PE20001063A1 - Nuevos agentes antibacterianos de isoxazolinona - Google Patents
Nuevos agentes antibacterianos de isoxazolinonaInfo
- Publication number
- PE20001063A1 PE20001063A1 PE1999000853A PE00085399A PE20001063A1 PE 20001063 A1 PE20001063 A1 PE 20001063A1 PE 1999000853 A PE1999000853 A PE 1999000853A PE 00085399 A PE00085399 A PE 00085399A PE 20001063 A1 PE20001063 A1 PE 20001063A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- formyl
- mercapto
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A ISOXAZOLINONAS DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C6, ALCOXI C1-C8; L ES O, S; A ES GRUPO a, b, HETEROCICLO DE 5 MIEMBROS CON S, N, O, HETEROCICLO DE 6 MIEMBROS CON N, ß-CARBONIL-3-ILO, INDOLIZINILO UNIDO AL ANILLO DE 6 MIEMBROS, GRUPO c, GRUPO d; R2 Y R3 SON H, F, Cl, Br, ALQUILO C1-C6, NO2, I, ALCOXI C1-C6, OH, AMINO, CIANO, R2 Y R3 SON O(CH2)h-O; R4 ES H, ALQUILO C1-C2, OH, R5 ES H, CF3, ALQUILO, FENILO, R5 Y R6 FORMAN UN ANILLO DE 5-7 MIEMBROS DE FORMULA e; O R5 Y R6 JUNTOS SON (CH2)k-; R6 Y R7 SON H, CF3, ALQUILO C1-C3, FENILO O FORMAN UN ANILLO DE 5-7 MIEMBROS DE FORMULA f; U ES CH2, O, S, NR16; R16 ES H, ALQUILO C1-C5; R8 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, -NR17R18, FENILO CON R19, ENTRE OTROS; R17 Y R18 SON H, ALQUILO C1-C4, CICLOALQUILO C5-C6; R19 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, NO2, -C(=O)NR20R21, -N(R20)(-SO2R22), ENTRE OTROS; R20 Y R21 SON H, ALQUILO C1-C6, FENILO; R22 ALQUILO C1-C4, FENILO; R9 ES CARBOXILO, HALO, CN, MERCAPTO, ALCOXI C1-C6, -NR23R24, ALQUENILFENILO C2-C8 CON R25, ENTRE OTROS; R23 Y R24 SON H, FORMILO, ALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R25 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, CF3, ENTRE OTROS. EL COMPUESTO I TIENE ACTIVIDAD ANTIBACTERIANA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9757498P | 1998-08-24 | 1998-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001063A1 true PE20001063A1 (es) | 2000-12-24 |
Family
ID=22264103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000853A PE20001063A1 (es) | 1998-08-24 | 1999-08-24 | Nuevos agentes antibacterianos de isoxazolinona |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1107756A4 (es) |
| JP (1) | JP2002523369A (es) |
| KR (1) | KR20010072945A (es) |
| CN (1) | CN1314813A (es) |
| AR (1) | AR020250A1 (es) |
| AU (1) | AU748750B2 (es) |
| BR (1) | BR9913225A (es) |
| CA (1) | CA2341271A1 (es) |
| CO (1) | CO5160266A1 (es) |
| CZ (1) | CZ2001669A3 (es) |
| HU (1) | HUP0103433A3 (es) |
| ID (1) | ID27690A (es) |
| IL (1) | IL141542A0 (es) |
| NO (1) | NO20010916L (es) |
| NZ (1) | NZ509867A (es) |
| PE (1) | PE20001063A1 (es) |
| PL (1) | PL346267A1 (es) |
| TR (1) | TR200100672T2 (es) |
| TW (1) | TW572757B (es) |
| UY (1) | UY25677A1 (es) |
| WO (1) | WO2000010566A1 (es) |
| ZA (1) | ZA200101505B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| JP2002020366A (ja) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | アルキルチオフェニル酢酸類の製造方法 |
| PE20020689A1 (es) | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| PE20030044A1 (es) * | 2000-11-17 | 2003-02-09 | Upjohn Co | Isoxazolinonas biciclicas de formula i |
| US6861433B2 (en) * | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| ATE319710T1 (de) | 2000-12-21 | 2006-03-15 | Pharmacia & Upjohn Co Llc | Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| JP2005512975A (ja) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | 抗菌薬として有用なイソキサゾリン誘導体 |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2003265090A1 (en) * | 2002-10-10 | 2004-05-04 | Pharmacia & Upjohn Comapny LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| MXPA05007724A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
| ES2308171T3 (es) | 2003-04-30 | 2008-12-01 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. |
| US20060270680A1 (en) * | 2003-06-03 | 2006-11-30 | Goldberg Joel A | Sulfonamide compounds and methods of making and using the same |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| AU2004267007C1 (en) | 2003-06-03 | 2010-04-29 | Melinta Subsidiary Corp. | Biaryl heterocyclic compounds and methods of making and using the same |
| WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| EP1713785A1 (en) | 2003-12-17 | 2006-10-25 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| PL1709044T5 (pl) | 2003-12-18 | 2014-03-31 | Morphochem Aktiengesellschaft Fuer Komb Chemie | Antybiotyki hybrydowe oksazolidynon-chinolon |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| KR101394307B1 (ko) | 2005-06-08 | 2014-05-13 | 멜린타 테라퓨틱스, 인크. | 트리아졸의 합성 방법 |
| AT503354B1 (de) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen |
| JP4518066B2 (ja) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | ジアルコキシニトリル誘導体及びその製法 |
| CN110423610B (zh) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | 一种检测双光子汞离子荧光探针及其制备方法与使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2045049A1 (de) * | 1970-09-11 | 1972-03-23 | Dr Karl Thomae GmbH, 7950 Biberach | Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| ATE161833T1 (de) * | 1992-12-08 | 1998-01-15 | Upjohn Co | Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel |
| JPH11511467A (ja) * | 1995-09-15 | 1999-10-05 | ファルマシア・アンド・アップジョン・カンパニー | ５−アミドメチルα，β−飽和および不飽和３−アリールブチロラクトン抗菌剤 |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| DE69716925T2 (de) * | 1996-08-21 | 2003-09-11 | Upjohn Co | Isoxazoline derivate und ihre verwendung als antimikroben |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/zh active
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/pt not_active IP Right Cessation
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/cs unknown
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/xx unknown
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/hu unknown
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-23 ID IDW20010439A patent/ID27690A/id unknown
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/ko not_active Application Discontinuation
- 1999-08-23 CO CO99053191A patent/CO5160266A1/es unknown
- 1999-08-23 PL PL99346267A patent/PL346267A1/xx not_active Application Discontinuation
- 1999-08-23 IL IL14154299A patent/IL141542A0/xx unknown
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/ja active Pending
- 1999-08-23 CN CN99809894A patent/CN1314813A/zh active Pending
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-24 AR ARP990104229A patent/AR020250A1/es not_active Application Discontinuation
- 1999-08-24 UY UY25677A patent/UY25677A1/es unknown
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/es not_active Application Discontinuation
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ID27690A (id) | 2001-04-19 |
| CA2341271A1 (en) | 2000-03-02 |
| TR200100672T2 (tr) | 2001-07-23 |
| CO5160266A1 (es) | 2002-05-30 |
| KR20010072945A (ko) | 2001-07-31 |
| AU748750B2 (en) | 2002-06-13 |
| AR020250A1 (es) | 2002-05-02 |
| CZ2001669A3 (cs) | 2001-08-15 |
| BR9913225A (pt) | 2001-05-22 |
| IL141542A0 (en) | 2002-03-10 |
| TW572757B (en) | 2004-01-21 |
| WO2000010566A1 (en) | 2000-03-02 |
| EP1107756A4 (en) | 2003-02-26 |
| NZ509867A (en) | 2003-08-29 |
| ZA200101505B (en) | 2002-02-22 |
| EP1107756A1 (en) | 2001-06-20 |
| JP2002523369A (ja) | 2002-07-30 |
| AU5783399A (en) | 2000-03-14 |
| CN1314813A (zh) | 2001-09-26 |
| UY25677A1 (es) | 2001-08-27 |
| NO20010916D0 (no) | 2001-02-23 |
| HUP0103433A2 (hu) | 2002-01-28 |
| PL346267A1 (en) | 2002-01-28 |
| NO20010916L (no) | 2001-04-10 |
| HUP0103433A3 (en) | 2002-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |