AR001787A1 - Un compuesto oxazolidin sustituido particularmenteutil como inhibidor de calpaina y/o catepsina b e n el tratamiento de trastornos neurodegenerativos agudos o cronicos y composiciones farmacéuticas que incluyen dicho compuesto - Google Patents

Un compuesto oxazolidin sustituido particularmenteutil como inhibidor de calpaina y/o catepsina b e n el tratamiento de trastornos neurodegenerativos agudos o cronicos y composiciones farmacéuticas que incluyen dicho compuesto

Info

Publication number
AR001787A1
AR001787A1 AR33495896A AR33495896A AR001787A1 AR 001787 A1 AR001787 A1 AR 001787A1 AR 33495896 A AR33495896 A AR 33495896A AR 33495896 A AR33495896 A AR 33495896A AR 001787 A1 AR001787 A1 AR 001787A1
Authority
AR
Argentina
Prior art keywords
compound
pharmaceutical compositions
compositions including
calpain
acute
Prior art date
Application number
AR33495896A
Other languages
English (en)
Inventor
Norton P Peet
Shujaath Mehdi
Matthew D Linnik
Michael R Angelastro
Hwa-Ok Kim
Original Assignee
Hoecht Marion Roussell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoecht Marion Roussell Inc filed Critical Hoecht Marion Roussell Inc
Publication of AR001787A1 publication Critical patent/AR001787A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos poseen la fórmula general (I), donde R y Q son cada uno independientemente hidrógeno, OH, alquilo C1-C4, alcoxi C1-C4, NO2, NH2 ohalógeno; R1 y R2 son cada uno independientemente alquilo C1-C4; R3 es hidrógeno, alcanoiloC1-C8 (II); R4 y R5 son cada uno independientementehidrógeno, alquilo C1-C4 o bencilo; R6 es T-butiloxicarbonilo, carbobenciloxi o (III); donde Z es N o CH y B es un grupo de fórmulas (IV), donde R eshidrógeno o un grupo alquilo C1-C6; R7 es hidrógeno o metilo; R8 es alquilo C1-C4; m es el entero cero o uno; n es el entero cero o uno; p es el enterocero a tres; y q es el entero cero a tres; y las sales farmacéuticamente aceptables del mismo. También se describen composiciones farmacéuticas queincluyen dichos compuestos y un vehículo farmacéuticamente aceptable.
AR33495896A 1995-01-11 1996-01-09 Un compuesto oxazolidin sustituido particularmenteutil como inhibidor de calpaina y/o catepsina b e n el tratamiento de trastornos neurodegenerativos agudos o cronicos y composiciones farmacéuticas que incluyen dicho compuesto AR001787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11

Publications (1)

Publication Number Publication Date
AR001787A1 true AR001787A1 (es) 1997-12-10

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33495896A AR001787A1 (es) 1995-01-11 1996-01-09 Un compuesto oxazolidin sustituido particularmenteutil como inhibidor de calpaina y/o catepsina b e n el tratamiento de trastornos neurodegenerativos agudos o cronicos y composiciones farmacéuticas que incluyen dicho compuesto

Country Status (23)

Country Link
US (1) US5691368A (es)
EP (1) EP0802909B1 (es)
JP (1) JP4157601B2 (es)
KR (1) KR100393701B1 (es)
CN (1) CN1088456C (es)
AR (1) AR001787A1 (es)
AT (1) ATE206413T1 (es)
AU (1) AU692044B2 (es)
CA (1) CA2210258C (es)
DE (1) DE69523072T2 (es)
DK (1) DK0802909T3 (es)
ES (1) ES2165441T3 (es)
FI (1) FI972935A (es)
HU (1) HUT77649A (es)
IL (1) IL116724A (es)
MX (1) MX9705235A (es)
NO (1) NO309267B1 (es)
NZ (1) NZ298999A (es)
PT (1) PT802909E (es)
SI (1) SI0802909T1 (es)
TW (1) TW454001B (es)
WO (1) WO1996021655A2 (es)
ZA (1) ZA96100B (es)

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JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
EP2300000A1 (en) * 2008-07-03 2011-03-30 University of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
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ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase
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Also Published As

Publication number Publication date
US5691368A (en) 1997-11-25
AU4473196A (en) 1996-07-31
CA2210258C (en) 2002-10-01
SI0802909T1 (en) 2002-02-28
CN1173174A (zh) 1998-02-11
MX9705235A (es) 1997-10-31
IL116724A (en) 2000-08-31
ATE206413T1 (de) 2001-10-15
FI972935A0 (fi) 1997-07-10
IL116724A0 (en) 1996-05-14
TW454001B (en) 2001-09-11
EP0802909B1 (en) 2001-10-04
HUT77649A (hu) 1998-07-28
NZ298999A (en) 1999-01-28
DK0802909T3 (da) 2002-01-28
ES2165441T3 (es) 2002-03-16
DE69523072D1 (en) 2001-11-08
ZA96100B (en) 1996-07-24
CA2210258A1 (en) 1996-07-18
NO973216L (no) 1997-09-09
EP0802909A2 (en) 1997-10-29
PT802909E (pt) 2002-03-28
CN1088456C (zh) 2002-07-31
NO309267B1 (no) 2001-01-08
DE69523072T2 (de) 2002-06-20
WO1996021655A3 (en) 1996-09-06
AU692044B2 (en) 1998-05-28
NO973216D0 (no) 1997-07-10
WO1996021655A2 (en) 1996-07-18
JP4157601B2 (ja) 2008-10-01
KR100393701B1 (ko) 2003-11-28
JPH10512257A (ja) 1998-11-24
FI972935A (fi) 1997-07-10

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