AR029870A1 - Proceso para la preparacion de amidas de octanoilo sustituido - Google Patents
Proceso para la preparacion de amidas de octanoilo sustituidoInfo
- Publication number
- AR029870A1 AR029870A1 ARP010103490A ARP010103490A AR029870A1 AR 029870 A1 AR029870 A1 AR 029870A1 AR P010103490 A ARP010103490 A AR P010103490A AR P010103490 A ARP010103490 A AR P010103490A AR 029870 A1 AR029870 A1 AR 029870A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- azide
- alkanoylamido
- alkanoyloxy
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 27
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001540 azides Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- -1 tetramethylene, pentamethylene Chemical group 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000007273 lactonization reaction Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Compuestos de la formula (1), donde R1 y R2 son, independientemente uno de otro, H, C1-6 alquilo C1-6 halogenalquilo, C1-6 alcoxi, C1-6 alcoxi-C1-6 alquilo o C1-6 alcoxi-C1-6 alquiloxi, R3 es C1-6 alquilo, R4 es C1-6 alquilo, y R5 es C1-6 alquilo, C1-6 hidroxialquilo, C1-6 alcoxi-C1-6 alquilo, C1-6 alcanoiloxi-C1-6 alquilo, C1-6 aminoalquilo, C1-6 alquilamino-C1-6-alquilo, C1-6-dialquilamino-C1-6-alquilo, C1-6 alcanoilamido-C1-6-alquilo, HO(O) C1-6-alquilo, C1-6 alquilo-O-(O) C-C1-6 alquilo, H2N-C (O)-C1-6 alquilo, C1-6 alquilo-HN-C (O)-C1-6 alquilo o (C1-6 alquilo)2 N-C (O)-C1-6-alquilo, R6 es hidrogeno, C1-20 alquilo o C3-12 cicloalquilo, C3-12 cicloalquilo-C1-6 alquilo, C6-10 arilo o C6-10-arilo-C1-6 alquilo, R9 es C1-6alquilo, R10 es C1-6 alquilo o C1-6 alcoxi, o R9 y R10 juntos son tetrametileno, pentametileno, 3 oxa-1,5-pentileno o -CH2CH2O- sustituido si fuera necesario con C1-4 alquilo, fenilo o benzilo, son simultáneamente halogenados en la posicion 5 e hidroxilados en la posicion 4 con lactonizacion, la halolactona reacciona con una amina para formar una carboxamida, el halogeno se reemplaza con azida, si fuera necesario después de la introduccion de un grupo de proteccion hidroxi, la azida resultante se convierte en una lactona, la lactona es amidada y luego la azida se convierte en un grupo amina con el fin de obtener compuestos de la formula (2) o una sal de los mismos, donde R5 es C1-6 alquilo, C1-6 hidroxialquilo, C1-6 alcoxi-C1-6 alquilo, C1-6 alcanoiloxi-C1-6 alquilo, C1-6 aminoalquilo, C1-6 alquilamino-C1-6 alquilo, C1-6-dialquilamino-C1-6-alquilo, C1-6 alcanoilamido-C1-6-alquilo, HO(O) C-C1-6-alquilo, C1-6 alquilo-O- (O) C-C1-6 alquilo, H2N-C (O)-C1-6 alquilo, C1-6 alquilo-HN-C(O)-C1-6 alquilo o (C1-6 alquilo)2N-C (O)-C1-6-alquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH14642000 | 2000-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029870A1 true AR029870A1 (es) | 2003-07-16 |
Family
ID=4565499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103490A AR029870A1 (es) | 2000-07-25 | 2001-07-20 | Proceso para la preparacion de amidas de octanoilo sustituido |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6800769B2 (es) |
| EP (1) | EP1303478B1 (es) |
| JP (1) | JP4853888B2 (es) |
| AR (1) | AR029870A1 (es) |
| AT (1) | ATE267800T1 (es) |
| AU (1) | AU2001273764A1 (es) |
| CA (1) | CA2412452C (es) |
| CY (1) | CY2007029I2 (es) |
| DE (2) | DE60103545T2 (es) |
| DK (1) | DK1303478T3 (es) |
| ES (1) | ES2220776T3 (es) |
| FR (1) | FR07C0070I2 (es) |
| NL (1) | NL300305I2 (es) |
| PT (1) | PT1303478E (es) |
| TR (1) | TR200401871T4 (es) |
| TW (1) | TWI222434B (es) |
| WO (1) | WO2002008172A1 (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154926A1 (en) * | 2002-06-11 | 2006-07-13 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
| ATE355263T1 (de) * | 2002-12-09 | 2006-03-15 | Asahi Glass Co Ltd | Verfahren zur herstellung von(4e)-5-chloro-2- isopropyl-4-pentensäureester und optischaktivem isomer davon |
| WO2006041062A1 (ja) * | 2004-10-15 | 2006-04-20 | Asahi Glass Company, Limited | （４ｅ）－５－クロロ－２－イソプロピル－４－ペンテン酸エステルおよびその光学活性体の製造方法 |
| TW200631929A (en) * | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
| ATE525367T1 (de) * | 2005-07-11 | 2011-10-15 | Novartis Ag | Neue pyrocatechinderivate |
| GB2431643A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431641A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431650A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431647A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431651A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431644A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431640A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431654A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431652A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| CA2631409C (en) * | 2005-12-16 | 2014-11-18 | Asahi Glass Company, Limited | Method for producing optically active (4e)-5-chloro-2-isopropyl-4-pentenoic acid or basic amino acid salt thereof |
| JP2009520753A (ja) * | 2005-12-23 | 2009-05-28 | ビーエーエスエフ ソシエタス・ヨーロピア | 純粋な形態のα−キラルクロロメチル化合物の製造方法 |
| DE102006017681A1 (de) * | 2006-04-12 | 2007-10-18 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Aryl-Octanoylderivaten |
| TW200837046A (en) * | 2006-11-08 | 2008-09-16 | Speedel Experimenta Ag | Process for preparing organic compounds |
| EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
| AR065792A1 (es) * | 2007-03-21 | 2009-07-01 | Speedel Experimenta Ag | Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| EA201190091A1 (ru) | 2009-02-05 | 2012-01-30 | Крка, Товарна Здравил, Д. Д., Ново Место | Активируемый влагой способ грануляции |
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| CN101774986B (zh) | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN102241650B (zh) * | 2010-05-14 | 2014-05-07 | 浙江九洲药业股份有限公司 | 用于制备阿立克仑的中间体化合物及相关制备方法 |
| WO2011148392A1 (en) * | 2010-05-28 | 2011-12-01 | Msn Laboratories Limited | Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof |
| IT1402925B1 (it) * | 2010-12-10 | 2013-09-27 | Chemo Iberica Sa | Processo per la produzione di aliskiren |
| TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
| WO2012034065A1 (en) * | 2010-09-09 | 2012-03-15 | Teva Pharmaceutical Industries Ltd. | Aliskiren intermediates and a process for analyzing the purity of aliskiren |
| PL2630118T3 (pl) | 2010-10-19 | 2015-04-30 | Mylan Laboratories Ltd | Synteza Aliskirenu |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| ITMI20111719A1 (it) * | 2011-09-23 | 2013-03-24 | Friulchem Spa | Sintesi totale di aliskiren con alta resa e purezza elevata per applicazione industriale |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| WO2013061224A1 (en) | 2011-10-25 | 2013-05-02 | Jubilant Life Sciences Limited | Process for the preparation of aliskiren |
