UY27451A1 - 2,5-diamidoindoles sustituidos y su utilización - Google Patents

2,5-diamidoindoles sustituidos y su utilización

Info

Publication number
UY27451A1
UY27451A1 UY27451A UY27451A UY27451A1 UY 27451 A1 UY27451 A1 UY 27451A1 UY 27451 A UY27451 A UY 27451A UY 27451 A UY27451 A UY 27451A UY 27451 A1 UY27451 A1 UY 27451A1
Authority
UY
Uruguay
Prior art keywords
diamidoindoles
replaced
men
animals
diseases
Prior art date
Application number
UY27451A
Other languages
English (en)
Inventor
Dr Keldenich
Dr Krahn
Dr Stasch
Dr Erguden
Dr Schroder
Dr Weigand
Dr Wild
Dr Brands
Dr Siegel
Dr Heimbach
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of UY27451A1 publication Critical patent/UY27451A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Se describen compuestos de fórmula (I) un procedimiento para su preparación así como su empleo medicamentos para el tratamiento de enfermedades de hombres y/o animales.
UY27451A 2001-09-27 2002-09-24 2,5-diamidoindoles sustituidos y su utilización UY27451A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10147672A DE10147672A1 (de) 2001-09-27 2001-09-27 Substituierte 2,5-Diamidoindole und ihre Verwendung

Publications (1)

Publication Number Publication Date
UY27451A1 true UY27451A1 (es) 2003-04-30

Family

ID=7700491

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27451A UY27451A1 (es) 2001-09-27 2002-09-24 2,5-diamidoindoles sustituidos y su utilización

Country Status (9)

Country Link
US (1) US7045544B2 (es)
EP (1) EP1432415B1 (es)
JP (1) JP2005508340A (es)
CA (1) CA2461919A1 (es)
DE (2) DE10147672A1 (es)
ES (1) ES2256530T3 (es)
PE (1) PE20030496A1 (es)
UY (1) UY27451A1 (es)
WO (1) WO2003028719A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
AU2003303217A1 (en) * 2002-12-20 2004-07-14 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
FR2888847B1 (fr) 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
FR2903985B1 (fr) * 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2910473B1 (fr) * 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
EP2078711A1 (en) * 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
CN102137858B (zh) 2008-05-23 2014-07-23 潘米拉制药有限责任公司 5-脂氧合酶-活化蛋白抑制剂
CN112996529A (zh) * 2018-10-02 2021-06-18 迪斯克医药公司 Matriptase 2抑制剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69231123T2 (de) * 1992-03-25 2001-02-15 Immunogen Inc Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
CA2290789A1 (en) * 1997-05-22 1998-11-26 Dale L. Boger Analogs of duocarmycin and cc-1065
SI1042287T1 (en) * 1997-12-24 2005-10-31 Aventis Pharma Deutschland Gmbh Indole derivatives as inhibitors of factor xa

Also Published As

Publication number Publication date
ES2256530T3 (es) 2006-07-16
CA2461919A1 (en) 2003-04-10
US20050038101A1 (en) 2005-02-17
EP1432415A1 (de) 2004-06-30
PE20030496A1 (es) 2003-07-13
EP1432415B1 (de) 2005-12-28
WO2003028719A1 (de) 2003-04-10
US7045544B2 (en) 2006-05-16
DE50205466D1 (de) 2006-02-02
JP2005508340A (ja) 2005-03-31
DE10147672A1 (de) 2003-04-10

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20141217