IT1403890B1 - Processo per la produzione di nicorandil - Google Patents

Processo per la produzione di nicorandil

Info

Publication number
IT1403890B1
IT1403890B1 ITMI2010A002419A ITMI20102419A IT1403890B1 IT 1403890 B1 IT1403890 B1 IT 1403890B1 IT MI2010A002419 A ITMI2010A002419 A IT MI2010A002419A IT MI20102419 A ITMI20102419 A IT MI20102419A IT 1403890 B1 IT1403890 B1 IT 1403890B1
Authority
IT
Italy
Prior art keywords
nicorandil
production process
production
nicorandil production
Prior art date
Application number
ITMI2010A002419A
Other languages
English (en)
Inventor
Alessandro Barozza
Matteo Colombo
Jacopo Roletto
Paolo Paissoni
Original Assignee
Procos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procos Spa filed Critical Procos Spa
Priority to ITMI2010A002419A priority Critical patent/IT1403890B1/it
Priority to ES11817220.4T priority patent/ES2525918T3/es
Priority to CN201180063046.2A priority patent/CN103370301B/zh
Priority to EP11817220.4A priority patent/EP2658839B1/en
Priority to PCT/EP2011/074152 priority patent/WO2012089769A1/en
Publication of ITMI20102419A1 publication Critical patent/ITMI20102419A1/it
Application granted granted Critical
Publication of IT1403890B1 publication Critical patent/IT1403890B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ITMI2010A002419A 2010-12-28 2010-12-28 Processo per la produzione di nicorandil IT1403890B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI2010A002419A IT1403890B1 (it) 2010-12-28 2010-12-28 Processo per la produzione di nicorandil
ES11817220.4T ES2525918T3 (es) 2010-12-28 2011-12-28 Proceso para la fabricación de Nicorandil
CN201180063046.2A CN103370301B (zh) 2010-12-28 2011-12-28 制备尼可地尔的方法
EP11817220.4A EP2658839B1 (en) 2010-12-28 2011-12-28 Process for the manufacture of nicorandil
PCT/EP2011/074152 WO2012089769A1 (en) 2010-12-28 2011-12-28 Process for the manufacture of nicorandil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A002419A IT1403890B1 (it) 2010-12-28 2010-12-28 Processo per la produzione di nicorandil

Publications (2)

Publication Number Publication Date
ITMI20102419A1 ITMI20102419A1 (it) 2012-06-29
IT1403890B1 true IT1403890B1 (it) 2013-11-08

Family

ID=43737071

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A002419A IT1403890B1 (it) 2010-12-28 2010-12-28 Processo per la produzione di nicorandil

Country Status (5)

Country Link
EP (1) EP2658839B1 (it)
CN (1) CN103370301B (it)
ES (1) ES2525918T3 (it)
IT (1) IT1403890B1 (it)
WO (1) WO2012089769A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103242165B (zh) * 2013-05-27 2015-05-13 西安嘉宏石化科技有限公司 一种硝酸酯合成方法
CN109516951B (zh) * 2017-09-18 2022-02-18 燃点(南京)生物医药科技有限公司 一种尼可地尔三聚体的制备方法
CN109516950B (zh) * 2017-09-18 2022-02-18 燃点(南京)生物医药科技有限公司 一种尼可地尔二聚体的制备方法
CN107721874B (zh) * 2017-11-20 2020-05-19 南京工业大学 一种采用微流场反应技术制备硝酸酯类化合物的方法
CN108623517B (zh) * 2018-06-29 2020-07-28 扬子江药业集团北京海燕药业有限公司 一种尼可地尔二聚体的制备方法
CN110845403A (zh) * 2019-10-30 2020-02-28 北京沃邦医药科技有限公司 一种尼可地尔的制备方法
CN111269175B (zh) * 2020-02-13 2022-11-29 张家港九力新材料科技有限公司 尼可地尔的制备方法
CN113105406B (zh) * 2021-04-09 2022-10-18 中国工程物理研究院化工材料研究所 轮状三嗪类硝酸酯含能分子及其合成方法
CN113501784A (zh) * 2021-06-22 2021-10-15 海口天行健药物研究有限公司 一种尼可地尔的制备方法
CN115745879A (zh) * 2022-11-16 2023-03-07 海南皇隆制药股份有限公司 尼可地尔的合成方法、注射用尼可地尔及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK145608C (da) 1976-04-02 1983-07-11 Chugai Pharmaceutical Co Ltd Analogifremgangsmaade til fremstilling af salpetersyreesteren af n-(2-hydroxyethyl)nicotinamid
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
ES8506278A1 (es) 1984-04-06 1985-07-01 Fides Lab Procedimiento para la obtencion de un derivado de la niacinamida
JPS6115847A (ja) 1984-07-03 1986-01-23 Kowa Co 硝酸エステル化方法
ES8505655A1 (es) 1984-08-08 1985-06-01 Fides Lab Procedimiento para la obtencion de derivados de acidos piridincarboxilicos
ES536328A0 (es) 1984-09-28 1985-09-01 Bioiberica Procedimiento de obtencion del 2-nicotinamida etil nitrato
ES542899A0 (es) 1985-05-08 1985-12-01 Elmu Sa Procedimiento de obtencion de n-(2-hidroxietil)-3-piridina- carboxamida nitrato ester
ES543857A0 (es) 1985-06-04 1986-01-01 Sune Coma Nuria Procedimiento de obtencion de la n-(2-(nitrooxi)etil)-3- piridincarboxamida
ES8604880A1 (es) 1985-11-08 1986-03-16 Verde Casanova M Jose Un procedimiento de obtencion del nitrato de n-(2-hidroxie- til)-3-piridincarboxamida
ES8605782A1 (es) 1985-11-22 1986-04-01 Berenguer Beneyto Lab Procedimiento de preparacion de nitrato ester de n-(2-hidro-xietil)nicotinamida
JPH02207072A (ja) 1989-02-06 1990-08-16 Sagami Kasei Kogyo Kk ピリジンカルボン酸アミドアルコール類の硝酸エステル化法
PL162496B1 (pl) 1990-01-31 1993-12-31 Inst Farmaceutyczny Sposób wytwarzania amidu kwasu N-[2-/nltrooksy/-etylo]-3-plrydynokarboksylowego
RU2147577C1 (ru) 1998-12-18 2000-04-20 Институт проблем химической физики РАН Способ получения n-(2-нитроксиэтил)никотинамида
RU2341517C2 (ru) 2005-09-14 2008-12-20 Некоммерческая организация Учреждение Институт проблем химической физики Российской академии наук (статус государственного учреждения (ИПХФ РАН) Способ получения n-(2-нитроксиэтил)никотинамида из этилникотината

Also Published As

Publication number Publication date
WO2012089769A1 (en) 2012-07-05
CN103370301B (zh) 2015-03-18
ES2525918T3 (es) 2015-01-02
CN103370301A (zh) 2013-10-23
EP2658839B1 (en) 2014-10-22
EP2658839A1 (en) 2013-11-06
ITMI20102419A1 (it) 2012-06-29

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