ES2186628T3 - Acidos heteroarilhidroxamicos biciclicos con orto-sulfonamidas y amidas del acido fosfinico acetilenicas como inhibidores de la "tace". - Google Patents

Acidos heteroarilhidroxamicos biciclicos con orto-sulfonamidas y amidas del acido fosfinico acetilenicas como inhibidores de la "tace".

Info

Publication number
ES2186628T3
ES2186628T3 ES00905788T ES00905788T ES2186628T3 ES 2186628 T3 ES2186628 T3 ES 2186628T3 ES 00905788 T ES00905788 T ES 00905788T ES 00905788 T ES00905788 T ES 00905788T ES 2186628 T3 ES2186628 T3 ES 2186628T3
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
carbon
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00905788T
Other languages
English (en)
Inventor
Jeremy Ian Levin
James Ming Chen
Xue-Mei Du
Jay Donald Albright
Arie Zask
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2186628T3 publication Critical patent/ES2186628T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos que tienen la fórmula:**(Fórmula)** en la que**(Fórmula)** es un anillo seleccionado a partir de los siguientes:**(Fórmula)** (es decir, B se selecciona partir de los siguientes:**(Fórmula)** en cuyas fórmulas: **(Fórmula)** , con tal de que cuando **(Fórmula)** y viceversa; W y X son cada uno, independientemente, carbono o nitrógeno; Y es carbono, nitrógeno, oxígeno o azufre, con tal de que al menos uno de W, X e Y no sea carbono; G es SO2 o -P(O)R10; L es un fenilo, naftilo o heteroarilo, con la salvedad de que G y Z no pueden estar unidos a átomos adyacentes de L, Z es O, NH, S o CH2;**(Fórmula)** donde K es O, NR9 o S; R5 es hidrógeno o alquilo de 1-6 átomos de carbono, R6 y R7 son, independientemente, hidrógeno, alquilo de 1-6 átomos de carbono, -CN o -CCH; R8 es hidrógeno, alquilo de 1-6 átomos de carbono, alquenilo de 2-6 átomos de carbono, alquinilo de 2-6 átomos de carbono, cicloalquilo de 3-6 átomos de carbono, fenilo, naftilo, o un heteroarilo de 5 a 10 miembros que tiene de 1-3 heteroátomos seleccionados a partir de N, NR9, O y S y; R9 es hidrógeno, alquilo de 1-6 átomos de carbono, cicloalquilo de 3-6 átomos de carbono, o fenilo; y R10 es fenilo, naftilo, alquilo de 1-6 átomos de carbono, cicloalquilo de 3-6 átomos de carbono, heteroarilo, o anillo heterocicloalquílico de 5-7 miembros; o una sal de los mismos, aceptable desde el punto de vista farmacéutico.
ES00905788T 1999-01-27 2000-01-27 Acidos heteroarilhidroxamicos biciclicos con orto-sulfonamidas y amidas del acido fosfinico acetilenicas como inhibidores de la "tace". Expired - Lifetime ES2186628T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23908499A 1999-01-27 1999-01-27

Publications (1)

Publication Number Publication Date
ES2186628T3 true ES2186628T3 (es) 2003-05-16

Family

ID=22900535

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00905788T Expired - Lifetime ES2186628T3 (es) 1999-01-27 2000-01-27 Acidos heteroarilhidroxamicos biciclicos con orto-sulfonamidas y amidas del acido fosfinico acetilenicas como inhibidores de la "tace".

Country Status (22)

Country Link
EP (2) EP1279674A3 (es)
JP (1) JP2002535404A (es)
KR (1) KR20010101690A (es)
CN (1) CN1207294C (es)
AR (1) AR022424A1 (es)
AT (1) ATE227288T1 (es)
AU (1) AU2741800A (es)
BR (1) BR0007760A (es)
CA (1) CA2355735A1 (es)
CZ (1) CZ20012721A3 (es)
DE (1) DE60000724T2 (es)
DK (1) DK1157024T3 (es)
EA (1) EA200100814A1 (es)
ES (1) ES2186628T3 (es)
HK (1) HK1038562B (es)
HU (1) HUP0105307A3 (es)
IL (1) IL144291A0 (es)
NO (1) NO20013673L (es)
PL (1) PL349070A1 (es)
PT (1) PT1157024E (es)
WO (1) WO2000044749A1 (es)
ZA (1) ZA200104324B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199155B2 (en) 2002-12-23 2007-04-03 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
EP2170884A2 (en) * 2007-06-25 2010-04-07 Boehringer Ingelheim International GmbH Chemical compounds
US20210393632A1 (en) 2018-10-04 2021-12-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU743901B2 (en) * 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
DE69718038D1 (de) * 1996-10-16 2003-01-30 American Cyanamid Co Herstellung und verwendung von ortho-sulfonamido-heteroarylhydroxamsäuren als matrix-metalloproteinase und tace inhibitoren

Also Published As

Publication number Publication date
ZA200104324B (en) 2002-08-26
DE60000724D1 (en) 2002-12-12
HK1038562A1 (en) 2002-03-22
EP1279674A2 (en) 2003-01-29
HUP0105307A2 (hu) 2002-05-29
DK1157024T3 (da) 2003-03-03
HUP0105307A3 (en) 2002-10-28
KR20010101690A (ko) 2001-11-14
HK1038562B (zh) 2003-02-21
AR022424A1 (es) 2002-09-04
EP1279674A3 (en) 2003-10-01
JP2002535404A (ja) 2002-10-22
AU2741800A (en) 2000-08-18
NO20013673D0 (no) 2001-07-26
EP1157024B1 (en) 2002-11-06
ATE227288T1 (de) 2002-11-15
DE60000724T2 (de) 2003-08-21
BR0007760A (pt) 2001-11-13
WO2000044749A1 (en) 2000-08-03
CN1337962A (zh) 2002-02-27
EA200100814A1 (ru) 2001-12-24
PL349070A1 (en) 2002-07-01
CN1207294C (zh) 2005-06-22
CA2355735A1 (en) 2000-08-03
EP1157024A1 (en) 2001-11-28
IL144291A0 (en) 2002-05-23
PT1157024E (pt) 2003-02-28
NO20013673L (no) 2001-09-21
CZ20012721A3 (cs) 2002-03-13

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