EP1107756A4 - NEW ANTIBACTERIAL ISOXAZOLINONE - Google Patents

NEW ANTIBACTERIAL ISOXAZOLINONE

Info

Publication number
EP1107756A4
EP1107756A4 EP99945157A EP99945157A EP1107756A4 EP 1107756 A4 EP1107756 A4 EP 1107756A4 EP 99945157 A EP99945157 A EP 99945157A EP 99945157 A EP99945157 A EP 99945157A EP 1107756 A4 EP1107756 A4 EP 1107756A4
Authority
EP
European Patent Office
Prior art keywords
antibacterial agents
novel
isoxazolinone antibacterial
novel isoxazolinone
isoxazolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99945157A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1107756A1 (en
Inventor
Lawrence B Snyder
Zhizhen Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1107756A1 publication Critical patent/EP1107756A1/en
Publication of EP1107756A4 publication Critical patent/EP1107756A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP99945157A 1998-08-24 1999-08-23 NEW ANTIBACTERIAL ISOXAZOLINONE Withdrawn EP1107756A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9757498P 1998-08-24 1998-08-24
US97574P 1998-08-24
PCT/US1999/019265 WO2000010566A1 (en) 1998-08-24 1999-08-23 Novel isoxazolinone antibacterial agents

Publications (2)

Publication Number Publication Date
EP1107756A1 EP1107756A1 (en) 2001-06-20
EP1107756A4 true EP1107756A4 (en) 2003-02-26

Family

ID=22264103

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99945157A Withdrawn EP1107756A4 (en) 1998-08-24 1999-08-23 NEW ANTIBACTERIAL ISOXAZOLINONE

Country Status (22)

Country Link
EP (1) EP1107756A4 (es)
JP (1) JP2002523369A (es)
KR (1) KR20010072945A (es)
CN (1) CN1314813A (es)
AR (1) AR020250A1 (es)
AU (1) AU748750B2 (es)
BR (1) BR9913225A (es)
CA (1) CA2341271A1 (es)
CO (1) CO5160266A1 (es)
CZ (1) CZ2001669A3 (es)
HU (1) HUP0103433A3 (es)
ID (1) ID27690A (es)
IL (1) IL141542A0 (es)
NO (1) NO20010916L (es)
NZ (1) NZ509867A (es)
PE (1) PE20001063A1 (es)
PL (1) PL346267A1 (es)
TR (1) TR200100672T2 (es)
TW (1) TW572757B (es)
UY (1) UY25677A1 (es)
WO (1) WO2000010566A1 (es)
ZA (1) ZA200101505B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2002020366A (ja) * 2000-07-05 2002-01-23 Sumitomo Seika Chem Co Ltd アルキルチオフェニル酢酸類の製造方法
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
PE20030044A1 (es) * 2000-11-17 2003-02-09 Upjohn Co Isoxazolinonas biciclicas de formula i
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
WO2002059116A2 (en) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
AU2003265090A1 (en) 2002-10-10 2004-05-04 Pharmacia & Upjohn Comapny LLC Antimicrobial 1-aryl dihydropyridone compounds
EP1594865A2 (en) * 2003-02-07 2005-11-16 Warner-Lambert Company LLC Antibacterial agents
WO2004096221A1 (en) 2003-04-30 2004-11-11 Morphochem Aktiengesellschaft für kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1646617A2 (en) * 2003-06-03 2006-04-19 Rib-X Pharmaceuticals, Inc. Sulfonamide compounds and methods of making and using the same
PT1656370E (pt) 2003-06-03 2012-11-29 Rib X Pharmaceuticals Inc Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar
US20070197541A1 (en) * 2003-07-29 2007-08-23 Oyelere Adegboyega K Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1709044B2 (en) 2003-12-18 2013-11-20 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
ATE496914T1 (de) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
AT503354B1 (de) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
JP4518066B2 (ja) * 2006-10-25 2010-08-04 宇部興産株式会社 ジアルコキシニトリル誘導体及びその製法
CN110423610B (zh) * 2019-08-29 2023-05-12 浙江理工大学 一种检测双光子汞离子荧光探针及其制备方法与使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717629A (en) * 1970-09-11 1973-02-20 Boehringer Sohn Ingelheim Nitrofuran derivatives
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
WO1997010235A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS
WO1997014690A1 (en) * 1995-10-20 1997-04-24 Zeneca Limited 5-(acetamidomethyl)-3-aryldihydrofuran-2-one and tetrahydrofuran-2-one derivatives with antibiotic activity
WO1998007708A1 (en) * 1996-08-21 1998-02-26 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE161833T1 (de) * 1992-12-08 1998-01-15 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717629A (en) * 1970-09-11 1973-02-20 Boehringer Sohn Ingelheim Nitrofuran derivatives
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
WO1997010235A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS
US5708169A (en) * 1995-09-15 1998-01-13 Pharmacia & Upjohn Company 5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents
WO1997014690A1 (en) * 1995-10-20 1997-04-24 Zeneca Limited 5-(acetamidomethyl)-3-aryldihydrofuran-2-one and tetrahydrofuran-2-one derivatives with antibiotic activity
WO1998007708A1 (en) * 1996-08-21 1998-02-26 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0010566A1 *

Also Published As

Publication number Publication date
AR020250A1 (es) 2002-05-02
CZ2001669A3 (cs) 2001-08-15
BR9913225A (pt) 2001-05-22
NZ509867A (en) 2003-08-29
EP1107756A1 (en) 2001-06-20
CA2341271A1 (en) 2000-03-02
AU748750B2 (en) 2002-06-13
NO20010916L (no) 2001-04-10
CO5160266A1 (es) 2002-05-30
UY25677A1 (es) 2001-08-27
HUP0103433A3 (en) 2002-08-28
ZA200101505B (en) 2002-02-22
PE20001063A1 (es) 2000-12-24
HUP0103433A2 (hu) 2002-01-28
PL346267A1 (en) 2002-01-28
TR200100672T2 (tr) 2001-07-23
KR20010072945A (ko) 2001-07-31
TW572757B (en) 2004-01-21
NO20010916D0 (no) 2001-02-23
WO2000010566A1 (en) 2000-03-02
JP2002523369A (ja) 2002-07-30
AU5783399A (en) 2000-03-14
ID27690A (id) 2001-04-19
CN1314813A (zh) 2001-09-26
IL141542A0 (en) 2002-03-10

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Legal Events

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