PT1362040E - Processo para a preparacao de mesilatos de derivados de piperazina - Google Patents
Processo para a preparacao de mesilatos de derivados de piperazinaInfo
- Publication number
- PT1362040E PT1362040E PT02719858T PT02719858T PT1362040E PT 1362040 E PT1362040 E PT 1362040E PT 02719858 T PT02719858 T PT 02719858T PT 02719858 T PT02719858 T PT 02719858T PT 1362040 E PT1362040 E PT 1362040E
- Authority
- PT
- Portugal
- Prior art keywords
- mesilates
- preparation
- piperazine derivatives
- piperazine
- derivatives
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200534 | 2001-02-16 | ||
| PCT/EP2002/001666 WO2002066449A2 (en) | 2001-02-16 | 2002-02-14 | Process for the preparation of mesylates of piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1362040E true PT1362040E (pt) | 2005-05-31 |
Family
ID=8179894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02719858T PT1362040E (pt) | 2001-02-16 | 2002-02-14 | Processo para a preparacao de mesilatos de derivados de piperazina |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7030241B2 (pt) |
| EP (1) | EP1362040B1 (pt) |
| JP (1) | JP4328528B2 (pt) |
| KR (2) | KR100859106B1 (pt) |
| CN (1) | CN1176079C (pt) |
| AR (1) | AR034206A1 (pt) |
| AT (1) | ATE284875T1 (pt) |
| AU (1) | AU2002250962B2 (pt) |
| BG (1) | BG66101B1 (pt) |
| BR (1) | BR0205683A (pt) |
| CA (1) | CA2422703C (pt) |
| CZ (1) | CZ301780B6 (pt) |
| DE (1) | DE60202261T2 (pt) |
| DK (1) | DK1362040T3 (pt) |
| DZ (1) | DZ3489A1 (pt) |
| ES (1) | ES2230481T3 (pt) |
| HK (1) | HK1059934A1 (pt) |
| HR (1) | HRP20030610B1 (pt) |
| HU (1) | HUP0400772A3 (pt) |
| IL (1) | IL153509A (pt) |
| IS (1) | IS2417B (pt) |
| ME (1) | MEP37508A (pt) |
| MX (1) | MXPA03002359A (pt) |
| MY (1) | MY130687A (pt) |
| NO (1) | NO324460B1 (pt) |
| NZ (1) | NZ524632A (pt) |
| PL (1) | PL208363B1 (pt) |
| PT (1) | PT1362040E (pt) |
| RS (1) | RS51126B (pt) |
| RU (1) | RU2272036C2 (pt) |
| SI (1) | SI1362040T1 (pt) |
| SK (1) | SK286143B6 (pt) |
| UA (1) | UA75390C2 (pt) |
| WO (1) | WO2002066449A2 (pt) |
| ZA (1) | ZA200301590B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| AR045362A1 (es) * | 2003-08-18 | 2005-10-26 | Solvay Pharm Bv | Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona |
| US7405216B2 (en) * | 2004-08-18 | 2008-07-29 | Solvay Pharmaceuticals, B.V. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| US7423040B2 (en) * | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US20070275977A1 (en) * | 2006-05-02 | 2007-11-29 | Van Aar Marcel P | N-oxides of pyridylmethyl -piperazine and -piperidine derivatives |
| US7786126B2 (en) * | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| US8106056B2 (en) * | 2006-06-16 | 2012-01-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising bifeprunox and a dopamine agonist |
| US20090068290A1 (en) * | 2006-08-31 | 2009-03-12 | Michel Bourin | Bifeprunox doses for treating schizophrenia |
| EP2059244A1 (en) | 2006-08-31 | 2009-05-20 | Solvay Pharmaceuticals B.V. | Titration schedule for bifeprunox for treating schizophrenia and kits for use therein |
| US20080132520A1 (en) * | 2006-08-31 | 2008-06-05 | Winsemius Antje A | Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds |
| CN101939009B (zh) | 2008-02-05 | 2013-07-17 | 哈博生物科学公司 | 药学固体形式 |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| UY32935A (es) | 2009-10-12 | 2011-05-31 | Abbott Healthcare Products Bv | Polimorfos de pardoprunox |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586794T2 (de) * | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| EP0190472B1 (en) * | 1984-12-21 | 1989-07-12 | Duphar International Research B.V | New pharmaceutical compositions having anti-psychotic properties |
| JPH0344383A (ja) * | 1989-07-12 | 1991-02-26 | Ihara Chem Ind Co Ltd | ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法 |
| JP3044383B2 (ja) * | 1990-05-22 | 2000-05-22 | コニカ株式会社 | 含窒素６員環化合物の製造方法 |
| NZ331860A (en) * | 1996-03-29 | 2000-04-28 | Duphar Int Res | Piperazine and piperidine compounds with affinity for both dopamine D2 and seratonin 5-HT1A receptors |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| US7435738B2 (en) * | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
-
2002
- 2002-02-12 AR ARP020100460A patent/AR034206A1/es active IP Right Grant
- 2002-02-14 KR KR1020037000026A patent/KR100859106B1/ko not_active IP Right Cessation
- 2002-02-14 CN CNB028016858A patent/CN1176079C/zh not_active Expired - Fee Related
- 2002-02-14 DK DK02719858T patent/DK1362040T3/da active
- 2002-02-14 PT PT02719858T patent/PT1362040E/pt unknown
- 2002-02-14 MX MXPA03002359A patent/MXPA03002359A/es active IP Right Grant
- 2002-02-14 AT AT02719858T patent/ATE284875T1/de active
- 2002-02-14 RS YUP-644/03A patent/RS51126B/sr unknown
- 2002-02-14 PL PL369330A patent/PL208363B1/pl unknown
- 2002-02-14 AU AU2002250962A patent/AU2002250962B2/en not_active Ceased
- 2002-02-14 MY MYPI20020505A patent/MY130687A/en unknown
- 2002-02-14 KR KR1020087015071A patent/KR101000733B1/ko not_active IP Right Cessation
- 2002-02-14 NZ NZ524632A patent/NZ524632A/en not_active IP Right Cessation
- 2002-02-14 UA UA2003098528A patent/UA75390C2/uk unknown
- 2002-02-14 ES ES02719858T patent/ES2230481T3/es not_active Expired - Lifetime
- 2002-02-14 CZ CZ20030697A patent/CZ301780B6/cs not_active IP Right Cessation
- 2002-02-14 ME MEP-375/08A patent/MEP37508A/xx unknown
- 2002-02-14 BR BR0205683-6A patent/BR0205683A/pt not_active Application Discontinuation
- 2002-02-14 EP EP02719858A patent/EP1362040B1/en not_active Expired - Lifetime
- 2002-02-14 CA CA2422703A patent/CA2422703C/en not_active Expired - Fee Related
- 2002-02-14 IL IL153509A patent/IL153509A/en not_active IP Right Cessation
- 2002-02-14 US US10/468,098 patent/US7030241B2/en not_active Expired - Fee Related
- 2002-02-14 SI SI200230061T patent/SI1362040T1/xx unknown
- 2002-02-14 DE DE60202261T patent/DE60202261T2/de not_active Expired - Lifetime
- 2002-02-14 JP JP2002565965A patent/JP4328528B2/ja not_active Expired - Fee Related
- 2002-02-14 DZ DZ023489A patent/DZ3489A1/fr active
- 2002-02-14 HU HU0400772A patent/HUP0400772A3/hu unknown
- 2002-02-14 WO PCT/EP2002/001666 patent/WO2002066449A2/en active IP Right Grant
- 2002-02-14 SK SK309-2003A patent/SK286143B6/sk not_active IP Right Cessation
- 2002-02-14 RU RU2003105902/04A patent/RU2272036C2/ru not_active IP Right Cessation
-
2003
- 2003-02-26 ZA ZA200301590A patent/ZA200301590B/en unknown
- 2003-04-15 NO NO20031754A patent/NO324460B1/no not_active IP Right Cessation
- 2003-07-17 IS IS6876A patent/IS2417B/is unknown
- 2003-07-28 HR HR20030610A patent/HRP20030610B1/xx not_active IP Right Cessation
- 2003-08-13 BG BG108090A patent/BG66101B1/bg unknown
-
2004
- 2004-04-22 HK HK04102835A patent/HK1059934A1/xx not_active IP Right Cessation
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