PE20001063A1 - NEW ANTIBACTERIAL AGENTS OF ISOXAZOLINONE - Google Patents
NEW ANTIBACTERIAL AGENTS OF ISOXAZOLINONEInfo
- Publication number
- PE20001063A1 PE20001063A1 PE1999000853A PE00085399A PE20001063A1 PE 20001063 A1 PE20001063 A1 PE 20001063A1 PE 1999000853 A PE1999000853 A PE 1999000853A PE 00085399 A PE00085399 A PE 00085399A PE 20001063 A1 PE20001063 A1 PE 20001063A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- formyl
- mercapto
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A ISOXAZOLINONAS DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C6, ALCOXI C1-C8; L ES O, S; A ES GRUPO a, b, HETEROCICLO DE 5 MIEMBROS CON S, N, O, HETEROCICLO DE 6 MIEMBROS CON N, ß-CARBONIL-3-ILO, INDOLIZINILO UNIDO AL ANILLO DE 6 MIEMBROS, GRUPO c, GRUPO d; R2 Y R3 SON H, F, Cl, Br, ALQUILO C1-C6, NO2, I, ALCOXI C1-C6, OH, AMINO, CIANO, R2 Y R3 SON O(CH2)h-O; R4 ES H, ALQUILO C1-C2, OH, R5 ES H, CF3, ALQUILO, FENILO, R5 Y R6 FORMAN UN ANILLO DE 5-7 MIEMBROS DE FORMULA e; O R5 Y R6 JUNTOS SON (CH2)k-; R6 Y R7 SON H, CF3, ALQUILO C1-C3, FENILO O FORMAN UN ANILLO DE 5-7 MIEMBROS DE FORMULA f; U ES CH2, O, S, NR16; R16 ES H, ALQUILO C1-C5; R8 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, -NR17R18, FENILO CON R19, ENTRE OTROS; R17 Y R18 SON H, ALQUILO C1-C4, CICLOALQUILO C5-C6; R19 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, NO2, -C(=O)NR20R21, -N(R20)(-SO2R22), ENTRE OTROS; R20 Y R21 SON H, ALQUILO C1-C6, FENILO; R22 ALQUILO C1-C4, FENILO; R9 ES CARBOXILO, HALO, CN, MERCAPTO, ALCOXI C1-C6, -NR23R24, ALQUENILFENILO C2-C8 CON R25, ENTRE OTROS; R23 Y R24 SON H, FORMILO, ALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R25 ES CARBOXILO, HALO, CN, MERCAPTO, FORMILO, CF3, ENTRE OTROS. EL COMPUESTO I TIENE ACTIVIDAD ANTIBACTERIANAREFERS TO ISOXAZOLINONES OF FORMULA I, WHERE R1 IS H, C1-C8 ALKYL, C3-C6 CYCLOALKYL, C1-C8 ALCOXY; L IS O, S; A IS GROUP a, b, 5-MEMBER HETEROCICLE WITH S, N, O, 6-MEMBER HETEROCICLE WITH N, ß-CARBONYL-3-ILO, INDOLIZINYL JOINTED TO THE 6-MEMBER RING, GROUP c, GROUP d; R2 AND R3 ARE H, F, Cl, Br, C1-C6 ALKYL, NO2, I, C1-C6 ALCOXY, OH, AMINO, CYANE, R2 AND R3 ARE O (CH2) h-O; R4 IS H, C1-C2 ALKYL, OH, R5 IS H, CF3, ALKYL, PHENYL, R5 AND R6 FORM A RING OF 5-7 MEMBERS OF FORMULA e; OR R5 AND R6 TOGETHER ARE (CH2) k-; R6 AND R7 ARE H, CF3, C1-C3 ALKYL, PHENYL OR FORM A RING OF 5-7 MEMBERS OF FORMULA f; U IS CH2, O, S, NR16; R16 IS H, C1-C5 ALKYL; R8 IS CARBOXYL, HALO, CN, MERCAPTO, FORMYL, -NR17R18, PHENYL WITH R19, AMONG OTHERS; R17 AND R18 ARE H, C1-C4 ALKYL, C5-C6 CYCLOALKYL; R19 IS CARBOXYL, HALO, CN, MERCAPTO, FORMYL, NO2, -C (= O) NR20R21, -N (R20) (- SO2R22), AMONG OTHERS; R20 AND R21 ARE H, C1-C6 ALKYL, PHENYL; R22 C1-C4 ALKYL, PHENYL; R9 IS CARBOXYL, HALO, CN, MERCAPTO, C1-C6 ALCOXY, -NR23R24, C2-C8 ALKENYLPHENYL WITH R25, AMONG OTHERS; R23 AND R24 ARE H, FORMYL, C1-C4 ALKYL, C3-C6 CYCLOALKYL, AMONG OTHERS; R25 IS CARBOXYL, HALO, CN, MERCAPTO, FORMYL, CF3, AMONG OTHERS. COMPOUND I HAS ANTIBACTERIAL ACTIVITY
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9757498P | 1998-08-24 | 1998-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001063A1 true PE20001063A1 (en) | 2000-12-24 |
Family
ID=22264103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000853A PE20001063A1 (en) | 1998-08-24 | 1999-08-24 | NEW ANTIBACTERIAL AGENTS OF ISOXAZOLINONE |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1107756A4 (en) |
| JP (1) | JP2002523369A (en) |
| KR (1) | KR20010072945A (en) |
| CN (1) | CN1314813A (en) |
| AR (1) | AR020250A1 (en) |
| AU (1) | AU748750B2 (en) |
| BR (1) | BR9913225A (en) |
| CA (1) | CA2341271A1 (en) |
| CO (1) | CO5160266A1 (en) |
| CZ (1) | CZ2001669A3 (en) |
| HU (1) | HUP0103433A3 (en) |
| ID (1) | ID27690A (en) |
| IL (1) | IL141542A0 (en) |
