HUP0303410A2 - Antimikrobiális hatású kinolonok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Antimikrobiális hatású kinolonok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0303410A2
HUP0303410A2 HU0303410A HUP0303410A HUP0303410A2 HU P0303410 A2 HUP0303410 A2 HU P0303410A2 HU 0303410 A HU0303410 A HU 0303410A HU P0303410 A HUP0303410 A HU P0303410A HU P0303410 A2 HUP0303410 A2 HU P0303410A2
Authority
HU
Hungary
Prior art keywords
atom
hydrogen atom
alkyl
group
hydrogen
Prior art date
Application number
HU0303410A
Other languages
English (en)
Inventor
Ji-In Almstead
Jeffrey Lyle Gray
Xiufeng Eric Hu
Benoit Ledoussal
Original Assignee
The Procter & Gamble Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Co. filed Critical The Procter & Gamble Co.
Publication of HUP0303410A2 publication Critical patent/HUP0303410A2/hu
Publication of HUP0303410A3 publication Critical patent/HUP0303410A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

A találmány tárgyát általános képletű - ahol A1 =N- vagy adott esetbenszubsztituált =CH-; X szén- vagy nitrogénatom; R1 alkil-, cikloalkil-,heterocikloalkil-, aril- vagy heteroaril-csoport; R2 hidrogénatom; R3hidrogénatom vagy hidroxicsoport, R5 hidrogén-, halogénatom, hidroxi-,amino-, alkil-, alkenil- vagy alkoxicsoport; R6 fluor- vagy klóratom;R7 összetett szubsztituens; R9 és R9' hidrogénatom, alkilcsoport vagyegyütt heterociklusos csoport; és R10 R7-től eltérő, hidrogén-,fluoratom, alkilcsoport - és optikai izomereik, diasztereomereik,enantiomereik, sóik, hidrátjaik, biológiailag hidrolizálhatószármazékaik és ezeket tartalmazó gyógyszerkészítmények képezik. Ó
HU0303410A 2000-12-14 2001-12-07 Antimicrobial quinolones, pharmaceutical compositions containing them and their use HUP0303410A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25563400P 2000-12-14 2000-12-14
PCT/US2001/048532 WO2002048138A1 (en) 2000-12-14 2001-12-07 Antimicrobial quinolones

Publications (2)

Publication Number Publication Date
HUP0303410A2 true HUP0303410A2 (hu) 2004-01-28
HUP0303410A3 HUP0303410A3 (en) 2005-12-28

Family

ID=22969211

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303410A HUP0303410A3 (en) 2000-12-14 2001-12-07 Antimicrobial quinolones, pharmaceutical compositions containing them and their use

Country Status (18)

Country Link
US (2) US6645981B2 (hu)
EP (1) EP1341781B1 (hu)
JP (1) JP2004515548A (hu)
AR (1) AR031809A1 (hu)
AT (1) ATE304539T1 (hu)
AU (2) AU3089102A (hu)
BR (1) BR0116217A (hu)
CA (1) CA2429951A1 (hu)
DE (1) DE60113450T2 (hu)
DK (1) DK1341781T3 (hu)
ES (1) ES2249489T3 (hu)
HU (1) HUP0303410A3 (hu)
IL (1) IL155679A0 (hu)
NO (1) NO20032665L (hu)
NZ (1) NZ525571A (hu)
PE (1) PE20020592A1 (hu)
PL (1) PL363323A1 (hu)
WO (1) WO2002048138A1 (hu)

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PL339408A1 (en) 1997-09-15 2000-12-18 Procter & Gamble Antimicrobial quinolones, agents containing them and their applications
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
EP1610759A4 (en) * 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc SUBSTITUTED QUINOBENZOXAZINE ANALOGUES
NZ553746A (en) * 2004-09-17 2010-06-25 Cylene Pharmaceuticals Inc Quinolone analogs as cell proliferation inhibitors
US7652134B2 (en) * 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
US20060100215A1 (en) * 2004-11-11 2006-05-11 Bradbury Barton J 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
WO2006113509A2 (en) * 2005-04-15 2006-10-26 Cylene Pharmaceuticals, Inc. Quinobenzoxazine analogs and methods of using thereof
PL1913004T3 (pl) 2005-07-27 2011-03-31 Achillion Pharmaceuticals Inc 8-metoksy-9H-izotiazolo[5,4-B] chinolino-3,4-diony i pokrewne związki jako środki przeciwzakaźne
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
AU2007331723B2 (en) 2006-12-14 2013-05-30 Syngenta Limited 4-phenyl-pyrane-3,5-diones, 4-phenyl-thiopyrane-3,5-diones and cyclohexanetriones as novel herbicides
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
EP2414368B1 (en) 2009-04-03 2013-11-27 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
EA201270568A1 (ru) 2009-10-16 2012-11-30 Риб-Экс Фармасьютикалз, Инк. Антимикробные композиции и способы их получения и применения
NZ713357A (en) * 2009-10-16 2017-05-26 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
WO2011047323A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN102617568B (zh) * 2012-03-06 2014-06-25 天津市汉康医药生物技术有限公司 一种稳定的盐酸莫西沙星化合物、其制备方法
CN103360409B (zh) * 2012-04-06 2016-02-10 天方药业有限公司 氧氟羧酸制备方法
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス，インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
CN105732660B (zh) * 2014-12-10 2017-11-21 浙江京新药业股份有限公司 左氧氟沙星中间体的制备方法
JP2018507881A (ja) 2015-03-11 2018-03-22 メリンタ セラピューティクス，インコーポレイテッド 抗微生物化合物ならびにこれらを作製および使用する方法
CN108440562A (zh) * 2018-05-08 2018-08-24 邳州易萨新型材料有限公司 一种左氟沙星药物中间体的合成方法
CN111253241B (zh) * 2018-11-30 2022-11-04 浙江新和成股份有限公司 一种2,4,5-三氟-3-甲氧基苯甲酰氯及其中间体的制备方法
CN110878047A (zh) * 2019-12-09 2020-03-13 怀化学院 加替沙星羧酸及其合成方法

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Also Published As

Publication number Publication date
NO20032665D0 (no) 2003-06-12
US6645981B2 (en) 2003-11-11
BR0116217A (pt) 2003-12-30
DE60113450D1 (de) 2005-10-20
NZ525571A (en) 2004-09-24
AU3089102A (en) 2002-06-24
JP2004515548A (ja) 2004-05-27
HUP0303410A3 (en) 2005-12-28
WO2002048138A1 (en) 2002-06-20
CA2429951A1 (en) 2002-06-20
ATE304539T1 (de) 2005-09-15
PE20020592A1 (es) 2002-08-14
DK1341781T3 (da) 2005-12-05
NO20032665L (no) 2003-08-07
ES2249489T3 (es) 2006-04-01
IL155679A0 (en) 2003-11-23
PL363323A1 (en) 2004-11-15
US20040029882A1 (en) 2004-02-12
US20030008894A1 (en) 2003-01-09
AR031809A1 (es) 2003-10-01
EP1341781B1 (en) 2005-09-14
EP1341781A1 (en) 2003-09-10
AU2002230891B2 (en) 2005-04-07
DE60113450T2 (de) 2006-07-13

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