IT1392387B1 - Processo per la preparazione di rotigotina - Google Patents

Processo per la preparazione di rotigotina

Info

Publication number
IT1392387B1
IT1392387B1 ITMI2008A001713A ITMI20081713A IT1392387B1 IT 1392387 B1 IT1392387 B1 IT 1392387B1 IT MI2008A001713 A ITMI2008A001713 A IT MI2008A001713A IT MI20081713 A ITMI20081713 A IT MI20081713A IT 1392387 B1 IT1392387 B1 IT 1392387B1
Authority
IT
Italy
Prior art keywords
rotigotine
preparation
rotigotine preparation
Prior art date
Application number
ITMI2008A001713A
Other languages
English (en)
Inventor
Roberta Pizzocaro
Claudio Fuganti
Aldo Banfi
Gianluca Belogi
Original Assignee
Solmag S P A Ora Fidia Farmaceutici S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solmag S P A Ora Fidia Farmaceutici S P A filed Critical Solmag S P A Ora Fidia Farmaceutici S P A
Priority to ITMI2008A001713A priority Critical patent/IT1392387B1/it
Priority to CA2738392A priority patent/CA2738392C/en
Priority to EP09752890A priority patent/EP2331494A1/en
Priority to PCT/IB2009/006934 priority patent/WO2010035111A1/en
Priority to US13/120,682 priority patent/US8519160B2/en
Publication of ITMI20081713A1 publication Critical patent/ITMI20081713A1/it
Application granted granted Critical
Publication of IT1392387B1 publication Critical patent/IT1392387B1/it
Priority to US13/948,667 priority patent/US20130345283A1/en
Priority to US13/948,633 priority patent/US20130317255A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
ITMI2008A001713A 2008-09-26 2008-09-26 Processo per la preparazione di rotigotina IT1392387B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI2008A001713A IT1392387B1 (it) 2008-09-26 2008-09-26 Processo per la preparazione di rotigotina
CA2738392A CA2738392C (en) 2008-09-26 2009-09-24 Process for the preparation of rotigotine
EP09752890A EP2331494A1 (en) 2008-09-26 2009-09-24 A process for the preparation of rotigotine
PCT/IB2009/006934 WO2010035111A1 (en) 2008-09-26 2009-09-24 A process for the preparation of rotigotine
US13/120,682 US8519160B2 (en) 2008-09-26 2009-09-24 Process for the preparation of rotigotine
US13/948,667 US20130345283A1 (en) 2008-09-26 2013-07-23 Process for the preparation of rotigotine
US13/948,633 US20130317255A1 (en) 2008-09-26 2013-07-23 Process for the preparation of rotigotine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001713A IT1392387B1 (it) 2008-09-26 2008-09-26 Processo per la preparazione di rotigotina

Publications (2)

Publication Number Publication Date
ITMI20081713A1 ITMI20081713A1 (it) 2010-03-27
IT1392387B1 true IT1392387B1 (it) 2012-03-02

Family

ID=40637856

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001713A IT1392387B1 (it) 2008-09-26 2008-09-26 Processo per la preparazione di rotigotina

Country Status (5)

Country Link
US (3) US8519160B2 (it)
EP (1) EP2331494A1 (it)
CA (1) CA2738392C (it)
IT (1) IT1392387B1 (it)
WO (1) WO2010035111A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
ITMI20111622A1 (it) * 2011-09-08 2013-03-09 Fidia Farmaceutici Processo per la preparazione di rotigotina
US10611749B2 (en) * 2018-02-15 2020-04-07 Solara Active Pharma Sciences Limited Process for preparation of Rotigotine and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US456428A (en) * 1891-07-21 Elevator and conveyer
US4564628A (en) * 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
ES2059828T3 (es) * 1988-01-15 1994-11-16 Abbott Lab Un procedimiento para la preparacion de un compuesto.
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
US5382596A (en) * 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins
CN1185225C (zh) * 1999-11-23 2005-01-19 阿德里斯制药公司 制备氮取代的氨基1,2,3,4－四氢化萘的改进方法

Also Published As

Publication number Publication date
US8519160B2 (en) 2013-08-27
CA2738392A1 (en) 2010-04-01
WO2010035111A1 (en) 2010-04-01
US20110230541A1 (en) 2011-09-22
US20130345283A1 (en) 2013-12-26
US20130317255A1 (en) 2013-11-28
EP2331494A1 (en) 2011-06-15
CA2738392C (en) 2017-06-06
ITMI20081713A1 (it) 2010-03-27

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