MX9708422A - Esteres de carbapenemas. - Google Patents

Esteres de carbapenemas.

Info

Publication number
MX9708422A
MX9708422A MX9708422A MX9708422A MX9708422A MX 9708422 A MX9708422 A MX 9708422A MX 9708422 A MX9708422 A MX 9708422A MX 9708422 A MX9708422 A MX 9708422A MX 9708422 A MX9708422 A MX 9708422A
Authority
MX
Mexico
Prior art keywords
alkyl
hydrogen
group
optionally substituted
formula
Prior art date
Application number
MX9708422A
Other languages
English (en)
Other versions
MXPA97008422A (es
Inventor
George Burton
Stephen Christopher Marti Fell
Stephen Frederick Moss
Alfred John Eglington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508959.5A external-priority patent/GB9508959D0/en
Priority claimed from GBGB9508960.3A external-priority patent/GB9508960D0/en
Priority claimed from GBGB9508964.5A external-priority patent/GB9508964D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MXPA97008422A publication Critical patent/MXPA97008422A/es
Publication of MX9708422A publication Critical patent/MX9708422A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de la formula general (I), en donde R es (a), en donde Ra es hidrogeno, alquilo (de 1 a 6 átomos de carbono) opcionalmente sustituido, o arilo opcionalmente sustituido, R beta es hidrogeno, alquilo (de 1 a 6 átomos de carbono) opcionalmente sustituido, o arilo opcionalmente sustituido; o R alfa y R beta forman juntos un anillo heterocíclico de 5 o 6 miembros opcionalmente con o sin heteroátomos adicionales, R1 es qluilo (de 1 a 6 átomos de carbono ) que está insustituido o sustituido por fluor, un grupo hidroxi que está opcionalmente protegido por un grupo protector de hidroxi fácilmente removible; o por un grupo amino que está opcionalmente protegido por un grupo protector de amino fácilmente removible, R2 es hidrogeno o metilo, y R3 se selecciona a partir del grupo que consiste en (a) un grupo de la formula (i), en donde R1 es hidrogeno o alquilo (de 1 a 6 átomos de carbono), R2 es hidrogeno, alquilo (de 1 a 6 átomos de carbono) opcionalmente sustituido por halogeno, alquenilo (de 1 a 6 átomos de carbono), alcoxi (de 1 a 6 átomos de carbono)-carbonilo, arilo, o heteroarilo, R3 es hidrogeno, alquilo (de 1 a 6 átomos de carbono), o alcoxi (de 1 a 6 átomos de carbono)-carbonilo, y R4 es un grupo formador de éster farmacéuticamente aceptable, y (b) un grupo de la formula CH(R3)O.CO.Rb, en donde R3 es hidrogeno, alquilo (de 1 a 6 átomos de carbono), cicloaqluilo (de 3 a 7 átomos de carbono), metilo, o fenilo; y Rb es alquilo (de 1 a 6 átomos de Carbono)-cicloalquiloxi (de 3 a 7 átomos de carbono); o alcoxi (de 1 a 6 átomos de carbono-alquilo (de 1 a 6 átomos de carbono; es util en el tratamiento de infecciones bacterianas.
MX9708422A 1995-05-03 1996-05-02 Esteres de carbapenemas. MX9708422A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9508959.5 1995-05-03
GB9508960.3 1995-05-03
GBGB9508959.5A GB9508959D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508960.3A GB9508960D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508964.5A GB9508964D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508964.5 1995-05-03
PCT/EP1996/001882 WO1996034869A1 (en) 1995-05-03 1996-05-02 Esters of carbapenems

Publications (2)

Publication Number Publication Date
MXPA97008422A MXPA97008422A (es) 1998-02-01
MX9708422A true MX9708422A (es) 1998-02-28

Family

ID=27267697

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708422A MX9708422A (es) 1995-05-03 1996-05-02 Esteres de carbapenemas.

Country Status (14)

Country Link
EP (1) EP0823911A1 (es)
JP (1) JPH11504912A (es)
KR (1) KR19990008354A (es)
CN (1) CN1184480A (es)
AU (1) AU5814196A (es)
BR (1) BR9608318A (es)
CA (1) CA2217885A1 (es)
CZ (1) CZ347697A3 (es)
HU (1) HUP9801061A3 (es)
MX (1) MX9708422A (es)
NO (1) NO974995D0 (es)
PL (1) PL323148A1 (es)
TR (1) TR199701289T2 (es)
WO (1) WO1996034869A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100771019B1 (ko) * 2002-03-20 2007-10-29 주식회사 만도 브레이크 액압제어장치
GB0400329D0 (en) * 2004-01-08 2004-02-11 Glaxo Group Ltd Novel processes
GB0400405D0 (en) * 2004-01-09 2004-02-11 Glaxo Group Ltd Novel processes
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
GB8809534D0 (en) * 1988-04-22 1988-05-25 Beecham Group Plc Novel compounds
WO1995011905A1 (en) * 1993-10-29 1995-05-04 Smithkline Beecham Plc 2-(pyrazol-3-yl)carbapenem derivatives

Also Published As

Publication number Publication date
HUP9801061A3 (en) 1999-01-28
TR199701289T2 (xx) 1998-08-21
CN1184480A (zh) 1998-06-10
BR9608318A (pt) 1999-01-26
NO974995L (no) 1997-10-30
WO1996034869A1 (en) 1996-11-07
NO974995D0 (no) 1997-10-30
PL323148A1 (en) 1998-03-16
KR19990008354A (ko) 1999-01-25
AU5814196A (en) 1996-11-21
JPH11504912A (ja) 1999-05-11
CZ347697A3 (cs) 1998-06-17
EP0823911A1 (en) 1998-02-18
HUP9801061A2 (hu) 1998-08-28
CA2217885A1 (en) 1996-11-07

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