KR930701454A - 페넴 화합물 - Google Patents

페넴 화합물

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Publication number
KR930701454A
KR930701454A KR1019930700428A KR930700428A KR930701454A KR 930701454 A KR930701454 A KR 930701454A KR 1019930700428 A KR1019930700428 A KR 1019930700428A KR 930700428 A KR930700428 A KR 930700428A KR 930701454 A KR930701454 A KR 930701454A
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KR
South Korea
Prior art keywords
group
aryl
compound according
aralkyl
alkyl group
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KR1019930700428A
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English (en)
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KR0178957B1 (ko
Inventor
히로미츠 이와타
다카시 나카츠카
리에 다나카
마사지 이시구로
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도리이 신이치로
산토리 가부시키가이샤
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Publication of KR930701454A publication Critical patent/KR930701454A/ko
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Publication of KR0178957B1 publication Critical patent/KR0178957B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

항균성 페넴화합물은 다음 일반식으로 표시된다.
상기 식에서, R은 다음 일반식의 기또는
식중, R1은 C1-C6의 직쇄 또는 분지쇄의 알킬기를 나타내고, R2는 치환 또는 비치환 알킬기, 아릴기 또는 아르알킬기를 나타내고, n은 1또는 2의 정수를 의미하며, R3은 치환 또는 비치환 알킬기, 아릴기 또는 아르알킬기를 나타낸다. 또한 경구투여용 항균 조성물이 개시되어 있다.

Description

페넴 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (23)

  1. 하기 일반식(Ⅰ)로 표시되는 페넴화합물
  3. 상기 식에서, R은 다음 일반식(Ⅱ), 또는 (Ⅲ)를 나타낸다; 즉,
  5. 식중, R1은 C1-C6의 직쇄 또는 분지쇄의 알킬기를 나타내고, R2는 C1-C6알킬기, C6-C10아릴기 또는 C7-C11아르알킬기를 나타내고, 각각의 기는 다시 C1-C6알킬기, C1-C10아릴기, C7-C11아르알킬기, 하이드록시기, C1-C6알콕시기 및 / 또는 할로겐 원자로 치환되어 있어도 좋고, n은 1 또는 2의 정수를 의미한다;
  7. 식중, R2은 C1-C6의 알킬기를 나타내고, C6-C10아릴기 또는 C7-C11아르알킬기를 나타내고, 각각의 기는 다시 C1-C6알킬기, C6-C10아릴기, C7-C11아르알킬기, 하이드록시기, C1-C6알콕시기 및 / 또는 할로겐 원자로 치환되어 있어도 좋다.
  8. 제1항에 있어서, R이 아세틸옥시메틸기인 화합물.
  9. 제1항에 있어서, R이 1-(아세틸옥시) 에틸기인 화합물.
  10. 제1항에 있어서, R이 피바로일옥시메틸기인 화합물.
  11. 제1항에 있어서, R이 1-(데톡시카르보닐옥시) 에틸기인 화합물.
  12. 제1항에 있어서, R이 1-(이소프로필옥시카르보닐옥시)에틸기인 화합물.
  13. 제1항에 있어서, R이 1-(싸이클로헥실옥시카르보닐옥시)에틸기인 화합물.
  14. 제1항에 있어서, R이 3-프탈리딜기인 화합물.
  15. 제1항에 있어서, R이 (5-메틸-2-옥소-1,3-디옥소렌-4-일)메틸기인 화합물.
  16. 하기 일반식(Ⅰ) 화합물의 유효량과 약학적으로 허용되는 담체를 함유하는 경구 투여용 항균제 조성물.
  18. 상기 식에서, R은 다음 일반식(Ⅱ), 또는 (Ⅲ)를 나타낸다; 즉,
  20. 식중, R1은 C1-C6의 직쇄 또는 분지쇄의 알킬기를 나타내고, R2는 C1-C6알킬기, C6-C10아릴기 또는 C7-C11아르알킬기를 나타내고, 각각의 기는 다시 C1-C6알킬기, C6-C10아릴기, C7-C11아르알킬기, 하이드록시기, C1-C6알콕시기 및 / 또는 할로겐 원자로 치환되어 있어도 좋고, n은 1 또는 2의 정수를 의미한다;
  22. 식중, R3은 C1-C6의 알킬기를 나타내고, C6-C10아릴기 또는 C7-C11아르알킬기를 나타내고, 각각의 기는 다시 C1-C6알킬기, C6-C10아릴기, C7-C11아르알킬기, 하이드록시기, C1-C6알콕시기 및 / 또는 할로겐 원자로 치환되어 있어도 좋다.
  23. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930700428A 1990-08-20 1991-08-16 페넴 화합물 KR0178957B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-218543 1990-08-20
JP21854390 1990-08-20
PCT/JP1991/001100 WO1992003444A1 (en) 1990-08-20 1991-08-16 Penem compounds

Publications (2)

Publication Number Publication Date
KR930701454A true KR930701454A (ko) 1993-06-11
KR0178957B1 KR0178957B1 (ko) 1999-03-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700428A KR0178957B1 (ko) 1990-08-20 1991-08-16 페넴 화합물

Country Status (12)

Country Link
US (1) US5703068A (ko)
EP (1) EP0544906B1 (ko)
JP (1) JP3148236B2 (ko)
KR (1) KR0178957B1 (ko)
AT (1) ATE186537T1 (ko)
AU (1) AU8333991A (ko)
CA (1) CA2089366C (ko)
DE (1) DE69131774T2 (ko)
ES (1) ES2140393T3 (ko)
IE (1) IE912909A1 (ko)
IL (2) IL99244A0 (ko)
WO (1) WO1992003444A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
AU2003268738A1 (en) * 2002-10-02 2004-04-23 Daiichi Suntory Pharma Co., Ltd. Processes for preparation of organic compounds
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
CN101868460A (zh) * 2007-11-23 2010-10-20 国际药品工业株式会社 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物
TW201922755A (zh) * 2017-10-04 2019-06-16 加拿大商格萊迪厄斯製藥有限公司 具有潛在反應性基團的頭孢烯化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0252885A1 (de) * 1986-07-10 1988-01-13 Ciba-Geigy Ag Bicyclische Thiaazaverbindungen
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
EP0275002A1 (en) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Process for the production of 7-oxo-4-thia-1-aza-bicyclo [3.2.0] hept-2-ene derivatives
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES2140393T3 (es) 2000-03-01
CA2089366A1 (en) 1992-02-21
DE69131774D1 (de) 1999-12-16
EP0544906A1 (en) 1993-06-09
KR0178957B1 (ko) 1999-03-20
EP0544906B1 (en) 1999-11-10
IE912909A1 (en) 1992-02-26
WO1992003444A1 (en) 1992-03-05
IL99244A (en) 1996-11-14
DE69131774T2 (de) 2000-06-21
ATE186537T1 (de) 1999-11-15
US5703068A (en) 1997-12-30
IL99244A0 (en) 1992-07-15
JPH06503805A (ja) 1994-04-28
AU8333991A (en) 1992-03-17
CA2089366C (en) 2001-10-16
JP3148236B2 (ja) 2001-03-19

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