| NO (1) | NO20010916L (en) |
| NZ (1) | NZ509867A (en) |
| PE (1) | PE20001063A1 (en) |
| PL (1) | PL346267A1 (en) |
| TR (1) | TR200100672T2 (en) |
| TW (1) | TW572757B (en) |
| UY (1) | UY25677A1 (en) |
| WO (1) | WO2000010566A1 (en) |
| ZA (1) | ZA200101505B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
| PE20020689A1 (en) | 2000-11-17 | 2002-08-03 | Upjohn Co | OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE |
| PE20030044A1 (en) * | 2000-11-17 | 2003-02-09 | Upjohn Co | BICYCLE ISOXAZOLINONES OF FORMULA I |
| US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| WO2002059116A2 (en) | 2000-12-21 | 2002-08-01 | Pharmacia & Upjohn Company | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
| ES2180456B1 (en) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | SUBSTITUTED ISOXAZOLS AND ITS USE AS ANTIBIOTICS. |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| US7022705B2 (en) | 2001-10-25 | 2006-04-04 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2003265090A1 (en) | 2002-10-10 | 2004-05-04 | Pharmacia & Upjohn Comapny LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| EP1594865A2 (en) * | 2003-02-07 | 2005-11-16 | Warner-Lambert Company LLC | Antibacterial agents |
| WO2004096221A1 (en) | 2003-04-30 | 2004-11-11 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| EP1646617A2 (en) * | 2003-06-03 | 2006-04-19 | Rib-X Pharmaceuticals, Inc. | Sulfonamide compounds and methods of making and using the same |
| PT1656370E (en) | 2003-06-03 | 2012-11-29 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
| US20070197541A1 (en) * | 2003-07-29 | 2007-08-23 | Oyelere Adegboyega K | Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same |
| DE10340485B4 (en) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Process for the preparation of oxazolidinone-quinolone hybrids |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| TW200526649A (en) | 2003-12-17 | 2005-08-16 | Rib X Pharmaceuticals Inc | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP1709044B2 (en) | 2003-12-18 | 2013-11-20 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| ATE496914T1 (en) | 2005-06-08 | 2011-02-15 | Rib X Pharmaceuticals Inc | METHOD FOR SYNTHESIS OF TRIAZOLES |
| AT503354B1 (en) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | METHOD FOR THE PRODUCTION OF 3,4-DISUBSTITUTED PHENYL ACETIC ACIDS, AND NEW INTERMEDIATE COMPOUNDS |
| JP4518066B2 (en) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | Dialkoxynitrile derivative and process for producing the same |
| CN110423610B (en) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | Fluorescent probe for detecting two-photon mercury ions and preparation method and use method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2045049A1 (en) * | 1970-09-11 | 1972-03-23 | Dr Karl Thomae GmbH, 7950 Biberach | New Nitrofurandenvate and processes for their production |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| ATE161833T1 (en) * | 1992-12-08 | 1998-01-15 | Upjohn Co | PHENYLOXAZOLIDINONE DERIVATIVES SUBSTITUTED BY A TROPONE GROUP AS AN ANTIBACTERIAL AGENT |
| DK0863890T3 (en) * | 1995-09-15 | 2003-03-24 | Upjohn Co | 5-amidomethyl alfa, beta-saturated and unsaturated 3-aryl-butyrolacetone antibacterial agents |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| DE69716925T2 (en) * | 1996-08-21 | 2003-09-11 | Pharmacia & Upjohn Co., Kalamazoo | ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTIMICROBE |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/en active
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/en not_active Application Discontinuation
- 1999-08-23 ID IDW20010439A patent/ID27690A/en unknown
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/en unknown
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/en unknown
