EP1107756A4 - Novel isoxazolinone antibacterial agents - Google Patents
Novel isoxazolinone antibacterial agentsInfo
- Publication number
- EP1107756A4 EP1107756A4 EP99945157A EP99945157A EP1107756A4 EP 1107756 A4 EP1107756 A4 EP 1107756A4 EP 99945157 A EP99945157 A EP 99945157A EP 99945157 A EP99945157 A EP 99945157A EP 1107756 A4 EP1107756 A4 EP 1107756A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibacterial agents
- novel
- isoxazolinone antibacterial
- novel isoxazolinone
- isoxazolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9757498P | 1998-08-24 | 1998-08-24 | |
| US97574P | 1998-08-24 | ||
| PCT/US1999/019265 WO2000010566A1 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1107756A1 EP1107756A1 (en) | 2001-06-20 |
| EP1107756A4 true EP1107756A4 (en) | 2003-02-26 |
Family
ID=22264103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99945157A Withdrawn EP1107756A4 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1107756A4 (en) |
| JP (1) | JP2002523369A (en) |
| KR (1) | KR20010072945A (en) |
| CN (1) | CN1314813A (en) |
| AR (1) | AR020250A1 (en) |
| AU (1) | AU748750B2 (en) |
| BR (1) | BR9913225A (en) |
| CA (1) | CA2341271A1 (en) |
| CO (1) | CO5160266A1 (en) |
| CZ (1) | CZ2001669A3 (en) |
| HU (1) | HUP0103433A3 (en) |
| ID (1) | ID27690A (en) |
| IL (1) | IL141542A0 (en) |
| NO (1) | NO20010916L (en) |
| NZ (1) | NZ509867A (en) |
| PE (1) | PE20001063A1 (en) |
| PL (1) | PL346267A1 (en) |
| TR (1) | TR200100672T2 (en) |
| TW (1) | TW572757B (en) |
| UY (1) | UY25677A1 (en) |
| WO (1) | WO2000010566A1 (en) |
| ZA (1) | ZA200101505B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
| PE20020689A1 (en) | 2000-11-17 | 2002-08-03 | Upjohn Co | OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE |
| PE20030044A1 (en) * | 2000-11-17 | 2003-02-09 | Upjohn Co | BICYCLE ISOXAZOLINONES OF FORMULA I |
| US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| CA2424402A1 (en) | 2000-12-21 | 2002-08-01 | Pharmacia & Upjohn Company | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
| ES2180456B1 (en) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | SUBSTITUTED ISOXAZOLS AND ITS USE AS ANTIBIOTICS. |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| US7105547B2 (en) | 2002-10-10 | 2006-09-12 | Pharmacia And Upjohn Company | Antimicrobial 1-aryl dihydropyridone compounds |
| EP1594865A2 (en) * | 2003-02-07 | 2005-11-16 | Warner-Lambert Company LLC | Antibacterial agents |
| JP4805139B2 (en) | 2003-04-30 | 2011-11-02 | モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー | Use of oxazolidinone-quinoline hybrid antibiotics to treat anthrax and other infections |
| EP2492264A3 (en) | 2003-06-03 | 2012-12-19 | Rib-X Pharmaceuticals, Inc. | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| CN100457742C (en) * | 2003-06-03 | 2009-02-04 | 瑞伯-X医药品有限公司 | Biaryl heterocyclic compounds and methods of making and using the same |
| WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
| DE10340485B4 (en) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Process for the preparation of oxazolidinone-quinolone hybrids |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| EP1713785A1 (en) | 2003-12-17 | 2006-10-25 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| PT1709044E (en) | 2003-12-18 | 2008-10-27 | Morphochem Aktiengese Fur Komb | Oxazolidinone-quinolone hybrid antibiotics |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| WO2006133397A2 (en) | 2005-06-08 | 2006-12-14 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| AT503354B1 (en) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | METHOD FOR THE PRODUCTION OF 3,4-DISUBSTITUTED PHENYL ACETIC ACIDS, AND NEW INTERMEDIATE COMPOUNDS |
| JP4518066B2 (en) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | Dialkoxynitrile derivative and process for producing the same |
| CN110423610B (en) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | Fluorescent probe for detecting two-photon mercury ions and preparation method and use method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717629A (en) * | 1970-09-11 | 1973-02-20 | Boehringer Sohn Ingelheim | Nitrofuran derivatives |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| WO1997010235A1 (en) * | 1995-09-15 | 1997-03-20 | Pharmacia & Upjohn Company | 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS |
| WO1997014690A1 (en) * | 1995-10-20 | 1997-04-24 | Zeneca Limited | 5-(acetamidomethyl)-3-aryldihydrofuran-2-one and tetrahydrofuran-2-one derivatives with antibiotic activity |
| WO1998007708A1 (en) * | 1996-08-21 | 1998-02-26 | Pharmacia & Upjohn Company | Isoxazoline derivatives useful as antimicrobials |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69316240T2 (en) * | 1992-12-08 | 1998-05-20 | Upjohn Co | PHENYLOXAZOLIDINONE DERIVATIVES SUBSTITUTED BY A TROPON GROUP AS AN ANTIBACTERIAL AGENT |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/en active
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/en unknown
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/en not_active Application Discontinuation
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/en unknown
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/en unknown
- 1999-08-23 IL IL14154299A patent/IL141542A0/en unknown
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/en active Pending
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 ID IDW20010439A patent/ID27690A/en unknown
- 1999-08-23 CN CN99809894A patent/CN1314813A/en active Pending
- 1999-08-23 CO CO99053191A patent/CO5160266A1/en unknown
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/en not_active IP Right Cessation
- 1999-08-23 PL PL99346267A patent/PL346267A1/en not_active Application Discontinuation
- 1999-08-24 AR ARP990104229A patent/AR020250A1/en not_active Application Discontinuation
- 1999-08-24 UY UY25677A patent/UY25677A1/en unknown
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/en not_active Application Discontinuation
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/en not_active Application Discontinuation
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717629A (en) * | 1970-09-11 | 1973-02-20 | Boehringer Sohn Ingelheim | Nitrofuran derivatives |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| WO1997010235A1 (en) * | 1995-09-15 | 1997-03-20 | Pharmacia & Upjohn Company | 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS |
| US5708169A (en) * | 1995-09-15 | 1998-01-13 | Pharmacia & Upjohn Company | 5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents |
| WO1997014690A1 (en) * | 1995-10-20 | 1997-04-24 | Zeneca Limited | 5-(acetamidomethyl)-3-aryldihydrofuran-2-one and tetrahydrofuran-2-one derivatives with antibiotic activity |
| WO1998007708A1 (en) * | 1996-08-21 | 1998-02-26 | Pharmacia & Upjohn Company | Isoxazoline derivatives useful as antimicrobials |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO0010566A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20010916L (en) | 2001-04-10 |
| AU748750B2 (en) | 2002-06-13 |
| CN1314813A (en) | 2001-09-26 |
| PE20001063A1 (en) | 2000-12-24 |
| HUP0103433A3 (en) | 2002-08-28 |
| CO5160266A1 (en) | 2002-05-30 |
| ID27690A (en) | 2001-04-19 |
| ZA200101505B (en) | 2002-02-22 |
| UY25677A1 (en) | 2001-08-27 |
| KR20010072945A (en) | 2001-07-31 |
| JP2002523369A (en) | 2002-07-30 |
| AR020250A1 (en) | 2002-05-02 |
| PL346267A1 (en) | 2002-01-28 |
| HUP0103433A2 (en) | 2002-01-28 |
| CA2341271A1 (en) | 2000-03-02 |
| AU5783399A (en) | 2000-03-14 |
| NZ509867A (en) | 2003-08-29 |
| TR200100672T2 (en) | 2001-07-23 |
| WO2000010566A1 (en) | 2000-03-02 |
| EP1107756A1 (en) | 2001-06-20 |
| IL141542A0 (en) | 2002-03-10 |
| TW572757B (en) | 2004-01-21 |
| BR9913225A (en) | 2001-05-22 |
| CZ2001669A3 (en) | 2001-08-15 |
| NO20010916D0 (en) | 2001-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20010320 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20030115 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 31/42 B Ipc: 7C 07D 413/12 B Ipc: 7C 07D 413/10 B Ipc: 7C 07D 261/12 A |
|
| 17Q | First examination report despatched |
Effective date: 20040713 |
|
| RTI1 | Title (correction) |
Free format text: ISOXAZOLINONE ANTIBACTERIAL AGENTS |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20051103 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1035674 Country of ref document: HK |