CO5160266A1 - Nuevos agentes antibacterianos de isoxazolinona - Google Patents

Nuevos agentes antibacterianos de isoxazolinona

Info

Publication number
CO5160266A1
CO5160266A1 CO99053191A CO99053191A CO5160266A1 CO 5160266 A1 CO5160266 A1 CO 5160266A1 CO 99053191 A CO99053191 A CO 99053191A CO 99053191 A CO99053191 A CO 99053191A CO 5160266 A1 CO5160266 A1 CO 5160266A1
Authority
CO
Colombia
Prior art keywords
isoxazolinona
antibacterial agents
new antibacterial
new
isoxazolinones
Prior art date
Application number
CO99053191A
Other languages
English (en)
Inventor
Lawrence B Snyder
Zheng Zhizhen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO5160266A1 publication Critical patent/CO5160266A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención describe derivados de isoxazolina que poseen actividad antibacteriana y son útiles en el tratamiento de enfermedades bacterianas. En forma más particular, se proporcionan nuevas isoxazolinonas que tienen la fórmula general:<EMI FILE="99053191_1" ID="1" IMF=JPEG >en donde A y R1 son como se describen en la especificación.
CO99053191A 1998-08-24 1999-08-23 Nuevos agentes antibacterianos de isoxazolinona CO5160266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9757498P 1998-08-24 1998-08-24

Publications (1)

Publication Number Publication Date
CO5160266A1 true CO5160266A1 (es) 2002-05-30

Family

ID=22264103

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99053191A CO5160266A1 (es) 1998-08-24 1999-08-23 Nuevos agentes antibacterianos de isoxazolinona

Country Status (22)

Country Link
EP (1) EP1107756A4 (es)
JP (1) JP2002523369A (es)
KR (1) KR20010072945A (es)
CN (1) CN1314813A (es)
AR (1) AR020250A1 (es)
AU (1) AU748750B2 (es)
BR (1) BR9913225A (es)
CA (1) CA2341271A1 (es)
CO (1) CO5160266A1 (es)
CZ (1) CZ2001669A3 (es)
HU (1) HUP0103433A3 (es)
ID (1) ID27690A (es)
IL (1) IL141542A0 (es)
NO (1) NO20010916L (es)
NZ (1) NZ509867A (es)
PE (1) PE20001063A1 (es)
PL (1) PL346267A1 (es)
TR (1) TR200100672T2 (es)
TW (1) TW572757B (es)
UY (1) UY25677A1 (es)
WO (1) WO2000010566A1 (es)
ZA (1) ZA200101505B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2002020366A (ja) * 2000-07-05 2002-01-23 Sumitomo Seika Chem Co Ltd アルキルチオフェニル酢酸類の製造方法
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
PE20030044A1 (es) * 2000-11-17 2003-02-09 Upjohn Co Isoxazolinonas biciclicas de formula i
US6861433B2 (en) * 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
US7105547B2 (en) 2002-10-10 2006-09-12 Pharmacia And Upjohn Company Antimicrobial 1-aryl dihydropyridone compounds
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
CA2529347C (en) 2003-04-30 2011-09-06 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
AU2004267007C1 (en) 2003-06-03 2010-04-29 Melinta Subsidiary Corp. Biaryl heterocyclic compounds and methods of making and using the same
SI1656370T1 (sl) * 2003-06-03 2012-12-31 Rib-X Pharmaceuticals, Inc. Biarilne heterociklične spojine in postopki za njihovo izdelavo in uporabo
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US20070197541A1 (en) * 2003-07-29 2007-08-23 Oyelere Adegboyega K Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
AR046782A1 (es) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
WO2005058888A2 (en) 2003-12-18 2005-06-30 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
KR101394307B1 (ko) 2005-06-08 2014-05-13 멜린타 테라퓨틱스, 인크. 트리아졸의 합성 방법
AT503354B1 (de) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
JP4518066B2 (ja) * 2006-10-25 2010-08-04 宇部興産株式会社 ジアルコキシニトリル誘導体及びその製法
CN110423610B (zh) * 2019-08-29 2023-05-12 浙江理工大学 一种检测双光子汞离子荧光探针及其制备方法与使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045049A1 (de) * 1970-09-11 1972-03-23 Dr Karl Thomae GmbH, 7950 Biberach Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
RU2119484C1 (ru) * 1992-12-08 1998-09-27 Дзе Апджон Компани Тропонзамещенный фенилоксазолидинон или его фармацевтически приемлемые соли или гидраты
WO1997010235A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
EP0920421B1 (en) * 1996-08-21 2002-11-06 PHARMACIA &amp; UPJOHN COMPANY Isoxazoline derivatives useful as antimicrobials

Also Published As

Publication number Publication date
IL141542A0 (en) 2002-03-10
HUP0103433A3 (en) 2002-08-28
NO20010916D0 (no) 2001-02-23
TW572757B (en) 2004-01-21
UY25677A1 (es) 2001-08-27
NO20010916L (no) 2001-04-10
BR9913225A (pt) 2001-05-22
CZ2001669A3 (cs) 2001-08-15
AR020250A1 (es) 2002-05-02
AU748750B2 (en) 2002-06-13
WO2000010566A1 (en) 2000-03-02
ID27690A (id) 2001-04-19
CN1314813A (zh) 2001-09-26
KR20010072945A (ko) 2001-07-31
PE20001063A1 (es) 2000-12-24
CA2341271A1 (en) 2000-03-02
TR200100672T2 (tr) 2001-07-23
EP1107756A1 (en) 2001-06-20
JP2002523369A (ja) 2002-07-30
NZ509867A (en) 2003-08-29
AU5783399A (en) 2000-03-14
PL346267A1 (en) 2002-01-28
ZA200101505B (en) 2002-02-22
EP1107756A4 (en) 2003-02-26
HUP0103433A2 (hu) 2002-01-28

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