o un número entero entre 1 y 6; y n, cada vez que aparezca, es independientemente un número entero entre 1 y 5.
ES99928479T 1998-06-12 1999-06-08 Compuestos de beta-carbolinas. Expired - Lifetime ES2188184T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9729798A 1998-06-12 1998-06-12
US8918098P 1998-06-12 1998-06-12

Publications (1)

Publication Number Publication Date
ES2188184T3 true ES2188184T3 (es) 2003-06-16

Family

ID=26780327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99928479T Expired - Lifetime ES2188184T3 (es) 1998-06-12 1999-06-08 Compuestos de beta-carbolinas.

Country Status (22)

Country Link
US (1) US6586445B1 (es)
EP (1) EP1086101B1 (es)
JP (1) JP2002517500A (es)
KR (1) KR20010071461A (es)
CN (1) CN1169808C (es)
AR (1) AR019153A1 (es)
AT (1) ATE229954T1 (es)
AU (1) AU761020B2 (es)
CA (1) CA2335339A1 (es)
CZ (1) CZ20004580A3 (es)
DE (1) DE69904595T2 (es)
DK (1) DK1086101T3 (es)
ES (1) ES2188184T3 (es)
HK (1) HK1032049A1 (es)
HU (1) HUP0302962A2 (es)
IL (1) IL140197A0 (es)
NO (1) NO319532B1 (es)
NZ (1) NZ508765A (es)
PL (1) PL345589A1 (es)
RU (1) RU2233841C2 (es)
TW (1) TWI236477B (es)
WO (1) WO1999064420A1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796945B1 (fr) * 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
US6696418B1 (en) 1999-09-01 2004-02-24 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
FR2812546B1 (fr) * 2000-08-01 2008-11-21 Sod Conseils Rech Applic Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
US6495589B2 (en) 2000-04-28 2002-12-17 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
US6720330B2 (en) 2000-11-17 2004-04-13 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
FR2818978B1 (fr) * 2000-12-28 2003-02-28 Sod Conseils Rech Applic Modulateurs de canaux sodiques derives de 2-piperidylimidazoles
GB0108337D0 (en) 2001-04-03 2001-05-23 Novartis Ag Organic compounds
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
CZ20033123A3 (cs) * 2001-06-25 2004-11-10 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farmaceutické prostředky, které inhibují proliferaci adenomů hypofýzy
DE10136842A1 (de) * 2001-07-23 2003-02-13 Schering Ag GABA¶A¶-Rezeptor-Modulatoren mit NMDA-antagonistischer Aktivität
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
CN101837127A (zh) 2003-05-05 2010-09-22 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
WO2004113300A1 (ja) 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
WO2005039548A2 (en) 2003-10-15 2005-05-06 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
AU2005210004B2 (en) 2004-02-05 2010-10-28 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
ATE541835T1 (de) * 2004-02-05 2012-02-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP2007534738A (ja) 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
WO2005103003A2 (en) 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP1829874B1 (en) 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
WO2006089053A2 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
JP5035865B2 (ja) * 2005-09-26 2012-09-26 国立大学法人高知大学 Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ菌株の増殖・運動抑制方法
WO2007062175A2 (en) * 2005-11-21 2007-05-31 Amgen Inc. Spiro-substituted tricyclic heterocycles cxcr3 antagonists
US7879859B2 (en) * 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
CN101346375B (zh) * 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法
US20080004306A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CA2693214A1 (en) * 2007-07-19 2009-01-22 Merck Sharp & Dohme Corp. Beta carboline derivatives as antidiabetic compounds
SG10201703086VA (en) * 2008-10-17 2017-05-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their use as therapeutic agents
WO2010051177A1 (en) * 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Triazole beta carboline derivatives as antidiabetic compounds
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
CN102844029A (zh) * 2009-12-28 2012-12-26 奥迪欧医药设备有限公司 用于治疗听力损伤和眩晕的β-咔啉
CN102695414A (zh) 2010-01-15 2012-09-26 默沙东公司 作为抗糖尿病化合物的噁二唑β-咔啉衍生物
KR101256588B1 (ko) * 2010-02-17 2013-04-19 부산대학교 산학협력단 베타-카르볼린 알칼로이드를 함유하는 멜라닌 생성 촉진용 조성물
KR101784284B1 (ko) * 2011-03-28 2017-10-11 에스제이티 몰레큘라 리서치, 에스.엘. 대사증후군 치료 화합물
CN105837569B (zh) * 2016-04-29 2017-12-26 华南农业大学 一种骆驼蓬碱噁唑啉类化合物及其制备方法和应用
CN107118212B (zh) * 2017-05-26 2019-12-03 广西师范大学 1-吡啶-6-甲氧基-9-(3-碘苄)-β-咔啉、合成和应用
CN107163041B (zh) * 2017-05-26 2019-06-21 广西师范大学 一种β-咔啉化合物及其合成方法和应用
CN106995440B (zh) * 2017-05-26 2019-09-03 广西师范大学 1-吡啶-6-甲氧基-9-(2，3，4，5-四氟苄基)β-咔啉化合物及其合成方法和应用
CN107141285B (zh) * 2017-05-26 2019-12-03 广西师范大学 1-吡啶-6-甲氧基-9-甲基苄-β-咔啉及其合成和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378803A (en) * 1987-12-11 1995-01-03 Sterling Winthrop Inc. Azole-fused peptides and processes for preparation thereof

