BG66101B1 - Метод за получаване на мезилатни пиперазинови производни - Google Patents

Метод за получаване на мезилатни пиперазинови производни

Info

Publication number
BG66101B1
BG66101B1 BG108090A BG10809003A BG66101B1 BG 66101 B1 BG66101 B1 BG 66101B1 BG 108090 A BG108090 A BG 108090A BG 10809003 A BG10809003 A BG 10809003A BG 66101 B1 BG66101 B1 BG 66101B1
Authority
BG
Bulgaria
Prior art keywords
mesylates
preparation
piperazine derivatives
methyl
benzyl
Prior art date
Application number
BG108090A
Other languages
English (en)
Other versions
BG108090A (bg
Inventor
AAR Marcel VAN
Stefanus Schouten
Jan Zorgdrager
Michiel HESLINGA
Original Assignee
Solvay Pharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals B.V. filed Critical Solvay Pharmaceuticals B.V.
Publication of BG108090A publication Critical patent/BG108090A/bg
Publication of BG66101B1 publication Critical patent/BG66101B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретението се отнася до мезилати от групата на пиперазиновите производни и до метод за получаването им по икономичен начин с повишени добив и чистота. Съгласно метода синтезът на пиперазиновия пръстен и образуването на мезилат са обединени само в един етап. Изобретението се отнася до мезилат на съединения с формула@@в която Х е бициклична хетероциклична фенилова група, а Y е метил, етил (евентуално заместен с флуор), циклоалкил (3-7С) метил, бензил или m-фенилбензил.
BG108090A 2001-02-16 2003-08-13 Метод за получаване на мезилатни пиперазинови производни BG66101B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200534 2001-02-16
PCT/EP2002/001666 WO2002066449A2 (en) 2001-02-16 2002-02-14 Process for the preparation of mesylates of piperazine derivatives

Publications (2)

Publication Number Publication Date
BG108090A BG108090A (bg) 2004-12-30
BG66101B1 true BG66101B1 (bg) 2011-04-29

Family

ID=8179894

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108090A BG66101B1 (bg) 2001-02-16 2003-08-13 Метод за получаване на мезилатни пиперазинови производни

Country Status (35)

Country Link
US (1) US7030241B2 (bg)
EP (1) EP1362040B1 (bg)
JP (1) JP4328528B2 (bg)
KR (2) KR101000733B1 (bg)
CN (1) CN1176079C (bg)
AR (1) AR034206A1 (bg)
AT (1) ATE284875T1 (bg)
AU (1) AU2002250962B2 (bg)
BG (1) BG66101B1 (bg)
BR (1) BR0205683A (bg)
CA (1) CA2422703C (bg)
CZ (1) CZ301780B6 (bg)
DE (1) DE60202261T2 (bg)
DK (1) DK1362040T3 (bg)
DZ (1) DZ3489A1 (bg)
ES (1) ES2230481T3 (bg)
HK (1) HK1059934A1 (bg)
HR (1) HRP20030610B1 (bg)
HU (1) HUP0400772A3 (bg)
IL (1) IL153509A (bg)
IS (1) IS2417B (bg)
ME (1) MEP37508A (bg)
MX (1) MXPA03002359A (bg)
MY (1) MY130687A (bg)
NO (1) NO324460B1 (bg)
NZ (1) NZ524632A (bg)
PL (1) PL208363B1 (bg)
PT (1) PT1362040E (bg)
RS (1) RS51126B (bg)
RU (1) RU2272036C2 (bg)
SI (1) SI1362040T1 (bg)
SK (1) SK286143B6 (bg)
UA (1) UA75390C2 (bg)
WO (1) WO2002066449A2 (bg)
ZA (1) ZA200301590B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045362A1 (es) * 2003-08-18 2005-10-26 Solvay Pharm Bv Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en) 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7964604B2 (en) * 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
EP2059244A1 (en) 2006-08-31 2009-05-20 Solvay Pharmaceuticals B.V. Titration schedule for bifeprunox for treating schizophrenia and kits for use therein
US20090068290A1 (en) * 2006-08-31 2009-03-12 Michel Bourin Bifeprunox doses for treating schizophrenia
US20080132520A1 (en) * 2006-08-31 2008-06-05 Winsemius Antje A Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds
EP2249838A4 (en) 2008-02-05 2012-05-02 Harbor Biosciences Inc PHARMACEUTICAL FORMS IN SOLID STATE
WO2011023796A1 (en) 2009-08-31 2011-03-03 Abbott Healthcare Products B.V. Bifeprunox for treating addiction
UY32935A (es) 2009-10-12 2011-05-31 Abbott Healthcare Products Bv Polimorfos de pardoprunox

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344383A (ja) * 1989-07-12 1991-02-26 Ihara Chem Ind Co Ltd ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
EP0185429A1 (en) * 1984-12-21 1986-06-25 Duphar International Research B.V New bicyclic heteroaryl piperazines
JP3044383B2 (ja) * 1990-05-22 2000-05-22 コニカ株式会社 含窒素６員環化合物の製造方法
DE69736704T2 (de) * 1996-03-29 2007-09-13 Duphar International Research B.V. Piperazin- und piperidin- derivate
SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
UA71590C2 (en) * 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344383A (ja) * 1989-07-12 1991-02-26 Ihara Chem Ind Co Ltd ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法

Also Published As

Publication number Publication date
NO324460B1 (no) 2007-10-22
BR0205683A (pt) 2004-07-06
HUP0400772A3 (en) 2008-02-28
KR20030077523A (ko) 2003-10-01
US7030241B2 (en) 2006-04-18
WO2002066449A2 (en) 2002-08-29
NO20031754D0 (no) 2003-04-15
WO2002066449A3 (en) 2002-10-24
UA75390C2 (en) 2006-04-17
SK3092003A3 (en) 2003-09-11
ES2230481T3 (es) 2005-05-01
CA2422703A1 (en) 2002-08-29
SK286143B6 (sk) 2008-04-07
JP2004518741A (ja) 2004-06-24
YU64403A (sh) 2006-05-25
IS6876A (is) 2003-07-17
NZ524632A (en) 2004-03-26
HRP20030610B1 (en) 2006-02-28
AU2002250962B2 (en) 2006-08-24
IS2417B (is) 2008-10-15
IL153509A (en) 2007-12-03
KR20080064206A (ko) 2008-07-08
PL369330A1 (en) 2005-04-18
CN1176079C (zh) 2004-11-17
CZ2003697A3 (cs) 2003-06-18
PL208363B1 (pl) 2011-04-29
ZA200301590B (en) 2004-02-05
RU2272036C2 (ru) 2006-03-20
CZ301780B6 (cs) 2010-06-23
SI1362040T1 (en) 2005-06-30
MY130687A (en) 2007-07-31
BG108090A (bg) 2004-12-30
US20040077631A1 (en) 2004-04-22
MEP37508A (en) 2011-02-10
JP4328528B2 (ja) 2009-09-09
HRP20030610A2 (en) 2005-06-30
RS51126B (sr) 2010-10-31
PT1362040E (pt) 2005-05-31
DZ3489A1 (fr) 2002-08-29
MXPA03002359A (es) 2003-06-30
CA2422703C (en) 2010-04-13
HK1059934A1 (en) 2004-07-23
EP1362040B1 (en) 2004-12-15
CN1463268A (zh) 2003-12-24
DE60202261D1 (de) 2005-01-20
IL153509A0 (en) 2003-07-06
KR101000733B1 (ko) 2010-12-14
DE60202261T2 (de) 2005-05-19
NO20031754L (no) 2003-04-15
AR034206A1 (es) 2004-02-04
ATE284875T1 (de) 2005-01-15
KR100859106B1 (ko) 2008-09-18
DK1362040T3 (da) 2005-01-24
EP1362040A2 (en) 2003-11-19
HUP0400772A2 (hu) 2004-08-30

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