MXPA04000978A - Procedimiento para la produccion de 4-amino-2,5-bisheterociclilquinazolinas. - Google Patents
Procedimiento para la produccion de 4-amino-2,5-bisheterociclilquinazolinas.Info
- Publication number
- MXPA04000978A MXPA04000978A MXPA04000978A MXPA04000978A MXPA04000978A MX PA04000978 A MXPA04000978 A MX PA04000978A MX PA04000978 A MXPA04000978 A MX PA04000978A MX PA04000978 A MXPA04000978 A MX PA04000978A MX PA04000978 A MXPA04000978 A MX PA04000978A
- Authority
- MX
- Mexico
- Prior art keywords
- ring
- optionally substituted
- heterocyclic ring
- membered heterocyclic
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invencion proporciona un procedimiento para la produccion de un compuesto de formula (A), o una sal o solvato farmaceuticamente aceptable del mismo, (ver formula). en la que R1 representa alcoxi CI-4 opcionalmente sustituido con uno o mas atomos de fluor; R2 representa H o alcoxi C1-6, opcionalmente sustituido con uno o mas atomos de fluor; R3 representa un anillo heterociclico de 5 o 6 miembros que esta opcionalmetne sustituido; R4 es un anillo heterociclico de 4, 5, 6 o 7 miembros que esta opcionalmente condensado con una anillo de benceno o un anillo heterociclico de 5 o 6 miembros, estando opcionalmente sustituido el sistema de anillo en conjunto; comprendiendo el procedimiento condensar un compuesto de formula (B) en la que R1 a R3 son como se han definido anteriormente; con un compuesto de formula (C), en la que R5 y R6, tomados conjuntamente con el atomo de N al que estan unidos, representan un anillo heterociclico que contiene N, de 4, 5, 6 o 7 miembros, estando opcionalmente condensado el anillo con un anillo de benceno o un anillo heterociclico de 5 o 6 miembros, estando opcionalmente sustituido el sistema de anillo en conjunto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0118752.5A GB0118752D0 (en) | 2001-08-01 | 2001-08-01 | Process for the production of quinazolines |
| PCT/IB2002/002872 WO2003011829A1 (en) | 2001-08-01 | 2002-07-19 | Process for the production of quinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04000978A true MXPA04000978A (es) | 2004-04-20 |
Family
ID=9919612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04000978A MXPA04000978A (es) | 2001-08-01 | 2002-07-19 | Procedimiento para la produccion de 4-amino-2,5-bisheterociclilquinazolinas. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7026479B2 (es) |
| EP (1) | EP1412331B1 (es) |
| JP (1) | JP2005501054A (es) |
| KR (1) | KR20040019097A (es) |
| CN (1) | CN1533378A (es) |
| AP (1) | AP1299A (es) |
| AR (1) | AR036204A1 (es) |
| AT (1) | ATE323677T1 (es) |
| BR (1) | BR0211670A (es) |
| CA (1) | CA2451075A1 (es) |
| CZ (1) | CZ2004151A3 (es) |
| DE (1) | DE60210778T2 (es) |
| DO (1) | DOP2002000443A (es) |
| EG (1) | EG23204A (es) |
| ES (1) | ES2260457T3 (es) |
| GB (1) | GB0118752D0 (es) |
| HN (1) | HN2002000197A (es) |
| HU (1) | HUP0401573A3 (es) |
| IL (1) | IL158998A0 (es) |
| MX (1) | MXPA04000978A (es) |
| PA (1) | PA8550301A1 (es) |
| PE (1) | PE20030346A1 (es) |
| PL (1) | PL368520A1 (es) |
| RU (1) | RU2261861C1 (es) |
| UY (1) | UY27399A1 (es) |
| WO (1) | WO2003011829A1 (es) |
| ZA (1) | ZA200309043B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
| ATE532782T1 (de) * | 2003-09-26 | 2011-11-15 | Exelixis Inc | C-met-modulatoren und anwendungsverfahren |
| CN1972688B (zh) * | 2004-05-06 | 2012-06-27 | 沃尼尔·朗伯有限责任公司 | 4-苯胺基-喹唑啉-6-基-酰胺类化合物 |
| US7985753B2 (en) * | 2006-08-04 | 2011-07-26 | Merz Pharma Gmbh & Co. Kgaa | Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators |
| EA019959B1 (ru) | 2009-01-16 | 2014-07-30 | Экселиксис, Инк. | Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее кристаллические формы для лечения рака |
| JP5795304B2 (ja) | 2009-03-18 | 2015-10-14 | レスバーロジックス コーポレイション | 新規抗炎症剤 |
