AR022424A1 - Compuestos derivados de acidos ortosulfonamido acetilenico e hidroxamico biciclico heteroarilo amido de acido fosfinico como inhibidores tace, composicionfarmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento - Google Patents
Compuestos derivados de acidos ortosulfonamido acetilenico e hidroxamico biciclico heteroarilo amido de acido fosfinico como inhibidores tace, composicionfarmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamentoInfo
- Publication number
- AR022424A1 AR022424A1 ARP000100324A ARP000100324A AR022424A1 AR 022424 A1 AR022424 A1 AR 022424A1 AR P000100324 A ARP000100324 A AR P000100324A AR P000100324 A ARP000100324 A AR P000100324A AR 022424 A1 AR022424 A1 AR 022424A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydroxamic
- tace
- compounds derived
- inhibitors
- ortosulfonamido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
- C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/78—Halides of sulfonic acids
- C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Abstract
Se provee compuestos derivados de ácido orto-sulfonamido acetilénico e hidroxámico bicíclico heteroarilo amido de ácido fosfínico inhibidores TACE y MMPque tienen las forumulas donde B es(1),(2),(3),(4) donde P y Q son (5) o -C(:O)-NHOH, si cuando Pes (5) Q es -C(:O)-NHOH en donde P, Q, W, X, Y, Z, L, G, R5,R6, R7 y R8 tiene sus significados dados en la memoria descriptiva. Además se describen composiciones farmacéuticas que contienen a dichos derivados y el usode dichos derivados para lamanuf actura de un medicamento para inhibir cambios patologicos mediados por la enzima de conversion de TNF- alfa (TACE) en unmamífero que lo necesita para ser en artritis reumatoidea, inflamacion, resistencia a insulina, falla coronaria congestiva,enferm edad inflamatoria delintestino o infecccion por HIV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23908499A | 1999-01-27 | 1999-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR022424A1 true AR022424A1 (es) | 2002-09-04 |
Family
ID=22900535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000100324A AR022424A1 (es) | 1999-01-27 | 2000-01-26 | Compuestos derivados de acidos ortosulfonamido acetilenico e hidroxamico biciclico heteroarilo amido de acido fosfinico como inhibidores tace, composicionfarmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP1279674A3 (es) |
JP (1) | JP2002535404A (es) |
KR (1) | KR20010101690A (es) |
CN (1) | CN1207294C (es) |
AR (1) | AR022424A1 (es) |
AT (1) | ATE227288T1 (es) |
AU (1) | AU2741800A (es) |
BR (1) | BR0007760A (es) |
CA (1) | CA2355735A1 (es) |
CZ (1) | CZ20012721A3 (es) |
DE (1) | DE60000724T2 (es) |
DK (1) | DK1157024T3 (es) |
EA (1) | EA200100814A1 (es) |
ES (1) | ES2186628T3 (es) |
HK (1) | HK1038562B (es) |
HU (1) | HUP0105307A3 (es) |
IL (1) | IL144291A0 (es) |
NO (1) | NO20013673L (es) |
PL (1) | PL349070A1 (es) |
PT (1) | PT1157024E (es) |
WO (1) | WO2000044749A1 (es) |
ZA (1) | ZA200104324B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003304456A1 (en) | 2002-12-23 | 2005-03-16 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors |
EP1449538A1 (en) | 2003-02-21 | 2004-08-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation |
WO2004110454A1 (ja) * | 2003-06-13 | 2004-12-23 | Ishihara Sangyo Kaisha, Ltd. | アデノシンA2a受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物 |
WO2009000832A2 (en) * | 2007-06-25 | 2008-12-31 | Boehringer Ingelheim International Gmbh | Chemical compounds |
CA3115038A1 (en) | 2018-10-04 | 2020-04-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Egfr inhibitors for treating keratodermas |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ335029A (en) * | 1996-10-16 | 2000-10-27 | American Cyanamid Co | Ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase (MMP) and TACE (tumor necrosis factor, TNF, alpha converting enzyme) inhibitors |
WO1998016514A1 (en) * | 1996-10-16 | 1998-04-23 | American Cyanamid Company | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
-
2000
- 2000-01-26 AR ARP000100324A patent/AR022424A1/es unknown
- 2000-01-27 AT AT00905788T patent/ATE227288T1/de not_active IP Right Cessation
- 2000-01-27 ES ES00905788T patent/ES2186628T3/es not_active Expired - Lifetime
- 2000-01-27 JP JP2000596005A patent/JP2002535404A/ja active Pending
- 2000-01-27 PL PL00349070A patent/PL349070A1/xx not_active Application Discontinuation
- 2000-01-27 CA CA002355735A patent/CA2355735A1/en not_active Abandoned
- 2000-01-27 IL IL14429100A patent/IL144291A0/xx unknown
- 2000-01-27 EP EP02024564A patent/EP1279674A3/en not_active Withdrawn
- 2000-01-27 HU HU0105307A patent/HUP0105307A3/hu unknown
- 2000-01-27 DK DK00905788T patent/DK1157024T3/da active
- 2000-01-27 DE DE60000724T patent/DE60000724T2/de not_active Expired - Fee Related
- 2000-01-27 PT PT00905788T patent/PT1157024E/pt unknown
- 2000-01-27 KR KR1020017009364A patent/KR20010101690A/ko not_active Application Discontinuation
- 2000-01-27 BR BR0007760-7A patent/BR0007760A/pt not_active IP Right Cessation
- 2000-01-27 EP EP00905788A patent/EP1157024B1/en not_active Expired - Lifetime
- 2000-01-27 AU AU27418/00A patent/AU2741800A/en not_active Abandoned
- 2000-01-27 WO PCT/US2000/002144 patent/WO2000044749A1/en not_active Application Discontinuation
- 2000-01-27 CZ CZ20012721A patent/CZ20012721A3/cs unknown
- 2000-01-27 EA EA200100814A patent/EA200100814A1/ru unknown
- 2000-01-27 CN CNB008030294A patent/CN1207294C/zh not_active Expired - Fee Related
-
2001
- 2001-05-25 ZA ZA200104324A patent/ZA200104324B/en unknown
- 2001-07-26 NO NO20013673A patent/NO20013673L/no not_active Application Discontinuation
-
2002
- 2002-01-08 HK HK02100116.7A patent/HK1038562B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1038562A1 (en) | 2002-03-22 |
HUP0105307A3 (en) | 2002-10-28 |
HK1038562B (zh) | 2003-02-21 |
BR0007760A (pt) | 2001-11-13 |
CN1337962A (zh) | 2002-02-27 |
EP1157024A1 (en) | 2001-11-28 |
AU2741800A (en) | 2000-08-18 |
PT1157024E (pt) | 2003-02-28 |
CZ20012721A3 (cs) | 2002-03-13 |
ES2186628T3 (es) | 2003-05-16 |
DE60000724D1 (en) | 2002-12-12 |
EP1157024B1 (en) | 2002-11-06 |
JP2002535404A (ja) | 2002-10-22 |
DE60000724T2 (de) | 2003-08-21 |
NO20013673D0 (no) | 2001-07-26 |
CA2355735A1 (en) | 2000-08-03 |
CN1207294C (zh) | 2005-06-22 |
WO2000044749A1 (en) | 2000-08-03 |
EP1279674A3 (en) | 2003-10-01 |
IL144291A0 (en) | 2002-05-23 |
ATE227288T1 (de) | 2002-11-15 |
NO20013673L (no) | 2001-09-21 |
KR20010101690A (ko) | 2001-11-14 |
DK1157024T3 (da) | 2003-03-03 |
EP1279674A2 (en) | 2003-01-29 |
ZA200104324B (en) | 2002-08-26 |
HUP0105307A2 (hu) | 2002-05-29 |
EA200100814A1 (ru) | 2001-12-24 |
PL349070A1 (en) | 2002-07-01 |
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