BR9713350A - Derivados de cefalosporina - Google Patents

Derivados de cefalosporina

Info

Publication number
BR9713350A
BR9713350A BR9713350-7A BR9713350A BR9713350A BR 9713350 A BR9713350 A BR 9713350A BR 9713350 A BR9713350 A BR 9713350A BR 9713350 A BR9713350 A BR 9713350A
Authority
BR
Brazil
Prior art keywords
group
halogen
hydrogen
derivatives
alkyl group
Prior art date
Application number
BR9713350-7A
Other languages
English (en)
Inventor
Dane M Springer
Bing Y Luh
Stanley V D Andrea
Thomas W Hudyma
Oak K Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR9713350A publication Critical patent/BR9713350A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DERIVADOS DE CEFALOSPORINA". São providos de cefem representados pela fórmula geral (I) em que Q é um grupo piridínio opcionalmente substituído ligado ao átomo de enxofre via um átomo de carbono do anel; X é halogênio; Y é hidrogênio ou halogênio; L^1^ é um grupo furano, um grupo tiofeno, um grupo alquila C~2~-10~, ou um grupo alquila C~ 2-10~ interrompido com um ou mais grupos independentemente selecionados dentre vinila, S, SO, SO~ 2~, SO~ 2~NH (IIa), (IIb); n é 0 ou 1; A é CO~ 2~H, PO~ 3~H~ 2~, SOP~ 3~H, ou tetrazol; e R^ 1^ é hidrogênio ou um grupo protetor de carboxila; e sais e/ou pró-medicamentos farmaceuticamente aceitáveis do mesmo. Os derivados são agentes antibacterianos gram-positivos, especialmente úteis no tratamento de doenças ocasionadas por Staphylococus aureus resistente à meticilina (MRSA).
BR9713350-7A 1996-11-27 1997-11-21 Derivados de cefalosporina BR9713350A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3404696P 1996-11-27 1996-11-27
PCT/US1997/021785 WO1998023621A1 (en) 1996-11-27 1997-11-21 Cephalosporin derivatives

Publications (1)

Publication Number Publication Date
BR9713350A true BR9713350A (pt) 2000-01-25

Family

ID=21873971

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713350-7A BR9713350A (pt) 1996-11-27 1997-11-21 Derivados de cefalosporina

Country Status (17)

Country Link
EP (1) EP0966472A1 (pt)
JP (1) JP2001506607A (pt)
KR (1) KR20000057283A (pt)
CN (1) CN1238775A (pt)
AR (1) AR010650A1 (pt)
AU (1) AU734948B2 (pt)
BR (1) BR9713350A (pt)
CA (1) CA2272717A1 (pt)
CZ (1) CZ185399A3 (pt)
HU (1) HUP9903621A3 (pt)
IL (1) IL129437A0 (pt)
NO (1) NO992526D0 (pt)
NZ (1) NZ335892A (pt)
PL (1) PL334558A1 (pt)
TW (1) TW414796B (pt)
WO (1) WO1998023621A1 (pt)
ZA (1) ZA9710662B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265394B1 (en) * 1997-07-31 2001-07-24 Bristol-Myers Squibb Company Bis quaternary MRSA cephem derivatives
KR20020085178A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085176A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085181A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085180A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20030071311A (ko) * 2002-02-28 2003-09-03 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조방법
CN103534237B (zh) * 2011-05-18 2016-06-15 先正达参股股份有限公司 基于芳硫基乙酰胺衍生物的杀虫化合物
CN105131018B (zh) * 2015-09-23 2017-12-26 浙江华方药业股份有限公司 一种头孢替唑酸的制备方法
CN114957056A (zh) * 2021-02-20 2022-08-30 帕潘纳(北京)科技有限公司 制备3-甲基-2-氯-4-甲基磺酰基苯甲酸甲酯及其中间体的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3345366A (en) * 1967-02-15 1967-10-03 American Cyanamid Co Substituted 7-acetylamino cephalosporanic acids
US4148997A (en) * 1977-11-07 1979-04-10 Yeda Research And Development Co., Ltd. 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
US5567698A (en) * 1995-02-15 1996-10-22 Bristol-Myers Squibb Company Pyridinium thiomethyl substituted chepholosporin derivatives
US5620969A (en) * 1995-04-25 1997-04-15 Bristol-Myers Squibb Company Cephalosporin derviatives
WO1997022611A1 (en) * 1995-12-20 1997-06-26 Bristol-Myers Squibb Company Cephalosporin derivatives

Also Published As

Publication number Publication date
NO992526L (no) 1999-05-26
ZA9710662B (en) 1999-05-26
NZ335892A (en) 2001-07-27
TW414796B (en) 2000-12-11
WO1998023621A1 (en) 1998-06-04
PL334558A1 (en) 2000-03-13
KR20000057283A (ko) 2000-09-15
AU734948B2 (en) 2001-06-28
CA2272717A1 (en) 1998-06-04
AU5365298A (en) 1998-06-22
CZ185399A3 (cs) 1999-08-11
EP0966472A4 (pt) 1999-12-29
IL129437A0 (en) 2000-02-17
CN1238775A (zh) 1999-12-15
HUP9903621A2 (hu) 2000-04-28
HUP9903621A3 (en) 2001-05-28
AR010650A1 (es) 2000-06-28
EP0966472A1 (en) 1999-12-29
JP2001506607A (ja) 2001-05-22
NO992526D0 (no) 1999-05-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A , 6A , 7A E 8A ANUIDADES.