| IN2012DN00352A (es) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| US9353063B2 (en) | 2011-11-30 | 2016-05-31 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| CA2888378C (en) * | 2012-10-15 | 2015-09-22 | Resverlogix Corp. | Compounds useful in the synthesis of benzamide compounds |
| EP3268007B1 (en) | 2015-03-13 | 2022-11-09 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719378D0 (en) * | 1987-08-15 | 1987-09-23 | Pfizer Ltd | Antiarrythmic agents |
| EP0894797A4 (en) * | 1997-01-09 | 2001-08-16 | Terumo Corp | NEW AMID DERIVATIVES AND INTERMEDIATES ON YOUR SYNTHESIS |
-
2001
- 2001-08-01 GB GBGB0118752.5A patent/GB0118752D0/en not_active Ceased
-
2002
- 2002-07-11 PA PA20028550301A patent/PA8550301A1/es unknown
- 2002-07-19 RU RU2004102692/04A patent/RU2261861C1/ru not_active IP Right Cessation
- 2002-07-19 ES ES02745749T patent/ES2260457T3/es not_active Expired - Lifetime
- 2002-07-19 JP JP2003517021A patent/JP2005501054A/ja active Pending
- 2002-07-19 CA CA002451075A patent/CA2451075A1/en not_active Abandoned
- 2002-07-19 DE DE60210778T patent/DE60210778T2/de not_active Expired - Fee Related
- 2002-07-19 AT AT02745749T patent/ATE323677T1/de not_active IP Right Cessation
- 2002-07-19 BR BR0211670-7A patent/BR0211670A/pt not_active IP Right Cessation
- 2002-07-19 KR KR10-2004-7001513A patent/KR20040019097A/ko not_active Application Discontinuation
- 2002-07-19 US US10/199,755 patent/US7026479B2/en not_active Expired - Fee Related
- 2002-07-19 IL IL15899802A patent/IL158998A0/xx unknown
- 2002-07-19 CZ CZ2004151A patent/CZ2004151A3/cs unknown
- 2002-07-19 PL PL02368520A patent/PL368520A1/xx not_active Application Discontinuation
- 2002-07-19 EP EP02745749A patent/EP1412331B1/en not_active Expired - Lifetime
- 2002-07-19 HU HU0401573A patent/HUP0401573A3/hu unknown
- 2002-07-19 MX MXPA04000978A patent/MXPA04000978A/es active IP Right Grant
- 2002-07-19 CN CNA028143256A patent/CN1533378A/zh active Pending
- 2002-07-19 WO PCT/IB2002/002872 patent/WO2003011829A1/en active IP Right Grant
- 2002-07-23 DO DO2002000443A patent/DOP2002000443A/es unknown
- 2002-07-26 PE PE2002000678A patent/PE20030346A1/es not_active Application Discontinuation
- 2002-07-29 UY UY27399A patent/UY27399A1/es not_active Application Discontinuation
- 2002-07-29 EG EG2002070853A patent/EG23204A/xx active
- 2002-07-29 HN HN2002000197A patent/HN2002000197A/es unknown
- 2002-07-31 AR ARP020102914A patent/AR036204A1/es unknown
- 2002-08-01 AP APAP/P/2002/002602A patent/AP1299A/en active
-
2003
- 2003-11-20 ZA ZA200309043A patent/ZA200309043B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2004151A3 (cs) | 2005-01-12 |
| HN2002000197A (es) | 2003-02-27 |
| ES2260457T3 (es) | 2006-11-01 |
| DOP2002000443A (es) | 2003-02-15 |
| UY27399A1 (es) | 2003-02-28 |
| AP2002002602A0 (en) | 2002-09-30 |
| HUP0401573A3 (en) | 2005-06-28 |
| RU2261861C1 (ru) | 2005-10-10 |
| DE60210778D1 (de) | 2006-05-24 |
| PL368520A1 (en) | 2005-04-04 |
| ZA200309043B (en) | 2004-11-22 |
| IL158998A0 (en) | 2004-05-12 |
| GB0118752D0 (en) | 2001-09-26 |
| ATE323677T1 (de) | 2006-05-15 |
| EG23204A (en) | 2004-07-31 |
| US7026479B2 (en) | 2006-04-11 |
| AP1299A (en) | 2004-09-06 |
| WO2003011829A1 (en) | 2003-02-13 |
| DE60210778T2 (de) | 2007-01-04 |
| CA2451075A1 (en) | 2003-02-13 |
| BR0211670A (pt) | 2004-07-13 |
| RU2004102692A (ru) | 2005-07-10 |
| KR20040019097A (ko) | 2004-03-04 |
| PE20030346A1 (es) | 2003-04-05 |
| EP1412331A1 (en) | 2004-04-28 |
| JP2005501054A (ja) | 2005-01-13 |
| EP1412331B1 (en) | 2006-04-19 |
| CN1533378A (zh) | 2004-09-29 |
| US20030100753A1 (en) | 2003-05-29 |
| PA8550301A1 (es) | 2003-09-05 |
| AR036204A1 (es) | 2004-08-18 |
| HUP0401573A2 (hu) | 2005-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |