DE69131774T2 - Antibakterielle penem-ester derivate - Google Patents

Antibakterielle penem-ester derivate

Info

Publication number
DE69131774T2
DE69131774T2 DE69131774T DE69131774T DE69131774T2 DE 69131774 T2 DE69131774 T2 DE 69131774T2 DE 69131774 T DE69131774 T DE 69131774T DE 69131774 T DE69131774 T DE 69131774T DE 69131774 T2 DE69131774 T2 DE 69131774T2
Authority
DE
Germany
Prior art keywords
pct
ester derivatives
group
sec
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131774T
Other languages
English (en)
Other versions
DE69131774D1 (de
Inventor
Hiromitsu Iwata
Takashi Nakatsuka
Rie Tanaka
Masaji Ishiguro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daichi Suntory Pharma Co Ltd Tokio/tokyo Jp
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of DE69131774D1 publication Critical patent/DE69131774D1/de
Application granted granted Critical
Publication of DE69131774T2 publication Critical patent/DE69131774T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pens And Brushes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE69131774T 1990-08-20 1991-08-16 Antibakterielle penem-ester derivate Expired - Fee Related DE69131774T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21854390 1990-08-20
PCT/JP1991/001100 WO1992003444A1 (en) 1990-08-20 1991-08-16 Penem compounds

Publications (2)

Publication Number Publication Date
DE69131774D1 DE69131774D1 (de) 1999-12-16
DE69131774T2 true DE69131774T2 (de) 2000-06-21

Family

ID=16721580

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131774T Expired - Fee Related DE69131774T2 (de) 1990-08-20 1991-08-16 Antibakterielle penem-ester derivate

Country Status (12)

Country Link
US (1) US5703068A (de)
EP (1) EP0544906B1 (de)
JP (1) JP3148236B2 (de)
KR (1) KR0178957B1 (de)
AT (1) ATE186537T1 (de)
AU (1) AU8333991A (de)
CA (1) CA2089366C (de)
DE (1) DE69131774T2 (de)
ES (1) ES2140393T3 (de)
IE (1) IE912909A1 (de)
IL (2) IL99244A0 (de)
WO (1) WO1992003444A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
WO2004031196A1 (ja) * 2002-10-02 2004-04-15 Nippon Soda Co., Ltd. 有機化合物の製造方法
CA2528065A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
PE20080940A1 (es) 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
JP2011504495A (ja) * 2007-11-23 2011-02-10 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド ２−アリールメチルアゼチジン−カルバペネム−３−カルボン酸エステル誘導体またはその塩、その製造方法及びそれを含む医薬組成物
US20190100534A1 (en) * 2017-10-04 2019-04-04 Gladius Pharmaceuticals, Inc. Cephem Compounds with Latent Reactive Groups

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0252885A1 (de) * 1986-07-10 1988-01-13 Ciba-Geigy Ag Bicyclische Thiaazaverbindungen
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
EP0275002A1 (de) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Verfahren zur Herstellung von 7-Oxo-4-thia-1-aza-bicyclo[3.2.0]-hept-2-en-Derivaten
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IL99244A (en) 1996-11-14
KR930701454A (ko) 1993-06-11
WO1992003444A1 (en) 1992-03-05
JPH06503805A (ja) 1994-04-28
EP0544906A1 (de) 1993-06-09
ATE186537T1 (de) 1999-11-15
DE69131774D1 (de) 1999-12-16
IE912909A1 (en) 1992-02-26
US5703068A (en) 1997-12-30
ES2140393T3 (es) 2000-03-01
KR0178957B1 (ko) 1999-03-20
EP0544906B1 (de) 1999-11-10
CA2089366A1 (en) 1992-02-21
JP3148236B2 (ja) 2001-03-19
IL99244A0 (en) 1992-07-15
CA2089366C (en) 2001-10-16
AU8333991A (en) 1992-03-17

Similar Documents

Publication Publication Date Title
BR1100412A (pt) Composto; método para propiciar tratamento imunomodulador; e composição farmacêutica para tratamento imunomodulador
DK0639186T3 (da) Taxolderivater
FI921451A0 (fi) Ny linker foer bioaktiva medel.
YU68792A (sh) Postupak za dobivanje derivata bakatina iii i 10-dezacetil-bakatina iii
AU2736088A (en) Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
ES8200011A1 (es) Procedimiento de preparacion de una composicion farmaceuticaen particular psicotropa.
HUP0100184A2 (hu) Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
GB9314758D0 (en) Heterocyclic derivatives
EP1468692A3 (de) Verwendung von 2,6-Dialkyl-4-Silyl-Phenol Derivaten zur Behandlung von Xanthom
NO307883B1 (no) Antibakterielle pyridonkarboksylsyrederivater
FI941836A0 (fi) 3-deoksioligosakkaridit, menetelmiä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
ATE186537T1 (de) Antibakterielle penem-ester derivate
CA2089368A1 (en) Antibacterial penem esters derivatives
RU93005114A (ru) Пенемовые соединения и фармацевтическая композиция на их основе
ES8201539A1 (es) Procedimiento de preparacion de nuevas ortoarilideneaminofe-netilaminas y de sus sales de adicion con acidos farmacolo- gicamente compatibles
MX9708422A (es) Esteres de carbapenemas.
IL106564A (en) Tetrahydronaphthalene derivatives their preparation and pharmaceutical compositions containing them
DE69217148T2 (de) Isoxazole derivate als lichtschutzmittel
FI914138A (fi) Laekemedel, vilka innehaoller substituerade 2-cyklohexenderivat och deras anvaendning vid vaord av sjukdomar.
IL102702A (en) OPTICALLY ACTIVE g-HALO- 2-AMINOALKANECARBOXYLIC ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE PREPARATION OF OPTICALLY ACTIVE PHOSPHORUS-CONTAINING a-AMINO ACIDS
ES2184311T3 (es) Polioxaalcanocarboxilatos de estaño y composiciones que los contienen.
KR950000638A (ko) 3, 4-디히드록시칼콘 유도체

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAICHI SUNTORY PHARMA CO., LTD., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee