BR9913225A - New isoxazolinone antibacterial agents - Google Patents
New isoxazolinone antibacterial agentsInfo
- Publication number
- BR9913225A BR9913225A BR9913225-7A BR9913225A BR9913225A BR 9913225 A BR9913225 A BR 9913225A BR 9913225 A BR9913225 A BR 9913225A BR 9913225 A BR9913225 A BR 9913225A
- Authority
- BR
- Brazil
- Prior art keywords
- new
- antibacterial agents
- isoxazolinone
- isoxazolinone antibacterial
- isoxazolinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"NOVOS AGENTES ANTIBACTERIANOS DE ISOXAZOLINONA" Esta invenção descreve derivados de isoxazolinona, que possuem atividade antibacteriana e são úteis no tratamento de doenças bacterianas. Mais particularmente, são proporcionadas novas isoxazolinonas tendo a fórmula geral na qual A e R~ 1~ são como descritos no relatório descritivo."NEW ISOXAZOLINONE ANTIBACTERIAL AGENTS" This invention describes isoxazolinone derivatives, which have antibacterial activity and are useful in the treatment of bacterial diseases. More particularly, new isoxazolinones are provided having the general formula in which A and R ~ 1 ~ are as described in the specification.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9757498P | 1998-08-24 | 1998-08-24 | |
PCT/US1999/019265 WO2000010566A1 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9913225A true BR9913225A (en) | 2001-05-22 |
Family
ID=22264103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9913225-7A BR9913225A (en) | 1998-08-24 | 1999-08-23 | New isoxazolinone antibacterial agents |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1107756A4 (en) |
JP (1) | JP2002523369A (en) |
KR (1) | KR20010072945A (en) |
CN (1) | CN1314813A (en) |
AR (1) | AR020250A1 (en) |
AU (1) | AU748750B2 (en) |
BR (1) | BR9913225A (en) |
CA (1) | CA2341271A1 (en) |
CO (1) | CO5160266A1 (en) |
CZ (1) | CZ2001669A3 (en) |
HU (1) | HUP0103433A3 (en) |
ID (1) | ID27690A (en) |
IL (1) | IL141542A0 (en) |
NO (1) | NO20010916L (en) |
NZ (1) | NZ509867A (en) |
PE (1) | PE20001063A1 (en) |
PL (1) | PL346267A1 (en) |
TR (1) | TR200100672T2 (en) |
TW (1) | TW572757B (en) |
UY (1) | UY25677A1 (en) |
WO (1) | WO2000010566A1 (en) |
ZA (1) | ZA200101505B (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
PE20030044A1 (en) | 2000-11-17 | 2003-02-09 | Upjohn Co | BICYCLE ISOXAZOLINONES OF FORMULA I |
PE20020689A1 (en) | 2000-11-17 | 2002-08-03 | Upjohn Co | OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE |
US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
CA2424402A1 (en) | 2000-12-21 | 2002-08-01 | Pharmacia & Upjohn Company | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
ES2180456B1 (en) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | SUBSTITUTED ISOXAZOLS AND ITS USE AS ANTIBIOTICS. |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
JP2005512975A (en) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | Isoxazoline derivatives useful as antibacterial agents |
US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
MXPA05003774A (en) * | 2002-10-10 | 2005-06-08 | Pharmacia & Upjohn Co Llc | Antimicrobial 1-aryl dihydropyridone compounds. |
WO2004069832A2 (en) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Antibacterial agents |
RU2351335C2 (en) | 2003-04-30 | 2009-04-10 | Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми | Application of oxozalidinon-chynolyn hybrid antibiotics for treatment of anthrax and other infections |
AR045690A1 (en) | 2003-06-03 | 2005-11-09 | Rib X Pharmaceuticals Inc | HETEROCICLIC BIARIL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME |
WO2005070904A2 (en) * | 2003-06-03 | 2005-08-04 | Rib-X Pharmaceutical, Inc. | Sulfonamide compounds and methods of making and using the same |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
DE10340485B4 (en) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Process for the preparation of oxazolidinone-quinolone hybrids |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
JP2007514782A (en) | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | Halogenated biaryl heterocyclic compounds and methods for making and using the same |
ES2310299T5 (en) | 2003-12-18 | 2014-02-10 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Oxazolidinone-quinolone-based hybrid antibiotics |
US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
WO2006133397A2 (en) | 2005-06-08 | 2006-12-14 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
AT503354B1 (en) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | METHOD FOR THE PRODUCTION OF 3,4-DISUBSTITUTED PHENYL ACETIC ACIDS, AND NEW INTERMEDIATE COMPOUNDS |
JP4518066B2 (en) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | Dialkoxynitrile derivative and process for producing the same |
CN110423610B (en) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | Fluorescent probe for detecting two-photon mercury ions and preparation method and use method thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2045049A1 (en) * | 1970-09-11 | 1972-03-23 | Dr Karl Thomae GmbH, 7950 Biberach | New Nitrofurandenvate and processes for their production |
US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
ATE161833T1 (en) * | 1992-12-08 | 1998-01-15 | Upjohn Co | PHENYLOXAZOLIDINONE DERIVATIVES SUBSTITUTED BY A TROPONE GROUP AS AN ANTIBACTERIAL AGENT |
US5708169A (en) * | 1995-09-15 | 1998-01-13 | Pharmacia & Upjohn Company | 5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents |
GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
PT920421E (en) * | 1996-08-21 | 2003-03-31 | Upjohn Co | UTEIS ISOXAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/en active
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/en not_active Application Discontinuation
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/en unknown
- 1999-08-23 ID IDW20010439A patent/ID27690A/en unknown
- 1999-08-23 CN CN99809894A patent/CN1314813A/en active Pending
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 PL PL99346267A patent/PL346267A1/en not_active Application Discontinuation
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/en not_active IP Right Cessation
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/en unknown
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/en unknown
- 1999-08-23 IL IL14154299A patent/IL141542A0/en unknown
- 1999-08-23 CO CO99053191A patent/CO5160266A1/en unknown
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/en active Pending
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/en not_active Application Discontinuation
- 1999-08-24 AR ARP990104229A patent/AR020250A1/en not_active Application Discontinuation
- 1999-08-24 UY UY25677A patent/UY25677A1/en unknown
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO5160266A1 (en) | 2002-05-30 |
AU748750B2 (en) | 2002-06-13 |
CZ2001669A3 (en) | 2001-08-15 |
KR20010072945A (en) | 2001-07-31 |
EP1107756A4 (en) | 2003-02-26 |
AU5783399A (en) | 2000-03-14 |
NO20010916D0 (en) | 2001-02-23 |
NZ509867A (en) | 2003-08-29 |
JP2002523369A (en) | 2002-07-30 |
HUP0103433A2 (en) | 2002-01-28 |
WO2000010566A1 (en) | 2000-03-02 |
ZA200101505B (en) | 2002-02-22 |
PL346267A1 (en) | 2002-01-28 |
UY25677A1 (en) | 2001-08-27 |
CN1314813A (en) | 2001-09-26 |
CA2341271A1 (en) | 2000-03-02 |
EP1107756A1 (en) | 2001-06-20 |
AR020250A1 (en) | 2002-05-02 |
HUP0103433A3 (en) | 2002-08-28 |
TR200100672T2 (en) | 2001-07-23 |
IL141542A0 (en) | 2002-03-10 |
ID27690A (en) | 2001-04-19 |
TW572757B (en) | 2004-01-21 |
NO20010916L (en) | 2001-04-10 |
PE20001063A1 (en) | 2000-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1919 DE 16/10/2007. |