Also Published As

Publication number Publication date
RU2233841C2 (ru) 2004-08-10
IL140197A0 (en) 2002-02-10
DE69904595D1 (de) 2003-01-30
CN1169808C (zh) 2004-10-06
DK1086101T3 (da) 2003-03-31
AR019153A1 (es) 2001-12-26
CA2335339A1 (en) 1999-12-16
ATE229954T1 (de) 2003-01-15
NO20006268D0 (no) 2000-12-11
DE69904595T2 (de) 2003-11-27
US6586445B1 (en) 2003-07-01
EP1086101B1 (en) 2002-12-18
WO1999064420A1 (en) 1999-12-16
PL345589A1 (en) 2001-12-17
JP2002517500A (ja) 2002-06-18
HK1032049A1 (en) 2001-07-06
NZ508765A (en) 2003-10-31
AU4553699A (en) 1999-12-30
AU761020B2 (en) 2003-05-29
EP1086101A1 (en) 2001-03-28
NO319532B1 (no) 2005-08-29
NO20006268L (no) 2001-01-29
CZ20004580A3 (cs) 2001-12-12
HUP0302962A2 (hu) 2003-12-29
CN1308632A (zh) 2001-08-15
TWI236477B (en) 2005-07-21
KR20010071461A (ko) 2001-07-28

Similar Documents

Publication Publication Date Title
ES2188184T3 (es) Compuestos de beta-carbolinas.
CY1107388T1 (el) Αγωνιστες αλφα υποδοχεα ενεργοποιουμενου απο πολλαπλασιαστες υπεροξυσωματων
NO20022317D0 (no) Trifenylalkylen-derivater og deres anvendelse som selektive östrogen-reseptor-modulater
ES2189462T3 (es) Derivados de acido aminometilcarboxilico.
CO5611126A2 (es) Derivados de indolinona utiles como inhibidores de la proteina cinasa
ES2196772T3 (es) Compuestos amino ciclicos.
CO4970713A1 (es) Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
TW336932B (en) Amino-substituted pyrazoles
HUP0301607A2 (hu) Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AR012032A1 (es) Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion
DK1260512T3 (da) Hidtil ukendte, cykliske amidderivater
AR001787A1 (es) Un compuesto oxazolidin sustituido particularmenteutil como inhibidor de calpaina y/o catepsina b e n el tratamiento de trastornos neurodegenerativos agudos o cronicos y composiciones farmacéuticas que incluyen dicho compuesto
CO5271680A1 (es) Compuestos
HRP20100283T8 (en) Derivatives of n-' (1,5-diphenyl-1h-pyrazol-3-yl) sulphonamide with cb1 receptor affinity
AR026505A1 (es) Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno
HRP20050390A2 (en) Substituted benzoxazinones and uses thereof
TW328089B (en) New azolidinediones as antihyperglycemic agents
CO5031246A1 (es) Compuestos calciliticos
PE20001063A1 (es) Nuevos agentes antibacterianos de isoxazolinona
EA200300927A1 (ru) Новый способ промышленного синтеза тетрасложных эфиров 5-[бис(карбоксиметил)амино]-3-карбоксиметил-4-циано-2-тиофенкарбоновой кислоты и применение для синтеза бивалентных солей ранелиновой кислоты и их гидратов
CO5021223A1 (es) Compuestos calciliticos calciliticos
CO4990972A1 (es) Derivados de eritromicina en puente 6,11
DK0677042T3 (da) Selektive ligander af 5HT1D-5HT1B-receptorer, der er afledt af indolpiperazin og er nyttige som lægemidler
AR054414A1 (es) Compuestos espiro-hidantoina sustituidos con piridilo. composiciones farmaceuticas.
RS50289B (sr) Novi razgranati supstituisani amino derivati od 3-amino-1- fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže