DE60113450D1 - Antimikrobielle chinolone - Google Patents

Antimikrobielle chinolone

Info

Publication number
DE60113450D1
DE60113450D1 DE60113450T DE60113450T DE60113450D1 DE 60113450 D1 DE60113450 D1 DE 60113450D1 DE 60113450 T DE60113450 T DE 60113450T DE 60113450 T DE60113450 T DE 60113450T DE 60113450 D1 DE60113450 D1 DE 60113450D1
Authority
DE
Germany
Prior art keywords
chinolone
antimicrobial
antimicrobial chinolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60113450T
Other languages
English (en)
Other versions
DE60113450T2 (de
Inventor
Benoit Ledoussal
Eric Hu
Ji-In Almstead
Lyle Gray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE60113450D1 publication Critical patent/DE60113450D1/de
Application granted granted Critical
Publication of DE60113450T2 publication Critical patent/DE60113450T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60113450T 2000-12-14 2001-12-07 Antimikrobielle chinolone Expired - Fee Related DE60113450T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25563400P 2000-12-14 2000-12-14
US255634P 2000-12-14
PCT/US2001/048532 WO2002048138A1 (en) 2000-12-14 2001-12-07 Antimicrobial quinolones

Publications (2)

Publication Number Publication Date
DE60113450D1 true DE60113450D1 (de) 2005-10-20
DE60113450T2 DE60113450T2 (de) 2006-07-13

Family

ID=22969211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60113450T Expired - Fee Related DE60113450T2 (de) 2000-12-14 2001-12-07 Antimikrobielle chinolone

Country Status (18)

Country Link
US (2) US6645981B2 (de)
EP (1) EP1341781B1 (de)
JP (1) JP2004515548A (de)
AR (1) AR031809A1 (de)
AT (1) ATE304539T1 (de)
AU (2) AU3089102A (de)
BR (1) BR0116217A (de)
CA (1) CA2429951A1 (de)
DE (1) DE60113450T2 (de)
DK (1) DK1341781T3 (de)
ES (1) ES2249489T3 (de)
HU (1) HUP0303410A3 (de)
IL (1) IL155679A0 (de)
NO (1) NO20032665L (de)
NZ (1) NZ525571A (de)
PE (1) PE20020592A1 (de)
PL (1) PL363323A1 (de)
WO (1) WO2002048138A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4669607B2 (ja) 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン類、その組成物およびその使用
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
AU2004229489B2 (en) 2003-04-07 2010-03-04 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs
CA2580749C (en) * 2004-09-17 2014-01-28 Cylene Pharmaceuticals, Inc. Quinolone analogs
US7652134B2 (en) * 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
WO2006118605A2 (en) * 2004-11-11 2006-11-09 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
EP1874731A4 (de) * 2005-04-15 2009-08-05 Cylene Pharmaceuticals Inc Chinobenzoxazinanaloga und verfahren zu deren anwendung
EP1913004B1 (de) 2005-07-27 2010-09-22 Achillion Pharmaceuticals, Inc. 8-methoxy-9h-isothiazolo[5,4-b]chinolin-3,4-dione und verwandte verbindungen als antiinfektive mittel
DK2001862T3 (da) 2006-03-28 2011-08-08 Warner Chilcott Co Llc Malatsalte og polymorfe af (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyklopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylsyre
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
US8680012B2 (en) 2006-12-14 2014-03-25 Syngenta Crop Protection Llc 4-phenyl-pyrane-3,5-diones,4-phenyl-thiopyrane-3,6-diones and cyclohexanetriones as novel herbicides
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
EA201101451A1 (ru) 2009-04-03 2012-03-30 Ачиллион Фармасьютикалз, Инк. Гидрокситиенохинолоны и родственные соединения как противоинфекционные средства
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
CN102712657A (zh) 2009-10-16 2012-10-03 Rib-X制药公司 抗微生物化合物和其制备和使用方法
SG10201406635QA (en) * 2009-10-16 2014-11-27 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
CA2777741A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN102617568B (zh) * 2012-03-06 2014-06-25 天津市汉康医药生物技术有限公司 一种稳定的盐酸莫西沙星化合物、其制备方法
CN103360409B (zh) * 2012-04-06 2016-02-10 天方药业有限公司 氧氟羧酸制备方法
JP2016536338A (ja) 2013-09-09 2016-11-24 メリンタ セラピューティクス,インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス,インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
CN105732660B (zh) * 2014-12-10 2017-11-21 浙江京新药业股份有限公司 左氧氟沙星中间体的制备方法
CA2979342A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
CA3023317A1 (en) 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
CN108440562A (zh) * 2018-05-08 2018-08-24 邳州易萨新型材料有限公司 一种左氟沙星药物中间体的合成方法
CN111253241B (zh) * 2018-11-30 2022-11-04 浙江新和成股份有限公司 一种2,4,5-三氟-3-甲氧基苯甲酰氯及其中间体的制备方法
CN110878047A (zh) * 2019-12-09 2020-03-13 怀化学院 加替沙星羧酸及其合成方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0717608B2 (ja) 1986-04-25 1995-03-01 杏林製薬株式会社 6−アルコキシキノロンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
US4921857A (en) 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
IE66202B1 (en) 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
JPH03115277A (ja) 1989-09-28 1991-05-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
IE911472A1 (en) 1990-05-02 1991-11-06 Abbott Lab Quinolizinone type compounds
US5726182A (en) 1990-05-02 1998-03-10 Abbott Laboratories Quinolizinone type compounds
US5072001A (en) 1990-11-30 1991-12-10 Warner-Lambert Company Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates
EP0596126A4 (en) 1991-12-27 1994-06-08 Wakunaga Seiyaku Kk Novel quinolone derivative or salt thereof and antibacterial containing the same.
JPH05112554A (ja) * 1992-02-19 1993-05-07 Chugai Pharmaceut Co Ltd 新規なキノロンカルボン酸誘導体
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
BR9407806A (pt) 1993-10-14 1997-08-19 Abbott Lab Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético
CA2196271C (en) 1994-08-12 2007-01-09 Yozo Todo Quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
JPH092953A (ja) * 1995-06-16 1997-01-07 Chugai Pharmaceut Co Ltd バルフロキサシン製剤
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
EP0947513B1 (de) 1996-10-25 2004-05-19 Daiichi Pharmaceutical Co., Ltd. Tricyclische aminderivate
JPH10287669A (ja) 1997-04-10 1998-10-27 Dai Ichi Seiyaku Co Ltd 置換アミノメチルピロリジン誘導体
CN1263527A (zh) 1997-05-21 2000-08-16 第一制药株式会社 顺式取代-取代氨基环烷基吡咯烷衍生物
ZA984527B (en) 1997-05-30 1998-12-03 Daiichi Seiyaku Co Substituted cyclobutylamine derivative
KR100241673B1 (ko) 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
JP4669607B2 (ja) * 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン類、その組成物およびその使用

Also Published As

Publication number Publication date
IL155679A0 (en) 2003-11-23
HUP0303410A2 (hu) 2004-01-28
JP2004515548A (ja) 2004-05-27
US6645981B2 (en) 2003-11-11
NZ525571A (en) 2004-09-24
ES2249489T3 (es) 2006-04-01
NO20032665L (no) 2003-08-07
US20040029882A1 (en) 2004-02-12
NO20032665D0 (no) 2003-06-12
BR0116217A (pt) 2003-12-30
AU3089102A (en) 2002-06-24
EP1341781B1 (de) 2005-09-14
US20030008894A1 (en) 2003-01-09
HUP0303410A3 (en) 2005-12-28
AR031809A1 (es) 2003-10-01
WO2002048138A1 (en) 2002-06-20
CA2429951A1 (en) 2002-06-20
PE20020592A1 (es) 2002-08-14
DK1341781T3 (da) 2005-12-05
EP1341781A1 (de) 2003-09-10
PL363323A1 (en) 2004-11-15
ATE304539T1 (de) 2005-09-15
DE60113450T2 (de) 2006-07-13
AU2002230891B2 (en) 2005-04-07

Similar Documents

Publication Publication Date Title
DE60113450D1 (de) Antimikrobielle chinolone
DZ3409A1 (fr) Association therapeuthique
DE50105915D1 (de) Schutzhülle
ATE290000T1 (de) Muscarinagonisten
ATE252099T1 (de) Biarylcarboxamide
DE10136334B8 (de) Hochgeschwindigkeitsvertikalresonatoroberflächenemissionslaser
ATE312098T1 (de) Thiazinoxazolidinon
DE60100567D1 (de) Antimikrobielle zusammensetzungen
ATA2932001A (de) Schneefräse
ATE298751T1 (de) 7-oxopyridoryrimidine
ATE262530T1 (de) Indolochinazolinone
DE10192638T1 (de) Bohrstangenladevorrichtung
AR028336A1 (es) 4-hidroxi-tetrahidropiridonas fenilsubstituidas
ATE264843T1 (de) Antibakterielle mutiline
ATE509008T1 (de) Sulfonylguanidine
AR028061A1 (es) 2-enamino-cetonitrilos fenil-substituidos
ATE342343T1 (de) Antimikrobielle abwischtücher
AR027931A1 (es) Antitranspirantes
DE10052925B4 (de) Schaukelbett
ATE476423T1 (de) Benzoylpyridazine
DE10085445T1 (de) Drahterodierbearbeitungseinrichtung
DE10195909T1 (de) Viehfüttervorrichtung
AR027982A1 (es) Aril- y heteroarilsulfonatos
ATE284887T1 (de) Thienopyrrolidinone
DE10054120B4 (de) Aufsparrendämmelement

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee