DE60008136D1 - Verbessertes verfahren zur herstellung von n-substituierte aminotetraline - Google Patents

Verbessertes verfahren zur herstellung von n-substituierte aminotetraline

Info

Publication number
DE60008136D1
DE60008136D1 DE60008136T DE60008136T DE60008136D1 DE 60008136 D1 DE60008136 D1 DE 60008136D1 DE 60008136 T DE60008136 T DE 60008136T DE 60008136 T DE60008136 T DE 60008136T DE 60008136 D1 DE60008136 D1 DE 60008136D1
Authority
DE
Germany
Prior art keywords
aminotetraline
substituted
producing
improved method
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60008136T
Other languages
English (en)
Other versions
DE60008136T2 (de
Inventor
Gevork Minaskanian
Keith Rippel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aderis Pharmaceuticals Inc
Original Assignee
Aderis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderis Pharmaceuticals Inc filed Critical Aderis Pharmaceuticals Inc
Publication of DE60008136D1 publication Critical patent/DE60008136D1/de
Application granted granted Critical
Publication of DE60008136T2 publication Critical patent/DE60008136T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DE60008136T 1999-11-23 2000-11-16 Verbessertes verfahren zur herstellung von n-substituierte aminotetraline Expired - Lifetime DE60008136T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16700999P 1999-11-23 1999-11-23
US167009P 1999-11-23
PCT/US2000/031415 WO2001038321A1 (en) 1999-11-23 2000-11-16 Improved process for preparing nitrogen-substituted aminotetralins

Publications (2)

Publication Number Publication Date
DE60008136D1 true DE60008136D1 (de) 2004-03-11
DE60008136T2 DE60008136T2 (de) 2004-09-09

Family

ID=22605581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008136T Expired - Lifetime DE60008136T2 (de) 1999-11-23 2000-11-16 Verbessertes verfahren zur herstellung von n-substituierte aminotetraline

Country Status (15)

Country Link
US (1) US6372920B1 (de)
EP (1) EP1232152B1 (de)
CN (1) CN1185225C (de)
AR (1) AR026505A1 (de)
AT (1) ATE258927T1 (de)
AU (1) AU1613101A (de)
CA (1) CA2392563C (de)
DE (1) DE60008136T2 (de)
DK (1) DK1232152T3 (de)
ES (1) ES2216992T3 (de)
HK (2) HK1049156B (de)
PL (1) PL202805B1 (de)
PT (1) PT1232152E (de)
TR (1) TR200400401T4 (de)
WO (1) WO2001038321A1 (de)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246979B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) * 2003-12-18 2005-07-28 Schwarz Pharma Ag (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) * 2004-02-20 2005-09-08 Schwarz Pharma Ag Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) * 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (de) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Im Mund-Nasen-Rachenraum verabreichbare pharmazeutische Zusammensetzungen enthaltend Dopaminagonisten zur Vorbeugung und/oder Behandlung von unruhigen Gliedmassen
WO2008146284A2 (en) * 2007-05-30 2008-12-04 Chemagis Ltd. Crystalline rotigotine base and preparation process therefor
WO2009053697A1 (en) * 2007-10-26 2009-04-30 Pliva Hrvatska D.O.O. Polymorphic forms of ( s ) -rotigotine hydrochloride
WO2009056791A1 (en) * 2007-11-02 2009-05-07 Pliva Hrvatska D.O.O. Processes for preparing pharmaceutical compounds
EA017836B1 (ru) 2007-11-28 2013-03-29 ЮСиБи ФАРМА ГМБХ Новая полиморфная форма ротиготина и способ ее получения
US20090202647A1 (en) * 2008-02-11 2009-08-13 Mayur Devjibhai Khunt Solid form of racemic rotigotine
IT1392387B1 (it) * 2008-09-26 2012-03-02 Solmag S P A Ora Fidia Farmaceutici S P A Processo per la preparazione di rotigotina
EP2376470B1 (de) * 2008-12-09 2013-04-10 Interquim, S.A Verfahren zur herstellung von (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotin)
WO2010073124A2 (en) 2008-12-26 2010-07-01 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
EP2281559A1 (de) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmazeutische Zusammensetzung enthaltend Rotigotin (Salze oder Na), insbesondere für Iontophorese
CN102010400B (zh) 2009-09-07 2015-02-04 药源药物化学（上海）有限公司 S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀
EP2490673A2 (de) 2009-10-19 2012-08-29 Actavis Group Ptc Ehf Amorphe rotigotin-copräzipitate
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
CN104189912A (zh) 2009-12-22 2014-12-10 优时比制药有限公司 用于使非结晶形式的罗替戈汀的固体分散体稳定化的聚乙烯吡咯烷酮
IN2012DN06562A (de) 2010-02-05 2015-10-23 Ucb Pharma Gmbh
JP5748848B2 (ja) 2010-06-25 2015-07-15 ウーツェーベー ファルマ ゲーエムベーハーＵｃｂ Ｐｈａｒｍａ Ｇｍｂｈ 窒素置換（ｓ）−５−アルコキシ−２−アミノテトラリン誘導体の分割方法
KR101478597B1 (ko) 2011-06-27 2015-01-02 산동 루예 파마슈티칼 컴파니 리미티드 질소 치환 아미노-5,6,7,8-테트라하이드로나프톨의 공업화 제조방법
CN103768043B (zh) * 2012-10-22 2015-12-09 苏州药明康德新药开发股份有限公司 采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法
US10611749B2 (en) 2018-02-15 2020-04-07 Solara Active Pharma Sciences Limited Process for preparation of Rotigotine and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062971D1 (en) 1979-09-14 1983-06-09 Sandoz Ag Derivatives of tetraline, their preparation and medicaments containing these compounds
US4564628A (en) 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US4968837A (en) 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
US5382596A (en) * 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins

Also Published As

Publication number Publication date
CA2392563C (en) 2011-02-15
HK1049156A1 (en) 2003-05-02
ATE258927T1 (de) 2004-02-15
CN1185225C (zh) 2005-01-19
PL202805B1 (pl) 2009-07-31
AR026505A1 (es) 2003-02-12
PT1232152E (pt) 2004-06-30
WO2001038321A1 (en) 2001-05-31
CA2392563A1 (en) 2001-05-31
TR200400401T4 (tr) 2004-03-22
HK1049156B (en) 2004-12-10
EP1232152A1 (de) 2002-08-21
HK1052514A1 (zh) 2003-09-19
CN1391569A (zh) 2003-01-15
PL355607A1 (en) 2004-05-04
DK1232152T3 (da) 2004-04-05
US6372920B1 (en) 2002-04-16
DE60008136T2 (de) 2004-09-09
EP1232152B1 (de) 2004-02-04
AU1613101A (en) 2001-06-04
ES2216992T3 (es) 2004-11-01

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