PE20020592A1 - Quinolonas como agentes antimicrobianos - Google Patents

Quinolonas como agentes antimicrobianos

Info

Publication number
PE20020592A1
PE20020592A1 PE2001001250A PE2001001250A PE20020592A1 PE 20020592 A1 PE20020592 A1 PE 20020592A1 PE 2001001250 A PE2001001250 A PE 2001001250A PE 2001001250 A PE2001001250 A PE 2001001250A PE 20020592 A1 PE20020592 A1 PE 20020592A1
Authority
PE
Peru
Prior art keywords
halo
amino
piperidine
quinolones
antimicrobial agents
Prior art date
Application number
PE2001001250A
Other languages
English (en)
Inventor
Benoit Nmn Ledoussal
Xiufeng Eric Hu
Ji-In Almstead
Jeffrey Lyle Gray
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20020592A1 publication Critical patent/PE20020592A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A QUINOLONAS DE FORMULA I DONDE A1 ES -N-, -C(R8)- DONDE R8 ES H, HALO, ALCOXI C1-C6, ALQUILTIO C1-C6, ENTRE OTROS; X ES -C-, -N- DONDE (i) SI X ES -C-, a ES UN DOBLE ENLACE Y b ES UN ENLACE INDIVIDUAL; Y ES -N(R1), -C(R1) SIEMPRE QUE Y ES N(R1) SOLAMENTE X ES -C-, Y ES -C(R1)- SOLAMENTE SI X ES N; R1 ES CICLOALQUILO C3-C6, HETEROCICLOALQUILO C4-C6. ALQUILO C1-C6, ENTRE OTROS; R2 ES H; R3 ES H, OH; R5 ES H, OH, AMINO, HALO, ALQUILO, ENTRE OTROS; R6 ES F, Cl; R7 ES -Q-C(R11)(R11')(R11'') DONDE Q ES S, -O-; R11, R11', R11'' SON H, OH, HALO; R9 Y R9' SON H, ALQUILO O SE UNEN PARA FORMAR UN ANILLO HETEROCICLICO QUE CONTIENE N AL QUE ESTAN UNIDOS; R10 REPRESENTA LA MITADES EN EL ANILLO DE PIPERIDINA DIFERENTES A R7. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. SON COMPUESTOS PREFERIDOS HIDROCLORURO DEL ACIDO 7-(TRANS-3-AMINO-4-ETIL-PIPERIDINA-1-IL)-1-CICLOPROPIL-1,4-DIHIDRO-6-FLUORO-8-METOXI-4-OXO-QUINOLIN-3-CARBOXILICO, HIDROCLORURO DEL ACIDO 7-[TRANS-3-AMINO-4-(2-HIDROXI-ETIL)-PIPERIDINA-1-IL]-1-CICLOPROPIL-1,4-DIHIDRO-6-FLUORO-8-METOXI-4-OXO-QUINOLIN-3-CARBOXILICO, ENTRE OTROS. LOS OCMPUESTOS MENCIONADOS SON UTILES COMO AGENTES ANTIMICROBIANOS
PE2001001250A 2000-12-14 2001-12-13 Quinolonas como agentes antimicrobianos PE20020592A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25563400P 2000-12-14 2000-12-14

Publications (1)

Publication Number Publication Date
PE20020592A1 true PE20020592A1 (es) 2002-08-14

Family

ID=22969211

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001250A PE20020592A1 (es) 2000-12-14 2001-12-13 Quinolonas como agentes antimicrobianos

Country Status (18)

Country Link
US (2) US6645981B2 (es)
EP (1) EP1341781B1 (es)
JP (1) JP2004515548A (es)
AR (1) AR031809A1 (es)
AT (1) ATE304539T1 (es)
AU (2) AU3089102A (es)
BR (1) BR0116217A (es)
CA (1) CA2429951A1 (es)
DE (1) DE60113450T2 (es)
DK (1) DK1341781T3 (es)
ES (1) ES2249489T3 (es)
HU (1) HUP0303410A3 (es)
IL (1) IL155679A0 (es)
NO (1) NO20032665L (es)
NZ (1) NZ525571A (es)
PE (1) PE20020592A1 (es)
PL (1) PL363323A1 (es)
WO (1) WO2002048138A1 (es)

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US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
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BRPI0709220A2 (pt) 2006-03-28 2011-07-12 Procter & Gamble processo de acoplamento para preparo de intermediários de quinolona
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FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
KR20120004510A (ko) 2009-04-03 2012-01-12 아칠리온 파르마세우티칼스 인코포레이티드 항감염제로서의 하이드록시티에노퀴놀론 및 관련 화합물
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
KR20180051676A (ko) 2009-10-16 2018-05-16 멜린타 테라퓨틱스, 인크. 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
MX339000B (es) 2009-10-16 2016-05-09 Melinta Therapeutics Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
CN108456211A (zh) * 2009-10-16 2018-08-28 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
CN102617568B (zh) * 2012-03-06 2014-06-25 天津市汉康医药生物技术有限公司 一种稳定的盐酸莫西沙星化合物、其制备方法
CN103360409B (zh) * 2012-04-06 2016-02-10 天方药业有限公司 氧氟羧酸制备方法
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CN105732660B (zh) * 2014-12-10 2017-11-21 浙江京新药业股份有限公司 左氧氟沙星中间体的制备方法
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CN108440562A (zh) * 2018-05-08 2018-08-24 邳州易萨新型材料有限公司 一种左氟沙星药物中间体的合成方法
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Also Published As

Publication number Publication date
PL363323A1 (en) 2004-11-15
ATE304539T1 (de) 2005-09-15
AU2002230891B2 (en) 2005-04-07
EP1341781A1 (en) 2003-09-10
US20030008894A1 (en) 2003-01-09
DE60113450T2 (de) 2006-07-13
NO20032665L (no) 2003-08-07
AU3089102A (en) 2002-06-24
DE60113450D1 (de) 2005-10-20
BR0116217A (pt) 2003-12-30
ES2249489T3 (es) 2006-04-01
CA2429951A1 (en) 2002-06-20
HUP0303410A3 (en) 2005-12-28
AR031809A1 (es) 2003-10-01
HUP0303410A2 (hu) 2004-01-28
IL155679A0 (en) 2003-11-23
US20040029882A1 (en) 2004-02-12
DK1341781T3 (da) 2005-12-05
US6645981B2 (en) 2003-11-11
WO2002048138A1 (en) 2002-06-20
NO20032665D0 (no) 2003-06-12
EP1341781B1 (en) 2005-09-14
NZ525571A (en) 2004-09-24
JP2004515548A (ja) 2004-05-27

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