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/en not_active IP Right Cessation
- 1999-08-23 CO CO99053191A patent/CO5160266A1/en unknown
- 1999-08-23 CN CN99809894A patent/CN1314813A/en active Pending
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/en unknown
- 1999-08-23 PL PL99346267A patent/PL346267A1/en not_active Application Discontinuation
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/en active Pending
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-23 IL IL14154299A patent/IL141542A0/en unknown
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/en not_active Application Discontinuation
- 1999-08-24 UY UY25677A patent/UY25677A1/en unknown
- 1999-08-24 AR ARP990104229A patent/AR020250A1/en not_active Application Discontinuation
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR020250A1 (en) | 2002-05-02 |
| CZ2001669A3 (en) | 2001-08-15 |
| BR9913225A (en) | 2001-05-22 |
| EP1107756A4 (en) | 2003-02-26 |
| NZ509867A (en) | 2003-08-29 |
| EP1107756A1 (en) | 2001-06-20 |
| CA2341271A1 (en) | 2000-03-02 |
| AU748750B2 (en) | 2002-06-13 |
| NO20010916L (en) | 2001-04-10 |
| CO5160266A1 (en) | 2002-05-30 |
| UY25677A1 (en) | 2001-08-27 |
| HUP0103433A3 (en) | 2002-08-28 |
| ZA200101505B (en) | 2002-02-22 |
| HUP0103433A2 (en) | 2002-01-28 |
| PL346267A1 (en) | 2002-01-28 |
| TR200100672T2 (en) | 2001-07-23 |
| KR20010072945A (en) | 2001-07-31 |
| TW572757B (en) | 2004-01-21 |
| NO20010916D0 (en) | 2001-02-23 |
| WO2000010566A1 (en) | 2000-03-02 |
| JP2002523369A (en) | 2002-07-30 |
| AU5783399A (en) | 2000-03-14 |
| ID27690A (en) | 2001-04-19 |
| CN1314813A (en) | 2001-09-26 |
| IL141542A0 (en) | 2002-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20001063A1 (en) | NEW ANTIBACTERIAL AGENTS OF ISOXAZOLINONE | |
| TW336932B (en) | Amino-substituted pyrazoles | |
| TW328089B (en) | New azolidinediones as antihyperglycemic agents | |
| ID21568A (en) | NEW USE FOR DOWN-1,3-PROPANADIOL | |
| HUP0104452A2 (en) | Medicinal compositions, containing tricyclo compounds | |
| ES2121183T3 (en) | SELECTIVE LINKS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOL-PIPERACINE USEFUL AS MEDICINES. | |
| PE10597A1 (en) | 2- (2-N-ALCOXIFENIL) -PURIN-6-ONAS 9 SUBSTITUTED | |
| SE8006365L (en) | CYKLOHEXANKARBOXYLSYRADERIVAT | |
| DE3879258D1 (en) | PREPARATION AGAINST ULCUS. | |
| FI942294A (en) | Benzopyran derivatives and their use | |
| DK0841327T3 (en) | Triazolant antifungal agent | |
| ID25477A (en) | SPIROPIPERIDINS | |
| PE20001052A1 (en) | HIV PROTEASE INHIBITORS | |
| KR900700470A (en) | Β-carbonyl-carboxyamide of 1, 3-thiazoladine | |
| PE51499A1 (en) | DERIVATIVES OF 5-AROILNAFTALENO | |
| SE8406338D0 (en) | 4,5,6,7-tetrahydrothiazolo / 5,4-c / -pyridine | |
| ES466363A1 (en) | N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative | |
| SE8504346L (en) | N-ALKYL (S) -N- (O, O-DISUBSTITUTED THIOPHOSPHORIAL) -N ', N'-DISUBSTITUTED GLYCINAMIDES, SET TO PREPARE THESE AND ACARICID, INSECTICID AND FUNGICIDE, INCLUDING ITS COMPOSITION OF ITS COMPOSITION | |
| ES2186628T3 (en) | BICYCLE HETEROARILHYDROXAMIC ACIDS WITH ORTO-SULPHONAMIDES AND AMIDAS OF THE ACETYLENE PHOSPHINIC ACID AS INHIBITORS OF "TACE". | |
| KR960703119A (en) | Novel intermediate for synthetic use and process for producing amino-piperazine derivative | |
| DE69004596D1 (en) | Benzodiazepine analogs. | |
| PT75495A (en) | NEW 6-ALPHA-METHOXY-PENICILLINE THEIR SALTS METHOD FOR THE PRODUCTION THEREOF AND THE COMPOSITIONS CONTAINING THESE COMPOUNDS | |
| ES2097319T3 (en) | DERIVATIVES OF ISOXAZOL AS AGENTS PROTECTING LIGHT. | |
| PT77928A (en) | NEW HETEROCYCLIC COMPOUNDS OF THEIR PREPARATION AND USE | |
| ES529415A0 (en) | PROCEDURE FOR THE PREPARATION OF PIRIDIN-PIRIMIDINONE DERIVATIVES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |