AR010650A1 - COMPUESTO DERIVADO DE CEFEm, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y USO DEL MISMO - Google Patents

COMPUESTO DERIVADO DE CEFEm, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y USO DEL MISMO

Info

Publication number
AR010650A1
AR010650A1 ARP970105544A ARP970105544A AR010650A1 AR 010650 A1 AR010650 A1 AR 010650A1 AR P970105544 A ARP970105544 A AR P970105544A AR P970105544 A ARP970105544 A AR P970105544A AR 010650 A1 AR010650 A1 AR 010650A1
Authority
AR
Argentina
Prior art keywords
cefem
pharmaceutical composition
group
tetrazole
halogen
Prior art date
Application number
ARP970105544A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of AR010650A1 publication Critical patent/AR010650A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proveen derivados de cefem, representados por la formula general (I); en donde Q es un grupo piridinilo opcionalmente sustituido conectado al átomo deazufre a través de un átomo de carbono de anillo, X es halogeno, Y es hidrogeno o halogeno, A esCO2H, PO3H2, SO3 H o tetrazol, L1 es grupo furano o grupotiofeno, un grupo C2-C10 alquilo o bien un grupo C2-C10 alquilo interrumpido por uno o más grupos que se selecionan independientemnte, a partir de vinilo,S, SO, SO2, SO2 NH, (II) n vale 0 (cero) o 1 (uno), A es CO2 H, PO3 H2, SO3 H tetrazol, y R1 es hidrogeno o bien un grupo protector de carboxilo, y las salesy/o un pro-fármaco correspondiente(s) que sea(n) farmacéuticamente aceptable(s) Los derivados son agentes antibacterianos Gramm-positivo especialmente utilespara su uso en el tratamiento de enfermedades causadas por el Staphylococus aereus resistente a la meticilina (MRSA) mediante la aplicacion a un pacientede una composicion farmacéutica que comprende dicho compuesto.
ARP970105544A 1996-11-27 1997-11-26 COMPUESTO DERIVADO DE CEFEm, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y USO DEL MISMO AR010650A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3404696P 1996-11-27 1996-11-27

Publications (1)

Publication Number Publication Date
AR010650A1 true AR010650A1 (es) 2000-06-28

Family

ID=21873971

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105544A AR010650A1 (es) 1996-11-27 1997-11-26 COMPUESTO DERIVADO DE CEFEm, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y USO DEL MISMO

Country Status (17)

Country Link
EP (1) EP0966472A1 (es)
JP (1) JP2001506607A (es)
KR (1) KR20000057283A (es)
CN (1) CN1238775A (es)
AR (1) AR010650A1 (es)
AU (1) AU734948B2 (es)
BR (1) BR9713350A (es)
CA (1) CA2272717A1 (es)
CZ (1) CZ185399A3 (es)
HU (1) HUP9903621A3 (es)
IL (1) IL129437A0 (es)
NO (1) NO992526D0 (es)
NZ (1) NZ335892A (es)
PL (1) PL334558A1 (es)
TW (1) TW414796B (es)
WO (1) WO1998023621A1 (es)
ZA (1) ZA9710662B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265394B1 (en) * 1997-07-31 2001-07-24 Bristol-Myers Squibb Company Bis quaternary MRSA cephem derivatives
KR20020085180A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085176A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085181A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085178A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20030071311A (ko) * 2002-02-28 2003-09-03 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조방법
US8895587B2 (en) * 2011-05-18 2014-11-25 Syngenta Participations Ag Insecticidal compounds based on arylthioacetamide derivatives
CN105131018B (zh) * 2015-09-23 2017-12-26 浙江华方药业股份有限公司 一种头孢替唑酸的制备方法
CN114957056A (zh) * 2021-02-20 2022-08-30 帕潘纳(北京)科技有限公司 制备3-甲基-2-氯-4-甲基磺酰基苯甲酸甲酯及其中间体的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3345366A (en) * 1967-02-15 1967-10-03 American Cyanamid Co Substituted 7-acetylamino cephalosporanic acids
US4148997A (en) * 1977-11-07 1979-04-10 Yeda Research And Development Co., Ltd. 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
US5567698A (en) * 1995-02-15 1996-10-22 Bristol-Myers Squibb Company Pyridinium thiomethyl substituted chepholosporin derivatives
US5620969A (en) * 1995-04-25 1997-04-15 Bristol-Myers Squibb Company Cephalosporin derviatives
AU1278197A (en) * 1995-12-20 1997-07-14 Bristol-Myers Squibb Company Cephalosporin derivatives

Also Published As

Publication number Publication date
JP2001506607A (ja) 2001-05-22
TW414796B (en) 2000-12-11
PL334558A1 (en) 2000-03-13
KR20000057283A (ko) 2000-09-15
HUP9903621A3 (en) 2001-05-28
NZ335892A (en) 2001-07-27
ZA9710662B (en) 1999-05-26
CA2272717A1 (en) 1998-06-04
AU734948B2 (en) 2001-06-28
BR9713350A (pt) 2000-01-25
EP0966472A1 (en) 1999-12-29
NO992526L (no) 1999-05-26
NO992526D0 (no) 1999-05-26
EP0966472A4 (es) 1999-12-29
IL129437A0 (en) 2000-02-17
HUP9903621A2 (hu) 2000-04-28
CZ185399A3 (cs) 1999-08-11
CN1238775A (zh) 1999-12-15
WO1998023621A1 (en) 1998-06-04
AU5365298A (en) 1998-06-22

Similar Documents

Publication Publication Date Title
DE60015927D1 (en) Phenylharnstoff und phenylthioharnstoffderivate
NO954072L (no) Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler
BRPI0014526B8 (pt) compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
ES2196344T3 (es) Derivados de sulfonamida y su uso en el tratamiento de trastornos de snc.
MXPA03005583A (es) Derivados de carbamato de quinuclidina y su uso como antagonistas m3.
CA2036304A1 (en) Pyrimidinedione derivatives, their production and use
HUP0003921A2 (hu) VLA-4 által közvetített leukocitaadhéziót gátló szulfonilezett dipeptidszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
DE68924681D1 (de) Heterocyclische Biphosphonsäurederivate.
ATE110729T1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
BRPI0508768A (pt) derivado de benzopirano da fórmula (i) ou (ii), ou sal farmaceuticamente aceitável do mesmo, medicamento e medicamento para o tratamento de arritmia
EP0348523A4 (en) Thienodiazepine compounds and their medicinal use
DE69720551D1 (de) Makrozyklische derivate von erythromycin a und b mit 13 ringatomen
TR200103395T2 (tr) 13-metil eritromisin türevleri.
HUP0104452A2 (hu) Triciklusos vegyületeket tartalmazó gyógyászati kompozíció
HUP0000343A2 (hu) 1,3-Propándiol-származékok alkalmazása szervátültetés után fellépő kilökődés megakadályozására
EP0339959A3 (en) Lactam derivatives
DE69005164D1 (de) Acryloylsubstituierte Pyrrol-Derivate.
AR010650A1 (es) COMPUESTO DERIVADO DE CEFEm, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y USO DEL MISMO
ATE186301T1 (de) An den positionen 2 und 9 substituierte 4h-pyrido-(1,2-a)pyrimidin-4-one
EP0385722A3 (en) Tricyclic lactam derivatives and pharmaceutical compositions containing them
DK0406119T3 (da) Hidtil ukendte peptidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
ES2098023T3 (es) Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen.
PE25998A1 (es) DERIVADOS DE OCTAHIDRO-PIRROLO(1,2-a)-PIRAZINA 2,7-SUSTITUIDOS
DE69415314D1 (de) Neue bisoxadiazolidinderivate
ATE215555T1 (de) 17-beta.-allyloxy(thio)alkyl-androstan derivative zur modulation von meiose