| WO2013118138A1 (en) | 2011-12-13 | 2013-08-15 | Laboratories Ltd Mylan | Novel process for the preparation of renin inhibitors |
| US9090537B2 (en) | 2012-02-17 | 2015-07-28 | Mylan Laboratories Limited | Process for the preparation of aliskiren |
| WO2013124868A2 (en) | 2012-02-21 | 2013-08-29 | Mylan Laboratories Limited | Solid form of aliskiren intermediate |
| WO2013144979A1 (en) | 2012-03-28 | 2013-10-03 | Maylan Laboratories Ltd | Process for the preparation of aliskiren |
| WO2013171767A1 (en) | 2012-05-18 | 2013-11-21 | Mylan Laboratories Limited | An improved process for the preparation of aliskiren |
| CN103130677B (zh) * | 2013-03-12 | 2015-01-07 | 博瑞生物医药技术(苏州)有限公司 | 一种阿利克仑的制备方法 |
| CN103351300A (zh) * | 2013-06-30 | 2013-10-16 | 北京万全德众医药生物技术有限公司 | 一种制备阿利克仑中间体侧链（s）-2-溴代异戊酸甲酯的方法 |
| CN103896794B (zh) * | 2014-04-23 | 2015-10-07 | 中国科学院长春应用化学研究所 | 阿利克仑中间体以及阿利克仑的制备方法 |
| CN105294478B (zh) * | 2014-07-01 | 2017-06-13 | 华润双鹤药业股份有限公司 | 阿利吉仑的一种非对映异构体、其制备方法及用途 |
| CN113387828A (zh) * | 2020-03-14 | 2021-09-14 | 江巨东 | 一种阿利克仑中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5659065A (en) * | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
-
2001
- 2001-06-26 US US10/333,847 patent/US6800769B2/en not_active Expired - Fee Related
- 2001-06-26 AU AU2001273764A patent/AU2001273764A1/en not_active Abandoned
- 2001-06-26 CA CA002412452A patent/CA2412452C/en not_active Expired - Lifetime
- 2001-06-26 PT PT01940048T patent/PT1303478E/pt unknown
- 2001-06-26 ES ES01940048T patent/ES2220776T3/es not_active Expired - Lifetime
- 2001-06-26 AT AT01940048T patent/ATE267800T1/de active
- 2001-06-26 DE DE60103545T patent/DE60103545T2/de not_active Expired - Lifetime
- 2001-06-26 EP EP01940048A patent/EP1303478B1/en not_active Expired - Lifetime
- 2001-06-26 TR TR2004/01871T patent/TR200401871T4/xx unknown
- 2001-06-26 DE DE122007000077C patent/DE122007000077I2/de active Active
- 2001-06-26 WO PCT/CH2001/000400 patent/WO2002008172A1/en active IP Right Grant
- 2001-06-26 DK DK01940048T patent/DK1303478T3/da active
- 2001-06-26 JP JP2002514081A patent/JP4853888B2/ja not_active Expired - Fee Related
- 2001-06-28 TW TW090115738A patent/TWI222434B/zh not_active IP Right Cessation
- 2001-07-20 AR ARP010103490A patent/AR029870A1/es active IP Right Grant
-
2007
- 2007-11-13 NL NL300305C patent/NL300305I2/nl unknown
- 2007-12-04 CY CY200700029C patent/CY2007029I2/el unknown
- 2007-12-17 FR FR07C0070C patent/FR07C0070I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2412452A1 (en) | 2002-01-31 |
| DK1303478T3 (da) | 2004-08-30 |
| DE122007000077I1 (de) | 2008-02-14 |
| NL300305I1 (nl) | 2008-01-02 |
| AU2001273764A1 (en) | 2002-02-05 |
| CY2007029I1 (el) | 2009-11-04 |
| TWI222434B (en) | 2004-10-21 |
| DE122007000077I2 (de) | 2008-08-21 |
| FR07C0070I2 (es) | 2009-01-15 |
| FR07C0070I1 (es) | 2008-01-02 |
| US6800769B2 (en) | 2004-10-05 |
| ATE267800T1 (de) | 2004-06-15 |
| DE60103545T2 (de) | 2005-08-25 |
| WO2002008172A1 (en) | 2002-01-31 |
| JP4853888B2 (ja) | 2012-01-11 |
| ES2220776T3 (es) | 2004-12-16 |
| CY2007029I2 (el) | 2009-11-04 |
| CA2412452C (en) | 2008-12-30 |
| TR200401871T4 (tr) | 2004-08-23 |
| PT1303478E (pt) | 2004-10-29 |
| DE60103545D1 (de) | 2004-07-01 |
| US20030181765A1 (en) | 2003-09-25 |
| JP2004504373A (ja) | 2004-02-12 |
| NL300305I2 (nl) | 2008-02-01 |
| EP1303478A1 (en) | 2003-04-23 |
| EP1303478B1 (en) | 2004-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |