HUP0104452A2 - Triciklusos vegyületeket tartalmazó gyógyászati kompozíció - Google Patents
Triciklusos vegyületeket tartalmazó gyógyászati kompozícióInfo
- Publication number
- HUP0104452A2 HUP0104452A2 HU0104452A HUP0104452A HUP0104452A2 HU P0104452 A2 HUP0104452 A2 HU P0104452A2 HU 0104452 A HU0104452 A HU 0104452A HU P0104452 A HUP0104452 A HU P0104452A HU P0104452 A2 HUP0104452 A2 HU P0104452A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- hydroxy
- alkyl
- independently
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000004043 oxo group Chemical group O=* 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical group C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya olyan gyógyászati kompozíció, amely tartalmazvalamely (I) általános képletű triciklusos vegyületet vagygyógyászatilag elfogadható sóját, egy oldódást/abszorpciót elősegítőanyagot, valamely gyógyászati alapot és kívánt esetben valamelyösszeférhetőséget elősegítő szert és/vagy sűrítő szert. Az (I)általános képletben R1 és R2; R3 és R4; és R5 és R6 szomszédos párokjelentése egymástól függetlenül (a) két szomszédos hidrogénatom, de R2lehet valamely alkilcsoport is; vagy (b) képezhetnek egy másik kötéstazok között a szénatomok között, amelyekhez rögzítve vannak; R7jelentése hidrogénatom vagy hidroxi-, védett hidroxi- vagyalkoxicsoport, vagy az R1-gyel együtt oxocsoportot jelenthet; R8 és R9jelentése egymástól függetlenül hidrogénatom vagy hidroxicsoport; R10jelentése hidrogénatom vagy alkil-, egy vagy több hidroxicsoporttalhelyettesített alkil-, alkenil-, egy vagy több hidroxicsoporttalhelyettesített alkenil- vagy egy oxocsoporttal helyettesítettalkilcsoport; X jelentése oxocsoport vagy hidrogénatom éshidroxicsoport, vagy hidrogénatom és hidrogénatom vagy egy -CH2O-képlettel jellemezhető csoport; Y jelentése oxocsoport vagyhidrogénatom és hidroxicsoport, vagy hidrogénatom és hidrogénatom vagyegy -N-NR11R12- vagy -N-OR13- képlettel jellemezhető csoport; R11 ésR12 jelentése egymástól függetlenül hidrogénatom vagy alkil-, aril-vagy tozilcsoport; R13, R14, R15, R16, R17, R18, R19, R22 és R23jelentése egymástól függetlenül hidrogénatom vagy alkilcsoport; R24jelentése kívánt esetben helyettesített gyűrűrendszer, amelytartalmazhat egy vagy több heteroatomot; n értéke egész számként 1vagy 2; és a fenti definíciókon kívül Y, R10 és R23 azokkal aszénatomokkal együtt, amelyhez rögződnek, képviselhetnek egy telítettvagy telítetlen 5 vagy 6 tagú, nitrogént, ként és/vagy oxigénttartalmazó heterociklusos gyűrűt, amely kívánt esetben helyettesítvelehet egy vagy több alkil-, hidroxi-, alkoxi- vagy benzilcsoporttalvagy -CH2Se(C6H5)- képletű csoporttal, vagy egy vagy többhidroxicsoporttal helyettesített alkilcsoporttal. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11727198 | 1998-04-27 | ||
| PCT/JP1999/002237 WO1999055332A1 (fr) | 1998-04-27 | 1999-04-26 | Compositions medicinales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104452A2 true HUP0104452A2 (hu) | 2002-03-28 |
| HUP0104452A3 HUP0104452A3 (en) | 2004-05-28 |
Family
ID=14707636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104452A HUP0104452A3 (en) | 1998-04-27 | 1999-04-26 | Medicinal compositions, containing tricyclo compounds |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6673808B1 (hu) |
| EP (1) | EP1074255B1 (hu) |
| JP (1) | JP3732525B2 (hu) |
| KR (1) | KR100406823B1 (hu) |
| CN (1) | CN1161117C (hu) |
| AR (1) | AR018330A1 (hu) |
| AT (1) | ATE363275T1 (hu) |
| AU (1) | AU749475B2 (hu) |
| BR (1) | BR9910336A (hu) |
| CA (1) | CA2326222C (hu) |
| DE (1) | DE69936195T2 (hu) |
| ES (1) | ES2284248T3 (hu) |
| HK (1) | HK1038884B (hu) |
| HU (1) | HUP0104452A3 (hu) |
| ID (1) | ID29262A (hu) |
| IL (1) | IL139210A (hu) |
| NO (1) | NO20005399D0 (hu) |
| NZ (1) | NZ507345A (hu) |
| PL (1) | PL343627A1 (hu) |
| RU (1) | RU2203058C2 (hu) |
| TR (1) | TR200003108T2 (hu) |
| TW (1) | TW565461B (hu) |
| WO (1) | WO1999055332A1 (hu) |
| ZA (1) | ZA200005378B (hu) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| ES2232439T3 (es) * | 1999-04-30 | 2005-06-01 | Sucampo Ag | Uso de compuestos macrolidos para el tratamiento de los ojos secos. |
| LT3143995T (lt) * | 2001-02-19 | 2019-01-25 | Novartis Ag | Rapamicino darinys, skirtas plaučių vėžio gydymui |
| GB0108498D0 (en) * | 2001-04-04 | 2001-05-23 | Novartis Ag | Organic Compounds |
| AUPR529701A0 (en) * | 2001-05-28 | 2001-06-21 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical composition |
| PE20030828A1 (es) * | 2002-03-04 | 2003-11-04 | Novartis Ag | Composicion oftalmica que comprende ascomicina |
| GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| AU2005251676B2 (en) | 2004-03-03 | 2011-09-29 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| WO2006001251A1 (ja) * | 2004-06-24 | 2006-01-05 | Kowa Co., Ltd. | アトルバスタチン外用剤組成物 |
| RU2007136616A (ru) | 2005-03-03 | 2009-04-10 | Риванс Терапьютикс, Инк. (Us) | Композиция и способ для местного применения и чрескожного введения ботулинового токсина |
| AU2006270041B2 (en) | 2005-07-18 | 2011-08-18 | Minu, Llc | Enhanced ocular neuroprotection/neurostimulation |
| FR2900052B1 (fr) * | 2006-04-19 | 2011-02-18 | Galderma Sa | Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine |
| CN101288643B (zh) * | 2008-06-17 | 2012-11-14 | 杨喜鸿 | 含有他克莫司的凝胶剂组合物及其制备方法和药物应用 |
| CA2738831C (en) * | 2008-10-08 | 2016-05-24 | Takata Seiyaku Co., Ltd. | Tacrolimus preparation for external applications |
| GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| JP2011102260A (ja) * | 2009-11-11 | 2011-05-26 | Takada Seiyaku Kk | タクロリムス外用剤 |
| JP5674786B2 (ja) * | 2010-07-23 | 2015-02-25 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| WO2012011192A1 (ja) * | 2010-07-23 | 2012-01-26 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
| US20130317053A1 (en) * | 2011-01-31 | 2013-11-28 | Osaka University | Externally-used drug for treating skin disorder and method for producing same |
| CN114585350A (zh) * | 2020-01-24 | 2022-06-03 | 耐贝医药株式会社 | 含有雷帕霉素的外用剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454113A (en) * | 1982-09-21 | 1984-06-12 | Scm Corporation | Stabilization of oil and water emulsions using polyglycerol esters of fatty acids |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
| ATE150304T1 (de) * | 1990-09-04 | 1997-04-15 | Fujisawa Pharmaceutical Co | Tricyclische verbindungen enthaltende salben |
| TW213418B (hu) * | 1991-05-02 | 1993-09-21 | Kuko Seiyaku Kk | |
| JPH06128148A (ja) * | 1992-04-30 | 1994-05-10 | Dotsuto:Kk | 皮膚外用剤 |
| JP2523428B2 (ja) * | 1992-12-04 | 1996-08-07 | エスエス製薬株式会社 | 消炎鎮痛ゲル製剤 |
| JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
| CN1089233C (zh) * | 1994-10-26 | 2002-08-21 | 诺瓦蒂斯有限公司 | 药物组合物 |
| ES2230571T3 (es) * | 1995-12-28 | 2005-05-01 | Mitsubishi Pharma Corporation | `composicion farmaceutica destinada para la administracion topica que comprende el 2-amino-2-(2-(4-octilfenil)etil) propan-1,3-diol para el tratamiento de las enfermedades causadas por una alteracion inmunitaria. |
| CZ267796A3 (cs) | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
| TW450810B (en) * | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
| JP4221762B2 (ja) * | 1997-04-11 | 2009-02-12 | アステラス製薬株式会社 | 医薬組成物 |
-
1999
- 1999-04-26 IL IL13921099A patent/IL139210A/xx not_active IP Right Cessation
- 1999-04-26 NZ NZ507345A patent/NZ507345A/xx unknown
- 1999-04-26 CN CNB998079367A patent/CN1161117C/zh not_active Expired - Fee Related
- 1999-04-26 US US09/673,260 patent/US6673808B1/en not_active Expired - Fee Related
- 1999-04-26 WO PCT/JP1999/002237 patent/WO1999055332A1/ja active IP Right Grant
- 1999-04-26 BR BR9910336-2A patent/BR9910336A/pt not_active IP Right Cessation
- 1999-04-26 JP JP54808699A patent/JP3732525B2/ja not_active Expired - Fee Related
- 1999-04-26 RU RU2000129665/14A patent/RU2203058C2/ru not_active IP Right Cessation
- 1999-04-26 TR TR2000/03108T patent/TR200003108T2/xx unknown
- 1999-04-26 AT AT99917179T patent/ATE363275T1/de not_active IP Right Cessation
- 1999-04-26 PL PL99343627A patent/PL343627A1/xx not_active Application Discontinuation
- 1999-04-26 ES ES99917179T patent/ES2284248T3/es not_active Expired - Lifetime
- 1999-04-26 EP EP99917179A patent/EP1074255B1/en not_active Expired - Lifetime
- 1999-04-26 ID IDW20002464A patent/ID29262A/id unknown
- 1999-04-26 HU HU0104452A patent/HUP0104452A3/hu unknown
- 1999-04-26 DE DE69936195T patent/DE69936195T2/de not_active Expired - Lifetime
- 1999-04-26 CA CA002326222A patent/CA2326222C/en not_active Expired - Fee Related
- 1999-04-26 KR KR10-2000-7011259A patent/KR100406823B1/ko not_active IP Right Cessation
- 1999-04-26 AU AU35372/99A patent/AU749475B2/en not_active Ceased
- 1999-04-26 AR ARP990101921A patent/AR018330A1/es unknown
- 1999-04-27 TW TW088106893A patent/TW565461B/zh active
-
2000
- 2000-10-03 ZA ZA200005378A patent/ZA200005378B/en unknown
- 2000-10-26 NO NO20005399A patent/NO20005399D0/no not_active Application Discontinuation
-
2001
- 2001-12-07 US US10/005,645 patent/US6586444B2/en not_active Expired - Fee Related
-
2002
- 2002-01-22 HK HK02100502.9A patent/HK1038884B/zh not_active IP Right Cessation
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